We support boolean queries, use +,-,<,>,~,* to alter the weighting of terms
Software package for visualization of functional enrichment results as network graphs.
Core provides guidance in planning and helps with executing gene expression modulation experiments. Currently uses technology based on shRNA for gene knock-down and cDNA libraries for overexpression studies. Core is equipped with genome-wide retroviral shRNA libraries for both human and mouse genomes, Mammalian Gene Collection (MGC) cDNA library, as well as smaller focused sets targeting selected gene families.
Mouse Behavior Core provides equipment and software for measuring mouse behavior. The MBC can support mouse phenotyping/drug discovery test batteries as well as more focused behavioral projects.
PanoScore is a commercial-grade pathology image analysis platform for quantitative tissue segmentation, AI-powered cell phenotyping, and spatial biology research. It supports whole-slide imaging (WSI), multiplex staining analysis (H&E/IHC/IF), and tissue microarray (TMA) processing, enabling reproducible quantification of tumor microenvironments, cell proximity metrics, and biomarker expression.
Weill Cornell Medicine, originally Cornell University Medical College, is the medical school of Cornell University, located on the Upper East Side of Manhattan in New York City.
Facility serves as central facility for human organoid technology to accelerate organoid-based scientific discovery. Provides human pluripotent stem cell (hPSC) derived as well as tissue derived cells and organoids.
Software Python package for construction of Slepian wavelets in the spherical and manifold (via meshes) settings. Slepian scale-discretised wavelets in Python.
Standalone software and web-based platform for predicting top lncRNA–disease associations using advanced biological feature processing and machine learning. Given input lncRNA or disease, along with associated sequences or target data, PrediLnc uses our custom model GARNet (Graph convolution Attention RNA Network) to return the most relevant predictions.Used for hypothesis generation in biomedical research. LncRNA diseases association predictor.
Arcadia organisms selection portal. Uses data to suggest model organisms based on relevance to human gene of interest or suggest monogenic diseases to model based on organism of interest.
Institutional laboratory of Nuclear Magnetic Resonance (NMR) of the Institute of Chemistry of UNICAMP.The Institutional Nuclear Magnetic Resonance Laboratory has 6 NMR spectrometers, two for solids and four for solution probes, with the possibility of analyzing different nuclei.
Software R package for Affymetrix Human Genome U133 Plus 2.0 Array annotation data.
Cytokine Multiplex Assay Kits allow researchers to simultaneously detect the levels of multiple cytokines in a single sample. This is particularly useful for identifying the wide array of changes that can be associated with different pathological conditions.
This instrument is precision liquid handling instrument that enables non-contact, nanoliter-to-microliter scale dispensing of small molecules, biologics, or other reagents directly into assay plates for high-throughput drug screening and dose-response studies.
Arrayer produces high quality microarrays of DNA, proteins, cell lysates and variety of other samples using its proprietary soft touch deposition technology.
Core features several high- and low-resolution mass spectrometers, coupled with liquid and gas chromatographs, as well as an ICP-MS. In addition, we have liquid chromatographs available that operate with other types of detectors. The laboratory collaborates with activities carried out at the Institute of Chemistry, in external academic sectors, and also within private enterprise.
High-speed, high-resolution light sheet microscope designed for imaging large, cleared tissue samples. Utilizes patented axially-swept light sheet technology to achieve uniform axial resolution across the entire sample, enabling rapid volumetric imaging. System is particularly well-suited for imaging cleared tissues, including whole organs and even entire juvenile mice, with options for both aqueous and organic clearing methods. Light sheet imaging for rapid volumetric acquisition of intact samples.
Light sheet fluorescence microscope designed for high-resolution, three-dimensional imaging of large, cleared, and fluorescently labeled biological samples. It excels at visualizing entire biological systems like organs, embryos, or even small animals with cellular resolution, making it suitable for studying complex biological structures and processes.
Facility provides access to imaging equipment and analysis tools. It houses widefield, laser scanning confocal, spinning disk confocal, multi-photon, light-sheet, and super-resolution microscopes, along with two transmission electron microscopes and high-content screener. Offers centralized workstation for image processing, high-performance computing capabilities, and data storage. Provides access to several commercial software programs for image analysis and data quantification. Services include consultations for sample preparation, training on the microscopes, full imaging support, and assistance with analysis strategies. Provides several services related to transmission electron microscopy: tissue/cell processing, image acquisition training or assistance, and image analysis support. CoRE scientists can collaborate with investigators to develop novel imaging methods and analysis approaches.