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Automation, synthetic biology and protein production facility. As founder member of Global Biofoundry Alliance we are part of UK government initiative to strengthen engineering biology capabilities in the country and beyond. GeneMill offers high-throughout, automated gene cloning, sequence diversity generation and phenotyping. Our portfolio also includes a full protein production service.
Software genome annotation lift-over tool capable of mapping genes between two assemblies of the same or closely related species. Aligns genes from reference genome to target genome and finds the mapping that maximizes sequence identity while preserving the structure of each exon, transcript and gene. Used for accurate mapping of gene annotations.
Database and respository for NMR data associated with natural products and specialized metabolites.
Software package for finding the location of m6A sites in MeRIP-seq data.
Software R library of utilities for performing analyses on TCGA and GTEx data using the Network Zoo. Streamlines routine steps in TCGA data processing, including filtering and mapping gene and sample identifiers between modalities and allows modality-specific data transformation, such as normalization and cleaning.
Repository of integrated data and knowledge about adaptive immune receptors, the complex genomic loci encoding AIRs, and the antigens and epitopes bound by AIR.
Cost-effective, compact foot-print, and open-source Raspberry Pi-based widefield imaging system. Used for close-proximity dual-brain cortical mesoscale functional-imaging to simultaneously observe activity in two head-fixed animals in staged social touch-like interaction. We provide all schematics, code, and protocols for a rail system where head-fixed mice are brought together to a distance where the macrovibrissae of each mouse make contact.
Oven used to control the temperature of the column in a liquid chromatography LC system.CTO-40S Slim Line column oven is ideal for saving space while maintaining excellent thermal stability.
High-performance liquid chromatography HPLC pump that s used for separation, sensitivity, and resolution. It s part of the Nexera series of HPLC and UHPLC systems from Shimadzu.
Triple Quadrupole Mass Spectrometer is liquid chromatograph mass spectrometer (LCMS) for fast, accurate detection, to quantify components of sample or to analyze their structure with increased specificity and sensitivity.
Ion trap mass spectrometer with electron transfer dissociation capabilities. Sets analytical standard for proteomics and small molecule applications.
Bruker MALDI-TOF mass spectrometry system. Enables time critical applications and faster decision making processes.
Hybrid Q-TOF mass spectrometer with integrated ion mobility.
4-in-1 digital hybrid microscope, combining four microscopes into one. ECHO Revolve is a hybrid microscope that can be used for viewing glass slides and live samples in fluidic chambers. It can be used for upright or inverted observation methods.
Multimode microplate reader with monochromator optics. Offers free wavelength selection and scanning capabilities. Used for all standard absorbance, fluorescence and luminescence assays.
Leica Bond III automated IHC – ISH stainer to processes up to 30 simultaneous slides in under 2.5 hours. Used for immunohistochemistry for in situ hybridization slides staining.
High-resolution digital slide scanner designed for wide-field imaging of tissue samples. It captures high-quality digital images of microscope slides at up to 40x optical magnification. NanoZoomer XR scanner is capable of capturing images with a maximum resolution of 0.23 microns per pixel.
Core offers imaging and analysis of intact biofilms to capture with ultimate precision the position, interactions, activity, and identification of microbes in real-time from intact samples. With our broad range of analytical capabilities, we can determine how microbes are interacting and altering their environmental conditions. We provide one-on-one training, method development, proposal writing, troubleshooting and data analysis services to help you meet your biofilm-related analytical and imaging needs.
Core provides access to XFe 96 Extracellular Flux Analyzer, seahorse technology, as well as additional services that include technical advice in experimental design, data analysis and basic training. Provides access to electrochemiluminescence immunoassays using MESO QuickPlex SQ 120. You can perform multiplex biomarker and cytokine assays, test for immunogenicity or toxicity, or we can help you develop your own unique assays. Core also provides access to ImageXpress Pico, the next generation of digital microscopy and access to SPECTRAMAX I3X, multi-mode microplate reader.
Core Facility houses 600 MHz Bruker Avance Neo NMR spectrometer available for both collaborative and fee-for-service use. The facility is equipped with a 14.1 T Bruker system and a nitrogen-cooled Prodigy probe, enabling a range of 3D experiments on isotopically labeled biomolecules with enhanced sensitivity for challenging samples. Services include biomolecular structure determination, characterization of biomolecular motions, and stable isotope-resolved metabolomics for studying metabolic pathways.