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Software tool for RNAi-target design and off-target prediction. Used for long double-stranded RNAi-target design and off-target prediction.
Software tools to find circRNAs in RNA-seq data. Used to detect head-to-tail spliced (back-spliced) sequencing reads, indicative of circular RNA (circRNA) in RNA-seq data.
Software tool for utilizing sequence intrinsic composition to classify protein-coding and long non-coding transcripts.
Software suite to search and cluster huge protein and nucleotide sequence sets. Sensitive protein sequence searching for analysis of massive data sets. Used for ultra fast and sensitive search and clustering.
Web application to automate germline genomic variant curation from clinical sequencing based on ACMG guidelines. Aggregates multiple tracks of genomic, protein and disease specific information from public sources.
Time-of-Flight mass spectrometer for high-speed acquisition of highly multi-parametric single cell data. Simultaneously resolves multiple parameters with minimal signal overlap, providing insights into the functional and phenotypic complexity of biological systems at the single-cell level. Analyzes cells labeled with panel of reagents conjugated to stable metal isotopes using time-of-flight mass cytometry technology. Includes over 120 detection channels and 35 Maxpar metal probes.
CyTOF instrument uses atomic mass spectrometry to allow simple, independent detection of up to 33 metal labeled antibodies (and two DNA intercalators) based on currently available reagents. Has capacity to measure 100 independent signals. CyTOF system is inorganic mass spectrometer specifically built for biologists and single cell applications. Inductively coupled plasma mass spectrometer used extensively by analytical chemists and is proven in the quantification of elements and stable isotopes in variety of complex matrices.
Web interface to easily import, visualize, and analyze brain signals. Used for analysis of longitudinal neural recording data.
Core provides broad range of spatial transcriptomic and targeted proteomics services including: Conventional nCounter analysis to determine RNA abundance, GeoMx Digital Spatial Profiling platform to determine protein and RNA abundance, CosMx Spatial Molecular Imaging platform for single cell spatial analysis of RNA and protein.
Software tool as data-driven network modeling algorithm for drug response analysis in cancer.
Data Science Platform focuses on Artificial Intelligence, Signal Processing, Computer Vision with the aim of advancing the research of Rockefeller Laboratories. DSP owns and operates fully dedicated computing infrastructure, equipped with state of the art GPUs and large storage capabilities.
Mass spectrometer used for research, particularly in proteomics and metabolomics, leveraging Trapped Ion Mobility Spectrometry (TIMS) and Parallel Accumulation Serial Fragmentation (PASEF) technologies for enhanced 4D-omics capabilities.
Mass spectrometry (MS)-based proteomics instrument designed for shotgun proteomics and phosphoproteomics, leveraging Parallel Accumulation Serial Fragmentation (PASEF) technology to enhance speed, sensitivity, and resolution.
Mass spectrometer is equipped with the 4th generation high capacity TIMS-XR analyzer and advanced digitizer technology (ADT). Offers higher dynamic range for unmatched analytical depth and quantitation in high-throughput proteomics experiments.
The timsTOF SCP (single-cell proteomics) is mass spectrometer from Bruker. Ultra-high sensitivity instrument for quantitative single cell biology research with unbiased, deep single-cell 4D-Proteomics, immunopeptidomics, epiproteomics and PTM analysis. It features an additional separation in the tims cell where ions get separated according to their ion mobility, leading to collision cross-section values.Allows the analysis of hundreds of samples with minimal sample load (<200 ng) at sequencing speeds exceeding 100 Hz.
Spectrometer timsTOF Ultra 2 is paired with CaptiveSpray Ultra 2 ion source for high sensitivity to work with challenging samples and detect low-abundance peptides. Used to analyze even the smallest amounts and uncover previously unseen peptides.
Mass spectrometer used for proteomics research. Offers the ultimate fusion of trapped ion mobility spectrometry (TIMS) with quadrupole time-of-flight (QTOF) technology.
Tissue homogenizer for 24 samples in microcentrifuge tubes with very powerful motor. Cooling with dry ice or liquid nitrogen to maintain 4°C sample temperature. Includes starter kit of beads, scoop and tubes. CE certified.
Confocal microscope provides enables collection of more data over wide area and down to deep regions in tissues. Its high sensitivity and high-speed scanning reduce phototoxicity to specimen and minimize damage. Equipped with image acquisition/analysis functions utilizing Artificial Intelligence (AI), the AX/AX R can efficiently acquire highly reliable data. Nikon Spatial Array Confocal (NSPARC) detector utilizes detector array to collect two-dimensional image at each scanned point. It adds additional potential to imaging by providing new level of ultra-low noise sensitive spatial detection, enabling improved lateral resolution of 1 airy unit/~230 nm and improved signal-to-noise ratio.
Facility offers NMR technologies to determine content and purity of sample as well as its molecular structure, interactions and chemometrics of biological mixtures.