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Platform for health data sharing and analytics that emphasizes patient privacy and security, provides transparent and speedy access, and simplifies data discovery and analysis. Houses datasets for applied AI learning and research. Repository of freely-available medical research data, managed by the University of Toronto Temerty Centre for AI Research and Education in Medicine.
Software package as set of tools, primarily shell scripts, for processing multi-modal, high-quality MRI images for the Human Connectome Project. Minimal preprocessing pipelines for structural, functional, and diffusion MRI that were developed by the HCP to accomplish many low level tasks, including spatial artifact/distortion removal, surface generation, cross-modal registration, and alignment to standard space.
Web application tool as interactive website for SEER cancer statistics.
Core is multi-user facility located on the 4th floor in the Translational Research Building (TRB) at A4-110. It houses microscopes and image data analysis computers to provide imaging for wide range of samples, including cell structures in tissue sections, and subcellular structures and 3D morphologies of single cells. A full-time technician provides training, consultation, and guidance to researchers, from sample preparation to data analysis.
Automated rodent behavioral scoring system, complete with 3D design files and code/software. System monitors behavioral engagement using open-source software. 3D design files and necessary software has been made available, as well as code that can be used for data analysis.
Collection of databases, domain theories, and data generators that are used by machine learning community for empirical analysis of machine learning algorithms. Datasets approved to be in the repository will be assigned Digital Object Identifier (DOI) if they do not already possess one. Datasets will be licensed under a Creative Commons Attribution 4.0 International license (CC BY 4.0) which allows for the sharing and adaptation of the datasets for any purpose, provided that the appropriate credit is given
Software R package for analyzing sparse chromatin-accessibility data by estimating gain or loss of accessibility within peaks sharing the same motif or annotation while controlling for technical biases. Enables accurate clustering of scATAC-seq profiles and characterization of known and de novo sequence motifs associated with variation in chromatin accessibility. Used for analysis of sparse chromatin accessibility data from single cell or bulk ATAC or DNAse-seq data.
Web tool for pan-cancer survival analysis and visualization by using results from single sample gene set enrichment analysis. Used for pathway enrichment score-based survival analysis in cancer.Users can quickly explore impact of target pathway on survival outcomes in different tumors, assisting clinicians and researchers in further investigating mechanism of tumor development and improving clinical decision-making.
Software tool as entropy-based metric for assessing purity of single cell populations. Used to accurately quantify purity of identified cell clusters.
Software pipelines for benchmarking workflow for evaluating graph-based pangenome construction tools. The repository contains scripts to compare the performance of Minigraph-Cactus, PGGB, Minigraph pipelines using both simulated and real-world datasets. It includes data processing steps, evaluation metrics, and reproducible scripts for analyzing structural variants in pangenomes.
Software R package to predict epigenetic age and calculate age acceleration from DNA methylation data.
System supports the main imaging applications of chemiluminescent and colorimetric western blots, in addition to fluorescent stained nucleic acid gels, fluorescent stained protein gels, colorimetric stained protein gels, and colorimetric membrane stains.
UCL light microscopy platform. Provides wide variety of microscopes available in the Confocal Imaging unit.
Core provides advanced mass-spectrometric instrumentation and for both proteomics and metabolomic experiments. Performs qualitative and quantitative analysis of proteins and post-translationally modified peptides and both targeted and untargeted LC/GC-MS based metabolomics.
Software R package for scRNA-seq normalization. Uses Simple Good-Turing estimator for the per cell relative gene expression estimation.
Software tool for formatting PhenoImager TIFF/OME-TIFF metadata for compatibility with MCMICRO workflow.
Software tool for automated projection pursuit clustering. Alternative clustering approach that alleviates the curse of dimensionality by sequentially projecting high-dimensional data into a low-dimensional representation.
Core is equipped with instrumentation in mass spectrometry, sample preparation, and automation technology. Bruker timsTOF Ultra 2 ultra-high speed and sensitivity mass spectrometer for single cell and other low input proteomics methods. It comes equipped with the Bruker nanoElute 2 UHPLC and the alternative EvosepOne HPLC for high throughput applications. Sample preparation can be automated using the Opentrons Flex liquid handling robot.
Core provides researchers with access to high-quality human induced-pluripotent stem cell (iPSC) production, expansion, validation, and quality control services, while strictly adhering to approved protocols, ensuring high-quality standards and consistency throughout the process.
Core produces and distributes of MHC/peptide tetramers and related reagents. Production and distribution to the research community of major histocompatibility complex (MHC) tetramers and related reagents for detection of T cell responses to viruses, bacteria, parasites, tumors, auto-antigens, and other model antigens. Reagents are provided to qualified investigators at no cost, except for shipping and handling fees and in cases where investigator is asked to provide the TCF with peptide or other appropriate ligands.