We support boolean queries, use +,-,<,>,~,* to alter the weighting of terms
Species-agnostic web-based application for processing genotypic data in no-code RShiny user-friendly interface. Allows users without coding experience to process genetic data in all genome ploidy ranges and for multiallelic data, starting from number of input formats (including VCF). Also allows to perform downstream QC analyses (e.g., PCA) and run genomic analysis (e.g., Linkage mapping, QTL analysis, genome-wide association studies (GWAS), and genomic selection (GS).
Web-based simulation tool that evaluates cancer control strategies. Microsimulation model calibrated to Canadian input data primarily used to inform health economic policy of cancer screening and prevention strategies.
Cell Sorter, equipped with 5 lasers (355, 405, 488, 561 and 640 nm excitation wavelengths) and 78 channels which can measure the entire emission spectra of the fluorescent dyes, is the first spectral flow cytometer sorter with sort-capable image analysis.
Software Python library for deep probabilistic analysis of single-cell and spatial omics data. Used for probabilistic modeling and analysis of single-cell omics data, built on top of PyTorch and AnnData.
Leica DMi8 microscope is an inverted light microscope, intended as a general microscope for routine examinations of biological specimens.
Multichannel, multimodal imager, with visible fluorescence, visible light, and UV excitation channels. The system is fully upgradeable to fluorescent Western Blot Imaging System.
Web server for management and validation of mass spectrometry-based proteomic data.
Software tool that performs alignment, XIC extraction, peak detection and quantification on data obtained from Liquid Chromatography-Mass Spectrometry (LC-MS) techniques. Performs LC-MS data alignment and peptide quantification by peak area integration on extracted ion chromatograms.
Core focused on metabolomics, lipidomics, medicinal chemistry, and small molecule analysis. Offers services, expertise, and collaboration for the research community. Instrumentation includes high field nuclear magnetic resonance (NMR), liquid chromatography–mass spectrometry (LC-MS), gas chromatography-mass spectrometry (GC-MS), high-performance liquid chromatography (HPLC), circular dichroism spectrometer (CD), inductively coupled plasma optical emission spectrometry (ICP-OES), and fluorimeter. Consulting is available to assist with experimental design and data interpretation.
Core offers quality controlled media at economical prices. Media is prepared in large batches ranging from 50L-300L from commercially produced powders. All products go through strict quality control program. Custom plates and media are offered by request and are usually available within 2-4 business days. All other orders placed online can be picked up on the next business day.
Core provides monoclonal antibody production services. Provides consultation to assist investigator in all aspects of monoclonal antibody production. Services are performed under strict quality control guidelines appropriate for antibodies that may have commercial potential.
Core provides glassware washing and sterilization of all types of glassware and pipettes. Facility maintains stock glassware in common storage area. Glassware personnel collect glassware from laboratories daily and cabinets are replenished regularly. Autoclaving of materials is offered on daily basis. Core can accommodate any special requests. Glassware Core maintains stock of all types of sterile laboratory glassware and pipettes in common storage area.
Core provides specialized cell culture services , ensures high-quality and contamination-free cultures by employing aseptic techniques and maintaining Mycoplasma and Quarantine facilities. Offers cell banking, with capacity to freeze and store up to 10,000 vials. Facility provides walk-in warm room and cold room, spinner apparatus capable of handling over 20 liters of cells in suspension, and roller bottle machine that accommodates more than 200 roller bottles. Additional equipment includes automated cell counter and ELISA reader.
Software tool as simple test framework for Nextflow pipelines. Enables pipeline developers to test individual process blocks, workflow patterns and entire pipelines in insolation.
Software Python package for modular causal inference analysis and model evaluations. Used for inferring causal effects from observational data.
Stand-alone Raspberry Pi-enabled IoT system to monitor near-realtime sensor data in MyVivarium web app. Used to track environmental conditions of vivaria.
Cloud-based lab animal colony management application with realtime ambient sensing. Platform for managing vivaria. It features cage management, user management, lab management, and real-time environmental monitoring with IoT sensors.
Web application as resource of known and predicted human ubiquitin ligase substrate interaction network. E3-substrate interactions are derived from six data sources: mannual cruration, protein ortholog, protein domain, protein motif and network topology.Designed to explore predicted and reported E3-substrate interactions for query E3 or substrate, and ubiquitination sites for substrate protein.
Core provides services for genomics analysis, from sample processing through data generation. Available technologies focus on Illumina RNA and DNA sequencing. RNA-seq can be performed from a variety of sample types, including purified total RNA, cell populations (including low input samples of 50-1000 cells), or single cells (either plate-sorted rare populations or high-throughput 10x single-cell analyses). DNA-seq pipelines can also be performed, including bulk CUT and Tag/CUT and RUN, and ATAC-seq and single cell ATACseq and multiome capture. Custom prepared libraries can also be submitted for sequencing. Core laboratory houses Illumina sequencers, NextSeq2000 instruments and Miseq, plus 10x Chromium X and 10x CytAssist. Additional equipment includes ThermoFisher Kingfisher Flex, for extracting nucleic acid from variety of sample types using magnetic bead technology with throughput of up to 96 samples. Qiagen QIAcube Connect instruments automate extraction of nucleic acid using spin column technology. Ancillary equipment for sample processing includes Formulatrix Mantis Liquid Handler, Agilent TapeStation 4200 and Tecan NanoQuant.
Core provides flow cytometry services. Staff members will help with experimental design, instrument training, sample acquisition, data analysis with software provided, and conventional/spectral cell sorting.