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Core with mission to harness data and expertise to power innovations that improve people’s health through unification and enhancement of interdisciplinary efforts at the intersection of artificial intelligence (AI) and health at the University of Michigan. Provides data services, secure computing resources, support to strategically integrate and study AI models in clinical workflows at Michigan Medicine.
Core staff provides personalized consultations, knowledge and resources focused on helping investigators leverage secondary data to advance their mental health research. Offers consultations and guide in areas:Identifying secondary data sources for mental health studies,Data preparation (e.g., merging/appending data, preparing variables for analysis), Developing analysis plan, including pre-registration, Statistical analysis.
Core provides University of Michigan investigators with guidance and resources needed to utilize mobile technologies and digital mental health measures in their studies. Our experienced faculty and staff offer hands-on consultative services to U-M investigators, regardless of research focus.
Core to enable the use of primary human tissue models for discovery, translation and regenerative medicine.
Fully automated digital PCR system integrating four functions: chip loading, droplet generation, PCR amplification, and signal reading, enabling ultra-multiplex quantitative detection. The device adopts innovative "solid oil-water separation" droplet generation technology, ensuring stable droplets with a high effective ratio. It supports multi-color fluorescence channels and independent temperature control for dual modules, equipped with AI intelligent denoising and recognition functions.
This integrated digital PCR device combines four functions—chip loading, droplet generation, PCR amplification, and signal reading—into one, achieving full process automation and significantly reducing human error. It is compact in size, making it easy to transport and maintain. It is compatible with multiple PCR mixes, has high droplet stability (≥95%), and uses a glass substrate chip to ensure high-quality signal output. It supports single-sample testing, avoiding waste of consumables, and is suitable for flexible and efficient experimental requirements. Translated with DeepL.com (free version)
Software tool to assess gene relevance while enhancing dimensionality-reduction performance. Used to quantify gene relevance and improve dimensionality reduction.
Employer-sourced medical and drugs claims database of the under-65 working population and their dependents, as well as 65+ with Medicare supplemental insurance paid by employers.
Web portal that ranks journals and countries based on their scientific influence, using data from the Scopus database. Provides bibliometric indicators like the SCImago Journal Rank (SJR) indicator, which measures citation impact, and the h-index, which reflects both the productivity and citation impact of a journal or researcher. Portal allows users to analyze journals by subject area, category, and country, offering a valuable tool for assessing research impact and comparing scientific performance.
Software application for identifying transcriptomic and epigenomic changes.
BioDigital Qing is a digital PCR system with automated droplet preparation and reagent formulation, enabling all essential steps of digital PCR—including compartmentalization, thermal cycling, and data acquisition—to be completed on a single instrument. Utilizing nucleic acid quantification technology, it allows for absolute quantification without the need for a standard curve. A large volume of reaction mixture is partitioned or digitized into thousands of small, independent reactions, such that each microchamber contains either one or zero target copies. The original concentration is then calculated using statistical methods based on the number of positive and negative microchambers.
Core provides access to gamma- and x-ray irradiation technologies, services, and scientific consultations basic and translational studies of cancer. Services provided by the ISR include: 1) radiation physics and technical consultation for YCC investigators on the best use of the irradiators; 2) routine quality assurance tests to ensure accurate dose delivery by the irradiators; 3) on-going user training for safe operation of the irradiators and regulatory compliance; (4) technical assistance of irradiation experiments, including security escort for users who lack security clearance to use the Cesium-137 irradiator; and (5) proactive irradiator maintenance to ensure all irradiators remain in optimal state, 24 hours/day and 7 days/week
Core performs next generation sequencing for RNA and DNA samples, as well as provides support for downstream analysis.
Cell DIVE Multiplex Imaging Solution is Leica Microsystems’ open, highly customizable platform that combines precision-engineered hardware, iterative staining/dye‑inactivation protocols, and intuitive software to visualize 60+ biomarkers from a single tissue section—delivering crystal-clear, whole‑tissue imaging at the single‑cell level.
X-Light V3 in combination with DeepSIM X-Light super-resolution system. Super-resolution microscopy system used to visualize cellular structures and dynamics at nanoscale resolution, typically around 100 nm in XY and 300 nm in Z. It's designed for both live and fixed cell imaging, including complex 3D models like tissues and organoids, and can be seamlessly integrated with existing confocal microscopes like the X-Light V3.
High-resolution mass spectrometer designed for comprehensive multiomics research. It combines a high-performance Orbitrap mass analyzer with a tribrid architecture (quadrupole, linear ion trap, and Orbitrap) for enhanced ion separation, fragmentation, and detection capabilities. This instrument is particularly well-suited for analyzing proteins, lipids, and metabolites in a single experiment, enabling researchers to gain deeper insights into biological systems
Software R package to identify, annotate and visualize isoform switches with functional consequences from both short- and long-read RNA-seq data. Analysis of alternative splicing and isoform switches with predicted functional consequences (e.g. gain/loss of protein domains etc.) from quantification of all types of RNASeq by tools such as Kallisto, Salmon, StringTie, Cufflinks/Cuffdiff etc.
LSFM and SPIM often generate very large quantities of image data that require highly efficient data processing capabilities. Bruker’s Luxendo Image Processor and LuxBundle software are powerful, user-friendly tools that combine flexible control of the microscope and image viewer with high-throughput, high-quality post-processing capabilities.
Light-sheet fluorescence microscopy generates large image data, which require efficient acquisition and processing software. Bruker's LuxBundle software for light-sheet microscopes integrates flexible microscope control with LuxControl, image viewing with LuxViewer, and post-processing with LuxProcessor. It also offers three add-on modules for sample tracking, experiment set-up and navigation in LuxViewer, and flatfield correction
Software tool, which combine graph deep learning and protein language model, for accurate enzyme function and catalytic site prediction.