We support boolean queries, use +,-,<,>,~,* to alter the weighting of terms
Core provides expert support and consulting in advanced bioinformatics analyses and state-of-the-art protein engineering.
Software toolbox for SPM5 which offers plotting effect sizes, fitted responses, and BOLD time courses averaged across subjects from within 2nd level (random effects) analyses. The toolbox offers a large variety of plot configuration both suitable for data exploration and producing high quality figures for publications.
Software pipeline that generates protein families from amino acid sequences and/or updates existing families with new sequences. It takes a protein fasta file as input, clusters the sequences and then generates protein family Hiden Markov Models (HMMs) along with their multiple sequence alignments (MSAs). Optionally, paths to existing family HMMs and MSAs can be given (must have matching base filenames one-to-one) in order to update with new sequences in case of matching hits.
Integrated web application for differential expression and pathway analysis of RNA-Seq data.
Georgia Cancer Center's Bioinformatics Core provides expertise in integrative computational based analysis solutions to basic, clinical, and translational research applications. Services include study design, analysis, and interpretation that may involve interaction with industry, government, and regulatory agencies in the areas of Clinical trials, Epidemiology, laboratory studies, in addition to data mining using local and national databases for hypotheses generation and scientific investigation.
Designed with non-statisticians in mind and intuitively developed, MarkerView software does the heavy lifting so you can focus on high-value decisions like reviewing trends and differences in targeted or untargeted mass spec workflows. Distil complex datasets quickly, find statistically significant differences and reveal key insights faster. MarkerView software is now integrated into the SCIEX OS ecosystem.
Orbitrap Exploris 120 LC-MS spectrometry instruments
Giotto Suite is a major upgrade to the Giotto package that provides tools to process, analyze and visualize spatial multi-omics data at all scales and multiple resolutions. The underlying framework is generalizable to virtually all current and emerging spatial technologies. Our Giotto Suite prototype pipeline is generally applicable on various different datasets, such as those created by state-of-the-art spatial technologies, including in situ hybridization, sequencing, and imaging-based multiplexing/proteomics. These technologies differ in terms of resolution (subcellular, single cell or multiple cells), spatial dimension (2D vs 3D), molecular modality (protein, RNA, DNA, …), and throughput (number of cells and analytes).
Core provides Next Generation Sequencing (NGS) services and Single Cell services predominantly focussing on single cell RNAseq. Processes samples for variety of cancer associated projects, in both mouse and human derived materials. Offers full end-to-end service, from initial study design and planning, through sample QC, full library preparation, sequencing and data return. Offers range of standard molecular tests covering, plasmid purifications, Sanger sequencing and mycoplasma screening.
Software tool for cell type based analysis of multiplexed imaging data. Interactive knowledge-based classifier for multiplexed images and proteomic datasets that avoids hard-set thresholds and manual labeling. Recovers fine-grained cell types, matching the gold standard annotations by human experts, can target ambiguous populations and discover phenotypically distinct cell subtypes.
Core offers comprehensive pathologist-led spatial biology service comprising spatial proteomic, transcriptomic, and multiomic experimental design, including platform and panel selection, assay development, image acquisition, and digital image processing. The facility houses 2x Ventana Discovery Ultra autostainers, 2x 10 x Genomics Xenium platforms, a Lunaphore COMET, an Akoya PhenoImager, an Akoya PhenoCycler, an Olympus VS200 slide scanner and a Visiopharm image analysis suite.
Software segmentation/resquiggling tool for ONT signals. Dynamic programming approach to segment ONT signals.
International Physical Activity Questionnaire to obtain comparable estimates of physical activity between populations and countries. It was designed for physical activity surveillance so it is particularly useful for large population studies, but can be used with care in other contexts.
Software tool as comprehensive analysis framework for T-cell and B-cell repertoire sequencing data.
Electronic CCI device, with adjustable depth, velocity, dwell time, and angle of impact used for neuroscience research.e CCI is constructed with sturdy aluminum frame to maximize rigidity thereby ensuring impact accuracy. The support base, animal platform, and impactor head are anodized to prevent oxidation and to ensure equipment longevity. The assembly includes the base and support frame, adjustable animal positioner with an aluminum animal platform to be used in conjunction with a variety of stereotactic mounts.
Software tool for interactive exploration and analysis of single-cell trajectories in 3D space.
The AIME methodology is detailed in the paper available at The AIME methodology is detailed in the paper available at https://ieeexplore.ieee.org/document/10247033. AIME is proposed to address the challenges faced by existing methods in providing intuitive explanations for black-box models. AIME offers unified global and local feature importance by deriving approximate inverse operators for black-box models. It introduces a representative instance similarity distribution plot, aiding comprehension of the predictive behavior of the model and target dataset. This software only supports the global feature importance of AIME.
Software tool to address challenges faced by existing methods in providing intuitive explanations for black-box models. Offers unified global and local feature importance by deriving approximate inverse operators for black-box models.
Software application to provide well defined metadata instances for selected schemas of the openMINDS metadata framework.
Software segmentation/resquiggling tool for ONT signals. Dynamic programming approach to segment ONT signals.