Curator Dashboard

An interactive 1D NMR spectra processing tool dedicated to metabolomics. This open source software provides a complete set of tools for processing and visualization of 1D NMR data, the whole within an interactive interface based on a spectra visualization.

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• RRID
• 3 years ago - submitted by Daniel Jacob

Open source software provides GUI tool for spectra processing from 1D NMR metabolomics data, based on interactive interface for spectra visualization, that helps spectra processing.

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• RRID
• 3 years ago - submitted by Daniel Jacob

Goat polyclonal antibody to tyrosine hydroxylase will reveal chatecholaminergic neurons in tissue sections and cell culture.

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• SciCrunch
• 3 years ago - submitted by Gerry Shaw

Goat polyclonal antibody to NF-H useful for the identification of neurons and their axons in cell culture and sections

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• SciCrunch
• 3 years ago - submitted by Gerry Shaw

Chicken polyclonal antibody to IBA-1, aka AIF1, is an antibody which can be used to identify microglia and other hematopoetic cells

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• SciCrunch
• 3 years ago - submitted by Gerry Shaw

The necessary steps involved in the analysis of 16S rRNA microbiota amplicons data from raw sequences to publication-quality visualizations and statistical analysis.

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• RRID
• 3 years ago - by Anonymous

King Fahad Specialist Hospital (KFSH) database

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• SciCrunch
• 3 years ago - submitted by Razan Saleh Alqarzaee

Multiscale Microscopy Core at OHSU is electron microscopy core that provides services and training to academic and corporate users.

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• SciCrunch
• 3 years ago - submitted by Edyta Vieth

We are the best online pharmacy at United states that caters the need of legitimate soma pill at an affordable price. We focus at providing the best and better solution to people who are suffering from severe body pain. Our orders have a unique tracking number for buyer to track from anywhere in the world. We are constantly working to serve our customer better. We value your trust and pledge to give you the best possible Services.

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• SciCrunch
• 3 years ago - submitted by Daniel Paul

Dual tube System with 300kV Microfokus and 190kV Nanofokus System

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• 3 years ago - submitted by Kristin Mahlow-Tillack

Handhold surface Scanning System with different Setups

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• RRID
• 3 years ago - submitted by Kristin Mahlow-Tillack

Complexity Analysis Viral Sequences

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• SciCrunch
• 3 years ago - submitted by Jorge da Silva

antibody...

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• RRID
• 3 years ago - submitted by Zhang Ziruizhuo

antibody

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• 3 years ago - submitted by Zhang Ziruizhuo

Understanding the mechanism of cell death and survival is the key content of toxicological analysis and drug development and application. Since the cell death pathway is complex and dynamic, multi-parameter analysis is very important for the accurate detection of this process.

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• 3 years ago - submitted by Linna Green

Protein synthesis can be controlled with the bacterial translation machinery. Control of invasion is necessary to carry the produced proteins into cells. Invasion requires both flagella and the type III secretion system-1 (T3SS-1). Flagella are essential for cell invasion because they sense the cell surface and determine the optimal location for invasion32. T3SS-1 is a needle apparatus that initiates invasion by injecting effector proteins into cells. These proteins rearrange the actin cytoskeleton and induce endocytosis of the bacteria. Production of these two bacterial structures is controlled by the factors fliZ and hilD, which are, in turn, controlled by the master regulator flhDC. Protein release requires the activation of bacterial genes specifically inside cells. In Salmonella, this can be controlled with the promoters of SPI2 genes.

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• 4 years ago - submitted by Jon Matthews

The fast development of genome sequencing technologies and the power of advanced computational analyses of the DNA sequences dramatically increased the potential for natural product discovery. Our knowledge on the biosynthesis of secondary metabolites by bacteria is constantly expanding, thereby adding new information that connects biosynthetic genes with metabolites of particular chemical classes. With the cost-effective and rapid increase in the number of bacterial genomes sequenced, one challenge encountered in current drug discovery efforts is how to effectively prioritize those strains with the greatest ability to produce new compounds and understand the extent of biosynthetic potential that exists in nature. Genomes mining approaches, which often involve identifying the genes involved in secondary metabolite production, have revealed an unprecedented biosynthetic potential in many microbial species. Associated techniques include molecular biology techniques, chemical analysis, cellular biology techniques, and bioinformatic analysis, etc. The genomes mining approaches can be applied in different ways based upon: (i) phenotype of the producer (e.g. bioactivity and biosynthesis of specific compounds or enzymes); (ii) targeted chemical class of natural products (e.g. terpenes, lasso peptides and aromatic polyketides); (iii) the potential uniqueness of the bacterial isolate that may yield novel compounds (e.g. novel or taxonomically divergent species, and isolates from unique environmental sources).

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• 4 years ago - submitted by Jon Matthews

Chemotaxonomy, also called chemosystematics, is the attempt to classify and identify organisms according to confirmable differences and similarities in their biochemical compositions. The chemical diversity and the resources of natural products are immense and nowhere near fully exploited. Chemotaxonomy-based strain selection is a prerequisite for successful natural product research. Combined with the fact that fungi, and probably also other types of microorganisms, produce very species-specific profiles of natural products that can be used as efficient tools to select one or a few representative strain(s) for biological testing, and with the revolution in molecular genomics several new strategies for natural products based drug discovery programs are being developed: Knowing the biodiversity and ecology; Using a metabolite profiling approach; Targeting certain ecological niches; Using a genome-based approach.

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• 4 years ago - submitted by Jon Matthews

Microorganisms and in particular actinomycetes and microfungi are known to produce a vast number of bioactive secondary metabolites. Natural product research needs to continually improve the efficiency of the selection, screening, dereplication, isolation, and structure elucidation processes, in order for natural product chemistry to continue to be competitive with purely synthetic-based discovery methods. For industrially important fungal genera such as Penicillium and Aspergillus, the production of these compounds has been demonstrated to be very consistent at the species level. This means that direct metabolite profiling techniques such as direct injection mass spectrometry or NMR can easily be used for metabolomics of strains from both culture collections and natural samples using modern informatics tools. Metabolomics can be used for the identification and classification of filamentous fungi and for the discovery of novel compounds when used in combination with modern methods for dereplication. Such approaches will be important for future effective drug discovery strategies, especially for the dereplication of culture collections in order to avoid redundancy in the selection of species. This will maximize the chemical diversity of the microbial natural product libraries that can be generated from fungal collections. Metabolomics aims to detect all small metabolites in a cell or organism. Rapid profiling techniques may determine all metabolites produced by a microorganism. These techniques are generally segregated into fingerprinting, footprinting, profiling, or target analysis.

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• 4 years ago - submitted by Jon Matthews

Drugs of natural origin have been classified as (i) original natural products, (ii) products derived or chemically synthesized from natural products or (iii) synthetic products based on natural product structures. Microbes have made a phenomenal contribution to the health and well-being of people throughout the world. In addition to producing many primary metabolites, such as amino acids, vitamins and nucleotides, they are capable of making secondary metabolites, which constitute half of the pharmaceuticals on the market today and provide agriculture with many essential products. For example, immunosuppressants have revolutionized medicine by facilitating organ transplantation. Other applications include antitumor drugs, enzyme inhibitors, gastrointestinal motor stimulator agents, hypocholesterolemic drugs, and other pharmacological activities.

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• RRID
• 4 years ago - submitted by Jon Matthews