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Provides advanced computing systems and services including supercomputer applications, AI and machine learning, big data analysis and storage. Offers suite of cyberinfrastructure coordination services targeted at supporting all areas of science and engineering research and education.
Software Python package for automated detection, morphology classification, tracking, and colocalization analysis of organelles in multichannel fluorescence microscopy data.
Benchtop plate reader with ResoVu software enables rapid, label-free detection in disposable 96-well plate format. Benchtop system with semi-automated fluidics with Disposable 96-well microarray plate format; User friendly, and easy to operate; Real-time data analysis features.
Software algorithm for restitching overlapping image crops with intensity adjustment. Crops are intensity corrected and weight adjusted to produce uniform intensity composite image.
Core offers proteomics and metabolomics services. Provides support from experimental design to execution, sample processing, data interpretation, and assistance with presentations, manuscript preparation for publication and deposition of data in public repository and data storage on local server. Provides service analysis of post-translational modifications, such as phosphorylation, ubiquitination, acetylation, and others, with precise site localization on either single protein or for entire proteome.Uses Orbitrap Fusion Lumos coupled to Easy-nLC 1200 HPLC system. Facility instruments are operated with various acquisition methods, including classic Data Dependent Analysis (DDA) or more recent Data Independent Analysis (DIA). Acquired data from different methods are used to accurately identify and measure abundance of proteins and peptides employing different quantitation strategies: Label-free, TMT, pulsed-SILAC and Isotope-labelled Iodoacetamide (for Cysteine oxidation).Provides specialized data analysis software like MaxQuant and Mascot for DDA, Spectronaut for DIA of clinical samples and Perseus and Scaffold for data compilation, analysis, and dissemination.
Core offers comprehensive protein expression, purification, characterization, and structural biology services, including advanced methods such as Cryo-Electron Microscopy (Cryo-EM) and X-ray Crystallography.
Software integrative pipeline for antimicrobial resistance genes, virulence factors, toxins, and biosynthetic gene clusters prediction in metagenomes. Used for predicting microbiome-based pathogenicity and resistance to better understand and address challenges posed by antimicrobial resistance and infectious diseases.
Cryo-Electron Microscopy Core facility at ISM offers EM services with state-of art instruments (Vitrobot for sample preparation, Glacios-2 TEM for imaging biological samples at atomic resolution). We offer single particle analysis (SPA) workflow, imaging drug delivery products (ex: liposomes, LNPs, AAVs..)
Integrative database for human proteome structural and functional sites. Used for understanding role of specific residues in protein structures, complexes, and interaction networks. Integrates various structural and functional annotation layers for each residue, offering comprehensive understanding of protein functionality.
Software R package for most bulk sequencing datasets. Creates shiny app for interactive data analysis and visualisation. Used for analysing and sharing bulk sequencing results.
Web application for data visualization and data mining system that offers efficient analysis and discovery by integrating big data with intelligent and intuitive functionality.
Software tool for comprehensive T‐Cell subsets abundance prediction and its application in cancer immunotherapy.
Core provides complete flow cytometry analysis and cell sorting services in terms of experimental design, instrumentation, training, technical assistance and scientific guidance from sample preparation to publication.
Core provides access to imaging instrumentation and expertise that is necessary to integrate advanced imaging technologies into basic and translational biomedical research. Services include Assistance in experimental design; Developing specialty equipment and innovative procedures for imaging; Preparing animals for studies, inducing and maintaining appropriate anesthesia and immobilization of animals during imaging;Processing and interpreting data for publication or grant preparation.
Three-dimensional brain reference atlas based on the RIKEN25v1 MRI-derived template, based on an average of 25 C. jacchus brains resampled to 70 um3 voxel resolution. Includes selected published subcortical parcellations to aid in comparing across parcellation schemes.
Three-dimensional brain reference atlas for macaque basal ganglia created based on annotation of BG structures on Mac25Rhesus template, an averaged MRI template from 25 M. Includes selected published subcortical parcellations to aid in comparing across parcellation schemes. Enables mapping of samples and integration of multimodal data within and across species.
IFGW glass workshop, equipped with specialized staff, provides expertise in glass forming, welding, and cutting of Quartz and Borosilicate, as well as in design and technical drawing.
Core produces and supplies liquid helium and nitrogen to the entire IFGW academic community. Laboratory is equipped with helium liquefier from Linde and nitrogen liquefier from Stirling Cryogenics. In addition, it maintains complex support infrastructure essential for production and distribution of cryogenic liquids.
IFGW hosts a mechanical workshop that produces precision components for advanced research projects.