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Integrated Animals is a virtual database currently indexing available animal strains and mutants from: AGSC (Ambystoma), BCBC (mice), BDSC (flies), European Xenopus Resource Center (frog), The National Xenopus Resource (frog), Xenopus Express (frog), CWRU Cystic Fibrosis Mouse Models (mice), DGGR (flies), FlyBase (flies), IMSR (mice), MGI (mice), MMRRC (mice), NSRRC (pig), RGD (rats), Sperm Stem Cell Libraries for Biological Research (rats), Tetrahymena Stock Center (Tetrahymena), WormBase (worms), XGSC (Xiphophorus), ZFIN (zebrafish), and ZIRC (zebrafish). Note, the IMSR data is linked, but users may need to re-execute the search if the top mouse is not returned properly.
Note: BCBC is no longer in service, so the links may not be functional.
| Organism Name | Proper Citation | Species | Synonyms |
Notes |
Phenotype | Affected Gene | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
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W-Cyp27b1em1Thka Resource Report Resource Website |
RRID:RGD_124713544 | Rattus norvegicus | This strain was established by injecting Jcl:Wistar embryo with CRISPR/Cas9 system to delete the cysteine at position 462 in exon 8, which is the 5th ligand of heme iron and an active center of Cyp27b1. The resulting mutation is a 25 amino acid deletion (75 bp deletion) in the target site. The mutant was maintained with CE-2 formula diet (CLEA Japan, Inc., Tokyo, Japan) containing 1.15% calcium and 2,100 IU vitamin D3/kg diet. Homozygotes Cyp27b1 mutants were maintained by mating of heterozygotes. | 124713544 | mutant | Rat Genome Database (RGD) | RGD | Unknown | 124713544 | 2026-02-14 03:50:08 | 0 | |||||
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SD-Shank2em13Sage Resource Report Resource Website |
RRID:RGD_126790496 | Rattus norvegicus | The Shank2 KO rat line 13 was generated by zinc finger nuclease technology targeting exon 31 for deletion . Line 13 has a 437 bp deletion around and including the entire exon 31, thereby causing a frameshift and premature stop codon in all three known isoforms of the rat Shank2 mRNA | 126790496 | mutant | Rat Genome Database (RGD) | RGD | Unknown | 126790496 | 2026-02-14 03:50:08 | 0 | |||||
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W-Vdrem2Thka Resource Report Resource Website |
RRID:RGD_124713548 | Rattus norvegicus | This strain was established by injecting Jcl:Wistar embryo with CRISPR/Cas9 system to disrupt the array near the arginine codon (CGC) at position 270 of the Vdr gene. This resulted in 1bp deletion and caused premature stop at p266 of the Vdr gene. They were allowed food and water ad libitum and fed a CE-2 formula diet ( CLEA Japan, Inc., Tokyo, Japan) containing 1.15% calcium and 2,100 IU vitamin D3/kg diet. The Vdr knock out rats for analysis were fed an F-2 formula diet (Oriental Yeast Co., Tokyo, Japan) containing 0.74% calcium and 2000 IU vitamin D/kg diet12 after weaning because the CE-2diet partially reversed their rickets symptoms. Homozygotes Vdr knock out mutants were maintained by mating of heterozygotes. | 124713548 | mutant | Rat Genome Database (RGD) | RGD | Unknown | 124713548 | 2026-02-14 03:50:08 | 0 | |||||
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SD-Cd59em1Ask-/- Resource Report Resource Website 1+ mentions |
RRID:RGD_13792606 | Rattus norvegicus | The CRISPR/Cas9 genome editing system was used to generate Cd59 mutation in the Sprague Dawley embryos. The CRISPR/Cas9 targeting exon 3 of the rat Cd59 created a 11 bp-deletion (TGCAAAACAAA) in exon 3. No protein expression was detected in the blood smear of homozygous mutants. | 13792606 | mutant | Rat Genome Database (RGD) | RGD | Unknown | 13792606 | 2026-02-14 03:50:08 | 1 | |||||
|
SD-Leprem4Lizh Resource Report Resource Website |
RRID:RGD_21079475 | Rattus norvegicus | The Lepr knockout rats were generated by CRISPR/Cas9. Two pairs of synthesized oligonucleotides for gRNA targeting on the exon 4 of Lepr, TAGGCAAATCATCTATAACTTC and AAACGAAGTTATAGATGATTTG; TAGGCTGAAAGCTGTCTTTCAG and AAACCTGAAAGACAGCTTTCAG were microinjected into Sprague Dawley (originally from Charles River) zygotes. The rat was genotyped by PCR with the primers, 5-prime-CTTGTGTCCAGAGCCTTCCTATAAC and 5-prime-ATTCCCCATGTTGTCTAGTAGTGATC. For genotyping, a 662-bp fragment of WT and a 368-bp fragment of the Lepr knockout gene were amplified with PCR. Founder 2 was chosen to establish a colony (designated as Lepr-/-), which carried a 298-bp deletion from No. 90043 bp to 90341 bp in the Lepr genome DNA sequence (NC_005104.4) and a 4-bp insertion and resulted in a termination codon TGA, deleting 997 amino acid of LEPR. Western blot analysis of total protein from liver tissue of the Lepr-/- rats confirmed the absence of LEPR. | 21079475 | mutant | Rat Genome Database (RGD) | RGD | Unknown | 21079475 | 2026-02-14 03:50:08 | 0 | |||||
|
SD-Abcc6em2Qlju+/- Resource Report Resource Website |
RRID:RGD_13792682 | Rattus norvegicus | This strain was produced by injecting ZFNs into SD embryos. ZFNs were designed to target exon 1 of rat Abcc6 gene at the binding site/cutting site 5-CACGCCTGGAGAGTCCTGcgcaggCCTGAGGGTGAGTCC-3 (c.24-c.62). The resulting mutation is a 23 bp-deletion (TGCGCAGGCCTGAGGGTGAGTCC) from the first coding exon of the rat Abcc6 gene. The mutation is predicted to cause out of frame translation and a premature stop codon. No protein in the homozygous mutant was detected by immunostaining. | 13792682 | mutant | Rat Genome Database (RGD) | RGD | Unknown | 13792682 | 2026-02-14 03:50:07 | 0 | |||||
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WI-Pmchm1Hubr Resource Report Resource Website |
RRID:RGD_150429963 | Rattus norvegicus | The Pmch mutant rat line was generated by target-selected ENU-driven mutagenesis, and high-throughput resequencing of genomic target sequences in progeny from mutagenized rats (Wistar/Crl background) revealed an ENU-induced premature stop codon in exon 1(K50X) of Pmch in a rat. The heterozygous mutant rat was backcrossed to wild-type Wistar background for six generations to eliminate confounding effects from background mutations induced by ENU. | 150429963 | mutant | Rat Genome Database (RGD) | RGD | Unknown | 150429963 | 2026-02-14 03:50:08 | 0 | |||||
|
Lew-Glp1rem1Mcwi Resource Report Resource Website |
RRID:RGD_13800749 | Rattus norvegicus | CRISPR/Cas9 system was used to introduce a 84-bp deletion and skipping of exon 5 of the Glp1r gene in Lew/NCrl embryos. Contact MCW rat distribution at mcwcustomrats@mcw.edu | 13800749 | mutant | Rat Genome Database (RGD) | RGD | Unknown | 13800749 | 2026-02-14 03:50:07 | 0 | |||||
|
WI-Mc4rm1Hubr Resource Report Resource Website |
RRID:RGD_13825199 | Rattus norvegicus | The Mc4r mutant rat line was generated by target-selected ENU-driven mutagenesis, and high-throughput resequencing of genomic target sequences in progeny from mutagenized rats (Wistar/Crl background) revealed an ENU-induced premature stop codon in helix 8 (K314X) of Mc4r. The heterozygous mutant rat was backcrossed to wild-type Wistar background for six generations to eliminate confounding effects from background mutations induced by ENU. | 13825199 | mutant | Rat Genome Database (RGD) | RGD | Unknown | 13825199 | 2026-02-14 03:50:08 | 0 | |||||
|
SD-Fahem15Dlli-/- Resource Report Resource Website |
RRID:RGD_14398825 | Rattus norvegicus | This strain was produced by injecting Sprague Dawley embryo with CRISPR/Cas9 system targeting the exon 2 of rat Fah gene. The resulting mutation is line 15 with a frameshift deletion causing Fah null in homozygotes. None of the Fah-/- newborns survived longer than three days after birth in the absence of NTBC. Upon NTBC addition to the drinking water, the Fah-/- rats underwent normal growth and were indistinguishable from their WT littermates. | 14398825 | mutant | Rat Genome Database (RGD) | RGD | Unknown | 14398825 | 2026-02-14 03:50:08 | 0 | |||||
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SD-Cryba1Nuc1Dbsa Resource Report Resource Website |
RRID:RGD_126925756 | Rattus norvegicus | This spontaneous mutation was identified in the offspring of pregnant Sprague-Dawley rats purchased from Taconic Farms. This mutant exhibited abnormal eye phenotype including nuclear cataracts and was called Nuc1 rat. Sequencing of the mutant allele revealed a 27 base pair insertion in exon 6 of Cryba1. | 126925756 | mutant | Rat Genome Database (RGD) | RGD | Unknown | 126925756 | 2026-02-14 03:50:09 | 0 | |||||
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SHR-Gja8m1+/-Cub Resource Report Resource Website |
RRID:RGD_150520205 | Rattus norvegicus | This strain is derived from SHR/OlaIpcv where a spontaneous mutation was observed in the NH2-terminal cytosolic domain of Cx50, L7Q. The connexin50 mutation in heterozygous state affects significantly the lipid profile and the oxidative stress parameters in SHR rats. | 150520205 | mutant | Rat Genome Database (RGD) | RGD | Unknown | 150520205 | 2026-02-14 03:50:09 | 0 | |||||
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SD-Mir31em1Sage Resource Report Resource Website |
RRID:RGD_127285380 | Rattus norvegicus | CRISPR/Cas9 system was used to introduce the gene knockout of Mir31 in the Sprague Dawley embryos. | 127285380 | mutant | Rat Genome Database (RGD) | RGD | Unknown | 127285380 | 2026-02-14 03:50:09 | 0 | |||||
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ACI-Pvt1em1Shul/Rrrc Resource Report Resource Website |
RRID:RGD_150520209 | Rattus norvegicus | The ACI-Pvt1em1Shul was created using CRISPR/Cas9 by Shull laboratory at UW madison. The exon 1b of the Pvt1 gene was excised from the ACI/SegHsd genome in a 1165bp deletion. This strain is now maintained at Rat Resource and Research Center. | 150520209 | mutant | Rat Genome Database (RGD) | RGD | Unknown | 150520209 | 2026-02-14 03:50:09 | 0 | |||||
|
LE-Nrxn1em1Mcwi Resource Report Resource Website |
RRID:RGD_25330089 | Rattus norvegicus | The rat strain was produced by injecting CRISPR/Cas9 targeting rat Nrxn1 into Crl:LE embryos. The result is a 4-bp deletion in exon 1. Autism Rat Model Resource. Contact MCW rat distribution at mcwcustomrats@mcw.edu | 25330089 | mutant | Rat Genome Database (RGD) | RGD | Unknown | 25330089 | 2026-02-14 03:50:09 | 0 | |||||
|
Wpk Resource Report Resource Website |
RRID:RGD_14995941 | Rattus norvegicus | The wpk mutation was first recognized in 1994 in a colony of outbred Wistar rats at Utrecht University (Utrecht, The Netherlands). In 1996, a breeding pair of test-proven heterozygotes were transferred to the University of Rotterdam (Rotterdam, The Netherlands), and a new subcolony was initiated. This colony has been maintained by brother-sister matings for more than five generations. Individuals heterozygous for the mutant allele were identified in each generation by test-crossing phenotypically normal offspring from known heterozygotes. A single C to T substitution in exon 12 was identified as the mutated allele in the Wpk rat. This mutation converts a proline to a leucine in the protein products(P394L). This mutation was not present in the parental Wistar strain. | 14995941 | mutant | Rat Genome Database (RGD) | RGD | Unknown | 14995941 | 2026-02-14 03:50:10 | 0 | |||||
|
SD-Tspoem2Vpl Resource Report Resource Website |
RRID:RGD_150429830 | Rattus norvegicus | Tspo-targeted genome editing in Sprague Dawley rats embryos by microinjecting with optimized and customized ZFNs designed for targeted gene KO. Locus-specific PCR was performed to identify Rat7 founders using the following primer pairs: COMPOZr-1kbF: 50-CCTGGATATGCTGTGTCCCC-30 and COMPOZr-1kbR: 50-TGATGGGTCATTTGTGCCCT-30.; Normal PCRs generated 818 bp for WT and 652 bp for the mutant (166 bp deletion). | 150429830 | mutant | Rat Genome Database (RGD) | RGD | Unknown | 150429830 | 2026-02-14 03:50:10 | 0 | |||||
|
SD-Ahrem2Sage Resource Report Resource Website 1+ mentions |
RRID:RGD_13838845 | Rattus norvegicus | ZFN constructs were designed to target exon 2 which contains the DNA binding bHLH motif of the AHR gene.This ZFN model contains a 29-bp deletion in the rat Ahr gene. | 13838845 | mutant | Rat Genome Database (RGD) | RGD | Unknown | 13838845 | 2026-02-14 03:50:09 | 1 | |||||
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SD-Abcc8em1Cgen Resource Report Resource Website |
RRID:RGD_127285409 | Rattus norvegicus | TALEN system targeting the rat Abcc8 (sulfonylurea receptor 1, SUR1 ) gene was injected into Crl:CD(SD) embryos. This strain carries a 16-bp deletion corresponding to CCT CAC GGG GCT TCTG compared with wild-type rats is homozygous. No Abcc8 protein was detected in the liver and muscle tissues. Cyagen Biosciences Inc., Guangzhou, China | 127285409 | mutant | Rat Genome Database (RGD) | RGD | Unknown | 127285409 | 2026-02-14 03:50:09 | 0 | |||||
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DA-Csf1rtm(EGFP)+/-/Hume Resource Report Resource Website |
RRID:RGD_126779587 | Rattus norvegicus | Heterozygotes "SD-Csf1rtm(EGFP)+/-/Tset" were back-crossed for at least 7 generations to the inbred dark agouti (DA) background from the Animal Resource Centre, Western Australia. | 126779587 | mutant | Rat Genome Database (RGD) | RGD | Unknown | 126779587 | 2026-02-14 03:50:09 | 0 |
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