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http://dkcoin.org/

THIS RESOURCE IS NO LONGER IN SERVICE, documented October 13, 2014. The resource has moved to the NIDDKInformation Network (dkNET) project. Contact them at info_at_dknet.org with any questions. Database of large pools of data relevant to the mission of NIDDKwith the goal of developing a community-based network for integration across disciplines to include the larger DKuniverse of diseases, investigators, and potential users. The focus is on greater use of this data with the objective of adding value by breaking down barriers between sites to facilitate linking of different datasets. To date (2013/06/10), a total of 1,195 resources have been associated with one or more genes. Of 11,580 total genes associated with resources, the ten most represented are associated with 359 distinct resources. The main method by which they currently interconnect resources between the providers is via EntrezGene identifiers. A total of 780 unique genes provide the connectivity between 3,159 resource pairs across consortia. To further increase interconnectivity, the groups have been further annotating their data with additional gene identifiers, publications, and ontology terms from selected Open Biological and Biomedical Ontologies (OBO).

Proper citation: dkCOIN (RRID:SCR_004438) Copy   

•   Source: SciCrunch Registry

http://okcam.cbi.pku.edu.cn/ontology.php

CAMO (Cell Adhesion Molecule Ontology) is a set of standard vocabulary that provide a hierarchical description of cell adhesion molecules and their functions. We compiled a list for cell adhesion molecules by integrating Gene Ontology annotations, domain structure information, and keywords query against NCBI Entrez Gene annotations. Totally 496 unique human genes were identified to function as cell adhesion molecules, which is by far the most comprehensive dataset including cadherin, immunoglobulin/FNIII, integrin, neurexin, neuroligan, and catenin families. CAMO was constructed as a directed acyclic graph (DAG) using DAG-Edit to input, manage and update data. We annotated each term with name, definition and source references, as well as the relationship to other terms, based on manual reviews of domain architecture and functional annotations. If vertices represent terms and the relationships between terms are represented by edges, the terms in a DAG can be connected via a directed graph without cycles. CAMO thus provides a hierarchical description of functions of CAMs with five top-level categories: CAM gene families, CAM genetics, CAM regulation, CAM expression and CAM diseases. Each top-level term is further divided into several categories to describe the functions in detail.

Proper citation: CAMO - Cell Adhesion Molecule Ontology (RRID:SCR_004392) Copy   

•   Source: SciCrunch Registry

http://kingdevicktest.com/

An accurate and reliable method for identifying athletes with head trauma, and a strong candidate rapid sideline screening test for concussion. The test is able to capture impairments of eye movement, attention, language and other symptoms of impaired brain function. It is a physical method of evaluating visual tracking and saccadic eye movements is based on the time to perform rapid number naming. It involves reading aloud a series of single digit numbers from left to right on three test cards. Participants are asked to read the numbers on each card from left to right as quickly as possible but without making any errors. The sum of the three test card time scores constitutes the summary score for the entire test. The test is a proven indicator of oculomotor inefficiencies regarding eye movements during reading. Published medical studies have determined that deficiencies in saccadic eye movements can be an indicator of mild Traumatic Brain Injury (mTBI) or concussions. Studies have shown that there is a significant relationship between poor oculomotor functions and learning disabilities (including dyslexia detection). Saccadic eye movement deficiencies can be improved with training and correspondingly reading performance also can be improved. Simply put, subjects who don''t perform well on this test are not efficient readers, although because there are many reasons for poor reading unrelated to eye movements, some poor readers do fine on the test. They believe that the test should be in the hands of teachers in order to help them determine if a student''s poor reading performance is related to deficiencies in their ability to move their eyes efficiently.

Proper citation: King-Devick Test (RRID:SCR_004500) Copy   

•   Source: SciCrunch Registry

http://www.essentialtremor.us/

Finding a cure for any neurological disorder begins with the scientific study of the disorder''s causes, processes, and development in the brain. For essential tremor (ET), rigorous study of this kind had not been undertaken until 2003, when the Essential Tremor Centralized Brain Repository (ETCBR) was established at Columbia University. For the past five years, brain tissue from ET donors has been collected, processed and compared alongside age-matched control brains at the ETCBR, and already several significant findings have been made. However, there is still much to learn and a severe shortage of ET brains for scientific study. If you have been diagnosed with essential tremor, donating your brain tissue in the hours immediately after your death is of utmost importance in providing crucial information about what causes ET. Direct analysis of the shape and number of nerve cells and their content will provide medical researchers with the information they need in order to understand this complex illness. By advancing our medical knowledge of ET, the gift of brain tissue is a central piece of the puzzle in the search to develop better treatments and find a cure.

Proper citation: Essential Tremor Centralized Brain Repository (RRID:SCR_004464) Copy   

•   Source: SciCrunch Registry

http://www.wicell.org/

A nonprofit organization offering research and clinical grade pluripotent stem cell lines, cytogenetic testing, quality control testing and cell banking services to researchers worldwide. The organization is focused on enhancing and expanding the study of human pluripotent stem cells by supporting basic research; establishing research protocols; creating and distributing cell lines; providing training to scientists worldwide; and supporting efforts to unlock the therapeutic potential of stem cell technologies. As home to the Wisconsin International Stem Cell (WISC) Bank, and previously the first US National Stem Cell Bank, WiCell serves the worldwide scientific stem cell community through banking, characterization, and distribution of stem cell lines as well as providing technical support. WiCell also offers cytogenetic services, quality control testing services and clinical grade cell lines to researchers across the globe.

Proper citation: WiCell Research Institute (RRID:SCR_004364) Copy   

•   Source: SciCrunch Registry

http://en.ecgpedia.org/wiki/Main_Page

Free online electrocardiography (ECG) course and textbook via a wiki where anyone can contribute and changes are supervised by physicians. Learn from cases and examples. It designed for medical professionals such as cardiac care nurses and physicians. All content is freely accessible. The information on this site should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. For questions like these we advise you to contact your physician.

Proper citation: ECGpedia (RRID:SCR_004486) Copy   

•   Source: SciCrunch Registry

http://www.mscenter.org/research/tissue-bank/

Scientists throughout the world depend on the Rocky Mountain MS Center Tissue Bank to supply high quality human brain tissue and cerebral spinal fluid to support their research. Funded in part by the National MS Society, the Tissue Bank is one of only four MS-related tissue banks in the nation. The Tissue Bank has distributed specimens to more than 160 investigators worldwide and over 1,600 people have consented to be donors after death. Tissue banks provide a unique bridge between those who live with MS and the scientific community. Studies conducted with samples from the Center have led to several important discoveries and 130 publications. While deeply personal, the decision to donate has far-reaching effects as scientists unlock the mysteries of multiple sclerosis. If you would like to donate, arrangements must be made in advance because it is important that tissue is taken within a few hours of death. For more information on making a donation, visit the How To Donate section of this website and contact the Rocky Mountain MS Center Tissue Bank at 303.788.4030 x111.

Proper citation: Rocky Mountain MS Center Tissue Bank (RRID:SCR_004361) Copy   

•   Source: SciCrunch Registry

http://www.who.int/ictrp/en/

Public database of information about all clinical trials involving humans, this global initiative provides a single point of access to information about ongoing and completed clinical trials. It contains the trial registration data sets made available by data providers around the world meeting criteria for content and quality control. It also aims to: * To improve the comprehensiveness, completeness and accuracy of registered clinical trial data * To communicate and raise awareness of the need to register clinical trials * To ensure the accessibility of registered data * To build capacity for clinical trial registration * To encourage the utilization of registered data * To ensure the sustainability of the ICTRP The mission of the WHO International Clinical Trials Registry Platform is to ensure that a complete view of research is accessible to all those involved in health care decision making. This will improve research transparency and will ultimately strengthen the validity and value of the scientific evidence base. The registration of all interventional trials is a scientific, ethical and moral responsibility. The ICTRP: * Publishes the ICTRP Search Portal * Supports the WHO Registry Network * Supports countries and regions wanting to establish WHO-compliant clinical trial registries or policies on trial registration.

Proper citation: WHO International Clinical Trials Registry Platform (RRID:SCR_004475) Copy   

•   Source: SciCrunch Registry

http://www.cvrgrid.org/

Infrastructure for sharing cardiovascular data and data analysis tools. Human ExVivo heart data set and canine ExVivo normal and failing heart data sets are available. Canine hearts atlas and human InVivo atlases are available.

Proper citation: CardioVascular Research Grid (CVRG) (RRID:SCR_004472) Copy   

•   Source: SciCrunch Registry

http://www.dvbic.org/

The Defense and Veterans Brain Injury Center (DVBIC) is a congressionally mandated collaboration of the Department of Defense (DoD) and Veterans Affairs (VA) health centers serving patients with traumatic brain injury (TBI). Its mission is to serve active duty military, their beneficiaries, and veterans with traumatic brain injuries (TBIs) through state-of-the-art clinical care, innovative clinical research initiatives and educational programs. DVBIC fulfills this mission through ongoing collaboration with military, VA and civilian health partners, local communities, families and individuals with TBI. In 2008, DVBIC''s mission expanded to include Force Health Protection and Management. This encompasses the following Department of Defense (DoD) programs: * TBI Surveillance * TBI Registry * Pre-deployment neurocognitive testing * Family Caregiver Curriculum * 15 year longitudinal study of TBI * Independent study of automated neurocognitive tests DVBIC has been named the Office of Responsibility or Executive Agency for these programs. The DVBIC multi-site network includes a growing number of DoD and VA hospitals as well as civilian TBI rehabilitation programs. Each DVBIC site works collaboratively to provide and improve TBI care for active duty military, veterans and their eligible beneficiaries. DVBIC''s multi-center network design and collaborations with forward medical commands allows for clinical innovation along the entire continuum of care: from initial injury in the war zone through to medical evacuation, acute care, rehabilitation and ultimately a return to community, family, and work or continued duty when possible. WHAT WE DO * Develop and provide advanced TBI-specific evaluation, treatment and follow-up care for military personnel, their beneficiaries, and veterans with mild to severe TBIs * Conduct clinical research that defines optimal care and treatment for individuals with TBI * Develop and deliver effective educational materials and programming for the prevention, assessment and treatment of TBI including the management of its continuing effects. DVBIC is specifically committed to the effort to prevent, treat, and provide education on TBI for US military members currently on active duty, National Guard and reservists recently injured in the line of duty, their beneficiaries, and retired military personnel. * Oversee congressionally-mandated DoD TBI programs All of the above are done through innovative collaborations among the Armed Forces, VA, federal agencies, and coordinating academic institutions.

Proper citation: Defense and Veterans Brain Injury Center (RRID:SCR_004505) Copy   

•   Source: SciCrunch Registry

http://stemcellcommons.org/

Open source environment for sharing, processing and analyzing stem cell data bringing together stem cell data sets with tools for curation, dissemination and analysis. Standardization of the analytical approaches will enable researchers to directly compare and integrate their results with experiments and disease models in the Commons. Key features of the Stem Cell Commons * Contains stem cell related experiments * Includes microarray and Next-Generation Sequencing (NGS) data from human, mouse, rat and zebrafish * Data from multiple cell types and disease models * Carefully curated experimental metadata using controlled vocabularies * Export in the Investigation-Study-Assay tabular format (ISA-Tab) that is used by over 30 organizations worldwide * A community oriented resource with public data sets and freely available code in public code repositories such as GitHub Currently in development * Development of Refinery, a novel analysis platform that links Commons data to the Galaxy analytical engine * ChIP-seq analysis pipeline (additional pipelines in development) * Integration of experimental metadata and data files with Galaxy to guide users to choose workflows, parameters, and data sources Stem Cell Commons is based on open source software and is available for download and development.

Proper citation: Stem Cell Commons (RRID:SCR_004415) Copy   

•   Source: SciCrunch Registry

https://www.med.unc.edu/pgc/

Consortium conducting meta-analyses of genome-wide genetic data for psychiatric disease. Focused on autism, attention-deficit hyperactivity disorder, bipolar disorder, major depressive disorder, schizophrenia, anorexia nervosa (AN), Tourette syndrome (TS), and obsessive-compulsive disorder (OCD). Used to investigate common single nucleotide polymorphisms (SNPs) genotyped on commercial arrays, structural variation (copy number variation) and uncommon or rare genetic variation. To participate you are asked to upload data from your study to central computer used by this consortium. Genetic Cluster Computer serves as data warehouse and analytical platform for this study . When data from your study have been incorporated, account will be provided on central server and access to all GWAS genotypes, phenotypes, and meta-analytic results relevant to deposited data and participation aims. NHGRI GWAS Catalog contains updated information about all GWAS in biomedicine, and is usually excellent starting point to find comprehensive list of studies. Files can be obtained by any PGC member for any disease to which they contributed data. These files can also be obtained by application to NIMH Genetics Repository. Individual-level genotype and phenotype data requires application, material transfer agreement, and informed consent consideration. Some datasets are also in controlled-access dbGaP and Wellcome Trust Case-Control Consortium repositories. PGC members can also receive back cleaned and imputed data and results for samples they contributed to PGC analyses.

Proper citation: Psychiatric Genomics Consortium (RRID:SCR_004495) Copy   

•   Source: SciCrunch Registry

http://www.nida.nih.gov/CTN/

A collaboration in which the National Institute on Drug Abuse, treatment researchers, and community-based service providers cooperatively develop, validate, refine, and deliver new treatment options to patients in Community Treatment Programs (CTPs). The partnership between CTPs and academic research leaders aims to achieve the following objectives: * Conducting studies of behavioral, pharmacological, and integrated behavioral and pharmacological treatment interventions of therapeutic effect in rigorous, multisite clinical trials to determine effectiveness across a broad range of community-based treatment settings and diversified patient populations; and * Ensuring the transfer of research results to physicians, clinicians, providers, and patients. The CTN, with its core of CTPs engaging diverse populations, is also designed to provide a platform for other studies, which would be funded under separate research grants. Three important ways to use the CTN are: to conduct ancillary studies in connection with CTN protocols; to utilize CTN Node facilities as a platform for investigations; and for Nodes to serve as home bases for NIH Training Centers and individual researchers who have NIH fellowships or career development awards.

Proper citation: National Drug Abuse Treatment Clinical Trials Network (RRID:SCR_004407) Copy   

•   Source: SciCrunch Registry

http://www.tbregistry.org/

A non-profit organization that promotes research on hearing and balance disorders. The Registry database allows researchers to perform simple searches to locate specimens of interest. The results show the laboratories where specimens that match the query are located. Investigators should contact the individual laboratories for studying the specimens or for access to the sections. The Registry also serves the public and the scientific community through the dissemination of public information on temporal bone donation and research, enrollment of temporal bone donors, publication of The Registry, a newsletter for researchers, conservation of existing human temporal bone collections, and professional educational activities for physicians and scientists.

Proper citation: National Temporal Bone Pathology Resource Registry (RRID:SCR_004705) Copy   

•   Source: SciCrunch Registry

http://www.chdifoundation.org/

A private, not-for-profit research organization that serves as an international collaborative enabler in order to discover drugs that slow the progression of Huntington's disease (HD). The activities of CHDI extend from exploratory biology to the identification and validation of therapeutic targets, and from drug discovery and development to clinical studies and trials. CHDI works with biotech and pharmaceutical companies and funds and works with academic HD researchers at universities.

Proper citation: CHDI Foundation (RRID:SCR_004622) Copy   

•   Source: SciCrunch Registry

http://www.nlmsf.org/

A volunteer, not for profit organization providing leadership in supporting research of LeioMyoSarcoma, improving treatment outcomes of those affected by this disease as well as fostering awareness in the medical community and general public. All dollars go to research and awareness. Leiomyosarcoma is a rare form of cancer, which affects about four people in every million. It spreads through the blood stream and can affect the lungs, liver, blood vessels or any other soft tissue in the body. Presently there is no cure, only remission if it can be attained, and this rare cancer can reappear anywhere and at any time. Because of its rarity, few doctors know how to treat it and it attracts little research. The National LeioMyoSarcoma Foundation hosts several Fundraising events throughout the year.

Proper citation: National LeioMyoSarcoma Foundation (RRID:SCR_004692) Copy   

•   Source: SciCrunch Registry

http://www.tbidx.net

Network evaluating consensus-based common data elements (CDE) for traumatic brain injury (TBI) and psychological health (TBI-CDE, www.commondataelements.ninds.nih.gov/TBI.aspx) while extensively phenotyping a cohort of TBI patients across the injury spectrum from concussion to coma. Institutions that participate in the TBI Network will be able to track the outcomes of patients through a 3, 6 and 12-month followup program and compare outcomes with other participating institutions. For the three acute care centers, patients were enrolled that presented to the emergency department within 24 hours of head injury and required computed tomography (CT). For the rehabilitation center, referrals from acute hospitals were enrolled. Patients were consented to participate in components: clinical profile; blood draws for measurement of proteomic and genomic markers; 3T MRI within 2 weeks; three-month Glasgow Outcome Scale-Extended (GOS-E); and six-month TBI-CDE Core outcome assessments. A web-enabled database, imaging repository, and biospecimen bank was developed using the TBI-CDE recommendations. A total of 605 patients were enrolled. Of these subjects, 88% had a GCS 13-15, 5% had a GCS 9-12, and 7% had a GCS of 8 or less. Three-month GOS-E''s were obtained for 78% of the patients. Comprehensive 6-month outcome measures, including PTSD assessment, are ongoing until September 2011. Blood specimens were collected from 450 patients. Initial CTs for 605 patients and 235 patients with 3T MRI studies were transferred to an imaging repository. The TRACK TBI Network will provide qualified institutions access to a web-based version of key forms in tracking TBI outcomes for Quality Improvement and institutional benchmarking.

Proper citation: TRACK TBI Network (RRID:SCR_004723) Copy   

•   Source: SciCrunch Registry

http://askdrwiki.com/mediawiki/index.php?title=Physician_Medical_Wiki

A medical, nonprofit, educational wiki created to support a collective online memory for physicians, nurses, and medical students. Users can publish review articles, clinical notes, pearls, and medical images on the site. Anyone with a medical background can contribute to or edit medical articles. Images include: EKG, x-ray, coronary angiograms, peripheral angiograms, structural angiograms, searchable angiograms, echocardiograms, and radiology. Tutorials include: EKG tutorials, coronary angiography tutorials, and ventriculography tutorials.

Proper citation: Ask Dr Wiki (RRID:SCR_004524) Copy   

•   Source: SciCrunch Registry

http://www.hema-quebec.qc.ca/index.en.html

Hema-Quebec''s mission is to efficiently provide adequate quantities of safe, optimal blood components, substitutes, human tissues and cord blood to meet the needs of all Quebecers; provide and develop expertise along with specialized and innovative services and products in the fields of transfusion medicine and human tissue transplantation. Hema-Quebec is driven by the commitment, support and recognition of its employees as well as the trust of its partners to remain the standard of quality and innovation with respect to the safe procurement of blood products, human tissues and stem cells.

Proper citation: Hema-Quebec (RRID:SCR_004700) Copy   

•   Source: SciCrunch Registry

http://www.globusmedical.com/

A privately held spinal company that is driving significant technological advancements across a complete suite of spinal products. Founded in 2003, Globus'' single-minded focus on advancing spinal surgery has made it the fastest growing company in the history of orthopedics. Globus is driven to utilize superior engineering and technology to achieve pain free, active lives for all patients with spinal disorders. The ultimate goal at Globus is to deliver innovation by utilizing superior engineering and technology to help improve patients'' lives. This clinical inspiration is central to every endeavor we undertake. We have developed a Spine Innovation Engine to focus our efforts on delivering industry leading solutions to surgeons and their patients. Our Spine Innovation Engine has developed a portfolio that includes a comprehensive line of technologically-advanced spine products. To date we have released over 50 major products and have over 30 more in various stages of development. Clinical Studies are the foundation for advancing innovative spine care and Globus is committed to a robust investment into prospective and retrospective clinical trials to evaluate the safety and efficacy of our products. Globus is currently conducting several FDA-approved Investigational Device Exemption (IDE) clinical studies.

Proper citation: Globus Medical, Inc. (RRID:SCR_004836) Copy   

•   Source: SciCrunch Registry