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http://www.brainarchitecture.org/mouse-home
An atlas project whose goal is to enerate brainwide maps of inter-regional neural connectivity that specify the inputs and outputs of every brain region, at a "mesoscopic" level of analysis. A 3D injection viewer is used to view the mouse brain. To determine the outputs of a brain region, anterograde tracers are used which are taken up by neurons locally ("the input"), then transported actively down the axons to the "output regions." The whole brain is then sliced thinly, and each slice is digitally imaged. These 2-D images are reconstructed in 3D. The majority of the resulting 3-D brain image is unlabeled. Only the injected region and its output regions have tracer in them, allowing for identification of this small fraction of the connectivity map. This procedure is repeated identically, to account for individual variability. To determine the inputs to the same brain region as above, a retrograde tracer is injected in the same stereotaxic location ("the input"), and the process is repeated. In order to accumulate data from different mice (each of whom has a slightly different brain shape and size), 3-D spatial normalization is performed using registration algorithms. These gigapixel images of whole-brain sections can be zoomed to show individual neurons and their processes, providing a "virtual microscope." Each sampled brain is represented in about 500 images, each image showing an optical section through a 20 micron-thick slice of brain tissue. A multi-resolution viewer permits users to journey through each brain, following the pathways taken through three-dimensional brain space by tracer-labeled neuronal pathways. A key point is that at the mid-range "mesoscopic" scale, the team expects to assemble a picture of connections that are stereotypical and probably genetically determined in a species-specific manner. By dividing the volume of a hemisphere of the mouse brain into 250 equidistant, predefined grid-points, and administering four different kinds of tracer injections at each grid point -- in different animals of the same sex and age a complete wiring diagram that will be stitched together in "shotgun" fashion from the full dataset.
Proper citation: Mouse Brain Architecture Project (RRID:SCR_004683) Copy
A non-profit organization that promotes research on hearing and balance disorders. The Registry database allows researchers to perform simple searches to locate specimens of interest. The results show the laboratories where specimens that match the query are located. Investigators should contact the individual laboratories for studying the specimens or for access to the sections. The Registry also serves the public and the scientific community through the dissemination of public information on temporal bone donation and research, enrollment of temporal bone donors, publication of The Registry, a newsletter for researchers, conservation of existing human temporal bone collections, and professional educational activities for physicians and scientists.
Proper citation: National Temporal Bone Pathology Resource Registry (RRID:SCR_004705) Copy
National Brain Tumor Society (NBTS) is a nonprofit organization committed to finding a cure for brain tumors. We aggressively drive strategic research, advocate for public policies that meet the critical needs of the brain tumor community, and provide patient information. Headquartered in Watertown, Massachusetts, with offices in San Francisco, California and Wilmington, Delaware, we host activities throughout the United States. Formed in 2008 by the merger of two leading organizations that had served the brain tumor community, the National Brain Tumor Foundation and the Brain Tumor Society, the National Brain Tumor Society is now the largest brain tumor nonprofit organization in the country. Both legacy organizations had been formed in the 1980s by parents and other people who were committed to increasing both research funding and access to resources specific to brain tumors. In 2010, the Kelly Heinz-Grundner Foundation, a Delaware-based organization, joined NBTS as a wholly-owned subsidiary. Founded in 2005, after the death of Kelly Heinz-Grundner to a brain tumor, the group has contributed to NBTS''s efforts to pursue research and public policies that benefit the brain tumor community. NBTS grant programs are effective for academic researchers, inclusive of industry expertise, and promising for the patient community. All funding is open to both the domestic and international research communities. The Innovation Research Grant Program supports catalytic transformative projects that will significantly move the field forward. These may include out-of-the-box projects or research that is critical to move therapies down the pipeline. Research that represents an incremental advance is not considered innovative. NBTS will accept Innovation Letters of Intent throughout the year. Researchers in academic or industry labs and at all stages of their career may be funded through this program.
Proper citation: National Brain Tumor Society (RRID:SCR_004744) Copy
The Alabama Head Injury Foundation (AHIF) was founded in 1983 to increase public awareness of Traumatic Brain Injury (TBI) and to stimulate the development of supportive services. Today, AHIF is among the largest state brain injury associations in the nation with model programs and statewide services. Its mission is to improve the quality of life for people who have survived traumatic brain injuries and for their families. Whether the injury is mild or severe the life of the injured person and their family is changed forever. The impact can be both emotionally and financially devastating. AHIF provides the information to help clients and families understand the results of injury. AHIF helps access available resources and provides services and programs which meet the unique needs of individuals with traumatic brain injury (TBI) as well as spinal cord injury (SCI) in certain programs.
Proper citation: Alabama Head Injury Foundation (RRID:SCR_004580) Copy
http://www.floridabraintumor.com/homepage.htm
The mission of the Florida Brain Tumor Association (FBTA) is to provide hope, support and education to brain tumor survivors, their families and friends; to conquer brain tumors by funding research into their causes and cures; and to enrich the quality of life of those touched by brain tumors. In October, 1991, the Florida Brain Tumor Association (formerly South Florida Brain Tumor Association) began due to a desperate need from brain tumor survivors and families who were searching for support and a safe place to share their life changing experiences. Beginning in Boca Raton, Florida, as a grass roots organization and a handful of people, the first support group was conceived. Today, there are many additional FBTA support groups, from coast to coast in the state of Florida. The Florida Brain Tumor Association (FBTA) has become a major force in the brain tumor community. We host many fundraisers yearly, donating funds for research to brain tumor centers. The FBTA has hosted over 20 three day conferences, seminars and meetings, attracting thousands of survivors, families and health care professionals in the United States and Canada. Many of the most renowned physicians in the world travel from far and near to present at FBTA conferences. We are proud and grateful for their commitment and dedication to our cause. The FBTA is a not-for-profit 501(c)(3) organization that is supported by contributions from individuals, corporations, and foundations. We are the only organization of this kind, relying on the strength and dedication of our members, who are brain tumor survivors, family members and friends. Our Medical Advisory Board is also voluntary; we are very thankful to them for their generous gifts of time.
Proper citation: Florida Brain Tumor Association (RRID:SCR_004739) Copy
http://www.braintumorkids.org/
Established in 1983 in Atlanta, GA, the Brain Tumor Foundation for Children (BTFC) was the first nonprofit organization in the United States to focus on pediatric brain tumor disease. The mission of the Brain Tumor Foundation for Children is to provide financial assistance, social support, and information for families of children with brain and spinal cord tumors; fund research projects that improve treatment options and search for a cure; and raise public awareness of the disease and advocate on behalf of children who are affected.
Proper citation: Brain Tumor Foundation For Children (RRID:SCR_004735) Copy
A network of specialized rehabilitation programs serving Veterans and Service Members with both combat and civilian related Traumatic Brain Injury (TBI) and polytrauma. Services available include: interdisciplinary evaluation and treatment, development of a comprehensive plan of care, case management, patient and family education and training, psychosocial support, and application of advanced rehabilitation treatments and prosthetic technologies.
Proper citation: VA Polytrauma / TBI System of Care (RRID:SCR_004697) Copy
The Brain Tumor Action Network is a not-for-profit 501(c)(3) organization established to bring awareness to the general public about brain tumors and to educate and empower brain tumor survivors, their families and friends. We foster grassroots advocacy on federal and state legislative issues affecting brain tumor survivors, their families and friends by providing information on brain tumor-related public issues and effective advocacy. BTAN has the following goals: * To encourage those living with brain tumors, their families and friends to become advocates for brain tumor awareness. * To foster grassroots advocacy on federal and state legislative issues affecting brain tumor survivors, their families and friends by providing information (and training) on brain tumor related public issues and effective advocacy. * To work independently and in collaboration with other brain tumor related organizations on behalf of the brain tumor community family. * To increase brain tumor awareness nationally through the Hidden Under Our Hats, National Brain Tumor Awareness Project in Washington, DC and at various treatment centers, conferences and fund raisers. * To raise funds to support specific research projects. * To create a PILOT respite care program for brain tumor survivors and their families at Moffitt Cancer Center & Research Institute (Tampa, FL). The respite care fund would assist brain tumor patients and their family members with additional care and support from home health care workers.
Proper citation: Brain Tumor Action Network (RRID:SCR_004733) Copy
http://www.pencerbraintrust.com/
The Gerry & Nancy Pencer Brain Trust is a not-for-profit organization with a mandate to make a difference in the quality of life of people living with brain tumors. This registered charity is the primary source of funding for The Gerry & Nancy Pencer Brain Tumor Centre, and carries out annual fundraising events to support its'' ongoing research and patient care activities. The Gerry & Nancy Pencer Brain Tumor Centre is located in Toronto, Canada at the world-renowned Princess Margaret Hospital. The Centre provides multidisciplinary care, treatment, support, and education for brain tumor patients and their families, and promotes brain tumor research in the hopes of one day finding a cure for brain cancer. All of this is made possible through your very generous donations.
Proper citation: Gerry and Nancy Pencer Brain Trust (RRID:SCR_004762) Copy
The Pediatric Brain Tumor Foundation (PBTF) is a nonprofit organization dedicated to eradicating childhood brain tumors and providing support to families. It is a 501(c)(3) nonprofit charitable organization that seeks to * find the cause of and cure for childhood brain tumors by supporting medical research * increase public awareness about the severity and prevalence of childhood brain tumors * aid in the early detection and treatment of childhood brain tumors * support a national database on all primary brain tumors * provide educational and emotional support for children and families affected by this life-threatening disease. As the world''s largest non-governmental source of funding for childhood brain tumor research, we''re dedicated to not only eradicating this disease, but to providing support to families. Our educational resources deliver comfort and hope to families in need of information, and our college scholarship program gives brain tumor survivors a boost for the future. Through our efforts to raise public awareness, more attention has been focused on this deadly disease. Whether addressing congressional briefings or funding international conferences, the PBTF is an unwavering advocate. Together, we''re making a difference in the lives of children with brain tumors. And with your continued help, we will cure the kids!
Proper citation: Pediatric Brain Tumor Foundation (RRID:SCR_004755) Copy
The Oklahoma Brain Tumor Foundation (OKBTF) is a nonprofit organization that provides education, advocacy and support for Oklahomans with brain tumors and their families to improve their quality of life and help find a cure. Founded by Nancy Thomason after the death of her son Cade Thomason to a brain stem PNET tumor on February 17, 2000, she vowed to fight the disease in honor and memory of her son Cade. OKBTF is dedicated to meeting the needs of Oklahoma families, caregivers and patients affected by primary brain or central nervous system tumors. We work to provide for needs through education, advocacy, research and service. Whatever your needs, whether financial, physical, mental or spiritual, we will work with you to fight the battle. Here you will find many of the services we offer in support of families just like yours, who are confused, hurting and just wanting straight answers. Feel free to browse around, get to know us, see what we are doing to help and send us your comments or questions... We are here for you.
Proper citation: Oklahoma Brain Tumor Foundation (RRID:SCR_004748) Copy
http://www.brainsciencepodcast.com/
Podcast, hosted by Dr. Ginger Campbell, featuring the latest books about neuroscience as well as interviews with leading scientists from around the world. In this podcast, she shares recent discoveries from the world of neuroscience in a way that people of all backgrounds can enjoy. Dr. Campbell is an experienced emergency physician with a long-standing interest in mind-body medicine, the brain, and consciousness. She believes that understanding how the brain works gives us insight into what makes us human. She is also committed to showing how the scientific method has unraveled many long-standing mysteries. Brain Science Transcripts are also available.
Proper citation: Brain Science Podcast (RRID:SCR_004491) Copy
http://www.blueprintnhpatlas.org/
Atlas of gene expression in the developing rhesus macaque brain. This atlas is a free online resource with a unique set of data and tools aimed to create a developmental neuroanatomical framework for exploring the cellular and molecular architecture of the developing postnatal primate brain with direct relevance for human brain development. The atlas includes: * Microarray ** Microdissection: Fine structure transcriptional profiling across postnatal development for fine nuclear subdivisions of the prefrontal cortex, primary visual cortex, hippocampus, amygdala and ventral striatum ** Macrodissection: Gross structure transcriptional profiling across postnatal development for the same structures * ISH: ** Cellular resolution in situ hybridization image data of five major brain regions during postnatal developmental periods for genes clinically important for a variety of human neurodevelopmental disorders, including prefrontal cortex, primary visual cortex, hippocampus, amygdala and ventral striatum. ** Serial analysis of selected genes across the entire adult brain, focusing on cellular marker genes, genes with cortical area specificity and gene families important to neural function. * ISH Anatomic Search: Detailed gene expression search on the ISH data based on expert annotation * Reference Data: Developmental stage-specific reference series, consisting of magnetic resonance imaging (MRI) and Nissl histology to provide a neuroanatomical context for the gene expression data. These data and tools are designed to provide a valuable public resource for researchers and educators to explore neurodevelopment in non-human primates, and a key evolutionary link between other Web-based gene expression atlases for adult and developing mouse and human brain.
Proper citation: NIH Blueprint NHP Atlas (RRID:SCR_010559) Copy
http://brainandsociety.org/the-brain-observatory
Formerly a topical portal studying the brain which collected and imaged 1000 human brains, the Brain Observatory has partnered with the Institute for Brain and Society to build virtual laboratories that will feed directly into the database of images and knowledge created in the context of the Human Brain Library. The Brain Observatory will also host exhibits, conferences, and events aimed at promoting a heightened awareness of brain research and how its results can benefit personal brain fitness and mental health.
Proper citation: Brain Observatory (RRID:SCR_010641) Copy
http://www.brain.northwestern.edu/index.html
The Cognitive Neurology and Alzheimer's Disease Center (CNADC) is a multidisciplinary organization dedicated to conducting research to discover how the brain coordinates mental functions such as memory, language, attention, and emotion; transferring the benefits of this research to patients with brain diseases that impair cognitive function; and training researchers and clinicians who want to work in this field. The CNADC's mission is to investigate the neurological basis of cognitive function, to elucidate causes of dementia, and to ensure that the patients and their families are the beneficiaries of resultant discoveries. * Clinical Services: Neurobehavior and Memory Health Clinical Services * Annual Grant Opportunities: Annual Core Pilot Project Funding Opportunities * Research Areas & Faculty: Alzheimer's Disease / Primary Progressive Aphasia / Frontal Dementia, Brain Endowment (Brains are permanently stored, and requests for tissue for research purposes are submitted to Dr. Bigio for review by the Northwestern Alzheimer's Disease Center); Cognitive Brain Mapping Group, Volunteer For A Study * Fellowships: Neuropathology Fellowship, Behavioral Neurology & Neuropsychiatry Fellowship * Training Programs: Mechanisms of Aging and Dementia (M.A.D.) Training Program; Training Program in the Neuroscience of Human Cognition
Proper citation: Northwestern University Cognitive Neurology and Alzheimers Disease Center (RRID:SCR_012747) Copy
https://www.nia.nih.gov/alzheimers
Portal for Alzheimer's disease that compiles, archives and disseminates information about current treatments, diagnostic tools and ongoing research for health professions, people with AD, their families and the public. The Center provides informational services and referrals for AD symptoms, diagnosis and treatment for patients; clinical trial information and literature searches for researchers; training materials and guidelines for caregivers; and Spanish language resources.
Proper citation: Alzheimer's Disease Education and Referral Center (RRID:SCR_012787) Copy
http://umcd.humanconnectomeproject.org
Web-based repository and analysis site for connectivity matrices that have been derived from neuroimaging data including different imaging modalities, subject groups, and studies. Users can analyze connectivity matrices that have been shared publicly and upload their own matrices to share or analyze privately.
Proper citation: USC Multimodal Connectivity Database (RRID:SCR_012809) Copy
Consortium for the cell census in the brain. Integrated network of data generating centers, data archives, and data standards developers, with the goal of systematic multimodal brain cell type profiling and characterization. Emphasis of the BICCN is on the whole mouse brain with demonstration of prototype feasibility for human and nonhuman primate brains.
Proper citation: BICCN (RRID:SCR_015820) Copy
Consortium studying the regulation and alternative splicing of gene expression in multiple tissues from human brains. The UKBEC dataset comprises of brains from individuals free of neurodegenerative disorders.
Proper citation: UK Brain Expression Consortium (RRID:SCR_015889) Copy
https://github.com/ABCD-STUDY/DEAP
Web service for data exploration and analysis of the ABCD Study - the largest long-term study of brain development and child health in the United States.
Proper citation: DEAP - Data Exploration and Analysis Portal (RRID:SCR_016158) Copy
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