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http://psidonline.isr.umich.edu/

Long-term longitudinal dataset with information on generational links and socioeconomic and health conditions of individuals over time. The central foci of the data are economic and demographic, with substantial detail on income sources and amounts, wealth, savings, employment, pensions, family composition changes, childbirth and marriage histories, and residential location. Over the life of the PSID, the NIA has funded supplements on wealth, health, parental health and long term care, housing, and the financial impact of illness, thus also making it possible to model retirement and residential mobility. Starting in 1999, much greater detail on specific health conditions and health care expenses is included for respondent and spouse. Other enhancements have included a question series about emotional distress (2001); the two stem questions from the Composite International Diagnostic Interview to assess symptoms of major depression (2003); a supplement on philanthropic giving and volunteering (2001-03); a question series on Internet and computer use (2003); linkage to the National Death Index with cause of death information for more than 4,000 individuals through the 1997 wave, updated for each subsequent wave; social and family history variables and GIS-linked environmental data; basic data on pension plans; event history calendar methodology to facilitate recall of employment spells (2001). The reporting unit is the family: single person living alone or sharing a household with other non-relatives; group of people related by blood, marriage, or adoption; unmarried couple living together in what appears to be a fairly permanent arrangement. Interviews were conducted annually from 1968 through 1997; biennial interviewing began in 1999. There is an oversample of Blacks (30%). Waves 1990 through 1995 included a 20% Hispanic oversample; within the Hispanic oversample, Cubans and Puerto Ricans were oversampled relative to Mexicans. All data from 1994 through 2001 are available as public release files; prior waves can be obtained in archive versions. The special files with weights for families are also available. Restricted files include the Geocode Match File with information for 1968 through 2001, the 1968-2001 Death File, and the 1991 Medicare Claims File. * Dates of Study: 1968-2003 * Study Features: Longitudinal, Minority Oversampling * Sample Size: 65,000+ Links * ICPSR Series: http://www.icpsr.umich.edu/icpsrweb/ICPSR/series/00131 * ICPSR 1968-1999: Annual Core Data: http://www.icpsr.umich.edu/icpsrweb/ICPSR/studies/07439 * ICPSR 1968-1999: Supplemental Files: http://www.icpsr.umich.edu/icpsrweb/ICPSR/studies/03202 * ICPSR 1989-1990: Latino Sample: http://www.icpsr.umich.edu/icpsrweb/ICPSR/studies/03203

Proper citation: Panel Study of Income Dynamics (RRID:SCR_008976) Copy   

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http://nis.princeton.edu/

Public use data set on new legal immigrants to the U.S. that can address scientific and policy questions about migration behavior and the impacts of migration. A survey pilot project, the NIS-P, was carried out in 1996 to inform the fielding and design of the full NIS. Baseline interviews were ultimately conducted with 1,127 adult immigrants. Sample members were interviewed at baseline, 6 months, and 12 months, with half of the sample also interviewed at three months. The first full cohort, NIS-2003, is based on a nationally representative sample of the electronic administrative records compiled for new immigrants by the US government. NIS-2003 sampled immigrants in the period May-November 2003. The geographic sampling design takes advantage of the natural clustering of immigrants. It includes all top 85 Metropolitan Statistical Areas (MSAs) and all top 38 counties, plus a random sample of other MSAs and counties. Interviews were conducted in respondents'' preferred languages. The baseline was multi-modal: 60% of adult interviews were administered by telephone; 40% were in-person. The baseline round was in the field from June 2003 to June 2004, and includes in the Adult Sample 8,573 respondents, 4,336 spouses, and 1,072 children aged 8-12. A follow-up was planned for 2007. Several modules of the NIS were designed to replicate sections of the continuing surveys of the US population that provide a natural comparison group. Questionnaire topics include Health (self-reports of conditions, symptoms, functional status, smoking and drinking history) and use/source/costs of health care services, depression, pain; background; (2) Background: Childhood history and living conditions, education, migration history, marital history, military history, fertility history, language skills, employment history in the US and foreign countries, social networks, religion; Family: Rosters of all children; for each, demographic attributes, education, current work status, migration, marital status and children; for some, summary indicators of childhood and current health, language ability; Economic: Sources and amounts of income, including wages, pensions, and government subsidies; type, value of assets and debts, financial assistance given/received to/from respondent from/to relatives, friends, employer, type of housing and ownership of consumable durables. * Dates of Study: 2003-2007 * Study Features: Longitudinal * Sample Size: 13,981

Proper citation: New Immigrant Survey (RRID:SCR_008973) Copy   

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http://www.midus.wisc.edu/

Data set from a collaborative, interdisciplinary investigation of patterns, predictors, and consequences of midlife development in the areas of physical health, psychological well-being, and social responsibility. Respondents were asked to provide extensive information on their physical and mental health throughout their adult lives, and to assess the ways in which their lifestyles, including relationships and work-related demands, contributed to the conditions experienced. An additional series of questions focusing on childhood queried respondents regarding the presence/absence of their parents, religion, rules/punishments, love/affection, physical/verbal abuse, and the quality of their relationships with their parents and siblings. Respondents were drawn from a nationally representative random-digit-dial sample of non-institutionalized, English-speaking adults, aged 25-74, selected from working telephone banks in the coterminous United States. Those queried participated in an initial telephone interview and responded to a mail questionnaire. MIDUS 2 carried forward MIDUS 1 and enlisted a new sample of African Americans. MIDUS2 also expanded the focus by incorporating detailed neurophysiological assessments on a large subsample in three geographic regions. Data collection largely repeats T1 assessments (45 minute phone interview, 100 page self-administered questionnaire) plus additions in select areas (e.g., cognitive functioning, optimism and coping, life events, caregiving). In addition, MIDUS 2 is using diary techniques to assess daily stressors in a subsample of respondents; conducting cognitive testing through telephone interviews; collecting biological data on a subsample of respondents, including baseline biomarkers as well as laboratory challenge studies, with assessments of salivary cortisol, blood pressure, and heart rate variability; and collecting EEG measures to focus on the central circuitry of emotion, related to affect and depression. Siblings and Twins: Similar data were collected from a survey of 951 siblings of a respondent in the main survey. MIDUS also contains twins data, from a separate national survey unrelated to the main MIDUS survey. From this separate national survey, a total of 1,996 twins agreed to participate. The Twins respondents were given the same assessments as the Main and Siblings samples. Additionally, the Twins sample was asked a series of questions about their birth, shared physical characteristics, childhood and adult relationships with their twin, whether they were dressed alike as children, and whether others experienced difficulty identifying them correctly. Data and comprehensive documentation for MIDUS 1 and 2 are available via ICPSR. * Dates of Study: 1995-2008 * Study Features: Longitudinal, Minority Oversampling, Anthropometric Measures * Sample Size: ** 1995-6: 4,242 (MIDUS 1) ** 2004-6: 7,108 (MIDUS 2) Links: * ICPSR ����?? MIDUS 1: http://www.icpsr.umich.edu/icpsrweb/ICPSR/studies/02760 * ICPSR ����?? MIDUS 2: http://www.icpsr.umich.edu/icpsrweb/ICPSR/studies/04652

Proper citation: National Survey of Midlife Development in the United States (RRID:SCR_008972) Copy   

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http://dx.doi.org/10.3886/ICPSR06842.v1

A panel data set for use in cross-cultural analyses of aging, health, and well-being between the U.S. and Japan. The questionnaires were designed to be partially comparable to many surveys of the aged, including Americans'' Changing Lives; 1984 National Health Interview Survey Supplement on Aging; Health and Retirement Study (HRS), and Well-Being Among the Aged: Personal Control and Self-Esteem (WBA). NSJE questionnaire topics include: * Demographics (age, sex, marital status, education, employment) * Social Integration (interpersonal contacts, social supports) * Health Limitations on daily life and activities * Health Conditions * Health Status (ratings of present health) * Level of physical activity * Subjective Well-Being and Mental Health Status (life satisfaction, morale), * Psychological Indicators (life events, locus of control, self-esteem) * Financial situation (financial status) * Memory (measures of cognitive functioning) * Interviewer observations (assessments of respondents) The NSJE was based on a national sample of 2,200 noninstitutionalized elderly aged 60+ in Japan. This cohort has been interviewed once every 3 years since 1987. To ensure that the data are representative of the 60+ population, the samples in 1990 and 1996 were refreshed to add individuals aged 60-62. In 1999, a new cohort of Japanese adults aged 70+ was added to the surviving members of previous cohorts to form a database of 3,990 respondents 63+, of which some 3,000 were 70+. Currently a 6-wave longitudinal database (1987, 1990, 1993, 1996, 1999, & 2002) is in place; wave 7 began in 2006. Data Availability: Data from the first three waves of the National Survey of the Japanese Elderly are currently in the public domain and can be obtained from ICPSR. Additional data are being prepared for future public release. * Dates of Study: 1987-2006 * Study Features: Longitudinal, International * Sample Size: ** 1987: 2,200 ** 1990: 2,780 ** 1993: 2,780 ** 1996: ** 1999: 3,990 ** 2002: ** 2006: Links: * 1987 (ICPSR): http://www.icpsr.umich.edu/icpsrweb/ICPSR/studies/06842 * 1990 (ICPSR): http://www.icpsr.umich.edu/icpsrweb/ICPSR/studies/03407 * 1993 (ICPSR): http://www.icpsr.umich.edu/icpsrweb/ICPSR/studies/04145 * 1996 (ICPSR): http://www.icpsr.umich.edu/icpsrweb/ICPSR/studies/26621

Proper citation: National Survey of the Japanese Elderly (RRID:SCR_008971) Copy   

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https://github.com/automaticanalysis/automaticanalysis

Integration framework for major open source packages in neuroimaging including SPM, FSL, FreeSurfer, EEGLAB, and Fieldtrip. Efficient neuroimaging workflows and parallel processing using Matlab and XML. Addresses challenges of processing multimodal datasets, like combining anatomy, functional MRI, diffusion, and EEG, to yield integrated views of brain. Allows to design, execute, and share pipelines utilizing multiple open source packages. Supports parallelized execution to address challenges of large cohort studies and provides quality control offering group statistics and reporting facilities to help identify outlier subjects and erroneous processing steps.

Proper citation: Automatic Analysis (RRID:SCR_003560) Copy   

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http://www.adgenetics.org/

Consortium to conduct genome-wide association studies (GWAS) to identify genes associated with an increased risk of developing late-onset Alzheimer''''s disease (LOAD). The goal of the ADGC is to identify genetic variants associated with risk for AD. It plans to do this through the following collaborative goals: # Identify genes responsible for AD susceptibility # Identify AD sub-phenotype genes rate-of-progression plaque / tangle load / distribution biomarker variability # Generate a genetic data resource for the AD research community Data generated by ADGC is available at the following website: https://www.niagads.org/content/alzheimers-disease-genetics-consortium-adgc-collection

Proper citation: Alzheimers Disease Genetics Consortium (RRID:SCR_004004) Copy   

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https://www.uab.edu/medicine/alzheimers/

The UAB Alzheimer's Disease Center provides comprehensive treatment for Alzheimer's patients while also promoting research for the prevention and cure of Alzheimer's disease and related disorders. The ADC is an interdisciplinary program of scientists working in areas including neurology, psychiatry, genetics, and psychology. The Center provides comprehensive treatment and promotes research for the prevention and/or cure of Alzheimer's disease and other related disorders with memory loss and impaired cognition. A major emphasis of research is the maintenance of a clinical research database comprised of neurological, medical, and neuropsychological test data from participants seen in the ADRC Clinical study since 1999, many of whom have been followed for several years in the study.

Proper citation: UAB Alzheimer's Disease Center (RRID:SCR_004305) Copy   

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http://www.nia.nih.gov/research/dab/nia-mutant-mouse-aging-colony-handbook

THIS RESOURCE IS NO LONGER IN SERVICE, documented on September 09, 2013. Supply aged mutant and transgenic mice for NIH-supported research directly related to the biology of aging. The mice are raised by the NIA's contractor, Taconic Farms, in Specific Pathogen-Free (SPF) barrier facilities. The strains in the mutant mouse aging colony have been donated by the investigators who developed the models, and those investigators are still the legally recognized owners of the intellectual property. A Material Transfer Agreement (MTA) is required to purchase the mice (a one-time requirement per strain). There are restrictions to the use of this colony as described in the MTA. These restrictions include a prohibition against breeding the mice purchased from the NIA Mutant Mouse Aging Colony, agreement that the mice will not be used for commercial purposes, and agreement that the mice and all derivatives will not be transferred to third parties. The restrictions are further spelled out in the MTA. Animals are sold by age, not weight, and ages are stated in 1 month intervals only; all animals born within a calendar month are considered to be the same age, so date of birth (DOB) is given as month/year. All mice are virgins. The mutant mouse aging colony is slated to end in September 2013. Old mice will be available until September 2013 but the availability of young mice will end earlier. Entries of different strains into the mutant mouse aging colony will end at different times, dependent on the lifespan and pattern of use of the strain. Mouse models include: * Snell Dwarf (3623) ??????????????? last entry will be the November 2011 DOB (date of birth) * Ames Dwarf (324) ??????????????? last entry will be the October 2012 DOB * A53T ???????????????????????-synuclein Transgenic (322) ??????????????? last entry will be the December 2012 DOB * GFP Transgenic (317) ??????????????? last entry will be the January 2013 DOB

Proper citation: NIA Mutant Mouse Aging Colony Handbook (RRID:SCR_007328) Copy   

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http://trans.nih.gov/CEHP/

Trans-NIH project to assess the state of longitudinal and epidemiological research on demographic, social and biologic determinants of cognitive and emotional health in aging adults and the pathways by which cognitive and emotional health may reciprocally influence each other. A database of large scale longitudinal study relevant to healthy aging in 4 domains was created based on responses of investigators conducting these studies and is available for query. The four domains are: * Cognitive Health * Emotional Health * Demographic and Social Factors * Biomedical and Physiologic Factors

Proper citation: Cognitive and Emotional Health Project: The Healthy Brain (RRID:SCR_007390) Copy   

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http://senselab.med.yale.edu/ordb/

Database of vertebrate olfactory receptors genes and proteins. It supports sequencing and analysis of these receptors by providing a comprehensive archive with search tools for this expanding family. The database also incorporates a broad range of chemosensory genes and proteins, including the taste papilla receptors (TPRs), vomeronasal organ receptors (VNRs), insect olfaction receptors (IORs), Caenorhabditis elegans chemosensory receptors (CeCRs), and fungal pheromone receptors (FPRs). ORDB currently houses chemosensory receptors for more than 50 organisms. ORDB contains public and private sections which provide tools for investigators to analyze the functions of these very large gene families of G protein-coupled receptors. It also provides links to a local cluster of databases of related information in SenseLab, and to other relevant databases worldwide. The database aims to house all of the known olfactory receptor and chemoreceptor sequences in both nucleotide and amino acid form and serves four main purposes: * It is a repository of olfactory receptor sequences. * It provides tools for sequence analysis. * It supports similarity searches (screens) which reduces duplicate work. * It provides links to other types of receptor information, e.g. 3D models. The database is accessible to two classes of users: * General public www users have full access to all the public sequences, models and resources in the database. * Source laboratories are the laboratories that clone olfactory receptors and submit sequences in the private or public database. They can search any sequence they deposited to the database against any private or public sequence in the database. This user level is suited for laboratories that are actively cloning olfactory receptors.

Proper citation: Olfactory Receptor DataBase (RRID:SCR_007830) Copy   

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http://www.adrc.pitt.edu/

A research center associated with the University of Pittsburgh that specializes in the diagnosis of Alzheimer's disease and related disorders. The overall objective of the ADRC is to study the pathophysiology of Alzheimer's disease, with the aim of improving the reliability of diagnosis of Alzheimer's and developing effective treatment strategies. Current research foci emphasize neuropsychiatry and neuropsychology, molecular genetics and epidemiology, basic neuroscience, and structural and functional imaging that aid in the diagnosis and treatment of Alzheimer's disease. Specific services at the ADRC include: comprehensive diagnostic evaluation of patients with suspected Alzheimer's disease and other forms of dementia; evaluation of memory, language, judgment, and other cognitive abilities; and education and counseling for patients and families.

Proper citation: University of Pittsburgh Alzheimer Disease Research Center (RRID:SCR_008084) Copy   

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http://www.nia.nih.gov/research/scientific-resources

A resource that provides information on the vast number of resources available from the National Institute of Aging. NIA maintains approximately 150 primates (Macaca mulatta) at four regional primate centers where aging-related research is conducted. NIA also maintains colonies of aged rats and mice that are used for age-related disease research. This resource supports a multi-institutional study, the Interventions Testing Program (ITP), that investigates diets and dietary supplements that extend lifespan, delay disease and avoid dysfunction. NIA is also in charge of a microarray facility which provides filter arrays of 17,000 mouse cDNA clone sets that were developed at the NIA Intramural Research Program Laboratory of Genetics. NIA supports studies that provide biospecimens that can be shared for later research. This resource also helps the C. elegans Genetic Center at the University of Minnesota, which contains 1,000 strains of C. elegans that can be used for aging studies. This resource also provides a searchable database for epidemiological research on aging. There is access to social and behavioral research materials, including books on aging and health, from the research was conducted and supported by NIA. There are links to federal web sites that are further resources for aging research that were supported by NIA.

Proper citation: NIA Scientific Resources (RRID:SCR_008269) Copy   

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https://skyline.gs.washington.edu/labkey/project/home/software/Skyline/begin.view

Software tool as Windows client application for targeted proteomics method creation and quantitative data analysis. Open source document editor for creating and analyzing targeted proteomics experiments. Used for large scale quantitative mass spectrometry studies in life sciences.

Proper citation: Skyline (RRID:SCR_014080) Copy   

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http://mayoresearch.mayo.edu/mayo/research/dickson_lab/

A brain bank and laboratory focused on memory and motor disorders. Brains are sent to the laboratory for diagnosis and research for the State of Florida Alzheimer Disease Initiative and for the Society for Progressive Supranuclear Palsy. As part of this brain banking function, fixed and frozen brain samples are obtained at autopsy and sent to the laboratory for diagnostic evaluation and for various types of research studies. The major types of analyses performed on the brain samples include neuro-histology, immunohistochemistry, confocal microscopy, electron microscopy and image analysis, as well as immunoassays. The latter are based upon Western blotting and enzyme linked immunoassays. The laboratory has a specific interest in the interface between normal aging and Alzheimer's disease, as well as in non-Alzheimer's degenerative disorders such as Lewy body dementia, corticobasal degeneration, progressive supranuclear palsy and frontotemporal dementia. The primary focus of research on aging is neuropathologic characterization of brains of individuals who had been prospectively and longitudinally evaluated during life. These studies aim to determine differences in a range of biologic parameters in brains of people with normal cognitive, mild cognitive impairment and dementia. Their focus on Parkinson's disease is to identify preclinical Parkinson's disease in order to develop means for early diagnosis.

Proper citation: Mayo Clinic Jacksonville: Neuropathology and Microscopy (RRID:SCR_008753) Copy   

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http://www.rad.upenn.edu/sbia/braid/braid_web/index.html

Large-scale archive of normalized digital spatial and functional data with an analytical query mechanism. One of its many applications is the elucidation of brain structure-function relationships. BRAID stores spatially defined data from digital brain images which have been mapped into normalized Cartesian coordinates, allowing image data from large populations of patients to be combined and compared. The database also contains neurological data from each patient and a query mechanism that can perform statistical structure-function correlations. The project is developing database technology for the manipulation and analysis of 3-dimensional brain images derived from MRI, PET, CT, etc. BRAID is based on the PostgreSQL server, an object/relational DBMS, which allows a standard relational DBMS to be augmented with application-specific datatypes and operators. The BRAID project is adding operations and datatypes to support querying, manipulation and analysis of 3D medical images, including: * Image Datatypes: BRAID supports a family of 3D image datatypes, each having an abstract type and an implementation type. Abstract types include boolean (for regions of interest), integer, float, vector (for representing morphological changes), tensor (for representing derivatives and standard deviations of vector images) and color. Implementation types at present include line-segment format and voxel array. * Image Operators: BRAID supports addition of images, multiplication (which is interpreted as intersection for boolean images), coercion of an image''s abstract or implementation type to another value, and determination of volumes of regions of interest. * Statistical Operators: A chi-squared test has been added to SQL as an aggregate operator on pairs of boolean values. * Web Interface: A general-purpose Web gateway allows the results of queries that return computed images to be displayed. You can download the BRAID source code 2.0. This version is developed under postgreSQL 7.3.4., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025.

Proper citation: BRAID (RRID:SCR_008702) Copy   

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http://med.emory.edu/ADRC/index.html

An Alzheimer's research center which focuses on mild cognitive impairment and early diagnosis and treatment of memory disorders. The Center hosts clinical trials in which the public can participate. Its resources for scientists include a tissue and biospecimen banking facility, the Emory neurology database, and research seminars.

Proper citation: Emory Alzheimer's Disease Research Center (RRID:SCR_008761) Copy   

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http://www.alzresearch.org/index.cfm

A Alzheimer's Disease Research Center (ADRC) whose goal is to conduct basic and clinical research aimed at understanding Alzheimer's disease. The Center enrolls a variety of individuals for clinical trials, evaluation and follow-up, including: normal control subjects, individuals with mild memory problems, and patients diagnosed with Alzheimer's Disease or related dementias. Researchers can request data and specimens obtained from ADRC subjects. These include blood or DNA, brain specimens, and cross-sectional or longitudinal clinical and cognitive data, all from ADRC subjects.

Proper citation: Johns Hopkins Alzheimer's Disease Research Center (RRID:SCR_008757) Copy   

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http://www.bri.ucla.edu/research/resources

Brain bank resources which include postmortem human frozen brain tissue and matched cerebrospinal fluid (CSF) and blood available for scientists to search for etiopathogeneses of human disease. The National Neurological Research Specimen Bank and the Multiple Sclerosis Human Neurospecimen Bank maintains a collection of quick frozen and formalin fixed postmortem human brain tissue and frozen cerebrospinal fluid from patients with neurological diseases, including Alzheimer's Disease, amyotrophic lateral sclerosis, depressive disorder/suicide, and epilepsy, among others. Diagnoses are documented by clinical medical records and gross/microscopic neuropathology. The Neuropathology Laboratory at the UCLA Medical Center maintains a bank of frozen, formalin and paraformaldehyde-fixed and paraffin-embedded postmortem human brain tissues and frozen cerebrospinal fluid (CSF) from patients who die with Alzheimer's disease and other dementing and degenerative illnesses, as well as control materials removed in a similar fashion from patients who are neurologically normal.

Proper citation: Brain Research Institute Biobank Resources (RRID:SCR_008756) Copy   

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http://www.mssm.edu/research/centers/alzheimers-disease-research-center/

A research facility and clinical program that is dedicated to the study and the treatment of both normal aging and Alzheimer's disease. This facility will accommodate requests for its resources (for example, data or tissue) from investigators that are not funded by the ADRC. Their team is composed of experts in geriatrics, geriatric psychiatry and psychology, neurology, pathology, and radiology. All team members work to provide services to those with memory disorders. This center sponsors educational programs for healthcare professionals and community groups. Data from the ADRC cores are available to all ADRC investigators after approval from the PI who collected the data. Data generated by the ADRC cores are communicated to the National Alzheimer's Coordinating Center (NACC) and can be available through them. Tissue can be distributed after approval of the Tissue Allocation Committee, and can be used for further research.

Proper citation: Mount Sinai Alzheimer's Disease Research Center (RRID:SCR_008780) Copy   

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http://depts.washington.edu/adrcweb/

Research center investigating the basic mechanisms underlying the development of Alzheimer's disease and related disorders, directing particular attention to biomarkers and experimental new treatments. They also continue to search for genetic risk factors underlying Alzheimer's disease (AD). Their main priorities are to find causes, effective treatments, and prevention strategies. Their investigators also are partnering with other Alzheimer's Centers across the country to evaluate promising new medications and other treatments for AD. The ultimate goal of their basic and clinical studies is to improve patient care and function, and improve the quality of life for both the patient and the caregiver. ADRC Cores: * Administration * Clinical Core * Satellite Core * Data Management & Biostatistics * Neuropathology Core * Education & Information Transfer * Genetics

Proper citation: University of Washington Alzheimers Disease Research Center (RRID:SCR_008814) Copy   

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