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https://www.utsouthwestern.edu/education/medical-school/departments/neurology/research/microscopy-facility/

Core suited to advance study of traumatic brain injury, as well as other neurological and psychiatric disorders.Utilizes microscopy strategies to evaluate neuropathology across micro-, meso-, and macro-scales of inquiry. Provides access to microscopes including TissueCyte 1000 multi-photon microscopes,Hamamatsu NanoZoomer 2.0-HT,Zeiss Axioscan.Z1. Offers access to fluorescence stereomicroscope and upright microscope, both with digital cameras, as well as sectioning equipment (cryostat, microtome, and vibrotome). Provide computer available for use running MicroBrightField Stereo Investigator and Neurolucida software packages for offline stereological analysis, neuron tracing, and 3D rendering of large, whole-brain datasets.

Proper citation: Texas University Southwestern Medical Center Whole Brain Microscopy Core Facility (RRID:SCR_017949) Copy   

•   Source: SciCrunch Registry

http://ncore.web.unc.edu/

Core provides physicochemical characterization of nanoscale entities. Offers characterization of several classes of nanomaterials:Polymer conjugates,Polymeric micelles,Liposomes,Nanogels,Polyion complexes of small drugs and biomacromolecules (proteins, DNA, and RNA),Inorganic/metal nanoparticles,Bio-derived nanoparticles such as exosomes with protein and nucleic acid cargo.

Proper citation: North Carolina University at Chapel Hill Nanomedicines Characterization Core Facility (RRID:SCR_017951) Copy   

•   Source: SciCrunch Registry

https://www.bidmc.org/research/research-by-department/radiology/mri-research/mri-facilities/translational-mri-research-core

Core provides MRI capabilities for imaging human subjects and potentially large animals as part of research studies. Facility operates GE Discovery MR750 3T whole-body scanner and can provide access to 1.5T system. Scanner is FDA cleared for clinical use. It has proprietary software including pulse programming environments and reconstruction programs and customizable software and protocols for applications including functional and structural brain imaging, abdominal perfusion and diffusion, muscle functional imaging and spectroscopy are available to users.Support for fMRI acquisition and visual and auditory stimulus presentation, diffusion tensor imaging, spectroscopy, and high quality anatomic imaging is available. The system has specialized receiver coils for sensitive imaging of particular anatomy. Additional customized coils can be manufactured in our RF lab. The system also has full broadband capability for multinuclear MRI and MRS, including (F-19, C-13, P-31, and Na-23).Our facility can also provide Image Post-processing and computerized image transfer, assistance to ensure MRI equipment safety, and can facilitate Clinical Readings.

Proper citation: Beth Israel Deaconess Medical Center Translational MRI Research Core Facility (RRID:SCR_017950) Copy   

•   Source: SciCrunch Registry

https://dentistry.musc.edu/research/gcohr

Core offers investigators opportunity to address research questions that require use of gnotobiotic animals. Standard services provide germ free mice (e.g. BALB/c, C57BL/6), deriving new strains of mice into germ free state by caesarean section, tissue collection and/or fluid from mice that have not received treatment or manipulations, exporting germ free mice in sterile transporters to other institutions. Non-Standard Services include maintaining and breeding newly derived germ free mice, administration of specialized diets, administration of compounds as therapeutic or disease-inducing agents, tissue collection and/or fluid from mice that have received treatment or manipulations.

Proper citation: Medical University of South Carolina College of Dental Medicine Gnotobiotic Animal Core Facility (RRID:SCR_018884) Copy   

•   Source: SciCrunch Registry

https://education.musc.edu/colleges/medicine/departments/pharmacology/redox-center/cores/analytical-redox-biology-core

Core provides analytical redox biochemistry methods and mentoring support for COBRE junior faculty with goal to advance their research endeavors, publications and fundability. Specific aims are:Provide ROS /RNS identification and quantification, Perform quantitative analysis of ROS/RNS. Provides expertise and technology for in depth biochemical analysis of thiol-centered enzyme activities and define protein:protein interactions.

Proper citation: South Carolina Medical University Analytical Redox Biology Core Facility (RRID:SCR_017955) Copy   

•   Source: SciCrunch Registry

https://education.musc.edu/colleges/medicine/departments/pharmacology/redox-center/cores/cell-and-molecular-imaging-core

Core provides COBRE investigators access and assistance for high end laser scanning confocal/multiphoton/super-resolution microscopy and related imaging techniques. Houses confocal/multiphoton systems: Zeiss LSM 880 NLO Quasar confocal/multiphoton microscope with Fast Airyscan super-resolution detector; Olympus FV1200 silicone oil optics multiphoton microscope configured especially for intravital imaging; Olympus FV10i LIV confocal microscope with water immersion optics for live cell imaging; Zeiss LSM 510 META laser scanning confocal microscope for general purpose imaging of live and fixed specimens; BD CARV II disk-scanning confocal microscope for video rate real-time confocal imaging providing sophisticated imaging technologies, expertise and training.

Proper citation: South Carolina Medical University Cell and Molecular Imaging Core Facility (RRID:SCR_017954) Copy   

•   Source: SciCrunch Registry

https://www.feinberg.northwestern.edu/research/cores/units/structural-bio.html

Core provides equipment, training, technical support, and maintenance of equipment for studying structures of biological macromolecules and materials. Serves with expertise in structural and computational biology. Services offered include Macromolecular Structure Determination and Analysis,Macromolecular crystallography at LS-CAT,Robotics equipment for crystallization experiments,UV crystal imaging capabilities,Software for structure analysis,Graphics facilities for visualization/presentation of molecular structures,Computer servers specialized for structural biology calculationss,Support and Training ,X-ray crystallography, from designing crystallization experiments to structure determination and refinemen,Molecular graphics for analysis and presentation,CryoEM and EM training.Resources Available:Crystallography Art Robbins, Inc. Phoenix and Gryphon crystallization robots,TTP Labtech Dragonfly liquid handler for crystal tray setup,Jansi UVEX UV/Vis microscope/imaging system,Stereomicroscopes (camera equipped, at room temperature and 4 degrees C),Incubators for temperature-controlled crystallization,Coordination of access to LS-CAT for Northwestern University users,CryoEM,JEOL 3200FS TEM equipped with in-column energy filter (omega filter), field emission gun capable of operating at 200 or 300 kV and Gatan K2 Summit Direct Electron Detector,JEOL 1400 with Gatan 4k x 4k Ultrascan CCD camera,Solarus Plasma Cleaner and Pelco easyGlow Discharge Cleaning System,Cressington 308R carbon coater,Gatan Cryoplunge 3 and FEI Vitrobot Mark IV,Gatan 626 cryoholders with 655 Turbo pump stations.Resources available Computational:50+ node cluster running Linux including several single- and multi-GPU nodes,7 Quad-core Intel Xeon 3.4GHz workstations (3D stereo equipped for visualization and model building) 3 Dual Quad-core Intel Xeon 3.5GHz workstations with GPU computing capabilities (3D stereo equipped for visualization, model building, and GPU computing),LTO6 writers for quick data backup,45 tape LTO6 system for continuous data backup,Over 200 Tb of disk storage including RAID systems,10 Gigabit fiber Ethernet connection to APS.Software Crystallography,CCP4 suite,PHENIX,SHARP,SOLVE,HKL2000,XDS,CryoEM,CryoSparc,Relion3,Leginon,cisTEM,Appion,NMR,CNS,FELIX,Aria Modeling, graphics, and simulations,COOT,Pymol,Chimera,APBS,GROMACS,AMBER,VMD/NAMD.

Proper citation: Northwestern University School of Medicine Structural Biology Core Facility (RRID:SCR_017952) Copy   

•   Source: SciCrunch Registry

https://www.unh.edu/research/welcome-university-instrumentation-center

University wide core facility offers NMR,SEM including FIB, EBS, EBSD, Tensile Stage,Confocal,X-Ray Photoelectron Spectroscopy,X-Ray Microscope aka Micro CT, Expert analysis of research and industrial samples,Training in scientific instrument operation and data analysis, Maintenance, repair, and calibration of instruments,Specialty instrument engineering design and application services,Facilitation of access to scientific instruments throughout the university.

Proper citation: University of New Hampshire University Instrumentation Center Core Facility (RRID:SCR_021101) Copy   

•   Source: SciCrunch Registry

https://www.lsi.umich.edu/science/centers-technologies/center-structural-biology

Comprehensive structural biology resource.Provides high throughput protein laboratory for protein engineering, protein purification facilities for small- and large-scale protein production, macromolecular crystallization and crystallography laboratories for solving crystal structures of biological molecules, and X-ray facility with access to high energy synchrotron radiation. Provides expert guidance to researchers through every stage of project, collaborating and consulting with researchers who use the facilities. Service categories are Chemical, Material and Protein Characterization, Molecular Biology. Services include Cloning, Crystallization, Differential thermal analysis, Drug development, NMR (small molecule), PCR, Protein crystallography, Protein engineering, Protein production, Structure determination, Xray.

Proper citation: University of Michigan Center for Structural Biology Core Facility (RRID:SCR_021065) Copy   

•   Source: SciCrunch Registry

https://www.colorado.edu/geologicalsciences/resources/research-facilities/raman-microspectroscopy-lab

Core research facility housed in Department of Geological Sciences for fast, non-destructive characterization and chemical imaging of diverse materials spanning minerals (thin sections and powders), biological samples, fluids, dissolved gases, and much more.

Proper citation: University of Colorado Boulder Raman Microspectroscopy Lab Core Facility (RRID:SCR_019305) Copy   

•   Source: SciCrunch Registry

https://instaar.colorado.edu/research/labs-groups/organic-geochemistry-laboratory/

Shared analytical facility for multidisciplinary and collaborative research in fields as diverse as biogeochemistry, geobiology, astrobiology, environmental microbiology, paleoceanography, paleoclimatology, and energy, among others.Focuses on extraction, purification, separation, and chemical and isotopic characterization of organic molecules extracted from environmental and culture samples.

Proper citation: University of Colorado Boulder Organic Geochemistry Laboratory Core Facility (RRID:SCR_019301) Copy   

•   Source: SciCrunch Registry

https://www.colorado.edu/lab/biocore/

Purpose is to connect MCDB, EBIO, and IPHY researchers to campus research resources.

Proper citation: University of Colorado Boulder BioCore Core Facility (RRID:SCR_019302) Copy   

•   Source: SciCrunch Registry

https://www.colorado.edu/geologicalsciences/resources/research-facilities/u-thhe-thermochronology-lab

Fully equipped (U-Th)/He thermochronology facility.

Proper citation: University of Colorado Boulder CU Thermochronology Research and Instrumentation Lab Core Facility (RRID:SCR_019303) Copy   

•   Source: SciCrunch Registry

http://www.biotech.ufl.edu/cores/gene-expression-genotyping/

Core provides services and consultation on Single Cell RNA-Seq, RNA-Seq, 16s metagenomics and Affymetrix gene expression arrays. High-throughput RNA-seq libraries, 16s libraries and sequencing capture libraries can be done by using Agilent Bravo robot. QuantiGene RNA Assays measure up to 80 gene targets directly with degraded and cross-linked RNA in FFPE tissues and blood, with no RNA purification required.BioRad QX200 AutoDG Droplet Digital PCR System provides absolute quantification of target DNA or RNA molecules with greater precision and sensitivity than qPCR, sensitivity off ddPCR System can facilitate expanded analysis of single cells. Genotyping services include fragment analysis using AB3730, 96 capillary technology, development of microsatellite libraries using Illumina sequence data, and genotyping using mouse tails or ear punches.

Proper citation: University of Florida ICBR Gene Expression and Genotyping Core Facility (RRID:SCR_019145) Copy   

•   Source: SciCrunch Registry

https://www.colorado.edu/geologicalsciences/resources/research-facilities/earth-systems-stable-isotope-laboratory

Designed to measure relative abundance of stable isotopes of light elements and molecules.

Proper citation: University of Colorado Boulder Earth Systems Stable Isotope Lab Core Facility (RRID:SCR_019300) Copy   

•   Source: SciCrunch Registry

https://www.cardiff.ac.uk/central-biotechnology-services

Core provides facilities including cell analysis and imaging, genomics and bioinformatics, proteins and diagnostics. Services include experimental design advice, sample preparation,data generation,data analysis.

Proper citation: Cardiff University Central Biotechnology Services Core Facility (RRID:SCR_019141) Copy   

•   Source: SciCrunch Registry

https://cami.northwestern.edu/

Provides access to range of preclinical imaging modalities and support services. These include MRI, nuclear imaging (PET, SPECT, and CT), in vivo bioluminescence and fluorescence imaging, animal housing and prep spaces, and tissue culture. Image analysis services are available, as are software packages (JIM, Amira, Matlab) and a workstation for users to perform their own data analysis. Imaging services can be provided for investigators' own animal models, or animal models can be supplied by the Developmental Therapeutics Core.

Proper citation: Northwestern University Center for Advanced Molecular Imaging Core Facility (RRID:SCR_021192) Copy   

•   Source: SciCrunch Registry

https://research.med.psu.edu/core-facilities/zebrafish/

Provides Penn State research community with modern, centralized facility for housing, breeding and performing experiments with zebrafish.Provides physical and intellectual infrastructure for investigators whose research can benefit from use of zebrafish as model system.

Proper citation: Penn State Hershey College of Medicine Zebrafish Functional Genomics Core Facility (RRID:SCR_021199) Copy   

•   Source: SciCrunch Registry

https://research.med.psu.edu/core-facilities/mri/

MRI and NMR magnetic resonance imaging facility for animal and human research, providing MRI methodologies and expertise for in vivo studies Laboratory space includes biochemical, electronic and surgical suites, and fully equipped machine shop with (2) 3D printers. MRI Core facility has two MRI systems and EEG MRI-compatible system.3T Siemens PRISMA-Fit scanner equipped with True 2 Channel Tx and 64 Channel Rx. The latest RF coil set including a 64 Channel head coil and software packages with full clinical capability.7T Biospec 70/20 as small animal imaging system (Bruker Biospin, Ettlingen, Germany). Latest Hardware and Software. Avance NEO with Paravision 360. Full sensory fMRI stimulation systems:SenSaVue System for visual and auditory stimulation (Invivo Corp, FL, USA), which includes an LCD visual display, audio system, button response unit and software (E-Prime) for paradigm creation, patient management, protocol planning, precise delivery of brain stimulation, and behavioral analysis.ETT Olfactometer with full-programmable 6 independent channels for odor and trigeminal stimulation (ETT, LLC, Hershey, PA).Olfact Smell Test System (Osmic Enterprises, Inc., Cincinnati, OH) is a computerized instrument to test the smell functions of human subjects. The smell functions that can be tested are odor threshold, odor identification, and odor memory.ETT Gustatometer with full-programmable 7 independent channels for taste stimulation (ETT,LLC, Hershey, PA) Eye Link 1000 Plus system via SR Research: The EyeLink 1000 Plus Host PC performs real-time eye tracking at 250, 500,1000, or 2000 samples per second while computing true gaze position on the display viewed by the participant. The Host PC also performs on-line detection and analysis of eye-motion events such as saccades, blinks, and fixations. In addition to the sample data, these events are stored in a data file on the Host PC. They can be sent through the Ethernet link to the Display PC with a minimal delay or output as analog signals (if the optional analog/digital I/O card is installed). From the Host PC, the operator performs participant setup, monitors their performance, and can communicate with applications running on a Display PC.

Proper citation: Penn State Hershey College of Medicine MRI Core Facility (RRID:SCR_021198) Copy   

•   Source: SciCrunch Registry

https://med.psu.edu/core/specimen-processing

Process, store and ship clinical trial samples from IRB approved studies. Collect remnant samples for outside company for instrument correlation, validation and specimen type verification with IRB approved protocol. CLIA Waver for urine pregnancy, urine dipstick results for participant study treatment.

Proper citation: Penn State Hershey College of Medicine Clinical Research Biospecimen Core Facility (RRID:SCR_021194) Copy   

•   Source: SciCrunch Registry