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https://www.fredhutch.org/en/research/shared-resources/partner-with-us/leica-center-of-excellence.html

Leica Microsystems and Fred Hutch established Leica Center of Excellence in Pacific Northwest to provide researchers with advanced microscopy technologies, support generating scientific discoveries and developing new approaches to preventing and treating cancer and related diseases.

Proper citation: Fred Hutchinson Cancer Center Leica Center of Excellence Core Facility (RRID:SCR_022720) Copy   

•   Source: SciCrunch Registry

https://www.vet.upenn.edu/research/core-resources-facilities/extracellular-vesicle-core

Provides comprehensive or selected services in necessary isolation, quantification and characterization of EVs. Isolation of EV is based on size exclusion using high-performance (SEC-HPLC) or gravity fed (e.g. iZon column) liquid chromatography, ultracentrifugation, and/or density gradient ultracentrifugation. Accurately characterizes EV particle size distribution and concentration using resistive pulse sensing techniques (nCS1, Spectradyne, LLC). Immunophenotype can be accomplished using nanoscale flow cytometry and/or chip array (ExoViewTM) techniques. Provides services in training and education for individuals and lab groups in all methods above and study design consultation.

Proper citation: University of Pennsylvania Penn Vet Extracellular Vesicle Core Facility (RRID:SCR_022444) Copy   

•   Source: SciCrunch Registry

https://www.fredhutch.org/en/research/shared-resources/core-facilities/cellular-imaging.html

Provides advanced light microscopy services for biomedical and translational research including workflow, training for independent work, assistance and technical support in microscopy techniques, quantitative image analysis. Offers training and support for imaging and analyzing gels and blots.

Proper citation: Fred Hutchinson Cancer Center Cellular Imaging Core Facility (RRID:SCR_022609) Copy   

•   Source: SciCrunch Registry

http://igm.ucsd.edu/genomics/

Provides services including sequencing library preparation and sequencing on Illumina MiSeq and NovaSeq 6000 platforms. Supports single cell sequencing on 10X Genomics Chromium Controller. Provides Illumina Infinium Beadchips, which includes variety of whole genome genotyping arrays as well as Infinium MethylationEPIC BeadChip.

Proper citation: University of California at San Diego Institute for Genomic Medicine Genomics Center Core Facilitiy (RRID:SCR_022740) Copy   

•   Source: SciCrunch Registry

https://www.fredhutch.org/en/research/shared-resources/core-facilities/preclinical-imaging.html

Provides in vivo imaging technology and infrastructure to support basic and preclinical research. Offers diverse array of imaging modalities, including ultrasound and optical imaging, MRI, micro-CT and multiphoton microscopy.

Proper citation: Fred Hutchinson Cancer Center Preclinical Imaging Core Facility (RRID:SCR_022616) Copy   

•   Source: SciCrunch Registry

https://www.fredhutch.org/en/research/shared-resources/core-facilities/immune-monitoring.html

Supports investigators seeking evaluations of immunologic responses in basic and early stage clinical research settings. Provides resources and expertise to evaluate cellular immunologic processes and responses through reagents, molecular and cellular assays, assay development support and research consulting services.

Proper citation: Fred Hutchinson Cancer Center Immune Monitoring Core Facility (RRID:SCR_022615) Copy   

•   Source: SciCrunch Registry

http://crc.pitt.edu

Supports leading edge research with free access to advanced computing hardware and software.

Proper citation: University of Pittsburgh Center for Research Computing Core Facility (RRID:SCR_022735) Copy   

•   Source: SciCrunch Registry

https://www.fredhutch.org/en/research/shared-resources/core-facilities/flow-cytometry.html

Includes services from sterile cell sorting for therapeutic applications to whole cell mass spectrometry, diagnostics and early stage clinical trials. Provides expertise from experimental design to data analysis and troubleshooting, therapeutic cell sorting. Supports isolation of cells for Phase 1 clinical trials of cellular immunotherapies.

Proper citation: Fred Hutchinson Cancer Center Flow Cytometry Core Facility (RRID:SCR_022613) Copy   

•   Source: SciCrunch Registry

https://www.fredhutch.org/en/research/shared-resources/core-facilities/electron-microscopy.html

Offers techniques to resolve structures from cellular ultrastructure to molecular interactions. Offers expertise in EM sample preparation and imaging, cryogenic electron microscopy, technologies and services, training through complexities of electron microscopy workflow, from sample preparation to image processing. All users must be trained by core staff.

Proper citation: Fred Hutchinson Cancer Center Electron Microscopy Core Facility (RRID:SCR_022611) Copy   

•   Source: SciCrunch Registry

https://www.fredhutch.org/en/research/shared-resources/core-facilities/preclinical-modeling-core-lab.html

Supports development and maintenance of preclinical mouse models, including patient derived xenografts, cell line xenografts and genetically engineered mouse models.

Proper citation: Fred Hutchinson Cancer Center Preclinical Modeling Core Facility (RRID:SCR_022617) Copy   

•   Source: SciCrunch Registry

https://www.bcchr.ca/flowcore

Core provides equipment for flow cytometric analysis, full service cell sorting, training, and dissemination.

Proper citation: British Columbia Children's Hospital Research Institute Flow Cytometry Core Facility (RRID:SCR_022790) Copy   

•   Source: SciCrunch Registry

https://asrc.gc.cuny.edu/neuroscience/facilities/live-imaging-bioenergetics-facility/

Provides Zeiss LSM880 upright two photon confocal microscope with Airyscan, FAST model and CLARITY lens; LSM880 inverted live cell imaging confocal microscope with Airyscan and FAST model; Agilent Seahorse XFe24 live cell metabolic analyzer.Supported applications include in vivo imaging of live animals, time lapse live cell imaging with high resolution optical sectioning, deep imaging of fixed CLARITY tissues, calcium imaging, photo switching and photo uncaging, Fluorescence Recovery After Photobleaching, Forster Resonance Energy Transfer, laser ablation, and measuring mitochondrial respiration and glycolysis in live cells in real time.Provides advanced imaging analysis software Imaris for data processing.

Proper citation: City University of New York Advanced Science Research Center Live Imaging and Bioenergetics Core Facility (RRID:SCR_022945) Copy   

•   Source: SciCrunch Registry

https://alms.cnsi.ucla.edu/become-a-user/

Offers microscopy services, consultation, and support for application of novel microscopic and spectroscopic methods and advanced image analysis techniques for study of macromolecules, cellular dynamics and nano-scale characterization of bio-materials. Provides collection of customized biological fluorescence microscopes and small-animal imaging devices to study biological processes with high spatial and temporal resolution in whole organisms and in living cells down to single molecule detection level with nanometer accuracy. Located in basement and second floor of CNSI building, two optical suites designed to house microscopes with the required environment control (low vibration, air-filtered, air-conditioned and light-tight) and services. Services include Wide-field Fluorescence Imaging Microscopy (on a limited basis), Confocal One-Photon and Two-Photon Laser Scanning Microscopy, (both point scanning and spinning disk), Fluorescence Correlation Spectroscopy (FCS), Fluorescence Resonance Energy Transfer (FRET), microscopic and macroscopic Fluorescence Lifetime Imaging (FLIM) with Time-Correlated-Single-Photon-Counting (TCSPC) and Near-Infrared (NIR) Detection, Stimulated Emission Depletion laser-scanning microscopy (STED) (a super-resolution technique), both microscopic and macroscopic (small animal) spectral unmixing and laser capture microdissection.

Proper citation: University of California at Los Angeles California NanoSystems Institute Advanced Light Microscopy and Spectroscopy Core Facility (RRID:SCR_022789) Copy   

•   Source: SciCrunch Registry

https://isotope.ucsc.edu/

Provides light stable isotope ratio analysis services to scientists from UCSC and from around the world.

Proper citation: University of California at Santa Cruz Stable Isotope Laboratory Core Facility (RRID:SCR_022947) Copy   

•   Source: SciCrunch Registry

https://www.research.chop.edu/chop-penn-proteomics-core

Core has established quality controlled protocols to quantitatively analyze whole proteomes, phosphoproteomes, ubiquitylomes, and/or lysine acetylomes at deep level through process of serial enrichment.

Proper citation: Children's Hospital of Philadelphia Research Institute Proteomics Core Facility (RRID:SCR_023099) Copy   

•   Source: SciCrunch Registry

https://www.rockefeller.edu/transgenics/

Provides services such as Pronuclear Injection, Blastocyst Injection, Embryo and Sperm Cryopreservation, Strain Recovery and Rederivation. Provides assisted reproductive techniques such as IVF and ICSI used for strain recovery. Core facility to the university for creation and maintenance of all transgenic animal models, refinement and development of new transgenic techniques, as well as training center for research personnel.

Proper citation: Rockefeller University Transgenic and Reproductive Technology Center Core Facility (RRID:SCR_023098) Copy   

•   Source: SciCrunch Registry

https://www.biocampus.cnrs.fr/index.php/en/facilities-en/browse-by-facility/platform/421-bacfly-en

Facility dedicated to expression of innovative recombinant proteins for all in vitro and in vivo studies. Innovative technology developed by the platform, called FlexiBac, uses baculovirus / insect cell expression system.

Proper citation: Montpellier Bacfly Core Facility (RRID:SCR_023096) Copy   

•   Source: SciCrunch Registry

https://mssr.cnsi.ucla.edu/

Services include use of high throughput screening technology, compounds in various libraries, siRNA sets of druggable genome for mouse and human and database of results from screens. For compounds screens, data points are in singlets.For functional genomics screens we use duplicates. We typically utilize 384 well plates but are flexible in this regard. We can accomodate any plate type ranging from 96 to 1536 well plates. Specialty plates can be handled on needed base. We have special rates for consumables with many vendors based on volume we use. These reduced rates are passed on directly to our screeners.

Proper citation: University of Califorania at Los Angeles California NanoSystems Institute Molecular Screening Shared Resource Core Facility (RRID:SCR_022956) Copy   

•   Source: SciCrunch Registry

https://www2.uottawa.ca/faculty-medicine/core-facilities/gem

Facility assists researchers in mammalian genome editing and molecular biology, including CRISPR genetic libraries and screens as well as custom viral vector/particle production. Projects are customized to researchers needs, from full service cell line creation to design and cloning.Supported by Canadian Foundation for Innovation.

Proper citation: University of Ottawa Genome Editing and Molecular Biology Core Facility (RRID:SCR_022954) Copy   

•   Source: SciCrunch Registry

https://research.med.psu.edu/core-facilities/custom-antibody-core/

Provides service for production and purification of custom antibodies.Primary services include immunization of mice and rabbits to make mouse and rabbit monoclonal antibodies to select targets. Primary screening of hybridomas will be conducted using standard ELISA technology and positive lines will be preserved for cloning. Supernatants containing antibody selected as positive will be made available to investigators for secondary analyses in their labs (Westerns, immunofluorescence, functional assays). Investigator selected lines will be cloned, isotyped, and adapted to serum free culture for future production of high titer antibody if investigator requires large quantities of antibody. Standard purifications will be conducted as needed, and various modifications (fluorochrome, enzyme, biotin) are also provided as Antibody Core services.

Proper citation: Pennsylvania State University Hershey College of Medicine Custom Antibody Core Facility (RRID:SCR_022799) Copy   

•   Source: SciCrunch Registry