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https://ki.mit.edu/sbc/nanocore

Provides instruments for materials and nanomaterials research and full service TEM and cryoTEM sample preparation and imaging. Conducts CLEM and cryoCLEM workflows utilizing cryoFluorescence, cryoSEM and cryoFIB with focus on bio samples.Provides equipment and expertise to work with nanomaterials for characterization and imaging purpose. Core imaging capabilities include high performance field emission transmission electron microscope equipped with STEM, EELS, EDS and cryo-imaging, high performance field emission scanning electron microscope and focused ion beam equipped with STEM and cryo-imaging, cryo-fluorescent confocal microscope for CLEM workflows, and atomic force microscope equipped with liquid cell. Instrumentation for material characterization includes high throughputdynamic light scattering, nanoparticle sizing and counting, and rheometry.

Proper citation: Massachusetts Institute of Technology Swanson Biotechnology Center Nanotechnology Materials Core Facility (RRID:SCR_018674) Copy   

•   Source: SciCrunch Registry

https://cibr.umaryland.edu/service_center/show_external/4322?name=flow-cytometry-and-mass-cytometry-core-cvd

Core provides researchers with flow cytometry and mass cytometry services and equipment and help from highly trained and experienced staff.

Proper citation: Maryland University School of Medicine Flow Cytometry and Mass Cytometry Core Facility (RRID:SCR_018835) Copy   

•   Source: SciCrunch Registry

https://www.labx.com/product/sciex-api-5000

Triple quadrupole liquid chromatography mass spectrometer for analysis of bioanalytical samples. It can be used for DMPK and ADME studies.API 5000 LC/MS/MS System delivers the lowest limits of detection for the most demanding DMPK and ADME studies.

Proper citation: API 5000 Triple Quadrupole Liquid Chromatography Mass Spectrometer System (RRID:SCR_018437) Copy   

•   Source: SciCrunch Registry

http://www.hcbi.fas.harvard.edu

Microscopy facility. Contains microscopes including confocal, super-resolution, multi-photon, light sheet, live cell imaging, high-content screening, slide scanning, laser dissection and macroscopy stations. Features wet lab space, eukaryotic and prokaryotic incubation, and access to nearby animal care facilities for wide range of species.Services include Cell Imaging,Confocal Microscopy,Consultations,Data Analysis,Data Processing And Interpretation,High Content Screening,Laser Capture Microdissection,Microscopy,Multiphoton Microscopy,Optical Imaging,Slide Scanning,Whole Slide Imaging.

Proper citation: Harvard Center for Biological Imaging Core Facility (RRID:SCR_018673) Copy   

•   Source: SciCrunch Registry

http://www.umassmed.edu/umpc

UMass Metabolic Disease Research Center (MDRC), formerly the National Mouse Metabolic Phenotyping Center, is a core facility that performs standardized experiments using state-of-the-art equipment for the purpose of investigating transgenic mouse models of diabetes, obesity, and metabolic liver disease. Provides metabolic and functional characterization of mouse models of human diseases that are developed by academic and industry researchers in joint efforts to understand metabolic diseases and to identify new therapies.

Proper citation: University of Massachusetts Medical School Metabolic Disease Research Center Core Facility (RRID:SCR_018672) Copy   

•   Source: SciCrunch Registry

https://www.uhcancercenter.org/research/shared-resources/genomics-and-bioinformatics

Core offers central service that uses genomic technologies combined with expert data analysis.Provides genomic analyses and bioinformatics as well as technical and scientific consultation,collaboration and initial data interpretation to all UH faculty with priority given to Cancer Center members with federal funding for cancer related projects. Offers expertise in molecular biology, genetics, genomics and bioinformatics, and can provide project planning, advice, and troubleshooting at all phases of the project.Genomic analysis services include DNA/RNA isolation, plating, and quality analysis, custom genotyping, Real-Time qPCR-based gene expression, copy number and methylation assays, pyrosequencing, Affymetrix and Illumina microarray based assays,Next Generation Sequencing on NextSeq500, iSeq100, NanoString nCounter analysis.

Proper citation: University of Hawaii at Manoa Cancer Center Genomics and Bioinformatics Shared Resource Core Facility (RRID:SCR_019085) Copy   

•   Source: SciCrunch Registry

http://psf.cobre.ku.edu/cores/bnmrl/about

NMR Laboratory maintains two high field NMR spectrometers in support of structural and dynamics studies of biomolecules. Its capabilities include determining high resolution structures, biological macromolecules, elucidation and structural mapping of protein-protein, protein-nucleic acid, protein-peptide, protein-drug interactions, and studies of dynamics of proteins and their complexes in solution. Laboratory staff provide advice,consultation, training,assistance and complete structure elucidation services.Staff is responsible for maintenance, upgrades, implementation of new NMR pulse sequences, and assisting local and remote users with technical problems.Equipped with Bruker Avance 800 MHz NMR instrument fitted with TCI cryoprobe and Bruker Avance III 600 MHz with variety of probes.

Proper citation: Kansas University Lawrence Biomolecular NMR Laboratory Core Facility (RRID:SCR_018671) Copy   

•   Source: SciCrunch Registry

https://ninc.centreforbrainhealth.ca

Core facility at Djavad Mowafaghian Centre for Brain Health located at University of British Columbia Hospital on Point Grey campus in Vancouver, BC. NINC offers access to advanced imaging systems and computational resources including confocal and two photon microscopes,live cell imaging, optical coherence tomography, training students and researchers in neuroscience research techniques.

Proper citation: University of British Columbia NeuroImaging and NeuroComputation Centre Core Facility (RRID:SCR_019086) Copy   

•   Source: SciCrunch Registry

https://www.urmc.rochester.edu/rochester-human-immunology-center.aspx

Designed to enhance multi-disciplinary research initiatives catalyzing key clinical and basic immunology research in vaccines, HIV/AIDS, autoimmunity, allergy/asthma, transplantation as well as cancer immunology.Provides expertise in multichromatic flow cytometry (immunophenotyping, antigen-specific intracellular cytokine staining and cell sorting), T and B cell Elispot, Fluorispot, T regulatory cell assays, magnetic bead selection of cell populations, and Luminex multiplexed bead array assays.Provides specialized clinical specimen analysis services for clinical studies or contracts.

Proper citation: Rochester University Human Immunology Center Core Facility (RRID:SCR_018670) Copy   

•   Source: SciCrunch Registry

http://www.biotech.ufl.edu/bioinformatics/

Core offers bioinformatics consulting and data analysis services to help researchers analyze and understand large data sets acquired from next generation sequencing and array based technologies.Bioinformatics staff members have extensive experience in bioinformatics, genomics, transcriptomics and translational informatics in plant, animal and microbial systems. Expertise includes big data analysis, statistical analysis, software development and high performance computing.

Proper citation: University of Florida ICBR Bioinformatics Core Facility (RRID:SCR_019120) Copy   

•   Source: SciCrunch Registry

https://www.claflin.edu//academics-research/schools-departments/school-of-natural-sciences-and-mathematics/facilities

Core facility is equipped with instrumentation to support proteomic and metabolomic research, as well as equipment for materials characterization. Key instruments include a Bruker 700MHz NMR, two Bruker XRDs (Powder and Crystal), and Bruker Micro ToF mass spectrometer.

Proper citation: Claflin University Molecular Science Research Center Core Facility (RRID:SCR_018836) Copy   

•   Source: SciCrunch Registry

https://www.med.unc.edu/neuroscience/core-facilities/neuro-microscopy/

Microscopy Core for high resolution imaging and aims to make this technology accessible to neuroscientists and other scientific researchers.Provides advanced systems for cellular and molecular imaging of in vitro and in vivo samples, implements new imaging technologies, particularly related to real time and tissue clearing based imaging of neurodevelopment and neural functions, offers training, consultation, data analysis, image processing, and centralized technical expertise.

Proper citation: University of North Carolina at Chapel Hill School of Medicine Neuroscience Microscopy Core Facility (RRID:SCR_019060) Copy   

•   Source: SciCrunch Registry

http://cores.musc.edu/Core/MS

Core provides expertise, services, education, and instrumentation to enhance biomedical research through LC-MS/MS-based proteomics. Services are offered for protein identification; characterization of post-translational modifications; and quantitative proteomics to identify differentially expressed/degraded proteins, regulated sites of post-translational modification, protein-protein interactions, and protein targets of drugs identified in phenotypic screens. Analyses include sample preparation, LC-MS/MS, database searching, generation of reports, and assistance with data interpretation. Faculty and staff assist with experimental design and development/optimization of customized methodology for analysis of post-translationally modified peptides (e.g. phosphorylation and O-GlcNAc modification, N- and O-linked glycosylation, Cys modifications including S-glutathionylation, and glycation of Lys and Arg). Quantitative approaches including metabolic labeling (SILAC), isobaric tagging (iTRAQ/TMT), and label free proteomics (LFQ) are performed on Orbitrap Elite or Orbitrap Fusion Lumos Mass Spectrometers. Developes methodology to identify alterations in post-translational modifications that impact signal transduction, transcription, translation, and response to therapeutics with goal of enabling investigators to discover molecular mechanisms underlying disease progression and therapeutic response.

Proper citation: South Carolina Medical University Mass Spectrometry Core Facility (RRID:SCR_017959) Copy   

•   Source: SciCrunch Registry

https://devsci.northwestern.edu/neurodevelopmental-resource-core-services/

Core provides services in support of research, education, and assessment technology related to neurodevelopmental research methods. Services include Scientific Consultation, Workshops and Training,EEG/ERP,Eye-tracking,Clinical and Behavioral Measure Services.Services include Data Collection, Use of Equipment, Experimental Task Creation and Preparation.

Proper citation: Northwestern University DevSci Neurodevelopmental Core Facility (RRID:SCR_017957) Copy   

•   Source: SciCrunch Registry

https://fralinlifesci.vt.edu/core-services/mass-spectrometry-incubator.html

Facility supports Virginia Tech's research infrastructure as mass spectrometry analysis and education center. Provides training in sample preparation, instrument operation and data analysis, with strong emphasis on metadata and analytical requirements for publication of metabolomic and proteomic results.

Proper citation: Virginia Tech Mass Spectrometry Incubator Core Facility (RRID:SCR_017956) Copy   

•   Source: SciCrunch Registry

http://www.umass.edu/ials/mass-spectrometry

Core offers instrumentation for characterizing elements and compounds across the entire mass range. Specialized mass spectrometers encompass variety of ionization techniques and separation devices to cover wide range of analytical capabilities.Facility accepts samples and will perform requested analysis.Offers training to conduct experimentation. Instruments include Bruker SolariX FT-ICR,Bruker MicroTOF II ESI,Bruker MicroFLEX MALDI,JEOL MStation sector with EI and FAB sources.

Proper citation: UMass Amherst Mass Spectrometry Core Facility (RRID:SCR_019063) Copy   

•   Source: SciCrunch Registry

https://www.themiamiproject.org/research-resources/core-facilities/viral-vector-core/

Produces high titer lentiviral and AAV viral particles. Stock viruses including GFP-, mCherry-, and LacZ-expressing lentiviral and AAV particles can be purchased. For generating custom viral particles, investigator provides high quality maxiprep of transfer plasmid to be packaged into viral particle of choice. Turn around time is about 2 weeks for lentivirus and AAV viral particles.

Proper citation: Miami University Miller School of Medicine Viral Vector Core Facility (RRID:SCR_018303) Copy   

•   Source: SciCrunch Registry

http://www.biotech.ufl.edu/cytometry/

Cytometry core offers project consulting, experimental design and optimization as well as data analysis services. Provides tools and staff expertise for both live and fixed cell analysis. Provides FACS ARIA and SONY SH800 sorters to help users sort cells of interest. Offers microscopes for self service users. Microscope brands include Leica SP5 Confocal, Nikon Multiphoton Confocal system, Nikon Live cell Imaging platform, Olympus spinning Disk Confocal instruments, Keyence BZX800.

Proper citation: University of Florida ICBR Cytometry Core Facility (RRID:SCR_019119) Copy   

•   Source: SciCrunch Registry

https://medicine.iu.edu/research/support/service-cores/chemical-genomics

Core provides collection of diversity-oriented, drug-like, and natural small molecules in non-redundant libraries, variety of automated liquid handling and assay detection systems such as EnVision Multiplate reader and ArrayScan HCA System, modern equipment for medicinal and analytical chemistry including NMR, LC-QTOF MS, HPLC, Peptide Synthesizer, and sophisticated chemoinformatics tools. Besides traditional high-throughput screening and hit compound optimization services, newly adapted technologies include arrayed CRISPR screening, phage display, and SAR by NMR.

Proper citation: Indiana University School of Medicine Chemical Genomics Core Facility (RRID:SCR_018785) Copy   

•   Source: SciCrunch Registry

http://www.pasteur.fr/biophysics

Provides services and instrumentation for characterization of biological macromolecules with technical and methodological expertise. Provides characterization of macromolecules including shape, folding, stability auto-association,and they interactions including stoichiometry,thermodynamic and kinetic parameters.

Proper citation: Pasteur Institute Biophysics of Macromolecules and their Interactions Core Facility (RRID:SCR_018267) Copy   

•   Source: SciCrunch Registry