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https://geiselmed.dartmouth.edu/dartmouse/

Core dedicated to facilitation and development of congenic mice for pre clinical projects across United States. Provides genotyping, background checks to verify purity of mice DNA.

Proper citation: Darthmouth Geisel School of Medicine DartMouse Core Facility (RRID:SCR_017756) Copy   

•   Source: SciCrunch Registry

http://www.greatlakesgenomics.uwm.edu

Core provides services which include massively parallel sequencing on Illumina MiSeq, traditional Sanger sequencing, fragment analysis, quantitative PCR, nucleic acid extractions and QC, and digital PCR. Offers various level of service for Sanger sequencing and qPCR from full service to ready to load plates. Trains researchers in laboratory techniques and provide protocols. Each MiSeq sequencing project and qPCR project is unique and specifically designed so experimental design should be discussed before collecting samples.

Proper citation: Wisconsin University Great Lakes Genomics Center Core Facility (RRID:SCR_017838) Copy   

•   Source: SciCrunch Registry

http://www.med.unc.edu/csb/sbi

Core provides consultations and collaborations on research studies requiring computational structural biology methods. Analyses available are to study of static structures, molecular dynamics studies for analyzing contribution of dynamic and collective motions to macromolecular functionality. Trains researchers in computational structural biology techniques, or works in collaborative manner with researchers.Provides access to software tools for protein and DNA sequence analysis, protein fold determination, homology modeling, active site identification, and analysis of effects of various mutations on structure and function of protein, along with additional computational analyses.

Proper citation: North Carolina University at Chapel Hill R.L. Juliano Structural Bioinformatics Core Facility (RRID:SCR_017836) Copy   

•   Source: SciCrunch Registry

http://www.scripps.edu/florida/technologies/xray/contacts.html

Core provides equipment and resources for crystallographic analysis of target macromolecules and small inorganic or organic molecules. Performes crystallization, X-ray diffraction data collection (both in-house and synchrotron sources) processing, phasing, crystallographic refinement, model building, and visualization. Structural data provide information including biological functions, 3D-folding, ligand binding (small molecule or protein), or mutational effect of target macromolecules. Services include Crystallization Screening; Data Collection Service: Diffraction experiments will be performed at in-house X-ray facility as well as synchrotron beam lines; Structure Determination and Analysis: complete data set collected at home or synchrotron will be processed for inorganic, organic, protein or nucleic acid structure determination, model building and crystallographic refinement. Other Structural Biology Related Services: core facility offers thorough analysis of macromolecular structure for publication or grant applications, also provides computational experiments such as homology modeling and in silico ligand docking.

Proper citation: Scripps Research Institute - Florida X ray Crystallography Core Facility (RRID:SCR_017835) Copy   

•   Source: SciCrunch Registry

https://www.med.unc.edu/csb/nmr/

Core to support academic and industrial users. Spectrometer time is available to trained users for an hourly fee. Lab manager trains new users, consults to determine whether NMR will be useful in their research, and helps design experimental plan to obtain information they need. Manager also operates spectrometer for users whose experiments do not justify time and expense of individual training.

Proper citation: North Carolina University at Chapel Hill School of Medicine Biomolecular NMR Laboratory Core Facility (RRID:SCR_017841) Copy   

•   Source: SciCrunch Registry

http://www.nationwidechildrens.org/genomics

Core performs and analyzes integrated clinical genomic, molecular, microarray, FISH, and cytogenetic analyses to diagnose broad range of inherited diseases and cancer. Serves as centralized clinical testing laboratory for Children Oncology Group leukemia, Wilms tumor, medulloblastoma, and rhabdomyosarcoma studies. Emphasizes collaborative interactions between clinicians, physician-scientists, and basic science investigators to quickly transition cutting edge research results into cutting edge diagnostics, using technology platforms. Services include Whole Exome Sequencing (WES),cytogenetic chromosome analysis,Fluorescence in situ Hybridization,Chromosomal microarray analysis,Molecular Genetic Testing - Inherited Diseases,Molecular Genetic Testing - Cancer.

Proper citation: Steve and Cindy Rasmussen Institute for Genomic Medicine Clinical Laboratory Core Facility at Nationwide Children�s Hospital (RRID:SCR_017840) Copy   

•   Source: SciCrunch Registry

http://iubemcenter.indiana.edu

Core provides access to electron microscopy equipment and services which includes AFS 2 Freeze Substitution robot,Denton DV502 Carbon Evaporator,JEOL JEM 1010,JEOL JEM 1400plus,JEOL JEM 3200FS,Polaron E5100 sputter coater,Vitrobot Mk3,Wohlwend High Pressure Freezer. Users have to be included on user e-mail lists and have iLab account in order to use core.

Proper citation: Indiana University - Bloomington Electron Microscopy Center Core Facility (RRID:SCR_017845) Copy   

•   Source: SciCrunch Registry

http://www.med.unc.edu/csb/pep

Core specializes in production of pure, functional proteins for structural, biophysical, and biochemical studies. Facility offers three categories of service:Protein Expression,Protein Purification,Scientific Consultation, Mentoring, and Training; Offers Isotope labeled proteins for NMR;High production scales for immunizations, drug discovery, structural biology;Endotoxin-free protein production;Stable cell line generation;Expert baculovirus expression;Custom packages to efficiently suit your needs.

Proper citation: North Carolina University at Chapel Hill School of Medicine Protein Expression and Purification Core Facility (RRID:SCR_017843) Copy   

•   Source: SciCrunch Registry

http://www.garvan.org.au/research/capabilities/molecular-genetics

Core facility for high throughput services covering the areas of Capillary Sequencing, Mouse Genotyping, SNP Genotyping, Clinical Diagnostic Sequencing, Cell Line Identification, Gene Expression Analysis and DNA/RNA extraction.

Proper citation: Garvan Institute of Medical Research Molecular Genetics Core Facility (RRID:SCR_017849) Copy   

•   Source: SciCrunch Registry

http://www.scripps.edu/florida/technologies/metaboliccore/index.html

Core provides researchers with equipment and expertise required for multi-dimensional imaging of cells and tissues at high resolution and to perform quantitative image analysis. Resources include widefield, confocal, multi-photon, TIRF, super-resolution and electron microscopy, as well as equipment for live cell imaging and image analysis. Services include sample preparation, imaging, molecular localization, and image analysis. Provides training, technical support, sample preparation, imaging assistance, collaboration and consultation.

Proper citation: Scripps Research Institute - Florida Core Microscopy Core Facility (RRID:SCR_017848) Copy   

•   Source: SciCrunch Registry

http://www.rockefeller.edu/monoclonal/

Core used to develop custom monoclonal antibodies and obtain large scale quantities of existing ones for experiments. Core provides cell line distribution service and tests samples for mycoplasma contamination.

Proper citation: Rockefeller University Antibody and Bioresource Core Facility (RRID:SCR_017847) Copy   

•   Source: SciCrunch Registry

http://mousebiology.org

Core located on campus of UC Davis, providing fully customized support for scientific research using genetically altered mice. Provides access to develop, plan, execute, and analyze research project involving genetically-altered mice. Provides description of project, including alternative approaches, accurate timelines, and cost estimates.Provides regular and informative communication throughout project, including email updates on completion of each milestone. Project progress can be followed at each stage by viewing detailed information anytime by accessing our online and secure project tracking system (PTS) available 24 hours a day.

Proper citation: University of California-Davis Mouse Biology Program CRISPR Based Genome Editing Service Core Facility (RRID:SCR_017851) Copy   

•   Source: SciCrunch Registry

http://www.mskcc.org/research/molecular-cytogenetics

Core supports cytogenetic analysis of cells from human and research animal sources. Range of chromosome analysis techniques are ranging from basic G-banded karyotyping, to 24-color Spectral Karyotyping (SKY), as well as Fluorescence in situ Hybridization (FISH) mapping of cloned DNAs.Services include:Karyotype characterization of new cell lines,Confirmation of cell line identity or stability,Karyotype screening of ES cells prior to transgenesis,Mapping of transgene integration sites,Chromosome or locus copy number enumeration,Publication-quality illustrations.Cytogenetic techniques available:Short-term cell culture,Metaphase chromosome preparation,G-banded karyotyping.FISH techniques available:DNA labeling for custom probe generation (for FISH projects),DNA amplification by DOP-PCR,Chromosome painting,FISH mapping (on chromosomes, interphase nuclei or DNA fibers),Tissue FISH (paraffin or frozen sections),Immuno-FISH (DNA FISH combined with fluorescent immunostaining) , Spectral karyotyping (SKY),Q-FISH (measurement of telomere lengths).

Proper citation: Memorial Sloan Kettering Cancer Center Molecular Cytogenetics Core Facility (RRID:SCR_017850) Copy   

•   Source: SciCrunch Registry

http://www.einstein.yu.edu/departments/genetics/resources/molecular-cytogenetics-core.aspx

Core provides tools for preparation of human and murine samples suitable for molecular genetic and cytogenetic analysis of entire genome. These tools include establishment of EBV transformed cell lines; isolation of DNA and mRNA from variety of tissue culture samples as well as primary biopsies; preparation of metaphase chromosomes suitable for fluorescence in situ hybridization (FISH) and Spectral Karyotyping (SKY) or whole chromosome paints for human and mouse genome. Core personnel is trained to hybridize commercial probes and to designed locus specific probes for regions of interest to investigators. All probes are custom designed and in house generated.

Proper citation: Albert Einstein College of Medicine Molecular Cytogenetics Core Facility (RRID:SCR_017815) Copy   

•   Source: SciCrunch Registry

https://umiamihealth.org/sylvester-comprehensive-cancer-center/research/research-resources/shared-resources/flow-cytometry-shared-resource

Core provides analytical and preparative flow cytometers, to facilitate range of experiments in biology of both normal and cancer cells. Experimental analyses, including:Complex, 19 fluorescence parameter immuno-phenotyping;DNA content, ploidy and cell cycle analysis; 17 fluorescence parameter cell sorting and single-cell flow cloning; High speed (10,000 � 30,000+ cells per second) and efficiency (95%+ purity) cell sorting;Assessment of apoptosis;Molecular cytogenetics;Cell function studies;Micro-biological applications;Multiplexed and micro-particle-based analysis;Mass cytometry analysis and imaging;Fluidigm Helios plasma mass cytometer. Cells are labeled with antibodies conjugated to heavy metal markers, vaporized in plasma and detected with time-of-flight mass spectrometry;Fluidigm Hyperion solid tissue imager provides simultaneous imaging of labeled solid tissue sections, for mass cytometry analysis. FCSR has bank of metal reagent kits (for custom antibody conjugation), available for purchase at favorable rates compared to those available commercially. The bank has 35 unique labeling metals, for users to create custom reagents and panels. Please contact FCSR for further information and pricing. Robotic automated cell transfer A.L.S. CellCelector automated cell transfer robot. For automated transfer of single cells and colonies from culture plates, without pre-treatment. Integral bio-safety cabinet for BSL-2 cultures.

Proper citation: Miami University SCCC Flow Cytometry Core Facility (RRID:SCR_017817) Copy   

•   Source: SciCrunch Registry

http://neuralsci.org/neuracell

Core facility provides neural stem cells (NSC) and everything you need to grow them, custom lentiviral shRNA and over-expression vectors, consult based characterization service where we can assess how your products or reagents affect stem cell performance and behavior. Services include:Cell Supply,Adult SVZ Neural Stem Cells,Any Age Embryonic stem cells from any region of the brain,Human Retinal Pigmented Epithelial cells,RPE iPSCs,iPSCs,Neural Progenitor Cells (NPCs),Custom Orders,Media/ Dissociation Reagents,High-performance Media formulated according to optimal cell growth conditions,Complete Defined Media for Neural Stem Cell Culture,Complete Defined Media for Human Retinal Pigmented Epithelial Culture,Cell characterization. Performs assays to verify how stem cell populations behave in response to certain environments, plastics, reagents, etc., using trade secret assays via FACS and cell culture techniques. This can be used for neural stem cells as well as embryonic stem cells.Cell banking solutions shall ensure that their integrity is maintained, and that sufficient supply is readily available. We will also expand cells, harvest cells, generation the freezing medium and thaw cells to test performance. Provides Generation of custom lentiviral shRNA constructs,Generation of custom lentiviral over-expression constructs,Supply of NSC lines already expressing these shRNA or over-expression constructs.

Proper citation: Neural Stem Cell Institute NeuraCell Core Facility (RRID:SCR_017821) Copy   

•   Source: SciCrunch Registry

http://www.ucdmc.ucdavis.edu/cancer/research/sharedresources/flowcytometry.html

Core provides access to expertise and instrumentation for analytical flow cytometry, cell sorting and laser scanning cytometry.Cell sorting and analytical cytometers are located at three sites in Davis and Sacramento for research use on recharge basis. Provides cell sorters for assisted sorting on appointment basis and provides training to investigators in acquiring data on analytic cytometers.Can advise on experiment design for flow cytometry, provides training to enable independent use of analytical cytometers, and familiarize investigators with popular data analysis software tools such as BD Diva and CellQuest, FlowJo, ModFit and iBrowser.

Proper citation: University of California Davis Flow Cytometry Shared Resource Laboratory Core Facility (RRID:SCR_017826) Copy   

•   Source: SciCrunch Registry

http://hihg.med.miami.edu/cgt/gene-expression

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on January 27,2025. CGT gene expression core utilizes Affymetrix GeneChip Arrays and Illumina BeadChips to identify gene expression variation in single genes, targeted set of genes, or entire genomes. Affymetrix GeneChip Arrays Human Gene ST,Human Transcriptome Array 2.0, Human Exon ST, Human miRNA, Illumina Expression, HumanHT-12 v4 BeadChip.

Proper citation: University of Miami Miller School of Medicine Gene Expression Core Facility (RRID:SCR_017825) Copy   

•   Source: SciCrunch Registry

https://chemistry.as.miami.edu/research-facilities/x-ray-crystallography-resources/index.html

Core provides upgraded Bruker SMART 1000 CCD single crystal diffractometer to SMART APEX II CCD Area Detector, and its low-temperature LT3 device to KRYO-FLEX low-temperature device. Instrument which is equipped with Mo radiation source is used for small molecule crystal structure determination.

Proper citation: Miami University X-Ray Crystallography Resources Core Facility (RRID:SCR_017824) Copy   

•   Source: SciCrunch Registry

https://med.virginia.edu/flow-cytometry-facility/

Services include unassisted and assisted sample acquisition, cell sorting, mass cytometry (CyTOF), Luminex cytokine assays, antibody conjugation and data analysis.

Proper citation: University of Virginia School of Medicine Flow Cytometry Core Facility (RRID:SCR_017829) Copy   

•   Source: SciCrunch Registry