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http://harvard.eagle-i.net/i/0000012e-5870-e12d-55da-381e80000000

The Forsyth Center for Clinical and Translational Research (CCTR) is a unique clinical facility with 6 fully-equipped dental units and associated laboratories that are specifically dedicated to conduct clinical research in oral and related systemic diseases. Clinical trials following FDA guidelines are performed at all levels, from early phase 1 trials to large, multicenter definitive clinical trials, with the goal of improving outcomes and the long-term health of patients. We routinely conduct studies in the oral environment, that include standard clinical measurement protocols for dental caries, dental calculus, gingivitis, periodontal diseases, intraoral local anesthetic evaluation, tooth restoration and tooth whitening evaluation. In addition, the clinic is equipped for obtaining and processing microbiological samples, gingival crevice fluid samples, blood and saliva samples for analysis of bacteria, inflammatory mediators, as well as for genomic and proteomic analyses. Under the new leadership of Dr. Thomas Van Dyke, Vice President of Clinical Research at The Forsyth Institute, the Center proposes new goals/efforts in discovering new techniques, testing new ideas and searching for valuable biomarkers for preventing and treating periodontal diseases and associated systemic inflammatory conditions. The CCTR is actively involved with the design and conduct of clinical research under Good Clinical Practices for submission to regulatory agencies. It has a published international reputation in evaluating intraoral local drug delivery devices, oral diagnostic systems, local anesthesia, restorative materials, tooth whitening systems and the association of oral diseases with systemic conditions. Forsyth''s Institutional Review Board is a member of the Harvard Catalyst Regulatory Group and meets on a monthly basis providing complete review of clinical protocols.

Proper citation: Harvard Forsyth Center for Clinical and Translational Research (RRID:SCR_009847) Copy   

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http://harvard.eagle-i.net/i/0000012c-60a9-25c8-c437-ff0b80000000

Core facility that provides the following services: MLV plasmid construction service, HIV plasmid construction service, Adenovirus plasmid construction service. The Harvard Gene Therapy Initiative was founded with the objective of promoting the use of gene therapy in both research and therapeutic applications and to conduct research developing new gene delivery vector technologies.

Proper citation: Harvard Gene Therapy Initiative Core (RRID:SCR_009848) Copy   

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http://harvard.eagle-i.net/i/00000135-5ed7-550c-be1e-73c480000000

The Small Molecule Mass Spectrometry Facility at the FAS Center for Systems Biology offers support for the analysis of a wide variety of analytes using mass spectrometry based techniques. We are located in the second basement (B2) level of the Northwest Laboratory building at 52 Oxford Street, Cambridge, MA 02138. We provide services for molecular formula confirmation (accurate mass measurement), structural elucidation (MS/MS) and quantitation of small molecules. In addition, we can assist you in the mass analysis of a wide variety of non-proteomics samples including metabolites, medium sized proteins and oligonucleotides. Please contact us and tell us about your samples prior to submission or use of our Open Access laboratory.

Proper citation: Harvard FAS Small Molecule Mass Spectrometry Facility (RRID:SCR_009845) Copy   

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http://harvard.eagle-i.net/i/0000012e-a1a6-4291-55da-381e80000000

Core facility that provides the following services: Progamming and sequencing classes and training. Research Computing (RC) facilitates the advancement of complex research by providing leading edge computing services across the Faculty of Arts & Sciences (FAS). RC staff maintain expertise in constantly changing computing technologies, while ''speaking the language'' of the FAS researchers, to help them use computing more effectively.

Proper citation: Harvard FAS Research Computing Core (RRID:SCR_009844) Copy   

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http://harvard.eagle-i.net/i/0000012f-e9eb-c410-de5a-673e80000000

The Neuroimaging facility has a 3-Tesla magnetic resonance imaging scanner for non-invasive human brain imaging. Our aim is to: * Provide functional and anatomic magnetic resonance imaging (MRI) to scientists studying human cognition, brain development and aging, and individual differences * Provide training for undergraduate and graduate students destined to become the next generation of neuroscientists * Pioneer innovative ways of imaging the human brain and is a first adopter of new neuroimaging technology, tools and applications * Develop and make available the data processing and visualization tools demanded by advancing neuroimaging technologies.

Proper citation: Harvard FAS Center for Brain Science - Neuroimaging Core Facility (RRID:SCR_009842) Copy   

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http://harvard.eagle-i.net/i/0000012f-e9ed-31bd-de5a-673e80000000

CBS hosts an optical imaging facility that houses advanced devices for widespread use by neuroscientists and is developing the next generation of optical techniques. The optical imaging is intended to be an extension of individual labs, housed in shared space. By pooling equipment, highly skilled technical management of the tools is available, allowing for routine technological upgrades, quicker troubleshooting, and expert advice. In addition, the joint space leads to camaraderie amongst users, and allows new technical advances in one lab to spread rapidly to other labs. This core facility also frees up space in individual labs that can be used in other ways. Finally, the shared equipment lowers barriers to adoption of the latest technology. This core facility provides: * Laser scanning microscopes with motorized stages for high throughput reconstructions of the nervous system * A histology suite for brain sectioning and tissue preparation * Stereo fluorescence macroscopes * The newest tools for high-resolution optical microscopy * Ultra-fast optical scanning microscopes

Proper citation: Harvard FAS Center for Brain Science - Imaging Core Facility (RRID:SCR_009840) Copy   

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http://harvard.eagle-i.net/i/0000012f-e9f0-3cf3-de5a-673e80000000

CBS houses a core facility with a transmission electron microscope (TEM) and several scanning electron microscopes. The SEMs are part of ongoing research that will lead to a three-dimensional electron microscopy facility, to image neural circuits with the highest possible resolution.

Proper citation: Harvard FAS Center for Brain Science - Electron Microscopy Core Facility (RRID:SCR_009838) Copy   

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http://harvard.eagle-i.net/i/0000012e-5e6d-9119-55da-381e80000000

The Flow and Imaging Cytometry Resource provides research flow and imaging cytometry services to all investigators in the PCIMM at Children''s Hospital, Boston and Immune Disease Institute, HMS and the local scientific community on a case-by-case basis. With state of the art instrumentation, such as the standard configuration 3-lasers FACSAria located in BL2+-facility, 20-parameters 4-lasers FACSAria SORP and DIVA FACSVantage SE TurboSort?, the facility offers high speed cell sorting and complex analytical services, development of collaborative projects as well as consulting on design and development of new protocols and methods.

Proper citation: Harvard PCMM Flow and Imaging Cytometry Resource (RRID:SCR_009839) Copy   

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https://joslinresearch.org/drc-cores/Flow-Cytometry-Core

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on October 27,2023. Core that provides cell sorting and flow cytometry services. Specific services include cell analysis, large object sorting,magnetic cell enrichment, and automatic cell counting.

Proper citation: Joslin Diabetes Center Flow Cytometry Core Facility (RRID:SCR_009878) Copy   

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http://harvard.eagle-i.net/i/0000012e-590e-5fe8-55da-381e80000000

Core facility that provides the following services: Data management service, SNP genotyping service. The Genetics Core was established in 1991 with the aim of promoting and facilitating genetic studies of diabetes and its complications in humans at the Joslin Diabetes Center and collaborating institutions. More than 1,000 DNA samples from human subjects have been collected in these years and are available to researchers. The Genetics Core also provides services assisting investigators in the use of these samples. Investigators wishing to use the Core resources should contact Dr. Alessandro Doria by phone at x4340 or (617) 732-2406, or by e-mail. A detailed project description is required for the use of DNA samples. There is no restriction on the Core access.

Proper citation: JDC Genetics Core (RRID:SCR_009879) Copy   

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https://joslinresearch.org/drc-cores/Animal-Physiology-Core

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on October 27,2023. Core that provides technically advanced physiological evaluation of metabolism in diabetes, obesity, and their associated complications in rodents for DRC investigators and outside users. It also provides training of investigators and trainees in several physiological procedures.

Proper citation: Joslin Diabetes Center Animal Physiology Core Facility (RRID:SCR_009876) Copy   

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https://joslinresearch.org/drc-cores/Advanced-Microscopy-Core

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on October 27,2023. Core that provides services for performing specific morphological procedures, providing training and access to equipment, maintaining the specialized microscopes, and giving advice and interpretation.

Proper citation: Joslin Diabetes Center Advanced Microscopy Core Facility (RRID:SCR_009875) Copy   

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http://hunter-cuny.eagle-i.net/i/00000136-a791-3ad9-949b-425080000000

Core facility that provides the following services: Single-crystal X-ray analysis. The mission of the CUNY X-ray Diffraction (X-ray) Facility is to perform single-crystal analyses for the structure determination of molecules, which make up a crystal. This technique is called single-crystal X-ray crystallography. It is the ultimate method for definitive determination of molecular structures at the atomic level for both organic and inorganic compounds. Its uses range from simple identification of compounds to various exotic configuration and conformational studies.

Proper citation: Hunter X-ray Diffraction Facility (RRID:SCR_009872) Copy   

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https://joslinresearch.org/drc-cores/Advanced-Genomics-and-Genetics-Core

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on October 27,2023. Core that provides services for genetic and genomic analysis, including DNA extraction from blood, access to DNA collections from the Core?s repository, SNP genotyping, and support for gene expression studies based on both high-density oligonucleotide arrays and real-time quantitative PCR.

Proper citation: Joslin Diabetes Center Advanced Genomics and Genetics Core Facility (RRID:SCR_009873) Copy   

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http://howard.eagle-i.net/i/00000135-5958-291c-bf4c-ca4080000000

Howard Nanoscale Science and Engineering Facility (HNF) occupies a specially renovated wing on the first floor of the Engineering Building.The five large laboratories cover ~6000 sq. ft. of space and the HNF has about 2000 sq ft of contiguous office space. The HNF is an established centralized user facility containing over $17M of micro- and nano fabrication and characterization equipment, accessible by external and internal academic, government and industrial users. Currently, HNF has integrated facilities in the following categories: Lithography Facilities Nanofabrication Facilities Plasma Etching / Deposition Facilities CVD Deposition Facilities (SiC,GaN) Nanomembrane Facilities Characterization Facilities Computer Facilities Societal and Ethical Issues

Proper citation: Howard Nanoscale Science and Engineering Facility (RRID:SCR_009867) Copy   

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http://howard.eagle-i.net/i/00000135-589a-a87e-bf4c-ca4080000000

Core facility that provides the following services: Equipment access, Training on proteomics equipment. Mission: To use mass spectrometry for studies of infectious and chronic diseases and to promote and facilitate biomedical and translational research at Howard University Objectives: To provide modern analytical instrumentation, technical expertise and essential services for biomolecular analysis To provide a broader training experience for students and faculty in biomolecular analysis through methodology- centered seminars, workshops, mini-courses, and internships To foster new multidisciplinary research collaborations using modern Proteomics technology The RCMI Proteomics Core Facility runs several research projects and provides collaborative consolidation of instrumentation, technical expertise, and support personnel to enhance the impact and availability of Mass Spectrometry and other analytical techniques for biological and biomedical science community at Howard University

Proper citation: Howard RCMI Proteomics Facility (RRID:SCR_009868) Copy   

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http://howard.eagle-i.net/i/00000134-aa20-c323-bf4c-ca4080000000

Core facility that provides the following services: SNP detection service, DNA sequencing service, EBV cell transformation service, DNA sequencer access. The molecular genetics research interests are in human population genetics, anthropological genetics, immunogenetics, and the genetics of complex diseases. Ultimate goals surround elucidating questions of human variation, the evolutionary history of genes within populations and how these gene histories are involved in the etiology of complex diseases. While the laboratory''s research goals have shared consequences for all humanity, specific interests focus on populations of African ancestry. Operational Objectives: 1. Develop a SNP database for mapping functional mutations linked to diseases common in African peoples. 2. Utilization of evolutionary history of candidate genes to identify polymorphisms that are associated with diseases. 3. Exploit the linkage disquilibrium generated by admixture in the African American population for gene mapping.

Proper citation: Howard Molecular Genetics Core (RRID:SCR_009865) Copy   

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http://eagle-i.itmat.upenn.edu/i/00000139-496b-76ed-eb5b-b63c80000000

Core facility that provides the following services: Informatics consultative support. The staff of this core gives guidance and/or coordinates data management, capture and analysis on behalf of the investigator within the Institute and assists more broadly with computing issues related to the approved protocol. This core provides services to investigators for their Clinical and Translational Research Center (CTRC)-approved studies that are utilizing other CTRC core services.

Proper citation: Penn/CHOP CTRC Informatics Services Core (RRID:SCR_009866) Copy   

•   Source: SciCrunch Registry

http://howard.eagle-i.net/i/00000134-a996-f935-bf4c-ca4080000000

The Biostatistics Core is a resource for Howard University Cancer Center (HUCC) that provides statistical and computer/data management support services to affiliated members. Members of the Biostatistics Core provide advice in matters of design, randomization, power analysis, data processing, quality control, database development and management and statistical analysis in clinical and population based studies. The Biostatistics Core aims at excellence in biostatistical and methodological issues related to cancer studies and to advocate proper use of statistics, data monitoring and data analysis.

Proper citation: Howard Biostatistics Core (RRID:SCR_009863) Copy   

•   Source: SciCrunch Registry

http://howard.eagle-i.net/i/00000134-a517-7b98-bf4c-ca4080000000

Core facility that provides the following services: Access to clinical physiology equipment. The Biobehavioral Core Laboratory houses the facilities for clinical exercise physiology and psycho-physiological research. The Clinical Exercise Physiology Research facility is equipped with a Cosmed Quark b2 metabolic cart and Cosmed electrocardiogram (ECG) equipment that is programmed into a Burdick Treadmill. This is used for performing graded exercise tests to assess risk for cardiovascular disease and functional work capacity training. An Ergoline 500 medical ergometer is used for exercise testing when a cycle ergometer is needed. In addition, the laboratory has 3 other treadmills that are used exercise intervention training programs. The Psychophysiology component consists of 3 computers (Dell Desktop Pentium 4, Gateway Pentium 4, and Toshiba Portege Tablet PC Pentium III). One desktop is used for data acquisition, one for data analysis and the third for internet usage. There is a surveillance camera (Security Labs) that is used to monitor participants as they take part in study tasks. To collect impedance cardiograph data, the HIC-2002 Impedance Cardiograph is used along with the COP ?Win 5.10 USB version cardiac output program for windows. This equipment is designed to measure a variety of cardiovascular measures (heart rate, stroke volume, cardiac output, pre-ejection period, left ventricular ejection time, total ejection period, and heather index). The Dinamap Vital Signs Monitor (Model 1846 SX) is used to assess systolic blood pressure and diastolic blood pressure. Lastly, a number of psychological tasks are also included in the lab such as the Automatic Mirror Tracer (Model 5403), the Peabody Picture Vocabulary Test (3 rd Edition Form IIIA and Form IIIB) and the Wisconsin Card Sorting Task for Windows.

Proper citation: Howard Biobehavioral Core Laboratory (RRID:SCR_009862) Copy   

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