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https://med.stanford.edu/obrienurology/research.html

Core leverages infrastructure of Stanford Urology and Pathology Departments to provide services to benefit O’Brien Center investigators in CAIRIBU Network. Procures and provides biospecimens, including fresh, freshly-frozen, and formalin-fixed paraffin-embedded (FFPE) prostate issues.Provides tissue characterization services, including histology, tissue microarrays, laser microdissection, and multiplex immunohistochemistry (IHC) using MIBI-TOF (Multiplexed Ion Beam Imaging by Time of Flight). Stores and provides access to images including prostate MRIs, whole-mount histology and IHC, and MIBI-TOF data, as well as integrated multiscale data platform.

Proper citation: Stanford University School of Medicine O’Brien Urology Research Center Biospecimen/Bioimaging Core Facility (RRID:SCR_022852) Copy   

•   Source: SciCrunch Registry

http://GeneEditing.wustl.edu/

Provides support with technologies for cell and animal model needs. Services are ranging from CRISPR reagents with or without validation, to cancer/iPS cell line modification or animal model creation. Works closely with mouse cores from design, reagent validation to genotyping, process improvement and troubleshooting, when necessary. Provides next-generation sequencing (NGS) based human cell authentication and NGS-based genotyping services and general molecular biology assistance. Offers to culture, bank and store primary fibroblasts and renal epithelial cells from patient samples for investigators, and iPSC reprogramming service is provided from fibroblasts, RECs as well as peripheral blood mononuclear cells. Provides differentiation services on growing list of cell types.

Proper citation: Washington University School of Medicine Genome Engineering and Stem Cell Center Core Facility (RRID:SCR_023243) Copy   

•   Source: SciCrunch Registry

https://asrc.gc.cuny.edu/neuroscience/facilities/live-imaging-bioenergetics-facility/

Provides Zeiss LSM880 upright two photon confocal microscope with Airyscan, FAST model and CLARITY lens; LSM880 inverted live cell imaging confocal microscope with Airyscan and FAST model; Agilent Seahorse XFe24 live cell metabolic analyzer.Supported applications include in vivo imaging of live animals, time lapse live cell imaging with high resolution optical sectioning, deep imaging of fixed CLARITY tissues, calcium imaging, photo switching and photo uncaging, Fluorescence Recovery After Photobleaching, Forster Resonance Energy Transfer, laser ablation, and measuring mitochondrial respiration and glycolysis in live cells in real time.Provides advanced imaging analysis software Imaris for data processing.

Proper citation: City University of New York Advanced Science Research Center Live Imaging and Bioenergetics Core Facility (RRID:SCR_022945) Copy   

•   Source: SciCrunch Registry

https://isotope.ucsc.edu/

Provides light stable isotope ratio analysis services to scientists from UCSC and from around the world.

Proper citation: University of California at Santa Cruz Stable Isotope Laboratory Core Facility (RRID:SCR_022947) Copy   

•   Source: SciCrunch Registry

https://www.research.chop.edu/chop-penn-proteomics-core

Core has established quality controlled protocols to quantitatively analyze whole proteomes, phosphoproteomes, ubiquitylomes, and/or lysine acetylomes at deep level through process of serial enrichment.

Proper citation: Children's Hospital of Philadelphia Research Institute Proteomics Core Facility (RRID:SCR_023099) Copy   

•   Source: SciCrunch Registry

https://www.rockefeller.edu/transgenics/

Provides services such as Pronuclear Injection, Blastocyst Injection, Embryo and Sperm Cryopreservation, Strain Recovery and Rederivation. Provides assisted reproductive techniques such as IVF and ICSI used for strain recovery. Core facility to the university for creation and maintenance of all transgenic animal models, refinement and development of new transgenic techniques, as well as training center for research personnel.

Proper citation: Rockefeller University Transgenic and Reproductive Technology Center Core Facility (RRID:SCR_023098) Copy   

•   Source: SciCrunch Registry

https://www.biocampus.cnrs.fr/index.php/en/facilities-en/browse-by-facility/platform/421-bacfly-en

Facility dedicated to expression of innovative recombinant proteins for all in vitro and in vivo studies. Innovative technology developed by the platform, called FlexiBac, uses baculovirus / insect cell expression system.

Proper citation: Montpellier Bacfly Core Facility (RRID:SCR_023096) Copy   

•   Source: SciCrunch Registry

https://mssr.cnsi.ucla.edu/

Services include use of high throughput screening technology, compounds in various libraries, siRNA sets of druggable genome for mouse and human and database of results from screens. For compounds screens, data points are in singlets.For functional genomics screens we use duplicates. We typically utilize 384 well plates but are flexible in this regard. We can accomodate any plate type ranging from 96 to 1536 well plates. Specialty plates can be handled on needed base. We have special rates for consumables with many vendors based on volume we use. These reduced rates are passed on directly to our screeners.

Proper citation: University of Califorania at Los Angeles California NanoSystems Institute Molecular Screening Shared Resource Core Facility (RRID:SCR_022956) Copy   

•   Source: SciCrunch Registry

https://www2.uottawa.ca/faculty-medicine/core-facilities/gem

Facility assists researchers in mammalian genome editing and molecular biology, including CRISPR genetic libraries and screens as well as custom viral vector/particle production. Projects are customized to researchers needs, from full service cell line creation to design and cloning.Supported by Canadian Foundation for Innovation.

Proper citation: University of Ottawa Genome Editing and Molecular Biology Core Facility (RRID:SCR_022954) Copy   

•   Source: SciCrunch Registry

https://www.dfhcc.harvard.edu/research/core-facilities/mouse-engineering/

Core provides services for generation of transgenic and knockout mice.Provides Nikon Diaphot microscope equipped with Nomarski Optics and Narishige micromanipulators for microinjections, Nikon surgical microscopes for egg isolation and transfer, sutter needle puller and de Fonbrune microforge. Facility maintains mice necessary for egg donors, egg recipients, and vasectomized males.Core offers electroporation of targeting vectors into ES cells. Provides investigators with DNA to identify ES cells carrying desired recombination events and ES cell expansion for microinjection into blastocysts.Services also include CRISPR injections, sperm and embryo cryopreservation, and reanimation with fresh or frozen sperm via IVF or thawing and implanting embryos.

Proper citation: Harvard Medical School Dana Farber Harvard Cancer Center Mouse Engineering Core Facility (RRID:SCR_022950) Copy   

•   Source: SciCrunch Registry

http://www.sylvester.org/CMSR

Provides small animal cancer modeling services to foster cancer research and to accelerate discovery of tailored anti-tumor therapies, including preclinical data for drug development, proof of principle for novel therapies, preclinical imaging, and disease biomarker studies. Services include facilitating in vivo modeling of human disease using mouse models; supporting preclinical in vivo efficacy and toxicity studies; devising treatment protocols; using noninvasive imaging for diagnosis and evaluation of responses to treatment; and performing histopathological analysis of targeted cancer therapies. Specific services include (1) support for the development of experimental murine models of cancer, including with cell line and patient-derived xenografts (PDXs), genetically engineered mouse models, and humanized models; (2) support for devising and implementing treatment protocols in a pre-clinical setting using murine models of human disease (e.g., drug toxicology and efficacy studies, drug formulation and delivery, and related assessments, like cell blood count, clinical chemistry, and flow cytometry analysis); and (3) diagnosis and evaluation of responses to treatment, using noninvasive small animal imaging for diagnosis and evaluation of responses to treatment, including in vivo bioluminescence and fluorescence optical imaging, high-frequency ultrasound imaging, structural and functional nuclear imaging, and magnetic resonance imaging (MRI); and (b) research histopathological analysis of targeted cancer therapies, including H&E and immunohistochemistry (IHC) sectioning, staining, scanning and analysis, and data storage of digital slide images. The CMSR also offers consultation, training, educational workshops and seminars. CMSR radiotherapy services support both small animal total body and image-guided radiation treatment delivery with sub-millimetric accuracy for development of radiation therapy regimens in a preclinical setting.

Proper citation: University of Miami Sylvester Comprehensive Cancer Center Cancer Modeling Shared Resource Core Facility (RRID:SCR_022891) Copy   

•   Source: SciCrunch Registry

http://www.sylvester.org/BSSR

Provides biorepository resources, services and expertise in support of oncology research.Facilitates translational cancer research with standard operating procedures for patient consenting; protection of patient personal and clinical data; specimen procurement and processing; quality control of specimens; secured specimen storage, retrieval, and distribution; and provision of relevant de-identified clinical data. BSSR services include: biospecimen collection, annotation, processing, storage and distribution (including tissue, blood, and other fluids); plasma, serum, and peripheral blood mononuclear cell processing and cryopreservation; rapid acquisition of surgical tissue and fresh biopsies; participant screening and enrollment for biospecimen collection studies;formalin-fixed, paraffin embedded and frozen tissue retrieval, processing, sectioning, histological staining, and digital whole slide scanning; tissue microarrays production; support for non-therapeutic trials; consultation on project design, data analysis and interpretation. Offers access tobiobank of diverse tissue types, including clinically annotated neoplastic and non-neoplastic samples from diverse anatomical sites, and provides banked specimen as well as fresh specimen procurement at institution wide level.Through BSSR, investigators have access to specimens collected fromUniversity of Miami Hospital, Sylvester Comprehensive Cancer Center, Bascom Palmer Eye Institute, Jackson Memorial Hospital, as well as to specimens collected in more broadly based multi-site studies.

Proper citation: University of Miami Sylvester Comprehensive Cancer Center Biospecimen Shared Resource Core Facility (RRID:SCR_022889) Copy   

•   Source: SciCrunch Registry

https://cbc.arizona.edu/research/support-services/facilities/wm-keck-center-nano-scale-imaging

Interdisciplinary research facility in areas of imaging, nano-science and spectroscopy for measuring surface topography, surface properties, electrical measurements, fluorescence, sub-monolayer visible spectroscopy, and molecular structures.

Proper citation: University of Arizona W.M. Keck Center for Nano Scale Imaging Core Facility (RRID:SCR_022884) Copy   

•   Source: SciCrunch Registry

https://chemh.stanford.edu/research/knowledge-centers/medicinal-chemistry

Core for drug discovery and prototyping. Provides chemical probes for biological pathways and supports small molecule custom synthesis.Provides expertise in medicinal chemistry to biologists and clinicians at Stanford. Expertise in each step of drug development process, including hit generation, drug design and optimization, and clinical selection. Provides instrumentation to support synthesis, purification and analysis of small molecules.

Proper citation: Stanford Sarafan Medicinal Chemistry Knowledge Center Core Facility (RRID:SCR_023232) Copy   

•   Source: SciCrunch Registry

https://ki.se/en/bionut/live-cell-imaging-core-facility-lci

Light microscopy facility. Offers microscopes and training to image cell and tissues, live or fixed, BSL1/BSL2.

Proper citation: Karolinska Institute Live Cell Imaging Core Facility (RRID:SCR_023198) Copy   

•   Source: SciCrunch Registry

https://www.gsb.stanford.edu/faculty-research/behavioral-lab

Interdisciplinary laboratory designed for study of human subjects.Lab resources are available to all Stanford GSB faculty and PhD students to support research that uses human participants, whether your focus is organizational behavior, behavioral marketing, political economics, or behavioral economics.Assists with research by programming study, posting study to one or more of the available subject pools, paying participants, running participants through experiments in the lab, or creating study materials.Engages with faculty members and doctoral students in preparing and carrying out human subjects research, both in-person laboratory experiments and online survey research.Provides expert consultation on behavioral experiments, and implementations of technology in behavioral research, such as eye-tracking, psychophysiology, and other specialized technology used in research with human subjects.

Proper citation: Stanford Graduate School of Business Behavioral Lab Core Facility (RRID:SCR_023231) Copy   

•   Source: SciCrunch Registry

https://voices.uchicago.edu/organoids/

The mission is to facilitate access, generation, banking, and usage of organoids and primary cells derived from patients and model organisms.

Proper citation: University of Chicago Organoid and Primary Culture Research Core Facility (RRID:SCR_022935) Copy   

•   Source: SciCrunch Registry

https://snf.stanford.edu/about-0/electronics-shop-spf

Electronics Shop where researchers can access and share expertise to build specialized electronics. Offers support to electronic sub-system design for researchers across campus in departments of Physics, Applied Physics, Electrical Engineering, Psychology, Psychiatry and Behavioral Sciences and Bioengineering.Provides expertise from independently using tools to requesting turnkey solution.

Proper citation: Stanford System Prototyping Core Facility (RRID:SCR_023229) Copy   

•   Source: SciCrunch Registry

https://www.urmc.rochester.edu/research/mass-spectrometry.aspx

Provides instrumentation and technical expertise to local researchers seeking to conduct MS-based protein or small molecule assays.Staff provide assistance with project design, sample preparation, collection and interpretation of mass spectrometric data.Common analyses services include identification of unknown proteins, characterization of protein complexes, mapping of post-translational modifications and relative quantitation of peptides and small molecules from range of sample types, including complex clinical matrices, tissue extracts and cell lysates. Specialized MS instrumentation include Fusion Lumos Tribrid Orbitrap and Thermo Q Exactive Plus Hybrid Quadrupole-Orbitrap. In addition, the laboratory has access to a variety of automated database searching software as well as resources to facilitate discovery-based proteomics projects.

Proper citation: University of Rochester Medical Center Mass Spectrometry Resource Laboratory Core Facilitiy (RRID:SCR_023106) Copy   

•   Source: SciCrunch Registry

https://www.lsi.umich.edu/science/centers-technologies/center-chemical-genomics

Provides high throughput screening of extensive small molecule, natural product and siRNA libraries along with assay development and optimization for basic biology and drug discovery projects.

Proper citation: University of Michigan Ann Arbor Center for Chemical Genomics Core Facility (RRID:SCR_023104) Copy   

•   Source: SciCrunch Registry