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http://cccb.dfci.harvard.edu

Core facility that provides the following services: Microarray and other genomic data analysis, MiSeq. The Center provides broad-based support for the generation, analysis, and interpretation of genomic and other large-scale data in the context of basic, clinical and translational research. The CCCB has three primary elements. * The CCCB sequencing facility offers a wide range of services to assist in the design and execution of next-generation sequencing projects. Utilizing the Illumina (Solexa) sequencing technology, they currently support a number of applications inlcuding ChIP-Seq, RNA-Seq, whole genome, whole exome, and targeted re-sequencing. * The analytical services and support platform aims to provide state-of-the-art assistance in the collection, management, analysis, and interpretation of large-scale data with a focus on data generated using ''''omic technologies. In addition, they offer software, services, and training designed to assist investigators in advancing their research. * The CCCB research program is focused on development of new methods for improving analysis and interpretation of genomic data through integration of diverse data types with the goal of creating open-source software tools to be made freely-available to the research community.

Proper citation: DFCI Center for Cancer Computational Biology (RRID:SCR_012688) Copy   

•   Source: SciCrunch Registry

http://www.norch.org/center-cores/genomics-and-cell-biology-core/

Core that facilitates the application of genomics, bioinformatics, cell biology, and immunology techniques to nutrition and metabolic research.

Proper citation: Nutrition and Obesity Research Centers at Harvard Genomics and Cell Biology Core (RRID:SCR_015427) Copy   

•   Source: SciCrunch Registry

https://www.umassmed.edu/biocore/

Core to evaluate, select, and implement computational solutions for analysis of biological data.

Proper citation: Massachusetts University Medical School Bioinformatics Core Facility (RRID:SCR_017701) Copy   

•   Source: SciCrunch Registry

http://www.nationwidechildrens.org/genomics

Core performs and analyzes integrated clinical genomic, molecular, microarray, FISH, and cytogenetic analyses to diagnose broad range of inherited diseases and cancer. Serves as centralized clinical testing laboratory for Children Oncology Group leukemia, Wilms tumor, medulloblastoma, and rhabdomyosarcoma studies. Emphasizes collaborative interactions between clinicians, physician-scientists, and basic science investigators to quickly transition cutting edge research results into cutting edge diagnostics, using technology platforms. Services include Whole Exome Sequencing (WES),cytogenetic chromosome analysis,Fluorescence in situ Hybridization,Chromosomal microarray analysis,Molecular Genetic Testing - Inherited Diseases,Molecular Genetic Testing - Cancer.

Proper citation: Steve and Cindy Rasmussen Institute for Genomic Medicine Clinical Laboratory Core Facility at Nationwide Children�s Hospital (RRID:SCR_017840) Copy   

•   Source: SciCrunch Registry

http://sites.northwestern.edu/htal/

Core provides expertise and resources for large scale biology. Helps to set up, run, gather data and perform analysis in drug discovery research, biochemistry, cell and organismal biology, functional genomic screening, and synthetic genetic. Works with proteins, nucleic acids, small model organisms, and microbial strains. Provides tissue culture,produces and uses lentivirus particles, screens compound libraries, does experiments for investigators,generates preliminary data to figure out if idea is workable, discusses project development. Services include Macromolecular binding, biochemical, and cell-based assays,High content screening with widefield or confocal optics,Nanoliter liquid handling up to 1536-well density,Whole-plate kinetic assays (ion currents, GPCR signaling),Compound library screening,CRISPR/Cas9 screening (multiplexed libraries),Analysis of large data sets,Fluorescence Thermal Shift assay (measures protein melting),Complex liquid handling work flows.

Proper citation: Northwestern University High Throughput Analysis Laboratory Core Facility (RRID:SCR_017879) Copy   

•   Source: SciCrunch Registry

https://research.med.psu.edu/core-facilities/genome-sciences/

Provides consultation, instrumentation and services in genomic, epigenomic and transcriptomic studies, analysis of candidate SNPs and mRNAs to whole genome, exome, epigenome and transcriptome sequencing. Services are also available for variety of study designs extending from few laboratory samples to large clinical projects involving hundreds or thousands of samples.Bioinformatics service is available for data analysis.Facility receives either tissue, DNA/RNA or customer generated NGS libraries. Samples are processed based on agreement reached during consultations on design of experiment.

Proper citation: Penn State College of Medicine Genome Sciences Core Facility (RRID:SCR_021123) Copy   

•   Source: SciCrunch Registry

https://unclineberger.org/tgl/

Core facility within Lineberger Comprehensive Cancer Center that performs sample processing for the molecular, pathologic, and genomic characterization of patient-derived specimens using high-end instrumentation and state-of-the-art methods. Service offerings include nucleic acid extraction, gene expression profiling, spatial genomics, next-generation sequencing library preparation, and high-throughput sequencing. Protocols leverage the reproducibility and reliability of automated instrumentation to minimize batch effects and processing errors (e.g. sample swaps). These workflows have been continuously optimized over the last decade, with a sample-to-answer historic success rate of ~90% for the >15,000 FFPE samples TGL has processed.

Proper citation: University of North Carolina at Chapel Hill Translational Genomics Lab Core Facility (RRID:SCR_025231) Copy   

•   Source: SciCrunch Registry