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Core supports basic and clinical research by providing histological and molecular expertise, technical support and consultation to research investigators. Provides histological, molecular and consultation services. Services are performed by American Society of Clinical Pathology certified histologists with expertise in routine histology, whole slide scanning, image and digital analysis, pathology services, immunohistochemistry, tissue microarray, bone histomorphometry, Visium preparations and RNAscope single and co-detection assays.
Proper citation: University of Texas MD Anderson Research Histology Core Facility (RRID:SCR_026932) Copy
https://www.cogentech.it/genomic_unit.php
Cogentech's Genomic Core Facility (GU) provides professional support for workflow of research projects, from counseling on experimental design to functional interpretation of results. Support includes identification of the most suitable methodology to achieve the experimental aim, quality control of nucleic acid, generation of indexed fragment library, sequencing according to experimental needs and bioinformatic support for selected applications. Customized protocols can be set-up as well. Sequencing data are delivered using a password protected user-friendly web interface. The laboratory is ISO9001 certified.
Proper citation: IFOM ETS Cogentech GU Genomics Core Facility (RRID:SCR_026935) Copy
https://www.cogentech.it/histology.php
Cogentech's Histopathology (HP) Core Facility provides services including consultation, tissue trimming and embedding, cutting, staining, photographic documentation for the evaluation and characterization of normal and pathological tissues. Provides Optimization of protocols for new stains or biological specimen.The laboratory is ISO9001 certified.
Proper citation: IFOM ETS Cogentech HP Histopathology Core Facility (RRID:SCR_026934) Copy
https://www.cogentech.it/integrated-genomics.php
Cogentech's Integrated Genomics Core Facility (IGU) consists of units: Molecular Biology and Sequencing, Histopathology and Bioinformatics. Molecular Biology group provides expertise in various fields of application: nucleic acid extraction from different matrices, ddPCR and various types of sequencing (customised gene panels, Lowpass WGS, WES, WGS, total RNA-Seq, mRNA Seq, TCR-Seq, 16S Metagenomic Seq, ATAC-Seq, genome-wide methylation profiling). Bioinformatics unit provides pipelines for analysis of data produced by all sequencing workflows. In addition, it provides its expertise for implementation and development of customised pipelines. Histopathology unit offers services for slide preparation and staining, image digitisation and laser-capture microdissection. The laboratory is ISO9001 certified.
Proper citation: IFOM ETS Cogentech IGU Integrative Genomics Core Facility (RRID:SCR_026938) Copy
https://cores.research.utdallas.edu/genome-center/
Core provides library prep and NGS services using Illumina NextSeq 2000. Our services include sample QC, DNA, RNA bulk sequencing, single cell sequencing, and Sanger sequencing.
Proper citation: University of Texas at Dallas UTD Genome Center Core Facility (RRID:SCR_027149) Copy
https://www.ucl.ac.uk/pharmacy/about/facilities/sop-nuclear-magnetic-resonance-nmr-facility
Core designed for range of solution-state pharmaceutical and biological chemistry applications. Facility is equipped with 600 MHz magnet equipped with high-throughput autosampler and QCI-F cryoprobe optimised for 1H and 19F sensitivity, and 400 MHz magnet dedicated to routine chemistry applications. Facility is also operating ligand-observed 19F-fragment library screening service for drug discovery.
Proper citation: University College London School of Pharmacy Nuclear Magnetic Resonance Core Facility (RRID:SCR_027123) Copy
https://www.umass.edu/ials/core-facilities/flow-cytometry
Core facility provides access to technologies in flow cytometry analysis including spectral analysis, high throughput imaging analysis (Amnis) and fluorescence assisted particle sorting (FACS). Instrument training, experiment and panel design, scientific consultation and sample processing are available. Offers training on facility equipment.
Proper citation: University of Massachusetts Flow Cytometry Core Facility (RRID:SCR_027100) Copy
https://www.birmingham.ac.uk/university/colleges/mds/facilities/protein-expression-facility
Core, within College of Medicine and Health, offers expert support for all aspects of recombinant protein production. Using range of expression systems, produces proteins suitable for diverse downstream applications.
Proper citation: University of Birmingham Protein Expression Core Facility (RRID:SCR_027106) Copy
https://www.goodmancancer.ca/en/mcgill-integrated-core-for-animal-modeling-micam
Core offers various services related to animal model generation and maintenance.
Proper citation: McGill University Integrated Core for Animal Modeling MICAM Core Facility (RRID:SCR_027118) Copy
Advanced high-field NMR facility combines many capabilities spanning solution and solid state NMR, high sensitivity cryoprobes, ultrafast spinning MAS probes, as well as Dynamic Nuclear Polarization.
Proper citation: Ohio State University Campus Chemical Instrument Center NMR Core Facility (RRID:SCR_027162) Copy
https://research.vcu.edu/cores/structural-biology/cryo-em/
Facility offers sample preparation, visualization and analysis for high resolution 3D reconstruction of frozen-hydrated proteins and macromolecular complexes. Facility is endowed with Thermofisher Scientific Tundra cryo-electron microscope, Vitrobot Mark IV cryo-plunger, Pelco easyGlow glow discharge unit, Denton DV 502B evaporator, and linux server dedicated to image processing.
Proper citation: Virginia Commonwealth University Cryo-Electron Microscopy Core Facility (RRID:SCR_027178) Copy
https://czt.amu.edu.pl/cytomika-i-analiza-komorkowa/
Core is utilized in medical biotechnology and in research focused on mammalian cells. Offers analyzing of impact of new drugs and pharmaceuticals on individual cells in vitro. Provides sorting of cell populations with desired characteristics, including fluorescent dye-stained cell sorting (FACS) analysis of cell populations for presence of specific factors, e.g. introduced fluorescent protein, surface markers, DNA content determining the size, granulation and shape of animal and other cells.
Proper citation: Adam Mickiewicz University Cytometry Laboratory Core Facility (RRID:SCR_027177) Copy
https://www.iqm.unicamp.br/institucional/infraestrutura/cemuiq/lirmn
Institutional laboratory of Nuclear Magnetic Resonance (NMR) of the Institute of Chemistry of UNICAMP.The Institutional Nuclear Magnetic Resonance Laboratory has 6 NMR spectrometers, two for solids and four for solution probes, with the possibility of analyzing different nuclei.
Proper citation: State University of Campinas Institute of Chemistry Nuclear Magnetic Resonance Laboratory LIRMN-IQ Core Facility (RRID:SCR_027247) Copy
https://wertheim.scripps.ufl.edu/cores-and-technologies/genetic-perturbation-screening/
Core provides guidance in planning and helps with executing gene expression modulation experiments. Currently uses technology based on shRNA for gene knock-down and cDNA libraries for overexpression studies. Core is equipped with genome-wide retroviral shRNA libraries for both human and mouse genomes, Mammalian Gene Collection (MGC) cDNA library, as well as smaller focused sets targeting selected gene families.
Proper citation: Herbert Wertheim University of Florida Scripps Institute for Biomedical Innovation and Technology Genetic Perturbation Screening Core Facility (RRID:SCR_027255) Copy
https://research.weill.cornell.edu/core-facilities/human-therapeutic-organoid-core
Facility serves as central facility for human organoid technology to accelerate organoid-based scientific discovery. Provides human pluripotent stem cell (hPSC) derived as well as tissue derived cells and organoids.
Proper citation: Weill Cornell Medicine Human Therapeutic Organoid Core Facility (RRID:SCR_027251) Copy
https://www.birmingham.ac.uk/university/colleges/mds/facilities/intravital-microscopy-suite
Imaging facility for intravital microscopy. Facility equipment includes widefield, confocal, and multiphoton microscopes. Additional tools, such as laser ablation systems, allow us to probe vascular events such as thrombosis in fine detail. We also have tools for measurement of vascular perfusion, such as full-field laser speckle and laser doppler.
Proper citation: University of Birmingham Intravital Microscopy Core Facility (RRID:SCR_027189) Copy
MRI facility is research-dedicated space that includes 3T Siemens Prisma (whole-body) scanner, an MR-compatible Brain Products system for EEG and psycho-physiological measures, eye tracker, mock scanner, and a MagPro X100 equipped with Localite TMS Navigator for brain stimulation.
Proper citation: Florida State University College of Medicine Magnetic Resonance Imaging Core Facility (RRID:SCR_027280) Copy
https://depressioncenter.org/research-services/mobile-technologies-core
Core provides University of Michigan investigators with guidance and resources needed to utilize mobile technologies and digital mental health measures in their studies. Our experienced faculty and staff offer hands-on consultative services to U-M investigators, regardless of research focus.
Proper citation: University of Michigan Eisenberg Family Depression Center Mobile Technologies Core Facility (RRID:SCR_027334) Copy
Core to enable the use of primary human tissue models for discovery, translation and regenerative medicine.
Proper citation: University of Michigan Translational Tissue Modeling Laboratory Core Facility (RRID:SCR_027333) Copy
Core with mission to harness data and expertise to power innovations that improve people’s health through unification and enhancement of interdisciplinary efforts at the intersection of artificial intelligence (AI) and health at the University of Michigan. Provides data services, secure computing resources, support to strategically integrate and study AI models in clinical workflows at Michigan Medicine.
Proper citation: University of Michigan AI and Digital Health Innovation Core Facility (RRID:SCR_027336) Copy
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