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https://www.cogentech.it/integrated-genomics.php
Cogentech's Integrated Genomics Core Facility (IGU) consists of units: Molecular Biology and Sequencing, Histopathology and Bioinformatics. Molecular Biology group provides expertise in various fields of application: nucleic acid extraction from different matrices, ddPCR and various types of sequencing (customised gene panels, Lowpass WGS, WES, WGS, total RNA-Seq, mRNA Seq, TCR-Seq, 16S Metagenomic Seq, ATAC-Seq, genome-wide methylation profiling). Bioinformatics unit provides pipelines for analysis of data produced by all sequencing workflows. In addition, it provides its expertise for implementation and development of customised pipelines. Histopathology unit offers services for slide preparation and staining, image digitisation and laser-capture microdissection. The laboratory is ISO9001 certified.
Proper citation: IFOM ETS Cogentech IGU Integrative Genomics Core Facility (RRID:SCR_026938) Copy
Advanced high-field NMR facility combines many capabilities spanning solution and solid state NMR, high sensitivity cryoprobes, ultrafast spinning MAS probes, as well as Dynamic Nuclear Polarization.
Proper citation: Ohio State University Campus Chemical Instrument Center NMR Core Facility (RRID:SCR_027162) Copy
https://cores.research.utdallas.edu/genome-center/
Core provides library prep and NGS services using Illumina NextSeq 2000. Our services include sample QC, DNA, RNA bulk sequencing, single cell sequencing, and Sanger sequencing.
Proper citation: University of Texas at Dallas UTD Genome Center Core Facility (RRID:SCR_027149) Copy
https://www.ucl.ac.uk/pharmacy/about/facilities/sop-nuclear-magnetic-resonance-nmr-facility
Core designed for range of solution-state pharmaceutical and biological chemistry applications. Facility is equipped with 600 MHz magnet equipped with high-throughput autosampler and QCI-F cryoprobe optimised for 1H and 19F sensitivity, and 400 MHz magnet dedicated to routine chemistry applications. Facility is also operating ligand-observed 19F-fragment library screening service for drug discovery.
Proper citation: University College London School of Pharmacy Nuclear Magnetic Resonance Core Facility (RRID:SCR_027123) Copy
https://www.uoflsequencing.com/services-2-1
Provides genomic sequencing services including next-generation sequencing (NGS), single-cell analysis, and spatial transcriptomics. Offers advanced short-read and long-read sequencing technologie including our status as a PacBio Certified Service Provider.
Proper citation: University of Louisville Sequencing Technology Center Genomics Services Core Facility (RRID:SCR_027013) Copy
https://www.bcm.edu/research/atc-core-labs/mass-spectrometry-proteomics-core
Core provides services including project evaluation and design, sample processing and biochemical purifications, mass spectrometry measurements, data processing, and bioinformatics analysis performed by the experienced core personnel.
Proper citation: Baylor College of Medicine BCM Mass Spectrometry Proteomics Core Facility (RRID:SCR_027015) Copy
Core is veterinary diagnostic laboratory and research pathology core. Provides laboratory animal diagnostics, clinical and health surveillance screening necessary for the care and use of animals in research, and expert pathology support for basic and translational research.
Proper citation: University of California Davis Comparative Pathology Laboratory Core Facility (RRID:SCR_027014) Copy
https://www.umass.edu/ials/core-facilities/flow-cytometry
Core facility provides access to technologies in flow cytometry analysis including spectral analysis, high throughput imaging analysis (Amnis) and fluorescence assisted particle sorting (FACS). Instrument training, experiment and panel design, scientific consultation and sample processing are available. Offers training on facility equipment.
Proper citation: University of Massachusetts Flow Cytometry Core Facility (RRID:SCR_027100) Copy
https://www.birmingham.ac.uk/university/colleges/mds/facilities/protein-expression-facility
Core, within College of Medicine and Health, offers expert support for all aspects of recombinant protein production. Using range of expression systems, produces proteins suitable for diverse downstream applications.
Proper citation: University of Birmingham Protein Expression Core Facility (RRID:SCR_027106) Copy
https://www.goodmancancer.ca/en/mcgill-integrated-core-for-animal-modeling-micam
Core offers various services related to animal model generation and maintenance.
Proper citation: McGill University Integrated Core for Animal Modeling MICAM Core Facility (RRID:SCR_027118) Copy
MRI facility is research-dedicated space that includes 3T Siemens Prisma (whole-body) scanner, an MR-compatible Brain Products system for EEG and psycho-physiological measures, eye tracker, mock scanner, and a MagPro X100 equipped with Localite TMS Navigator for brain stimulation.
Proper citation: Florida State University College of Medicine Magnetic Resonance Imaging Core Facility (RRID:SCR_027280) Copy
https://research.vcu.edu/cores/structural-biology/cryo-em/
Facility offers sample preparation, visualization and analysis for high resolution 3D reconstruction of frozen-hydrated proteins and macromolecular complexes. Facility is endowed with Thermofisher Scientific Tundra cryo-electron microscope, Vitrobot Mark IV cryo-plunger, Pelco easyGlow glow discharge unit, Denton DV 502B evaporator, and linux server dedicated to image processing.
Proper citation: Virginia Commonwealth University Cryo-Electron Microscopy Core Facility (RRID:SCR_027178) Copy
https://czt.amu.edu.pl/cytomika-i-analiza-komorkowa/
Core is utilized in medical biotechnology and in research focused on mammalian cells. Offers analyzing of impact of new drugs and pharmaceuticals on individual cells in vitro. Provides sorting of cell populations with desired characteristics, including fluorescent dye-stained cell sorting (FACS) analysis of cell populations for presence of specific factors, e.g. introduced fluorescent protein, surface markers, DNA content determining the size, granulation and shape of animal and other cells.
Proper citation: Adam Mickiewicz University Cytometry Laboratory Core Facility (RRID:SCR_027177) Copy
https://www.janelia.org/support-team/janelia-experimental-technology
Core team designs, builds and tests instruments, tools, and software that enable novel scientific investigation. Offers expertise in Data acquisition and analysis; Machine vision and image processing; Precision machining; Embedded systems design and programming; Laser, microscopy, and optical imaging systems engineering; Custom circuit design; Novel sensor systems; Lab automation, robotics and motion control; Mechanical design, machined and/or fabricated components and assemblies; Process automation.
Proper citation: Howard Hughes Medical Institute at Janelia Research Campus Janelia Experimental Technology jET Core Facility (RRID:SCR_027301) Copy
https://www.augusta.edu/cancer/research/shared-resources/biorepository/
Core provides collection, annotation, and storage solutions. This Biorepository is also home to a state-wide resource, the Biorepository Alliance of Georgia for Oncology (BRAG-Onc), which functions to collect samples from 6 participating sites across the State to represent the diversity of cancer patients within the State and to enhance cancer research in Georgia.Tissue specimens are fast-frozen in vapor phase liquid nitrogen to preserve their integrity and stored in large cryofreezers at -170 to -190°C. Blood is routinely separated into serum or plasma and buffy coats prior to freezing. Blood derivatives are stored at -70 to -80°C. The freezers are monitored constantly and are connected to an alarm system to ensure that the low temperatures are maintained.
Proper citation: Augusta University Georgia Cancer Center Biorepository Core Facility (RRID:SCR_027271) Copy
https://www.augusta.edu/research/core/human-physiology.php
Core provides services including body/bone composition, comprehensive assessments of cardiovascular health (conduit vessel, microvascular, and central arterial stiffness), comprehensive assessment of lung health (spirometry, diffusion, lung clearance index, exhaled NO), and metabolic/exercise testing. Expanded core services in humans include oral glucose tolerance testing and continuous glucose monitoring, 24h ambulatory blood pressure monitoring, and assessments of autonomic nervous system, cognitive function, mitochondrial function, intramuscular fat, and electrocardiograms.
Proper citation: Augusta University Human Physiology Core Facility (RRID:SCR_027270) Copy
Offers processing fixed tissue for paraffin-embedded histology, cryo-microtomy, cell pellet processing, H+E staining and special histology stains or cellular material supplied. Immunohistochemistry, immunofluorescence and in-situ hybridisation service is available along with the capability to provide digital scanning and analysis. Many other techniques such as provision of tissue microarrays and other staining techniques such as TUNEL can be provided or set-up as required.
Proper citation: Cancer Research UK Scotland Institute Histology Core Facility (RRID:SCR_027306) Copy
https://emfacility.science.oregonstate.edu/
Core offers negative staining of protein, tissue processing including dehydration, fixation, staining and utra-microtomy, image biological samples at 80 keV on Generation 2 Titan with Rio CMOS side mount camera for low magnification too high magnification shots of cellular structures. Can also rapidly screen grids with Helios STEM in SEM capability. Provides Helios with auto slicenview and fully licensed Avizo for rendering 3D images of cells.
Proper citation: Oregon State University Electron Microscopy Core Facility (RRID:SCR_027308) Copy
https://www.iqm.unicamp.br/institucional/infraestrutura/cemuiq/lirmn
Institutional laboratory of Nuclear Magnetic Resonance (NMR) of the Institute of Chemistry of UNICAMP.The Institutional Nuclear Magnetic Resonance Laboratory has 6 NMR spectrometers, two for solids and four for solution probes, with the possibility of analyzing different nuclei.
Proper citation: State University of Campinas Institute of Chemistry Nuclear Magnetic Resonance Laboratory LIRMN-IQ Core Facility (RRID:SCR_027247) Copy
https://wertheim.scripps.ufl.edu/cores-and-technologies/genetic-perturbation-screening/
Core provides guidance in planning and helps with executing gene expression modulation experiments. Currently uses technology based on shRNA for gene knock-down and cDNA libraries for overexpression studies. Core is equipped with genome-wide retroviral shRNA libraries for both human and mouse genomes, Mammalian Gene Collection (MGC) cDNA library, as well as smaller focused sets targeting selected gene families.
Proper citation: Herbert Wertheim University of Florida Scripps Institute for Biomedical Innovation and Technology Genetic Perturbation Screening Core Facility (RRID:SCR_027255) Copy
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