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https://www.cincinnatichildrens.org/research/cores/imaging

Provides access to advanced analytical imaging and image post-processing methods for collaborators involved in basic and clinical research.

Proper citation: Cincinnati Children's Hospital Imaging Research Center Core Facility (RRID:SCR_022631) Copy   

•   Source: SciCrunch Registry

https://www.med.uvm.edu/vigr/mpsf

Provides support for design, execution, and analysis of experiments involving Next Generation Sequencing through access and use of Illumina HiSeq 1500. Sequencer performs wide range of analysis including target preparation for RNAseq, Exome Seq, ChIP seq, Methyl Seq, whole genome sequencing, and small RNA sequencing.Core is involved in all aspects of Nanopore sequencing.

Proper citation: University of Vermont Larner College of Medicine Advanced Genome Technologies Massively Parallel Sequencing Core Facility (RRID:SCR_022696) Copy   

•   Source: SciCrunch Registry

https://www.vet.upenn.edu/research/core-resources-facilities/extracellular-vesicle-core

Provides comprehensive or selected services in necessary isolation, quantification and characterization of EVs. Isolation of EV is based on size exclusion using high-performance (SEC-HPLC) or gravity fed (e.g. iZon column) liquid chromatography, ultracentrifugation, and/or density gradient ultracentrifugation. Accurately characterizes EV particle size distribution and concentration using resistive pulse sensing techniques (nCS1, Spectradyne, LLC). Immunophenotype can be accomplished using nanoscale flow cytometry and/or chip array (ExoViewTM) techniques. Provides services in training and education for individuals and lab groups in all methods above and study design consultation.

Proper citation: University of Pennsylvania Penn Vet Extracellular Vesicle Core Facility (RRID:SCR_022444) Copy   

•   Source: SciCrunch Registry

http://igm.ucsd.edu/genomics/

Provides services including sequencing library preparation and sequencing on Illumina MiSeq and NovaSeq 6000 platforms. Supports single cell sequencing on 10X Genomics Chromium Controller. Provides Illumina Infinium Beadchips, which includes variety of whole genome genotyping arrays as well as Infinium MethylationEPIC BeadChip.

Proper citation: University of California at San Diego Institute for Genomic Medicine Genomics Center Core Facilitiy (RRID:SCR_022740) Copy   

•   Source: SciCrunch Registry

http://crc.pitt.edu

Supports leading edge research with free access to advanced computing hardware and software.

Proper citation: University of Pittsburgh Center for Research Computing Core Facility (RRID:SCR_022735) Copy   

•   Source: SciCrunch Registry

https://www.bcchr.ca/flowcore

Core provides equipment for flow cytometric analysis, full service cell sorting, training, and dissemination.

Proper citation: British Columbia Children's Hospital Research Institute Flow Cytometry Core Facility (RRID:SCR_022790) Copy   

•   Source: SciCrunch Registry

https://asrc.gc.cuny.edu/neuroscience/facilities/live-imaging-bioenergetics-facility/

Provides Zeiss LSM880 upright two photon confocal microscope with Airyscan, FAST model and CLARITY lens; LSM880 inverted live cell imaging confocal microscope with Airyscan and FAST model; Agilent Seahorse XFe24 live cell metabolic analyzer.Supported applications include in vivo imaging of live animals, time lapse live cell imaging with high resolution optical sectioning, deep imaging of fixed CLARITY tissues, calcium imaging, photo switching and photo uncaging, Fluorescence Recovery After Photobleaching, Forster Resonance Energy Transfer, laser ablation, and measuring mitochondrial respiration and glycolysis in live cells in real time.Provides advanced imaging analysis software Imaris for data processing.

Proper citation: City University of New York Advanced Science Research Center Live Imaging and Bioenergetics Core Facility (RRID:SCR_022945) Copy   

•   Source: SciCrunch Registry

https://alms.cnsi.ucla.edu/become-a-user/

Offers microscopy services, consultation, and support for application of novel microscopic and spectroscopic methods and advanced image analysis techniques for study of macromolecules, cellular dynamics and nano-scale characterization of bio-materials. Provides collection of customized biological fluorescence microscopes and small-animal imaging devices to study biological processes with high spatial and temporal resolution in whole organisms and in living cells down to single molecule detection level with nanometer accuracy. Located in basement and second floor of CNSI building, two optical suites designed to house microscopes with the required environment control (low vibration, air-filtered, air-conditioned and light-tight) and services. Services include Wide-field Fluorescence Imaging Microscopy (on a limited basis), Confocal One-Photon and Two-Photon Laser Scanning Microscopy, (both point scanning and spinning disk), Fluorescence Correlation Spectroscopy (FCS), Fluorescence Resonance Energy Transfer (FRET), microscopic and macroscopic Fluorescence Lifetime Imaging (FLIM) with Time-Correlated-Single-Photon-Counting (TCSPC) and Near-Infrared (NIR) Detection, Stimulated Emission Depletion laser-scanning microscopy (STED) (a super-resolution technique), both microscopic and macroscopic (small animal) spectral unmixing and laser capture microdissection.

Proper citation: University of California at Los Angeles California NanoSystems Institute Advanced Light Microscopy and Spectroscopy Core Facility (RRID:SCR_022789) Copy   

•   Source: SciCrunch Registry

https://isotope.ucsc.edu/

Provides light stable isotope ratio analysis services to scientists from UCSC and from around the world.

Proper citation: University of California at Santa Cruz Stable Isotope Laboratory Core Facility (RRID:SCR_022947) Copy   

•   Source: SciCrunch Registry

https://www.research.chop.edu/chop-penn-proteomics-core

Core has established quality controlled protocols to quantitatively analyze whole proteomes, phosphoproteomes, ubiquitylomes, and/or lysine acetylomes at deep level through process of serial enrichment.

Proper citation: Children's Hospital of Philadelphia Research Institute Proteomics Core Facility (RRID:SCR_023099) Copy   

•   Source: SciCrunch Registry

https://www.rockefeller.edu/transgenics/

Provides services such as Pronuclear Injection, Blastocyst Injection, Embryo and Sperm Cryopreservation, Strain Recovery and Rederivation. Provides assisted reproductive techniques such as IVF and ICSI used for strain recovery. Core facility to the university for creation and maintenance of all transgenic animal models, refinement and development of new transgenic techniques, as well as training center for research personnel.

Proper citation: Rockefeller University Transgenic and Reproductive Technology Center Core Facility (RRID:SCR_023098) Copy   

•   Source: SciCrunch Registry

https://www.biocampus.cnrs.fr/index.php/en/facilities-en/browse-by-facility/platform/421-bacfly-en

Facility dedicated to expression of innovative recombinant proteins for all in vitro and in vivo studies. Innovative technology developed by the platform, called FlexiBac, uses baculovirus / insect cell expression system.

Proper citation: Montpellier Bacfly Core Facility (RRID:SCR_023096) Copy   

•   Source: SciCrunch Registry

https://mssr.cnsi.ucla.edu/

Services include use of high throughput screening technology, compounds in various libraries, siRNA sets of druggable genome for mouse and human and database of results from screens. For compounds screens, data points are in singlets.For functional genomics screens we use duplicates. We typically utilize 384 well plates but are flexible in this regard. We can accomodate any plate type ranging from 96 to 1536 well plates. Specialty plates can be handled on needed base. We have special rates for consumables with many vendors based on volume we use. These reduced rates are passed on directly to our screeners.

Proper citation: University of Califorania at Los Angeles California NanoSystems Institute Molecular Screening Shared Resource Core Facility (RRID:SCR_022956) Copy   

•   Source: SciCrunch Registry

https://www2.uottawa.ca/faculty-medicine/core-facilities/gem

Facility assists researchers in mammalian genome editing and molecular biology, including CRISPR genetic libraries and screens as well as custom viral vector/particle production. Projects are customized to researchers needs, from full service cell line creation to design and cloning.Supported by Canadian Foundation for Innovation.

Proper citation: University of Ottawa Genome Editing and Molecular Biology Core Facility (RRID:SCR_022954) Copy   

•   Source: SciCrunch Registry

https://research.med.psu.edu/core-facilities/custom-antibody-core/

Provides service for production and purification of custom antibodies.Primary services include immunization of mice and rabbits to make mouse and rabbit monoclonal antibodies to select targets. Primary screening of hybridomas will be conducted using standard ELISA technology and positive lines will be preserved for cloning. Supernatants containing antibody selected as positive will be made available to investigators for secondary analyses in their labs (Westerns, immunofluorescence, functional assays). Investigator selected lines will be cloned, isotyped, and adapted to serum free culture for future production of high titer antibody if investigator requires large quantities of antibody. Standard purifications will be conducted as needed, and various modifications (fluorochrome, enzyme, biotin) are also provided as Antibody Core services.

Proper citation: Pennsylvania State University Hershey College of Medicine Custom Antibody Core Facility (RRID:SCR_022799) Copy   

•   Source: SciCrunch Registry

https://www.dfhcc.harvard.edu/research/core-facilities/mouse-engineering/

Core provides services for generation of transgenic and knockout mice.Provides Nikon Diaphot microscope equipped with Nomarski Optics and Narishige micromanipulators for microinjections, Nikon surgical microscopes for egg isolation and transfer, sutter needle puller and de Fonbrune microforge. Facility maintains mice necessary for egg donors, egg recipients, and vasectomized males.Core offers electroporation of targeting vectors into ES cells. Provides investigators with DNA to identify ES cells carrying desired recombination events and ES cell expansion for microinjection into blastocysts.Services also include CRISPR injections, sperm and embryo cryopreservation, and reanimation with fresh or frozen sperm via IVF or thawing and implanting embryos.

Proper citation: Harvard Medical School Dana Farber Harvard Cancer Center Mouse Engineering Core Facility (RRID:SCR_022950) Copy   

•   Source: SciCrunch Registry

http://www.sylvester.org/CMSR

Provides small animal cancer modeling services to foster cancer research and to accelerate discovery of tailored anti-tumor therapies, including preclinical data for drug development, proof of principle for novel therapies, preclinical imaging, and disease biomarker studies. Services include facilitating in vivo modeling of human disease using mouse models; supporting preclinical in vivo efficacy and toxicity studies; devising treatment protocols; using noninvasive imaging for diagnosis and evaluation of responses to treatment; and performing histopathological analysis of targeted cancer therapies. Specific services include (1) support for the development of experimental murine models of cancer, including with cell line and patient-derived xenografts (PDXs), genetically engineered mouse models, and humanized models; (2) support for devising and implementing treatment protocols in a pre-clinical setting using murine models of human disease (e.g., drug toxicology and efficacy studies, drug formulation and delivery, and related assessments, like cell blood count, clinical chemistry, and flow cytometry analysis); and (3) diagnosis and evaluation of responses to treatment, using noninvasive small animal imaging for diagnosis and evaluation of responses to treatment, including in vivo bioluminescence and fluorescence optical imaging, high-frequency ultrasound imaging, structural and functional nuclear imaging, and magnetic resonance imaging (MRI); and (b) research histopathological analysis of targeted cancer therapies, including H&E and immunohistochemistry (IHC) sectioning, staining, scanning and analysis, and data storage of digital slide images. The CMSR also offers consultation, training, educational workshops and seminars. CMSR radiotherapy services support both small animal total body and image-guided radiation treatment delivery with sub-millimetric accuracy for development of radiation therapy regimens in a preclinical setting.

Proper citation: University of Miami Sylvester Comprehensive Cancer Center Cancer Modeling Shared Resource Core Facility (RRID:SCR_022891) Copy   

•   Source: SciCrunch Registry

http://www.sylvester.org/BSSR

Provides biorepository resources, services and expertise in support of oncology research.Facilitates translational cancer research with standard operating procedures for patient consenting; protection of patient personal and clinical data; specimen procurement and processing; quality control of specimens; secured specimen storage, retrieval, and distribution; and provision of relevant de-identified clinical data. BSSR services include: biospecimen collection, annotation, processing, storage and distribution (including tissue, blood, and other fluids); plasma, serum, and peripheral blood mononuclear cell processing and cryopreservation; rapid acquisition of surgical tissue and fresh biopsies; participant screening and enrollment for biospecimen collection studies;formalin-fixed, paraffin embedded and frozen tissue retrieval, processing, sectioning, histological staining, and digital whole slide scanning; tissue microarrays production; support for non-therapeutic trials; consultation on project design, data analysis and interpretation. Offers access tobiobank of diverse tissue types, including clinically annotated neoplastic and non-neoplastic samples from diverse anatomical sites, and provides banked specimen as well as fresh specimen procurement at institution wide level.Through BSSR, investigators have access to specimens collected fromUniversity of Miami Hospital, Sylvester Comprehensive Cancer Center, Bascom Palmer Eye Institute, Jackson Memorial Hospital, as well as to specimens collected in more broadly based multi-site studies.

Proper citation: University of Miami Sylvester Comprehensive Cancer Center Biospecimen Shared Resource Core Facility (RRID:SCR_022889) Copy   

•   Source: SciCrunch Registry

https://cbc.arizona.edu/research/support-services/facilities/wm-keck-center-nano-scale-imaging

Interdisciplinary research facility in areas of imaging, nano-science and spectroscopy for measuring surface topography, surface properties, electrical measurements, fluorescence, sub-monolayer visible spectroscopy, and molecular structures.

Proper citation: University of Arizona W.M. Keck Center for Nano Scale Imaging Core Facility (RRID:SCR_022884) Copy   

•   Source: SciCrunch Registry

https://www.mdc-berlin.de/genomics

Facility comprises Next Generation Sequencing, Single Cell Technologies and Data Management teams. Offers professional project counseling, library preparation, and sequence production support for Max Delbruck Center for Molecular Medicine and Berlin Institute of Health at Charite institutes in Berlin.

Proper citation: MDC and BIH Technology Platform Genomics Core Facility (RRID:SCR_022782) Copy   

•   Source: SciCrunch Registry