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http://www.scienceexchange.com/facilities/brains-on-line

Our mission at Brains On-Line is to provide preclinical research services to facilitate the development of new drugs that target the central nervous system. Brains On-Line benefits from its intimate connections with academia, as well as with several associated contract research organizations (CRO). Using our expertise, we aim to give full insight in the possibilities of your compound.

Proper citation: Brains On-Line (RRID:SCR_012565) Copy   

•   Source: SciCrunch Registry

http://cancer.dartmouth.edu/res/transgenics_genetic.html

Core facility that provides the following services: Cigarette smoke exposure analysis service, Oocyte injection for transgenic animal production, Transgenic mice consultation, Generation of chimeric mice from ES cells, Transgenic lines establishment, Genotyping service, Tail biopsies and other services, Humanized mice production. The mission of the TGCSR is to support the generation and utilization of genetically modified mice by members of the Dartmouth research community. The support starts with intellectual support in planning and designing transgenic experiments provided by consultation with the TGCSR director. The TGCSR is now able to offer not only assistance with design of genetic constructs but also the production of genetic constructs for use in transgenic animal production through recombineering in either yeast or E. coli. TGCSR provides a full range of ES cell manipulation services. The tasks of manipulating the mouse embryo are fully provided by the TGCSR either in house or through an established relationship with the University of Vermont. Jackson labs is now providing cryopreservation services to protect and preserve valuable transgenic mouse lines. The TGCSR can also provide genotyping and mouse husbandry services. As currently organized, the TGCSR can provide the full range of services required to design, generate and maintain transgenic mouse lines. TGCSR currently maintains two specialized transgenic lines that express Cre or Flp in the germline for genetic manipulation of transgene/knockouts in vivo. TGCSR has a fully equipped embryo manipulation laboratory in the Borwell animal facility and an adjoining 4 room suite of mouse husbandry rooms.

Proper citation: Dartmouth Transgenics and Genetic Constructs Shared Resource (RRID:SCR_012443) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/histopathology-and-tissue-shared-resource-georgetown

The HTSR offers a full complement of histology services through our combined Human Tissue Bank, histology, and IHC departments. The Human Tissue Bank supports tissue procurement and the retrieval of fresh frozen and archival paraffin blocks. The Histology laboratory provides processing, embedding and microtomy services both for fresh frozen and fixed tissues. The Histology lab also provides numerous routine and non-routine histological stains. The Immunohistochemistry (IHC) laboratory supports colorimetric and fluorescent IHC staining for established antibodies as well as the development of protocols for new antibodies. The IHC lab also supports TUNEL labeling and novel labeling techniques.

Proper citation: Georgetown Histopathology and Tissue Shared Resource (RRID:SCR_012489) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/respiratory-disease-immunology-core-laboratory-rdicl-uc-davis

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 24,2024. Respiratory Disease Immunology Core Laboratory is to provide technical expertise and resources to investigators interested in the immunological evaluation of rhesus macaque models for lung disease. Studies are primarily carried out in conjunction with the Inhalation Exposure Core and the Computational Imaging Core at UCDavis, in order to provide a comprehensive evaluation of pathophysiological responses in the lung. Services provided by the RDICL include assistance with experimental design, allergen characterization and preparation (through Resource Services), evaluation of allergen-specific IgE and IgG, and quantitation of histamine. We also provide technical support for sample processing, including bronchoalveolar lavage, lung tissue, and blood. Flow cytometry and molecular analysis of lung and blood samples are coordinated with the Flow Cytometry Core Laboratory and the Infectious Disease Immunology Core Laboratory. In addition to immunological evaluation, the Respiratory Disease Immunology Core Laboratory can provide investigators with primary cell isolates and in vitro culture of rhesus lung epithelial cells and fibroblasts. The Core does not conduct studies with human lung cultures. Please inquire for additional assays that are in development. In the future, immunohistochemistry of lung samples will be offered in conjunction with the Computational Imaging Core at UCDavis.

Proper citation: UC Davis Respiratory Disease Immunology Core Laboratory (RRID:SCR_012647) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/division-of-comparative-pathology-miami

The Division of Comparative Pathology is a full service veterinary pathology laboratory with both clinical pathology and histology services. Routine hematology and serum biochemistry testing is available for multiple species; we work well with low volume samples. Specialized testing is available or can be implemented as needed. Routine histology services including processing, embedding, and sectioning are available with many routine and special staining options.

Proper citation: UM Miller School of Medicine Division of Comparative Pathology (RRID:SCR_012492) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/institute-for-behavioral-genetics

The Institute for Behavioral Genetics (IBG) is an organized research unit of the University of Colorado Graduate School dedicated to conducting and facilitating research on the genetic and environmental bases of individual differences in behavior. Founded in 1967, IBG is one of the top research facilities in the world for genetic research on behavior. Data collection and analysis is ongoing for several internationally renowned studies including the Colorado Adoption Project, the Colorado Twin Registry, the National Youth Survey Family Study, the Colorado Learning Disabilities Research Center, and the National Longitudinal Study of Adolescent Health. IBG is home to one of the nation''''s largest DNA repositories for research on human behavior, as well as housing a wide array of behaviorally and genetically defined lines of selected, recombinant inbred, transgenic, and knockout-gene mice. Current research includes studies of aging ( The Johnson Lab, The Link Lab), psychopathology, reading disability, cognition, substance abuse, behavioral development, and evolution. In addition to our research, we provide training opportunities for graduate students in affiliated programs at the University of Colorado campuses in Boulder and Denver. IBG receives funding from several federal agencies, principally through the National Institutes of Health, as well as a broad spectrum of Associations, Foundations and Programs. Welcome to our site, please feel free to contact us with any questions about our research or programs.

Proper citation: CU Boulder Institute for Behavioral Genetics (RRID:SCR_012495) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/genomics-and-epigenomics-shared-resource-gesr-georgetown

The Genomics & Epigenomics Shared Resource (GESR) provides services for various high throughput experiments including gene expression profiling, SNP genotyping, CNV analysis, DNA methylation, microRNA expression profiling, siRNA screening, DNA/RNA isolation, RNA quality assessment, DNA plating and assay preparation, DNA sequencing, and fragment analysis. GESR uses state-of-the-art instruments and assays to provide these services. These include Affymetrix Microarray System, Agilent Microarray System, Applied Biosystems TaqMan assays, Illumina BeadXpress, Qiagen PyromarkMD, Qiagen Qiacube, Agilent Bioanalyzer, Beckman Multimek NXP Robotic Liquid Handling System, and Applied Biosystems Sequence Analyzer. In addition, GESR houses several user-operated specialized instruments for which the shared resource personnel provide technical support and training.

Proper citation: Georgetown Genomics and Epigenomics Shared Resource (RRID:SCR_012498) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/microarray-resource-core-bu

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 22,2024. Microarray Resource Core offers the full line of microarray products available from Affymetrix. This includes expression profiling, miRNA, exon, genotyping, resequencing, and tiling arrays. As part of our standard service, the resource provides assistance with experimental design and data analysis. Arrays for other organisms are available; please contact us for with specific requests.

Proper citation: Boston University Microarray Resource Core (RRID:SCR_012491) Copy   

•   Source: SciCrunch Registry

https://genomics.umn.edu/

Provides genomic technologies and services to researchers and clinicians. Services include Next Generation Sequencing, Epigenomics, SARS-CoV-2 services, GBS, Third Generation Sequencing, NGS Library Creation, Sanger Sequencing, DNA and RNA Extraction, Gene Expression.

Proper citation: University of Minnesota Genomics Center Core Facility (RRID:SCR_012413) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/animal-and-food-sciences-department-udel

We offer a wide range of disciplines including virology, physiology, nutrition, microbiology, immunology, molecular biology, engineering, and genomics. Our research addresses contemporary and future scientific challenges by using cutting edge technologies with the goal of assisting stakeholders in the poultry, livestock, and food industries.

Proper citation: UD Animal and Food Sciences Department (RRID:SCR_012415) Copy   

•   Source: SciCrunch Registry

https://siperg.las.iastate.edu/stable-isotope-lab-sil/

Core performes continuous flow isotopic and elemental analyses of carbon, nitrogen, oxygen and hydrogen in organic and inorganic substrates (solids, liquids, and gases). Supports research in oceanography, paleoclimatology, geology, ecology, agronomy, and chemistry. Laboratory consists of ThermoFinnigan Delta Plus XL mass spectrometer coupled with several sample introduction systems, including GasBench II with CombiPal autosampler, Costech elemental analyzer and TC/EA with Conflo III interface. Additionally, the SIL operates Picarro L2130-i Isotopic Liquid Water Analyzer with autosampler for rapid measurements of deuterium and oxygen.

Proper citation: Iowa State University SIPERG Stable Isotope Lab Core Facility (RRID:SCR_012541) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/waksman-institute-of-microbiology

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on October 10, 2023. Our mission is to conduct research in microbial molecular genetics, developmental molecular genetics, plant molecular genetics, and structural and computational biology. We also provide a catalyst for general university initiatives, a life science infrastructure, undergraduate and graduate education, and a public service function for the State of New Jersey. The Institute employs faculty teams that concentrate on certain classes of organisms amenable to genetic analysis such as bacteria and fungi (E. coli and yeast), animal systems (e.g., Drosophila), and plants (Arabidopsis, tobacco, and maize). Although the Institute focuses on basic questions in microbial, animal, and plant research, it continues to engage in extensive technology transfer of its basic discoveries.

Proper citation: Rutgers Waksman Institute of Microbiology Labs and Facilities (RRID:SCR_012728) Copy   

•   Source: SciCrunch Registry

http://cccb.dfci.harvard.edu

Core facility that provides the following services: Microarray and other genomic data analysis, MiSeq. The Center provides broad-based support for the generation, analysis, and interpretation of genomic and other large-scale data in the context of basic, clinical and translational research. The CCCB has three primary elements. * The CCCB sequencing facility offers a wide range of services to assist in the design and execution of next-generation sequencing projects. Utilizing the Illumina (Solexa) sequencing technology, they currently support a number of applications inlcuding ChIP-Seq, RNA-Seq, whole genome, whole exome, and targeted re-sequencing. * The analytical services and support platform aims to provide state-of-the-art assistance in the collection, management, analysis, and interpretation of large-scale data with a focus on data generated using ''''omic technologies. In addition, they offer software, services, and training designed to assist investigators in advancing their research. * The CCCB research program is focused on development of new methods for improving analysis and interpretation of genomic data through integration of diverse data types with the goal of creating open-source software tools to be made freely-available to the research community.

Proper citation: DFCI Center for Cancer Computational Biology (RRID:SCR_012688) Copy   

•   Source: SciCrunch Registry

http://ocs.med.nyu.edu/immunohistochemistry

The Immunohistochemistry Core, a component of the Experimental Pathology Shared Resource, is located in Bellevue Hospital within the NYULMC Department of Pathology''s Anatomic Pathology clinical space. The laboratory serves as an immunohistochemical antibody repository with a catalog of over 900 antibodies. Antibodies are in stock and available for use in the core laboratory for the collection of experimental immunohistochemistry data. The laboratory develops immunohistochemical protocols for new antibodies (commercial or proprietary) that have not been tested in fresh, frozen, fixed human or animal tissues and cells. In addition to performing manual labeling, the laboratory is equipped with two Ventana NEXES and one Discovery automated immunohistochemical staining instruments. The laboratory uses human and animal tissue micro-arrays for validation and employs a wide variety of antigen retrieval methods for protocol development. The core offers tyramide and polymer amplification methods (manual) and single or two color chromogenic immunohistochemistry. The laboratory has also commenced developing protocols and validating antibodies for immunoflorescence in frozen and FFPE tissue samples. The laboratory faculty and staff are available to provide hands-on informal training, as well as guidance and support for the design and execution of experiments involving histopathology and immunohistochemistry of human and animal cells and tissues. In conjunction with the Histopathology Core Laboratory, the Immunohistochemistry Laboratory can also assist investigators with routine and advanced histopathologic services for tissue and cell specimens (including guidance on initial processing steps: grossing/tissue preparation, processing, embedding, paraffin/frozen microtomy) for samples destined for histopathological interpretation and analysis. In addition, we offer extensive options for special and routine histochemical and immunohistochemical labeling of both human and animal model cells and tissues.

Proper citation: NYU Immunohistochemistry Core (RRID:SCR_012721) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/specialist-device-fabrication

THIS RESOURCE IS NO LONGER IN SERVCE, documented September 22, 2016. The ANFF provides leading-edge research capability and supports excellence in science. The capability provided by ANFF enables users to process hard materials (metals, composites and ceramics) and soft materials (polymers and polymer-biological moieties) and transform these into structures that have application in sensors, medical devices, nanophotonics and nanoelectronics. It has a strong emphasis on service provision to the research community. ANFF seeks to enhance national and international collaborations and enable world-class-research.

Proper citation: ANFF Specialist Device Fabrication (RRID:SCR_012689) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/high-throughput-screening-service-uc-irvine

With the completion of the genome sequence, that offers us a variety of new genes to study, and advances in combinatorial chemistry, that delivers large numbers of synthetic compounds to test, high__������throughput screening (HTS) is becoming a necessary research endeavor. We specialize in HTS of G protein__������coupled receptors (GPCRs). Ligand recognition is quantified in binding experiments or monitored by second messenger responses. One technology that we use is the FLIPR technology that allows for real__������time fluorescent measurements.

Proper citation: UC Irvine High Throughput Screening Service (RRID:SCR_012725) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/macromolecular-x-ray-crystallography-core-facility

The Macromolecular X-ray Crystallography Core Facility of Scripps FL offers state-of-the-art equipment and resources to scientists inside and outside of the Scripps FL campus by providing crystallographic analysis of their chosen biological macromolecules. The core facility offers and operates as a full service core by performing protein crystallization, X-ray diffraction data collection (both in-house and at Argonne National Laboratory) and processing, phasing, crystallographic refinement, model building, and visualization. The structural data obtained by the core will provide scientists with a wealth of information including but not limited to biological functions, 3D-folding, ligand binding (small molecule or protein), or mutational effect of target macromolecules of their interests.

Proper citation: Scripps Florida Macromolecular X-ray Crystallography Core Facility (RRID:SCR_012727) Copy   

•   Source: SciCrunch Registry

http://www.ohsu.edu/xd/research/centers-institutes/onprc/research-services/research-support/virology.cfm

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on December 5, 2022. Core facility that provides the following services: DNA isolation service, RNA isolation service, Cloning and endotoxin-free plasmid preparation service, Virus plaque assay, SIV p27 protein ELISA, HIV p24 protein ELISA with sample prep, Real time PCR titer of lentivirus prep with sample prep, Coculture of animal tissues/fluids service, Virus plaque purification service, Virus growth curve service, Protein determination, Bradford method, Crude viral DNA prep service, Gradient purified viral DNA prep service, Southern blot for viral DNA, Viral Real-time PCR, RhCMV Real-time PCR, HSV 1/2 B virus antibody ELISA, single dilution service, RhRRV antibody ELISA, single dilution, RhSFV antibody ELISA, single dilution, SIV antibody ELISA, single dilution, Virus antibody ELISA, RhCMV antibody ELISA, Virus neutralization service, Polyclonal IgG preparation, SIV in vitro susceptibility, p27 ELISA, Vaccinia (MVA) virus plaque assays, Antiviral antibody determination by ELISA, SIV in vitro infectivity (leukocytes) service, Viral load quantification with qPCR, Virus detection using nested PCR, Virus stock production, Cytomegalovirus plaque assays and purification, Cytomegalovirus stock and vector production, Western blot service for viral protein, Cell sample processing and banking, Nucleic acid isolation and purification service, Virus cloning and plasmid preparation service, Vaccinia (MVA) virus stock and vector production. The Core''''s overall goal is to advance the efforts of the Oregon National Primate Research Center (ONPRC), the Vaccine and Gene Therapy Institute (VGTI), and collaborative research programs focused on nonhuman primate (NHP) infectious disease models and those using viral vectors as tools to modify genes or deliver macromolecules through provision of expertise, reagents, standardized assays, and training in the use of infectious viral agents in their research programs. The MVSC provides specialized expertise and infrastructure in five essential areas: * Virus identification and quantification in clinical specimens * Production of virus stocks, virus vectors, and viral antigen preparations * Serologic assays to assess host antiviral immune responses * Maintenance of cell stocks and sample processing * Development of new reagents and standardized assays The MVSC has considerable experience and expertise in both viral diagnostics and production, particularly for AIDS and CMV pathogenesis and vaccine studies, and in adenoviral vector production.

Proper citation: OHSU Molecular Virology Support Core (RRID:SCR_012730) Copy   

•   Source: SciCrunch Registry

https://planttransformationlab.wordpress.ncsu.edu/

Provides innovative solutions, technologies, expertise, training, and services for research and applications related to plant transformation. The PTL staff and facilities are available for research collaborations; core resources are available for user-driven projects with cost recovery; fee-based plant transformation services can be provided for the NCSU community and external partners.

Proper citation: North Carolina State University Plant Transformation Laboratory Core Facility (RRID:SCR_012706) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/histology-core-wustl

The Histology Core has all the requisite equipment and reagents to enable a variety of tissue processing, embedding and sectioning protocols, including epon/araldite, glycol and methyl methacrylate, polyethylene glycol (PEG), paraffin and cryosectioning. Users of the Histology Core can choose to submit full service jobs and allow core personnel to embed, section and counterstain fixed tissue samples or they can sign up to use a microtome and cut the tissue themselves. Training on any aspect of the histologic process is available on request. All core services are equally available to core members and non-members on a first-come first-served basis.

Proper citation: WUSTL Histology Core (RRID:SCR_012700) Copy   

•   Source: SciCrunch Registry