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Resource Name Proper Citation Abbreviations Resource Type Description Keywords Resource Relationships Related Condition Funding Defining Citation Availability Website Status Alternate IDs Alternate URLs Old URLs Parent Organization Resource ID Synonyms Record Last Update Mentions Count
TopHat
 
Resource Report
Resource Website
5000+ mentions
Rating or validation data
TopHat (RRID:SCR_013035) software application, sequence analysis software, data processing software, software resource, alignment software, image analysis software, data analysis software Software tool for fast and high throughput alignment of shotgun cDNA sequencing reads generated by transcriptomics technologies. Fast splice junction mapper for RNA-Seq reads. Aligns RNA-Seq reads to mammalian-sized genomes using ultra high-throughput short read aligner Bowtie, and then analyzes mapping results to identify splice junctions between exons.TopHat2 is accurate alignment of transcriptomes in presence of insertions, deletions and gene fusions. align, RNA-Seq, read, cDNA, sequencing, transcriptomics, fast, splice, junction, mapper, exon, analysis, bio.tools uses: Bowtie
is used by: CIRCexplorer
is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
is listed by: SoftCite
is related to: HISAT2
has parent organization: University of Maryland; Maryland; USA
has parent organization: University of California at Berkeley; Berkeley; USA
has parent organization: Johns Hopkins University; Maryland; USA
has parent organization: University of Washington; Seattle; USA
works with: GeneScissors
NHGRI R01 HG006102;
NHGRI R01 HG006677
PMID:23618408
PMID:19289445
DOI:10.1093/bioinformatics/btp120
Free, Available for download, Freely available biotools:tophat, OMICS_01257 https://github.com/infphilo/tophat
https://bio.tools/tophat
https://sources.debian.org/src/tophat/
http://tophat.cbcb.umd.edu/ SCR_013035 tophat, TopHat1, Tophat2 2026-02-15 09:20:23 9575
MitoBreak
 
Resource Report
Resource Website
10+ mentions
MitoBreak (RRID:SCR_012949) MitoBreak database, service resource, storage service resource, data repository, data or information resource Database with curated datasets of mitochondrial DNA (mtDNA) rearrangements. Users may submit new mtDNA rearrangements. mitochondrial dna rearrangement, mitochondrial dna, deletion, duplication, linear, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
PMID:24170808 Free, The community can contribute to this resource biotools:mitobreak, OMICS_01640 https://bio.tools/mitobreak SCR_012949 2026-02-15 09:20:40 10
NGSEP
 
Resource Report
Resource Website
50+ mentions
NGSEP (RRID:SCR_012827) NGSEP software application, data processing software, data analysis software, software resource Software whose main functionality is the variants detector, which allows to make simultaneous discovery of SNVs, small indels, and CNVs.Accurate variant calling across species and sequencing protocols.Used for analysis of DNA high throughput sequencing data. matlab, variants detector, SNVs discovery, CNVs discovery, variant calling, species, sequencing protocols, bio.tools is listed by: bio.tools PMID:31099384 Free, Available for download, Freely available OMICS_00067, biotools:NGSEP https://bio.tools/NGSEP SCR_012827 NGSEP3, Next Generation Sequencing Eclipse Plugin, Next Generation Sequencing Experience Platform 2026-02-15 09:20:39 69
minfi
 
Resource Report
Resource Website
100+ mentions
minfi (RRID:SCR_012830) minfi software application, data visualization software, data processing software, software resource, data analysis software Software tools for analyzing and visualizing Illumina''s 450k array data. Illumina, array data, Analyze Illumina Infinium DNA methylation arrays, DNA methylation array, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
is listed by: SoftCite
is related to: SWAN
has parent organization: Bioconductor
PMID:28035024 Free, Available for download, Freely available biotools:minfi, OMICS_00799, BioTools:minfi https://bio.tools/minfi
https://bio.tools/minfi
https://bio.tools/minfi
SCR_012830 2026-02-15 09:20:36 390
affy
 
Resource Report
Resource Website
1000+ mentions
affy (RRID:SCR_012835) Affy software application, data processing software, data analysis software, software resource Software R package of functions and classes for the analysis of oligonucleotide arrays manufactured by Affymetrix. Used to process probe level data and for exploratory oligonucleotide array analysis. analysis, oligonucleotide, array, Affymetrix, process, probe, data, function, bio.tools is listed by: OMICtools
is listed by: Bioconductor
is listed by: Debian
is listed by: bio.tools
is listed by: SoftCite
is related to: affydata
is related to: R Project for Statistical Computing
is related to: OMICtools
Danish Biotechnology Instrument Center PMID:14960456 Free, Available for download, Freely available BioTools:affy, OMICS_00740, biotools:affy https://bio.tools/affy
https://sources.debian.org/src/r-bioc-affy/
SCR_012835 Affymetrix, analysis of Affymetrix GeneChip data at the probe level, analysis of Affymetrix GeneChip data 2026-02-15 09:20:39 2996
edgeR
 
Resource Report
Resource Website
10000+ mentions
edgeR (RRID:SCR_012802) edgeR software application, data processing software, data analysis software, software resource Bioconductor software package for Empirical analysis of Digital Gene Expression data in R. Used for differential expression analysis of RNA-seq and digital gene expression data with biological replication. empirical, analysis, digital, gene, expression, data, R, RNA-seq data, bio.tools is used by: Glimma
is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
is related to: SARTools
is related to: Bioconductor
works with: tximport
NHMRC 406657;
Independent Research Institutes Infrastructure Support Scheme 361646;
Victorian State Government OIS grant ;
Melbourne International Research Scholarship ;
Harris and IBS Honours scholarships
PMID:19910308
DOI:10.1093/bioinformatics/btp616
Free, Available for download, Freely available OMICS_01308, biotools:edger https://bio.tools/edger
https://sources.debian.org/src/r-bioc-edger/
SCR_012802 edgeR, empirical analysis of digital gene expression data in R, Empirical analysis of Digital Gene Expression data in R 2026-02-15 09:20:39 21899
IMGT - the international ImMunoGeneTics information system
 
Resource Report
Resource Website
500+ mentions
IMGT - the international ImMunoGeneTics information system (RRID:SCR_012780) IMGT portal, data analysis service, database, service resource, production service resource, data or information resource, topical portal, analysis service resource A high-quality integrated knowledge resource specialized in the immunoglobulins (IG) or antibodies, T cell receptors (TR), major histocompatibility complex (MHC) of human and other vertebrate species, and in the immunoglobulin superfamily (IgSF), MHC superfamily (MhcSF) and related proteins of the immune system (RPI) of vertebrates and invertebrates, serving as the global reference in immunogenetics and immunoinformatics. IMGT provides a common access to sequence, genome and structure Immunogenetics data, based on the concepts of IMGT-ONTOLOGY and on the IMGT Scientific chart rules. IMGT works in close collaboration with EBI (Europe), DDBJ (Japan) and NCBI (USA). IMGT consists of sequence databases, genome database, structure database, and monoclonal antibodies database, Web resources and interactive tools. immunogenetics, immunoinformatics, immunoglobulin, antibody, t cell receptor, major histocompatibility complex, immunoglobulin superfamily, major histocompatibility complex superfamily, protein, immune system, sequence, genome, structure, monoclonal antibody, gold standard, bio.tools is listed by: bio.tools
is listed by: Debian
is related to: IMGT Repertoire
has parent organization: Montpellier 2 University; Montpellier; France
is parent organization of: IMGT/LIGM-DB
is parent organization of: IMGT/GENE-DB
is parent organization of: IMGT-ONTOLOGY
is parent organization of: IMGT/V-QUEST
is parent organization of: IMGT/HLA
CNRS ;
MESR ;
Reseau National des Genopoles ;
Region Languedoc-Roussillon ;
European Union BIOMED1 BIOCT930038;
European Union Biotechnology BIOTECH2 BIO4CT960037;
European Union 5th PCRDT Quality of Life and Management of Living Resources QLG2-2000-01287;
Agence Nationale de la recherche ANR BIOSYS06_135457;
EU ImmunoGrid IST-028069
PMID:18978023 nif-0000-03011, biotools:imgt https://bio.tools/imgt http://imgt.cines.fr SCR_012780 ImMunoGeneTics Information System, IMGT/LIGM, ImMunoGeneTics 2026-02-15 09:20:38 746
GeneSigDB
 
Resource Report
Resource Website
10+ mentions
GeneSigDB (RRID:SCR_013275) GeneSigDB data analysis service, software resource, database, data access protocol, web service, service resource, storage service resource, production service resource, data repository, data or information resource, analysis service resource Database of traceable, standardized, annotated gene signatures which have been manually curated from publications that are indexed in PubMed. The Advanced Gene Search will perform a One-tailed Fisher Exact Test (which is equivalent to Hypergeometric Distribution) to test if your gene list is over-represented in any gene signature in GeneSigDB. Gene expression studies typically result in a list of genes (gene signature) which reflect the many biological pathways that are concurrently active. We have created a Gene Signature Data Base (GeneSigDB) of published gene expression signatures or gene sets which we have manually extracted from published literature. GeneSigDB was creating following a thorough search of PubMed using defined set of cancer gene signature search terms. We would be delighted to accept or update your gene signature. Please fill out the form as best you can. We will contact you when we get it and will be happy to work with you to ensure we accurately report your signature. GeneSigDB is capable of providing its functionality through a Java RESTful web service. gene, gene signature, curated gene signature, gene expression, gene expression signature, bio.tools is listed by: Debian
is listed by: bio.tools
has parent organization: Dana-Farber Cancer Institute
has parent organization: Computational Biology and Functional Genomics Laboratory at Harvard
Cancer Genome Research Institute ;
Dana-Farber Cancer Institute ;
Women's Cancers Program ;
Claudia Adams Barr Foundation ;
NLM 1R01 LM010129;
NCI 1U19 CA148065;
NHGRI 1P50 HG004233
PMID:22110038 biotools:genesigdb, nlx_149342 https://bio.tools/genesigdb SCR_013275 Gene Signature Data Base, GeneSigDB - Curated Gene Signatures Database 2026-02-15 09:20:42 24
PlantNATsDB - Plant Natural Antisense Transcripts DataBase
 
Resource Report
Resource Website
1+ mentions
PlantNATsDB - Plant Natural Antisense Transcripts DataBase (RRID:SCR_013278) PlantNATsDB data analysis service, database, service resource, production service resource, data or information resource, analysis service resource Natural Antisense Transcripts (NATs), a kind of regulatory RNAs, occur prevalently in plant genomes and play significant roles in physiological and/or pathological processes. PlantNATsDB (Plant Natural Antisense Transcripts DataBase) is a platform for annotating and discovering NATs by integrating various data sources involving approximately 2 million NAT pairs in 69 plant species. PlantNATsDB also provides an integrative, interactive and information-rich web graphical interface to display multidimensional data, and facilitate plant research community and the discovery of functional NATs. GO annotation and high-throughput small RNA sequencing data currently available were integrated to investigate the biological function of NATs. A ''''Gene Set Analysis'''' module based on GO annotation was designed to dig out the statistical significantly overrepresented GO categories from the specific NAT network. PlantNATsDB is currently the most comprehensive resource of NATs in the plant kingdom, which can serve as a reference database to investigate the regulatory function of NATs. natural antisense transcript, annotation, high-throughput, small rna sequencing, function, regulatory function, predict, sequence, small rna, blast, bio.tools is listed by: Debian
is listed by: bio.tools
is related to: Gene Ontology
is related to: Gene Expression Omnibus
has parent organization: Zhejiang University; Zhejiang; China
National Natural Sciences Foundation of China 30971743;
National Natural Sciences Foundation of China 31050110121;
National Natural Sciences Foundation of China 31071659;
Ministry of Science and Technology of China 2009DFA32030;
Program for New Century Excellent Talents in University of China NCET-07-0740;
Huazhong Agricultural University Scientific and Technological Self-innovation Foundation 2010SC07
PMID:22058132 Free nlx_151492, biotools:plantnatsdb https://bio.tools/plantnatsdb SCR_013278 Plant Natural Antisense Transcripts DataBase 2026-02-15 09:20:26 9
Dali Server
 
Resource Report
Resource Website
500+ mentions
Dali Server (RRID:SCR_013433) data analysis service, software resource, service resource, production service resource, analysis service resource Network service for comparing protein structures in 3D. You submit the coordinates of a query protein structure and Dali compares them against those in the Protein Data Bank (PDB). You receive an email notification when the search has finished. In favourable cases, comparing 3D structures may reveal biologically interesting similarities that are not detectable by comparing sequences. Requests can also be submitted by e-mail to dali-server at helsinki dot fi. The body of the e-mail message must contain atomic coordinates in PDB format. If you want to know the structural neighbours of a protein already in the Protein Data Bank (PDB), you can find them in the Dali Database. If you want to superimpose two particular structures, you can do it in the pairwise DaliLite server. Academic users may download the DaliLite program for local use. Protein structure comparison server, protein structure, comparison server, bio.tools, FASEB list is listed by: Debian
is listed by: bio.tools
has parent organization: University of Helsinki; Helsinki; Finland
PMID:20457744 Free, Freely available biotools:dali https://bio.tools/dali SCR_013433 Dali 2026-02-15 09:20:46 509
ENIGMA
 
Resource Report
Resource Website
100+ mentions
ENIGMA (RRID:SCR_013400) software application, data processing software, data analysis software, software resource A software tool to extract gene expression modules from perturbational microarray data, based on the use of combinatorial statistics and graph-based clustering. The modules are further characterized by incorporating other data types, e.g. GO annotation, protein interactions and transcription factor binding information, and by suggesting regulators that might have an effect on the expression of (some of) the genes in the module. Version : ENIGMA 1.1 used GO annotation version : Aug 29th 2007 genome, gene, genetic software, bio.tools is listed by: bio.tools
is listed by: Debian
has parent organization: Ghent University; Ghent; Belgium
is parent organization of: ENIGMA-DTI Pipeline
PMID:18402676 biotools:enigma, nlx_144365 https://bio.tools/enigma SCR_013400 2026-02-15 09:20:27 130
COPASI
 
Resource Report
Resource Website
100+ mentions
COPASI (RRID:SCR_014260) COPASI software application, data processing software, software resource, standalone software, simulation software, data analysis software Software application for simulation and analysis of biochemical network models and their dynamics. COPASI supports models in the SBML standard and can simulate their behavior using ODEs or Gillespies stochastic simulation algorithm. Arbitrary discrete events can be included in such simulations. Models in COPASI are based on reactions that convert a set of species into another set of species. Simulation can be performed either with stochastic kinetics or with differential equations. COPASI also includes various methods of analysis and data visualization. standalone software, simulation software, data analysis, biochemical system simulator, biochemical network model, biochemical network dynamics, bio.tools is listed by: Debian
is listed by: bio.tools
DOI:10.1093/bioinformatics/btl485 Free, Available for download, Acknowledgement requested biotools:copasi https://bio.tools/copasi SCR_014260 COPASI: Biochemical System Simulator 2026-02-15 09:20:54 435
CYANA
 
Resource Report
Resource Website
100+ mentions
CYANA (RRID:SCR_014229) software application, data processing software, data analysis software, software resource Software for automated structure calculation of biological macromolecules on basis of conformational constraints from nuclear magnetic resonance. Program for automated NMR protein structure calculation. CYANA requires a sufficient list of assigned chemical shifts and lists of cross-peak positions and columns from 2D, 3D, or4D NOESY spectra in order to calculate the assignment of the NOESY cross-peaks and the 3D structure of the protein in solution. protein structure, nmr, noesy, 3d structure, bio.tools is listed by: bio.tools
is listed by: Debian
has parent organization: Goethe University Frankfurt am Main; Hessen; Germany
has parent organization: RIKEN
PMID:15318003
PMID:25801209
Available to the academic community, Available to commercial user, Pay for license SCR_021949, biotools:cyana http://www.las.jp/english/products/cyana.html
https://bio.tools/cyana
https://dbpedia.org/page/CYANA_(software)
SCR_014229 2026-02-15 09:20:40 425
SCRATCH
 
Resource Report
Resource Website
100+ mentions
SCRATCH (RRID:SCR_014291) software resource, data access protocol, web service, service resource, production service resource, analysis service resource Web protein structure and structural feature prediction server.Software suite includes predictors for secondary structure, relative solvent accessibility, disordered regions, domains, disulfide bridges, single mutation stability, residue contacts versus average, individual residue contacts and tertiary structure. User provides amino acid sequence and selects desired predictions, then submits to the server. Protein predictor, secondary structure, relative solvent accessibility, disordered regions, domains, disulfide bridges, single mutation stability, residue contacts versus average, individual residue contacts, tertiary structure prediction, bio.tools is listed by: Debian
is listed by: bio.tools
PMID:15980571 Free, Freely available biotools:scratch https://bio.tools/scratch http://www.igb.uci.edu/servers/psss.html SCR_014291 Scratch Protein Predictor 2026-02-15 09:20:52 136
NNcon
 
Resource Report
Resource Website
1+ mentions
NNcon (RRID:SCR_014292) software tool, prediction Protein contact map prediction is useful for protein folding rate prediction, model selection and 3D structure prediction. Here we describe NNcon, a fast and reliable contact map prediction server and software. NNcon was ranked among the most accurate residue contact predictors in the Eighth Critical Assessment of Techniques for Protein Structure Prediction (CASP8), 2008. text mining objective, bio.tools is listed by: Debian
is listed by: bio.tools
PMID:19420062 biotools:nncon https://bio.tools/nncon http://casp.rnet.missouri.edu/nncon.html SCR_014292 2026-02-15 09:21:00 2
Coot
 
Resource Report
Resource Website
10000+ mentions
Coot (RRID:SCR_014222) COOT software application, software resource, model, simulation software, data or information resource, software toolkit Software for macromolecular model building, model completion and validation, and protein modelling using X-ray data. Coot displays maps and models and allows model manipulations such as idealization, rigid-body fitting, ligand search, Ramachandran plots, non-crystallographic symmetry and more. Source code is available. software toolkit, simulation software, model manipulation, protein modeling, bio.tools is used by: PDB-REDO
is listed by: bio.tools
is listed by: Debian
is listed by: SoftCite
is related to: MolProbity
has parent organization: MRC Laboratory of Molecular Biology
PMID:15572765 Available for download, Acknowledgement requested biotools:coot http://strucbio.biologie.uni-konstanz.de/ccp4wiki/index.php/Coot
https://bio.tools/coot
SCR_014222 Crystallographic Object-Oriented Toolkit 2026-02-15 09:20:53 14789
SHELX
 
Resource Report
Resource Website
500+ mentions
SHELX (RRID:SCR_014220) software application, data processing software, software resource, standalone software, image analysis software, image reconstruction software A set of software programs that utilizes dual spaces algorithms for the determination of small and macromolecular crystal structures by single crystal X-ray and neutron diffraction. Libraries, extra files and environment variables are not required for the executables. SHELX is intended to be run on a command prompt but may be called from GUIs such as shelXle, Olex2, Oscail or WinGX, or hkl2map., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025. standalone software, image reconstruction software, image analysis software, crystal structure, crystal xray, neutron diffraction, bio.tools is listed by: bio.tools
is listed by: Debian
DOI:10.1107/S2053273314026370 THIS RESOURCE IS NO LONGER IN SERVICE biotools:shelx https://bio.tools/shelx SCR_014220 2026-02-15 09:20:58 520
Crystallography and NMR System (CNS)
 
Resource Report
Resource Website
1+ mentions
Crystallography and NMR System (CNS) (RRID:SCR_014223) CNS software application, data visualization software, data processing software, software resource, software toolkit Software designed to provide a multi-level hierachical approach for the most commonly used algorithms in macromolecular structure determination. Features include heavy atom searching, experimental phasing (including MAD and MIR), density modification, crystallographic refinement with maximum likelihood targets, and NMR structure calculation using NOEs, J-coupling, chemical shift, and dipolar coupling data. Modules, libraries, utility programs, tutorials, and a syntax manual are available on the website. structure determination, software suite, macromolecular structure determination, data visualization software, bio.tools is listed by: Debian
is listed by: bio.tools
has parent organization: Yale University; Connecticut; USA
PMID:9757107 Available to academic institutions, Request form must be submitted biotools:cnssolve https://bio.tools/cnssolve SCR_014223 Crystallography and NMR System 2026-02-15 09:20:50 8
PsyGeNET
 
Resource Report
Resource Website
10+ mentions
PsyGeNET (RRID:SCR_014406) software application, data processing software, software resource, database, data or information resource, data analysis software Knowledge platform on psychiatric disorders and their genes. Resource for exploratory analysis of psychiatric diseases and their associated genes. PsyGeNET is composed of database and set of analysis tools and is the result of the integration of information from DisGeNET and data extracted from the literature by text mining, followed by curation by domain experts. psychiatric disease, associated gene, database, analysis tool, bio.tools is used by: DisGeNET
is listed by: Debian
is listed by: bio.tools
Psychiatric disorder DOI:10.1093/bioinformatics/btv301 Available for the research community biotools:psygenet2r https://bio.tools/psygenet2r SCR_014406 Psychiatric disorders Gene association NETwork, Psychiatric disorders Gene association Network 2026-02-15 09:20:43 11
Cufflinks
 
Resource Report
Resource Website
5000+ mentions
Cufflinks (RRID:SCR_014597) software application, sequence analysis software, data processing software, software resource, data analysis software Software tool for transcriptome assembly and differential expression analysis for RNA-Seq. Includes script called cuffmerge that can be used to merge together several Cufflinks assemblies. It also handles running Cuffcompare as well as automatically filtering a number of transfrags that are likely to be artifacts. If the researcher has a reference GTF file, the researcher can provide it to the script to more effectively merge novel isoforms and maximize overall assembly quality. transcriptome, rna-seq, rna seq, cuffmerge, cufflink, cuffcompare, transfrags, artifacts, gtf file, transcriptome assembly, expression analysis, bio.tools, bio.tools is listed by: Debian
is listed by: bio.tools
is listed by: OMICtools
is listed by: SoftCite
works with: GeneScissors
is hosted by: GitHub
DOI:10.1038/nbt.1621 Acknowledgement requested, Source code available on GitHub biotools:cufflinks, OMICS_01304, SCR_013307 https://github.com/cole-trapnell-lab/cufflinks
https://bio.tools/cufflinks
https://sources.debian.org/src/cufflinks/
SCR_014597 2026-02-15 09:20:59 8838

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