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http://www.scienceexchange.com/facilities/protein-production-and-cell-biology-laboratory-cddi

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 25,2024. Protein production can be a significant bottleneck during early phase drug discovery. Our production facilities are fully equipped and staffed to help researchers produce proteins in bacteria, yeast or insect cells. Whether the protein is hopelessly insoluble or difficult to produce in quantity, the core staff is ready to work with individuals to turn failure into success. The Cell Biology facility provides researchers access to cell sorting and analysis for target characterization and validation. The BD FACS Aria II sorter is BSL2 capable permitting levels of safety in cell sorting not available in most flow cores. A second BD Canto II flow cytometer provides automated sampling for analytical flow cytometry. Fully automated Zeiss Axiovert 100 deconvolution and Lecia DM 6000 (laser microcapture) microscopes provide tools for cell imaging and content analyses.

Proper citation: USF Protein Production and Cell Biology Laboratory (RRID:SCR_012263) Copy   

•   Source: SciCrunch Registry

http://sydneynano.com/

The MAU is comprised of five separate characterisation nodes: (1) Electron microscopy and microanalysis (2) Scanning probe microscopy (3) X-ray characterisation (4) Electrical measurement and characterisation (5)Optical characterisation. As well as a materials fabrication and processing equipment suite. This research infrastructure is supported by an academic Director, a Research Laboratory Manager and three highly experienced and highly skilled Professional Officers.

Proper citation: UTS Microstructural Analysis Unit (RRID:SCR_012268) Copy   

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http://www.scienceexchange.com/facilities/chemical-technologies-research-facility-uts

The research facility in Chemical Technologies pulls together the resources of several well equipped laboratories specialising in chemistry and materials science. The facility is particularly focused on chemical, forensic, material and biochemical analysis, and materials technology, and is set up to serve the needs of Australian industry and academia in these areas. Specialties of the facility include the physical and mechanical characterization of engineering materials, and the chemical and physical characterisation of forensic and pharmaceutical samples. The facility is equipped to produce and characterise a diverse range of organic and inorganic materials, and is backed by a team of experienced researchers.

Proper citation: UTS Chemical Technologies Research Facility (RRID:SCR_012267) Copy   

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http://www.scienceexchange.com/facilities/center-for-biophysical-sciences-and-engineering-cbse

Since 1986, The Center for Biophysical Sciences and Engineering (CBSE) has integrated our strengths to become a leading structural biology center capable of embracing the _������������_genes to drug_���� paradigm. We are one of the world''''s largest Structure Based Drug Discovery facilities with over 110 employees, including 15 Ph.D. level crystallographers. The CBSE is centered on a suite of integrated high throughput laboratories allowing us to offer a cost-effective platform of discovery services designed to increase the efficiency and success for drug discovery projects with industry, academic and government partners.

Proper citation: UAB Center for Biophysical Sciences and Engineering (RRID:SCR_012509) Copy   

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http://www.scienceexchange.com/facilities/flow-cytometry-core-facility-uchicago

Flow Cytometry Facility at the University of Chicago is committed to providing the highest quality services to all its investigators.

Proper citation: UChicago Flow Cytometry Core Facility (RRID:SCR_012508) Copy   

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http://www.scienceexchange.com/facilities/dna-microarray-core-facility-duke

The Duke Microarray Facility provides services for the analysis of gene expression. The facility is operated jointly with the Duke Cancer Institute and provides: Affymetrix Microarrays Agilent Microarrays Real-Time PCR RNA Quality Check with Agilent Bioanalyzer The Microarray Facility also maintains a comprehensive database server to manage the massive amounts of data generated by microarray analysis. The facility provides data analysis support through various software packages as well as gene annotation support.

Proper citation: Duke DNA Microarray Core Facility (RRID:SCR_012629) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/w-m-keck-biomedical-mass-spectrometry-laboratory-virginia

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 15,2024. W.M. Keck Biomedical Mass Spectrometry Laboratory within the Biomolecular Research Facility identifies and analyzes proteins from gels and solution using current mass spectrometry techniques. There are techniques to compare samples which have different amounts of the same proteins. Analyses available: - Protein identification and sequencing from gel or solution by either peptide mass fingerprinting or ESI-LC/MS/MS at the low femtomole level. - Analysis of protein mixtures such as tissue and media analysis of tissue samples prepared by Laser Capture Microdissection - Proteomics, comparison of proteins in tissue samples using chemical/isotopic labels or label free analysis - Absolute quantitation of proteins using labeled peptides and selective reaction monitoring - Identification of phosphorylation sites using titanium dioxide enrichment - Identification of post-translational modifications (deamination, ubiquitination, etc) - De Novo (manual) sequence analysis of novel proteins to obtain sufficient sequence data for cloning - High resolution, high mass accuracy measurements of peptides and small proteins - Confirmation of peptide identity by MALDI mass measurements - Identification of binding partners Equipment Our current mass spectrometers: - Thermo Scientific LTQ Orbitrap Velos for high accuracy, high sensitivity analysis - Bruker Microflex for mass analysis by MALDI - Thermo Scientific TSQ Quantum Access MAX triple quadrupole instrument Sample types analyzed: - gel bands, stained with Coomassie, silver, fluorescent stains - proteins in solution - tissue samples - media - Laser Capture Microdissection tissue samples.

Proper citation: UVa W.M. Keck Biomedical Mass Spectrometry Laboratory (RRID:SCR_012589) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/advanced-optical-microscopy-facility

The Advanced Optical Microscopy Facility (AOMF) is centrally located in the Discovery District in Toronto, Ontario, serving University Health Network as well as external academic and industrial users. It is the largest microscopy facility in Canada with instruments at Princess Margaret Hospital and Toronto General Hospital. With over 30 instruments and 4 staff members, the AOMF is equipped to help you with nearly any optical microscopy application including: confocal, multiphoton, FRAP, FRET, live-cell, timelapse, spectral unmixing, in-vivo bioluminescence and fluorescence, whole-slide scanning, 3D rendering, colocalization and more. We offer: Free consultations to determine which microscopes would best suit your application Comprehensive training and support on our various instruments Full-service image capture and analysis (a great way to get started quickly) High-resolution whole slide scanning service for histology slides Practical courses on microscopy, including one-on-one hands-on sessions (eg: Fundamentals of Microscopy) and larger workshops tailored to your group''''s applications Software and training for image processing and quantification

Proper citation: UHN Advanced Optical Microscopy Facility (RRID:SCR_012622) Copy   

•   Source: SciCrunch Registry

https://www.umassmed.edu/MSF/Proteomics/

The University of Massachusetts Medical School Proteomics and Mass Spectrometry Facility is an analytical laboratory resource offering state-of-the-art proteomic, lipid, and small molecule mass spectrometric analyses to both the academic and external scientific community. This includes resources for study design, sample preparation and cleanup, sample fractionation, instrumentation, informatics, data interpretation, and publication assistance.

Proper citation: UMMS Proteomics and Mass Spectrometry Facility (RRID:SCR_012500) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/dna-microarray-core-facility-ualbany

Core provides microarray services for Affymetrix GeneChip arrays, Agilent microarrays, NimbleGen microarrays and custom-produced spotted cDNA microarrays. Projects developed through DNA Microarray Center have made use of arrays from variety of genomes, eukaryotic, prokaryotic, and plant. Core services includes RNA/DNA isolation, gene expression, miRNA, Chip-chip, Rip-chip and DNA methylation services. Provides bioinformatics tools for further analysis of results of expression experiments.

Proper citation: University at Albany Center for Functional Genomics DNA Microarray Core Facility (RRID:SCR_012502) Copy   

•   Source: SciCrunch Registry

https://www.mcgill.ca/cian/

Core facility at Biology Department in McGill Faculty of Science. Expertise in Light Microscopy and Image Analysis. Provides light microscopes, ranging from Point Scanning and Spinning Disc Confocals to Multi-Photon, TIRF, Light Sheet and Super-Resolution microscopes. Provides services in Automation/High throughput screening (liquid handler, pinning robot), Protein expression and antibody production. Users get training.

Proper citation: McGill Cell Imaging and Analysis Network Core Facility (RRID:SCR_012623) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/cellular-and-molecular-biology-core-uvm

This is a free facility for everyone at the University of Vermont; however, preference will be given to the principle investigators listed on the COBRE grant, followed by members of the neuroscience community and finally, the university as a whole. Check in advance when planning experiments to determine space and equipment availability.

Proper citation: UVM Cellular and Molecular Biology Core (RRID:SCR_012505) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/stem-cell-core-facility-usc

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 16,2024. USC Stem Cell Core facility is a CIRM funded comprehensive support center and central hub for the provision of knowledge, resources and state of the art technology to researchers working with stem cells. Our primary aims are to facilitate stem cell and biomedical research at USC and the LA area and to develop new technologies for working with pluripotent stem cells. We offer a wide range of services in the following areas: Cells and Reagents Reproducibility in experimental science is dependent on homogeneity and consistency. One of the primary aims of the USC Stem Cell Core is to standardize stem cell research by providing quality controlled cells and reagents. Equipment The USC Stem Cell Core is a shared laboratory space housing communal cell culture workstations, a state of the art imaging core, spectral karyotyping facilities, a Q-PCR machine, fully equipped molecular biology work stations and a variety of equipment for performing histological analysis. Flow cytometry and high content screening equipment are made available through the FACS core. Laboratory Space As a shared research facility we offer communal laboratory space for investigators to conduct collaborative or start up research involving stem cells. Our goal is to expand stem cell research in the LA area and to encourage collaboration between novice and seasoned researchers. Technical Assistance The USC Stem Cell Core is staffed with a team of highly experienced technicians, boasting a combined technical expertise of over 60 years. We provide comprehensive assistance, which includes a biobanking and histology service. Training and Education Training and education are pivotal to the advancement of Stem Cell Research. The USC Stem Cell Core offers a broad range of educational services including technical protocols, one on one customized training and a week long course covering human pluripotent stem cell culture techniques. Research and Development The USC Stem Cell Core Research and Development program was established with two main aims: 1) to develop and centralize new technologies for working with human pluripotent stem cells, 2) to support researchers embarking on collaborative and pilot projects.

Proper citation: USC Stem Cell Core Facility (RRID:SCR_012628) Copy   

•   Source: SciCrunch Registry

http://www.ap-lab.com

Alliance Protein Laboratories is a contract research and consulting firm specializing in biophysical analysis. We offer a broad and unique range of biophysical characterization services, as well as contract purification services (research scale) A.P.L. is a spin-off from the Protein Chemistry department at Amgen. It was founded in 1998 by Drs. Tsutomu Arakawa and John Philo. Our laboratory is located in San Diego, CA. Our clients include over 250 companies in North America, Europe, Asia, and Australia as well as major universities and non-profit institutes.

Proper citation: CSUCI Alliance Protein Laboratories (RRID:SCR_012592) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/institute-for-biomolecular-design

The IBD provides a range of mass spectrometry and proteomic services such as protein identification and molecular weight determination. Additionally we also perform Amino Acid Analysis and Peptide Synthesis.

Proper citation: UAlberta Institute for Biomolecular Design (RRID:SCR_012591) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/bioanalytical-service-laboratory

The BioAnalytical Service Laboratory at the Institute of Marine and Environmental Technology assists researchers by providing state-of-the-art instrumentation and training to conduct routine analytical, synthetic and separation projects.

Proper citation: UMD BioAnalytical Service Laboratory (RRID:SCR_012594) Copy   

•   Source: SciCrunch Registry

https://mgm.ku.edu/

Provides or assists with docking and virtual screening of small molecule ligands against protein targets of interest, molecular dynamics simulation and modeling of small/macro molecules, proteins, and biomolecular systems, analysis of structure-activity relationships, visualization and graphics of biomolecules and biomolecular systems, and custom algorithm/software development along with databases and web applications.

Proper citation: University of Kansas Molecular Graphics and Modeling Laboratory Core Facility (RRID:SCR_012595) Copy   

•   Source: SciCrunch Registry

https://nmrlab.ku.edu/

Nuclear Magnetic Resonance Laboratory is responsible for maintaining the high field NMR spectrometers, training users, providing spectra on a service basis, and assisting users with design, execution, and interpretation of NMR experiments. Our capabilities extend from small molecules to isotopically enriched proteins, semisolids, and flow samples. We are part of the Molecular Structures Group (MSG) at KU, a campuswide facility encompassing NMR, MS, X-ray Crystallography, Biochemical Service, and Molecular Graphics and Modeling Laboratories.

Proper citation: University of Kansas Nuclear Magnetic Resonance Laboratory Core Facility (RRID:SCR_012510) Copy   

•   Source: SciCrunch Registry

https://www.isu.edu/mrcf/

Core facility aides ISU investigators in the areas of molecular genetics, microbiology, developmental biology, physiology, anatomy, neurobiology, molecular evolution and systematics, phylogenetics, population genetics, bioinformatics, comparative and computational genetics, and pharmaceutical sciences. In addition the MRCF also serves the DNA sequencing and genotyping needs of an increasing number of investigators at other institutions throughout the state and the nation. Routine activities in the MRCF include automated DNA sequencing and microsatellite analysis (Genotyping), PCR, electrophoresis, and gel documentation and analysis.

Proper citation: Idaho State University Molecular Research Core Facility (RRID:SCR_012598) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/high-throughput-gene-expression-biomarker-core-laboratory-umass

The High Throughput Gene Expression/Biomarker Core Laboratory run by Drs. Tanriverdi and Freedman provides High Throughput/Rapid Gene Expression and Complete miRNA profiling analysis by using gold standard qRT-PCR with the combination of custom Integrated Fluidic Circuit (IFC) technology from Fluidigm (South San Francisco, CA). Also, high-throughput SNP and multi-plate immunoassay services are available. The core lab is located in a modular class 10,000 clean room.

Proper citation: UMass Medical School High Throughput Gene Expression/Biomarker Core Laboratory (RRID:SCR_012631) Copy   

•   Source: SciCrunch Registry