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http://www.scienceexchange.com/facilities/protein-production-analysis-core

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 25,2024. Sanford-Burnham''s Protein Production Core offers state-of-the-art resources with advanced biochemical engineering and bioprocessing capabilities. Specialized protein production scale-up services (65L bacterial or 25-50L insect/mammalian cell production) include optimization of production runs. Analytical services include measurement of protein-protein and protein-small molecule interactions using a variety of approaches such as surface plasmon resonance and isothermal titration calorimetry. Assistance in experimental design and technical support are also provided by the Core''s knowledgeable staff.

Proper citation: Sanford-Burnham Protein Production and Analysis Core (RRID:SCR_012272) Copy   

•   Source: SciCrunch Registry

http://www.neurodiscovery.harvard.edu/research/neurobehavior_laboratory.html

Core facility that provides the following services: Surgery/necropsy service. Mouse models have become a popular and successful approach to elucidating the physiological and pathological roles of individual genes and are truly crucial to accelerate the development of effective treatments and cures for Alzheimer''''s, Parkinson''''s, ALS, MS and other neurodegenerative diseases. The increasing demand for mouse behavioral studies within the neuroscience community has led the Harvard NeuroDiscovery Center to develop a major new, state of the art mouse behavior laboratory, located in the Longwood medical area and carefully designed to meet the exacting standards required for this type of work. The NeuroBehavior Laboratory (NBL) will provide the Harvard community and other investigators access to a broad range of reliable behavioral/cognitive tests necessary to analyze and interpret the impact of a genetic, surgical or pharmacologic manipulation on specific behaviors. They can provide: * Assistance with experimental design. * Support for grant applications that have a significant component of mouse neurobehavioral research. * Full, fee-for-service, mouse behavioral testing services. * Training in all aspects of mouse neurobehavioral testing. * Assistance with data analysis and interpretation.

Proper citation: HNDC NeuroBehavior Laboratory Core (RRID:SCR_012396) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/meg-mcgill

MEG (Magnetoencephalography) is a neuroimaging technology for cognitive and clinical brain research. In a nutshell, MEG measures non-invasively the tiny magnetic fields generated by neuronal currents. A unique asset of MEG imaging is its unrivaled temporal resolution, reaching the millisecond time scale across the entire brain volume. On the clinical side, MEG has been typically indicated for the pre-surgical work-up of severe, drug-resistant epilepsy and the functional pre-surgical mapping of brain tumors. There is however great potential to use MEG as an instrument of choice to investigate other neurological syndromes and neuropsychiatric disorders (e.g., stroke, dementia, movement disorders, depression, etc.). Overall, MEG has strong value in revealing the dynamics of brain activity involved in subject''''s perception, cognition and responses: it has provided unique insight on the time-resolved processes ruling brain functions (resting-state dynamics, language, motor control, visual and auditory perception, etc.) and dysfunctions (movement disorders, tinnitus, chronic pain, dementia, etc.). MEG(at)McGill provides a full-suite of services related to MEG and MEG/EEG studies. This includes a variety of training programs for use of the MEG and related data acquisition and analysis software, Brainstorm.

Proper citation: MEG(at)McGill (RRID:SCR_012277) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/electron-microscopy-core-facility-bgsu

The Microscopy Core Facility at BGSU offers a range of services, including Scanning electron microscopy (SEM) and Transmission electron microscopy (TEM).

Proper citation: BGSU Electron Microscopy Core Facility (RRID:SCR_012271) Copy   

•   Source: SciCrunch Registry

http://microscopy.dfci.harvard.edu

Core facility that provides state-of-the-art imaging microscopy technology for fixed and live cells, tissues and multi-photon animal imaging along with scientific and technical expertise to assist in experimental design and optimal image collection. Imaging techniques available include Standard fluorescence, Live-cell long term imaging, Confocal, Deconvolution, Fluorescence spectral detection, TIRF, FRET, Calcium imaging, Multi-photon, and Fluorescence lifetime imaging. Available equipment includes: Yokogawa spinning disk confocal microscope (Andor), Leica SP5 laser scanning confocal with a white light laser, Zeiss 710 confocal/multi-photon, Nikon inverted widefield fluorescence microscope. Other services include training on all equipment, consultation about various imaging techniques and assistance with image analysis. In addition, staff are available to assist with troubleshooting regarding microscopes in individual research labs. All services are available on a fee basis, and equipment is available for either assisted use or unassisted use after training by core staff. NEW: The core has established a collaboration with Rockland Immunochemicals to provide free, trial-size samples of primary and secondary antibodies that may be useful in your experiments.

Proper citation: DFCI Confocal and Light Microscopy Core Facility (RRID:SCR_012314) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/electron-microprobe-laboratory

An electron microprobe is an electron microscope designed for the non-destructive x-ray microanalysis and imaging of solid materials. It is capable of high spatial resolution (1 micron beam size) and relatively high analytical sensitivity. The analytical facilities'''' JEOL JXA-8600 can acquire digital secondary-electron and backscattered-electron images as well as elemental x-ray maps. It is equipped with 4 wavelength-dispersive spectrometers and an energy-dispersive spectrometer. Most of the periodic table can in principle be analyzed (Be through U), subject to several important considerations. The quality of analyses performed depends essentially on the quality of sample preparation, character of the sample material, and availability of appropriate primary and secondary calibration standards for the desired elements. A precision usually less than 0.5% relative depending on element abundance, and accuracy as good as 1-2% can be obtained with this instrument. The analytical sensitivity ranges from a low of ~50 parts per million for optimum cases, to a typical detection limit of several hundred ppm, but can be as high as several weight percent for problem elements. The volume sampled is typically a few cubic microns, corresponding to a weight of a few picograms.

Proper citation: CU Boulder Electron Microprobe Laboratory (RRID:SCR_012321) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/ccib-dna-core-mgh-harvard

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on January 2025.Welcome to the CCIB DNA Core at Massachusetts General Hospital! The mission of the DNA Core is to accelerate fundamental scientific discoveries that will improve human health. Our professional team is committed to help investigators solve highly diverse biological and biomedical research questions by providing a portfolio of state-of-the-art molecular biology services, specialized expertise, detailed advice and support. We are constantly striving to advance research productivity by reliably generating the highest quality data with rapid turn-around time and competitive pricing, and by working with our clients on an individual basis to address and satisfy their specific research needs. Realizing the constant changes of our customers_������������_ demands, we make every effort to continuously improve our services and to offer new and innovative solutions. The DNA Core, founded in 1996, is a non-profit research core laboratory within the Center for Computational and Integrative Biology of Massachusetts General Hospital Boston providing high-quality genomics technology services and expertise for academic research institutions and for business (for-profit) organizations. The majority of the core''''s clients are investigators from Massachusetts General Hospital and the greater Partners research community. The core also serves researchers from external academic institutions and biotech companies in Massachusetts as well as other states in the United States. Our facility provides high-quality molecular biology services in three major areas: Our DNA Sequencing group functions both as a small-scale sequencing facility and a center for large-scale sequencing projects. It is offering various genomics technologies, including ABI Sanger DNA sequencing, Microsatellite analysis, plasmid validation and primer walking. Currently, we are exploring new opportunities and are planning to expand our service portfolio soon. Our DNA Synthesis lab serves the research community with custom oligonucleotides (standard, degenerate, and modified). To diversify our current service options, we are in the process of exploring potential partnerships with third party vendors. Our Research Laboratory Automation group has been designed as a flexible entity within the DNA Core to extend the benefits of laboratory automation to a diverse user group and to assist in the execution of a variety of molecular biology projects that require large-scale robotics support. The group offers standard and custom high-throughput sample processing services, including protocol development, for various molecular biology and genomics applications. Current services include Mouse genotyping, cDNA and siRNA library screening, bacterial colony picking, library replication and archiving, 96-well plasmid DNA purification, large-scale PCR purification, and custom qPCR assays. In addition to providing the currently existing services for the research community, all three groups of the DNA Core are continuously engaged in the evaluation and/or development of new service options and in the optimization of current and new technologies and services.

Proper citation: MGH CCIB DNA Core (RRID:SCR_012281) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/chemical-probe-synthesis-facility

Located in the new Northwest Corner building on the Morningside campus of Columbia University in New York City, the Columbia University Chemical Probe Synthesis Facility (CPS facility) is a shared resource that assists researchers in designing and synthesizing small molecule probes for stem cell research projects. The CPS facility offers expertise, advice and services in the following areas: 1. Virtual screening and computational design of small molecules 2. Organic synthesis of individual compounds, building blocks or libraries of compounds 3. Drug metabolism/pharmacokinetics (DMPK) and metabolic profiling of small molecules

Proper citation: Columbia Chemical Probe Synthesis Facility (RRID:SCR_012247) Copy   

•   Source: SciCrunch Registry

https://rtsf.natsci.msu.edu/genomics/gene-expression-analysis/index.aspx

RTSF Genomics Core offers services for investigators looking to utilize gene expression for their research. Our range of applications includes solutions for quantifying gene expression levels in nearly any species regardless of sample size. Services include Next Generation Sequencing using Illumina instruments, qPCR using the ABI QuantStudio 7 Flex Real-Time PCR System, and gene expression using NanoString nCounter system.

Proper citation: Michigan State University RTSF Genomics Core Facility (RRID:SCR_012406) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/experimental-pathology-core-laboratory-uark

The Experimental Pathology Shared Resource Laboratory is a non-profit laboratory that provides investigators with centralized, comprehensive histological services. The laboratory currently works with over 70 investigators at the University of Arkansas, regionally, and nationally. By providing a centralized laboratory, we offer convenient access to all services within one facility, save costs for investigators and the institution, increase efficiency of sample processing, eliminate duplication of services and equipment, and maintain stringent quality control standards. The laboratory director, consultants, and technicians have extensive experience in routine histology and immunohistochemistry involving both human and animal tissues.

Proper citation: UAMS Experimental Pathology Core Laboratory (RRID:SCR_012373) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/protein-chemistry-technology-core

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 25,2024. Protein Chemistry Technology Core was established to provide efficient, high quality services to researchers in the academic community. The services presently offered include peptide synthesis and Edman protein sequencing. Our facility, its state-of-the-art instrumentation, and computer software is constantly upgraded to ensure the highest possible level of support. It is our aim to provide quality performance and offer experienced support, both through our products and people.

Proper citation: UT Southwestern Protein Chemistry Technology Core (RRID:SCR_012254) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/genoseq-core-facility-ucla

THIS RESOURCE IS NO LONGER IN SERVCE, documented January 23, 2019. Core is involved in a broad range of scientific research. Medical research performed at the GenoSeq Core includes studies of human neurological disorders, such as: autism, bipolar disorder, and epilepsy; cancers of breast, colon, lung, and prostate; cardiac disease; and digestive disorders. Core also carries out studies of the genetics of non-human organisms. The GenoSeq Core is closely linked to the UCLA Bioinformatics Core in Gonda Center, which provides the computing power and sophisticated software needed to analyze and interpret the unprecedented volume of genetic data being generated with modern laboratory automation.

Proper citation: University of California Los Angeles GenoSeq Core Facility (RRID:SCR_012411) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/center-of-biomedical-analysis-tsinghua-university

The center of biomedical analysis (CBA) is a multiple discipline platform. CBA is bound to provide the best services and support to our investigators in all research fields. We welcome any suggestions and recommendations. In consultation with the Advisory Committee for each facility, the facility manager sets up the fee structures and makes decision on equipment purchase and upgrade.

Proper citation: Tsinghua University Center of Biomedical Analysis (RRID:SCR_012382) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/protein-production-and-cell-biology-laboratory-cddi

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 25,2024. Protein production can be a significant bottleneck during early phase drug discovery. Our production facilities are fully equipped and staffed to help researchers produce proteins in bacteria, yeast or insect cells. Whether the protein is hopelessly insoluble or difficult to produce in quantity, the core staff is ready to work with individuals to turn failure into success. The Cell Biology facility provides researchers access to cell sorting and analysis for target characterization and validation. The BD FACS Aria II sorter is BSL2 capable permitting levels of safety in cell sorting not available in most flow cores. A second BD Canto II flow cytometer provides automated sampling for analytical flow cytometry. Fully automated Zeiss Axiovert 100 deconvolution and Lecia DM 6000 (laser microcapture) microscopes provide tools for cell imaging and content analyses.

Proper citation: USF Protein Production and Cell Biology Laboratory (RRID:SCR_012263) Copy   

•   Source: SciCrunch Registry

http://sydneynano.com/

The MAU is comprised of five separate characterisation nodes: (1) Electron microscopy and microanalysis (2) Scanning probe microscopy (3) X-ray characterisation (4) Electrical measurement and characterisation (5)Optical characterisation. As well as a materials fabrication and processing equipment suite. This research infrastructure is supported by an academic Director, a Research Laboratory Manager and three highly experienced and highly skilled Professional Officers.

Proper citation: UTS Microstructural Analysis Unit (RRID:SCR_012268) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/chemical-technologies-research-facility-uts

The research facility in Chemical Technologies pulls together the resources of several well equipped laboratories specialising in chemistry and materials science. The facility is particularly focused on chemical, forensic, material and biochemical analysis, and materials technology, and is set up to serve the needs of Australian industry and academia in these areas. Specialties of the facility include the physical and mechanical characterization of engineering materials, and the chemical and physical characterisation of forensic and pharmaceutical samples. The facility is equipped to produce and characterise a diverse range of organic and inorganic materials, and is backed by a team of experienced researchers.

Proper citation: UTS Chemical Technologies Research Facility (RRID:SCR_012267) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/center-for-biophysical-sciences-and-engineering-cbse

Since 1986, The Center for Biophysical Sciences and Engineering (CBSE) has integrated our strengths to become a leading structural biology center capable of embracing the _������������_genes to drug_���� paradigm. We are one of the world''''s largest Structure Based Drug Discovery facilities with over 110 employees, including 15 Ph.D. level crystallographers. The CBSE is centered on a suite of integrated high throughput laboratories allowing us to offer a cost-effective platform of discovery services designed to increase the efficiency and success for drug discovery projects with industry, academic and government partners.

Proper citation: UAB Center for Biophysical Sciences and Engineering (RRID:SCR_012509) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/flow-cytometry-core-facility-uchicago

Flow Cytometry Facility at the University of Chicago is committed to providing the highest quality services to all its investigators.

Proper citation: UChicago Flow Cytometry Core Facility (RRID:SCR_012508) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/dna-microarray-core-facility-duke

The Duke Microarray Facility provides services for the analysis of gene expression. The facility is operated jointly with the Duke Cancer Institute and provides: Affymetrix Microarrays Agilent Microarrays Real-Time PCR RNA Quality Check with Agilent Bioanalyzer The Microarray Facility also maintains a comprehensive database server to manage the massive amounts of data generated by microarray analysis. The facility provides data analysis support through various software packages as well as gene annotation support.

Proper citation: Duke DNA Microarray Core Facility (RRID:SCR_012629) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/w-m-keck-biomedical-mass-spectrometry-laboratory-virginia

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 15,2024. W.M. Keck Biomedical Mass Spectrometry Laboratory within the Biomolecular Research Facility identifies and analyzes proteins from gels and solution using current mass spectrometry techniques. There are techniques to compare samples which have different amounts of the same proteins. Analyses available: - Protein identification and sequencing from gel or solution by either peptide mass fingerprinting or ESI-LC/MS/MS at the low femtomole level. - Analysis of protein mixtures such as tissue and media analysis of tissue samples prepared by Laser Capture Microdissection - Proteomics, comparison of proteins in tissue samples using chemical/isotopic labels or label free analysis - Absolute quantitation of proteins using labeled peptides and selective reaction monitoring - Identification of phosphorylation sites using titanium dioxide enrichment - Identification of post-translational modifications (deamination, ubiquitination, etc) - De Novo (manual) sequence analysis of novel proteins to obtain sufficient sequence data for cloning - High resolution, high mass accuracy measurements of peptides and small proteins - Confirmation of peptide identity by MALDI mass measurements - Identification of binding partners Equipment Our current mass spectrometers: - Thermo Scientific LTQ Orbitrap Velos for high accuracy, high sensitivity analysis - Bruker Microflex for mass analysis by MALDI - Thermo Scientific TSQ Quantum Access MAX triple quadrupole instrument Sample types analyzed: - gel bands, stained with Coomassie, silver, fluorescent stains - proteins in solution - tissue samples - media - Laser Capture Microdissection tissue samples.

Proper citation: UVa W.M. Keck Biomedical Mass Spectrometry Laboratory (RRID:SCR_012589) Copy   

•   Source: SciCrunch Registry