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http://www.scienceexchange.com/facilities/electron-microscopy-core-facility-bgsu

The Microscopy Core Facility at BGSU offers a range of services, including Scanning electron microscopy (SEM) and Transmission electron microscopy (TEM).

Proper citation: BGSU Electron Microscopy Core Facility (RRID:SCR_012271) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/animal-models-core

The UNC Animal Models Core Facility provides the full range of mouse genetic modification services, reagents and related technologies. The Core''s services are available to both UNC and Non-UNC clients. Transgenic (pronuclear injection) animals can be generated in C57BL/6, FVB or C57BL/6 X DBA2 hybrid strains. Services for creating transgenic mice include transgene design, construct generation, isolation of the transgene fragment, pronuclear microinjection, founder genotyping and breeding. The core also offers the full suite of services for BAC (bacterial artificial chromosome) recombineering and microinjection of BAC transgenes. Gene targeting services are available in ES cells from C57BL/6 or 129P2/Ola strains. Other strains available upon request. Gene targeting services include design and cloning of targeting vectors, creating gene-targeted ES cells, blastocyst microinjection of the ES cells to create transmitting chimeras and chimera breeding for germline transmission. The core can also provide Southern blot validation and blastocyst microinjection of ES cells from EUCOMM, KOMP or other consortia. Additional services include Cre- or Flp-mediated excision in ES cells or in vivo, chromosome counting, PCR screening and Southern blotting. Rat model production is also available.

Proper citation: UNC School of Medicine Animal Models Core (RRID:SCR_012167) Copy   

•   Source: SciCrunch Registry

https://www.acellera.com/

Acellera is company focused on developing high-throughput molecular dynamics techniques that deliver solutions for estimating common physico-chemical properties such as binding affinities, kinetics, poses and pathways with validated accuracy.Company mission is to accelerate transition to rational, computerized drug discovery via simulations and machine learning.

Proper citation: Acellera (RRID:SCR_012200) Copy   

•   Source: SciCrunch Registry

https://www.moffitt.org/research-science/shared-resources/proteomics-and-metabolomics/

Provides instrumentation for proteomics and metabolomics studies, including protein, peptide and metabolite separations, MS instrumentation for protein, peptide and metabolite analysis, and data systems, software, and bioinformatics tools for data archiving and analysis. Proteomics Core performs routine analytical proteomics services, including target discovery, identification and quantitation, and also provides platforms for functional proteomics using variety of strategies for protein separation, sub-proteome enrichment, post-translational modification analysis, and quantitation.

Proper citation: Moffitt Cancer Center Proteomics and Metabolomics Core Facility (RRID:SCR_012168) Copy   

•   Source: SciCrunch Registry

https://www.uclahealth.org/departments/pathology/research-services/translational-pathology-core-laboratory-tpcl

Facility in the UCLA Department of Pathology and Laboratory Medicine and UCLA Jonsson Comprehensive Cancer Center Shared Facility. Provids pathology related services in support of basic, translational and clinical research at UCLA. Provides consultative services to investigators in pathology-related study design, tissue selection, microscopic interpretation, immunohistochemistry, laser capture microdissection, digital image analysis, and IRB-related tissue questions.

Proper citation: University of California at Los Angeles Translational Pathology Core Facility (RRID:SCR_012201) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/ccib-dna-core-mgh-harvard

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on January 2025.Welcome to the CCIB DNA Core at Massachusetts General Hospital! The mission of the DNA Core is to accelerate fundamental scientific discoveries that will improve human health. Our professional team is committed to help investigators solve highly diverse biological and biomedical research questions by providing a portfolio of state-of-the-art molecular biology services, specialized expertise, detailed advice and support. We are constantly striving to advance research productivity by reliably generating the highest quality data with rapid turn-around time and competitive pricing, and by working with our clients on an individual basis to address and satisfy their specific research needs. Realizing the constant changes of our customers_������������_ demands, we make every effort to continuously improve our services and to offer new and innovative solutions. The DNA Core, founded in 1996, is a non-profit research core laboratory within the Center for Computational and Integrative Biology of Massachusetts General Hospital Boston providing high-quality genomics technology services and expertise for academic research institutions and for business (for-profit) organizations. The majority of the core''''s clients are investigators from Massachusetts General Hospital and the greater Partners research community. The core also serves researchers from external academic institutions and biotech companies in Massachusetts as well as other states in the United States. Our facility provides high-quality molecular biology services in three major areas: Our DNA Sequencing group functions both as a small-scale sequencing facility and a center for large-scale sequencing projects. It is offering various genomics technologies, including ABI Sanger DNA sequencing, Microsatellite analysis, plasmid validation and primer walking. Currently, we are exploring new opportunities and are planning to expand our service portfolio soon. Our DNA Synthesis lab serves the research community with custom oligonucleotides (standard, degenerate, and modified). To diversify our current service options, we are in the process of exploring potential partnerships with third party vendors. Our Research Laboratory Automation group has been designed as a flexible entity within the DNA Core to extend the benefits of laboratory automation to a diverse user group and to assist in the execution of a variety of molecular biology projects that require large-scale robotics support. The group offers standard and custom high-throughput sample processing services, including protocol development, for various molecular biology and genomics applications. Current services include Mouse genotyping, cDNA and siRNA library screening, bacterial colony picking, library replication and archiving, 96-well plasmid DNA purification, large-scale PCR purification, and custom qPCR assays. In addition to providing the currently existing services for the research community, all three groups of the DNA Core are continuously engaged in the evaluation and/or development of new service options and in the optimization of current and new technologies and services.

Proper citation: MGH CCIB DNA Core (RRID:SCR_012281) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/chemical-probe-synthesis-facility

Located in the new Northwest Corner building on the Morningside campus of Columbia University in New York City, the Columbia University Chemical Probe Synthesis Facility (CPS facility) is a shared resource that assists researchers in designing and synthesizing small molecule probes for stem cell research projects. The CPS facility offers expertise, advice and services in the following areas: 1. Virtual screening and computational design of small molecules 2. Organic synthesis of individual compounds, building blocks or libraries of compounds 3. Drug metabolism/pharmacokinetics (DMPK) and metabolic profiling of small molecules

Proper citation: Columbia Chemical Probe Synthesis Facility (RRID:SCR_012247) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/protein-chemistry-technology-core

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 25,2024. Protein Chemistry Technology Core was established to provide efficient, high quality services to researchers in the academic community. The services presently offered include peptide synthesis and Edman protein sequencing. Our facility, its state-of-the-art instrumentation, and computer software is constantly upgraded to ensure the highest possible level of support. It is our aim to provide quality performance and offer experienced support, both through our products and people.

Proper citation: UT Southwestern Protein Chemistry Technology Core (RRID:SCR_012254) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/protein-production-and-cell-biology-laboratory-cddi

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 25,2024. Protein production can be a significant bottleneck during early phase drug discovery. Our production facilities are fully equipped and staffed to help researchers produce proteins in bacteria, yeast or insect cells. Whether the protein is hopelessly insoluble or difficult to produce in quantity, the core staff is ready to work with individuals to turn failure into success. The Cell Biology facility provides researchers access to cell sorting and analysis for target characterization and validation. The BD FACS Aria II sorter is BSL2 capable permitting levels of safety in cell sorting not available in most flow cores. A second BD Canto II flow cytometer provides automated sampling for analytical flow cytometry. Fully automated Zeiss Axiovert 100 deconvolution and Lecia DM 6000 (laser microcapture) microscopes provide tools for cell imaging and content analyses.

Proper citation: USF Protein Production and Cell Biology Laboratory (RRID:SCR_012263) Copy   

•   Source: SciCrunch Registry

http://sydneynano.com/

The MAU is comprised of five separate characterisation nodes: (1) Electron microscopy and microanalysis (2) Scanning probe microscopy (3) X-ray characterisation (4) Electrical measurement and characterisation (5)Optical characterisation. As well as a materials fabrication and processing equipment suite. This research infrastructure is supported by an academic Director, a Research Laboratory Manager and three highly experienced and highly skilled Professional Officers.

Proper citation: UTS Microstructural Analysis Unit (RRID:SCR_012268) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/chemical-technologies-research-facility-uts

The research facility in Chemical Technologies pulls together the resources of several well equipped laboratories specialising in chemistry and materials science. The facility is particularly focused on chemical, forensic, material and biochemical analysis, and materials technology, and is set up to serve the needs of Australian industry and academia in these areas. Specialties of the facility include the physical and mechanical characterization of engineering materials, and the chemical and physical characterisation of forensic and pharmaceutical samples. The facility is equipped to produce and characterise a diverse range of organic and inorganic materials, and is backed by a team of experienced researchers.

Proper citation: UTS Chemical Technologies Research Facility (RRID:SCR_012267) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/nanofabrication-facility

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 16, 20224. Nanofabrication Facility houses three instruments for patterning of flat surfaces and selective etching of materials. Researchers fabricate devices and structures to demonstrate novel device concepts and to characterize new materials. To carry out these functions this new facility consists of three instruments: a Tescan Electron-Beam Lithography Tool, an OAI high resolution Mask Aligner and Advanced Vacuum/Plasma Therm Reactive Ion Etcher.

Proper citation: UConn Nanofabrication Facility (RRID:SCR_012346) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/metabolite-profiling-facility-purdue

The Metabolite Profiling Facility (MPF) provides state-of-the-art technologies that enable both qualitative (defining all components of a metabolome) and quantitative (determining differential concentrations of metabolites) metabolomics in complex biological systems. This facility employs highly sensitive mass spectrometry coupled with liquid chromatography and multi-dimensional gas chromatography for precise sample analysis. Metabolite profiling is an integral component of systems biology, an exciting field that combines genomics, transcriptomics and proteomics to define cellular functionality. Our elite scientists will empower researchers with new technologies, methods development, expert training and consultation.

Proper citation: Bindley Bioscience Metabolite Profiling Facility (RRID:SCR_012352) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/eicosanoid-core-laboratory

Eicosanoid is an umbrella term used to describe any oxidized derivative of arachidonic acid, a ubiquitous polyunsaturated fatty acid (PUFA) in humans. Arachidonic acid can be oxidized in vivo via both enzymatic and non-enzymatic mechanisms to yield bioactive lipid mediators that are of central importance to human physiology and pathophysiology. The Eicosanoid Core Laboratory at Vanderbilt University was established in 1988 in order to provide investigators at the university with a central location for analysis of prostaglandins, leukotrienes, and isoprostanes. Today the Eicosanoid Core Laboratory serves investigators not only at Vanderbilt but indeed around the world.

Proper citation: VUSM Eicosanoid Core Laboratory (RRID:SCR_012357) Copy   

•   Source: SciCrunch Registry

https://www.urmc.rochester.edu/research/rochester-genomics-center.aspx

Provides core laboratory support, technical consultation, assistance with experimental design and data analysis for investigators using high throughput genomic sequencing, genotyping and gene expression in their research programs.Provides support for RNA-Seq, ATAC-seq, ChIP-Seq, Single Cell RNA-seq, Spatial Transcriptomics, Exome/Genome sequencing, Whole Genome and Reduced Representation Bisulfite Sequencing (WGBS, RRBS), 16S rRNA Sequencing, Small RNA-Seq, Metatranscriptomics, qRT-PCR, processing of RNA/DNA, as well as custom applications and approaches. Bioinformatic analysis support is also available.

Proper citation: University of Rochester Genomics Research Center Core Facility (RRID:SCR_012359) Copy   

•   Source: SciCrunch Registry

http://www.montana.edu/massspec/index.html

Provides access to mass spectrometers and mass spectrometry expertise. The facility currently maintains the following equipment Waters Synapt-XS Q-IMS-TOF with Waters I-Class UHPLC; Agilent 6538 Q-TOF with Agilent 1290 UHPLC;Agilent 7800 Inductively Coupled Plasma with Laser Ablation (193 nm);Bruker micrOTOF with Agilent 1290 UHPLC; Agilent 6490 Triple Quadrupole Mass Spectrometer; Bruker MALDI Autoflex; Agilent GC-MS; Waters Synapt G2S-i Q-TOF with Ion Mobility.

Proper citation: Montana State University Mass Spectrometry Core Facility (RRID:SCR_012482) Copy   

•   Source: SciCrunch Registry

https://www.urmc.rochester.edu/research/flow-core.aspx

Provides investigators with instrumentation along with expertise. Core instrumentation includes traditional analytical cytometers, full spectrum cytometer, cell sorters, imaging cytometers, small(nano) particle detection system, metabolomics instrument, and mass cytometer.

Proper citation: University of Rochester Medical Center Flow Cytometry Core Facility (RRID:SCR_012360) Copy   

•   Source: SciCrunch Registry

https://research.ku.edu/ku-core-research-labs

COBRE Protein Production Group focuses on the cloning, expression and purification of prokaryotic and eukaryotic proteins for COBRE and other investigators in Kansas and the region. The laboratory maintains a variety of equipment to support the production of properly folded proteins in quantities suitable for structural studies (X-ray and NMR), functional studies (catalytic or biological), label-free binding studies (SPR) and/or high throughput (HTP) screening studies.

Proper citation: University of Kansas Protein Production Group Core Facility (RRID:SCR_012484) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/multiphoton-microscopy-core-rochester

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 16,2024.The mission of the URSMD Multiphoton Core Facility is to provide state-of-the-art multiphoton imaging capabilities to further the biomedical and bio-optical research at the URSMD and the University of Rochester with emphasis on intravital imaging and systems physiology. The Multiphoton Core Facility provides access to an Olympus Fluoview 1000 AOM-MPM imaging system and a Spectra-Physics MaiTai HP DeepSee Ti:Sa laser system with dispersion compensation. Further capabilities include engineering applications for opto-electronics and spectroscopy. Initial meeting with the director regarding the design of the experiments begins the process. Imaging will be initially performed by highly skilled staff to make sure all features of software are added for the study, thereafter, the investigator is trained until they are able to operate the microscope independently. Also offered is a blood gas analysis machine and supporting equipment.

Proper citation: URMC Multiphoton Microscopy Core (RRID:SCR_012362) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/crocker-nuclear-laboratory-uc-davis

Crocker Nuclear Laboratory hosts a diverse group of research programs, nearly all of which are related to applied science programs. Constructed in the mid-sixties, CNL, houses a low energy particle accelerator. The accelerator, an isochronous cyclotron, is one of the few of this design remaining in productive operation. The Crocker Nuclear Labortory''''s Isochronous Cyclotron began operating in 1965, accelerating protons, alpha particles, and other light ions into various targets to study nuclear structure. Instead of the uniform magnetic fields used in the earlier cyclotrons, the isochronous design employed tailored sectors with a varying magnetic field. This design compensated for increases in the mass of ions as they accelerated, both focusing their paths and keeping them in resonance at high energies. In its day, this design was considered a major technological breakthrough.

Proper citation: UC Davis Crocker Nuclear Laboratory (RRID:SCR_012486) Copy   

•   Source: SciCrunch Registry