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http://www.scienceexchange.com/facilities/the-ramaciotti-centre-for-gene-function-analysis

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 22, 2024. Ramaciotti Centre for Gene Function Analysis was established in August 2000 as a focus for the development and application of Functional Genomics in New South Wales. The Centre is consortium of five universities and five medical research centres in the Sydney-Newcastle region.

Proper citation: MQ Ramaciotti Centre for Gene Function Analysis (RRID:SCR_011071) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/chemical-probe-synthesis-facility

Located in the new Northwest Corner building on the Morningside campus of Columbia University in New York City, the Columbia University Chemical Probe Synthesis Facility (CPS facility) is a shared resource that assists researchers in designing and synthesizing small molecule probes for stem cell research projects. The CPS facility offers expertise, advice and services in the following areas: 1. Virtual screening and computational design of small molecules 2. Organic synthesis of individual compounds, building blocks or libraries of compounds 3. Drug metabolism/pharmacokinetics (DMPK) and metabolic profiling of small molecules

Proper citation: Columbia Chemical Probe Synthesis Facility (RRID:SCR_012247) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/protein-chemistry-technology-core

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 25,2024. Protein Chemistry Technology Core was established to provide efficient, high quality services to researchers in the academic community. The services presently offered include peptide synthesis and Edman protein sequencing. Our facility, its state-of-the-art instrumentation, and computer software is constantly upgraded to ensure the highest possible level of support. It is our aim to provide quality performance and offer experienced support, both through our products and people.

Proper citation: UT Southwestern Protein Chemistry Technology Core (RRID:SCR_012254) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/genomics-core-facility-umass

A Resource for UMass Medical School and the entire UMass system, UMass Memorial Medical Center, and the research community.

Proper citation: UMass Medical School Genomics Core Facility (RRID:SCR_011058) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/nanofabrication-facility

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 16, 20224. Nanofabrication Facility houses three instruments for patterning of flat surfaces and selective etching of materials. Researchers fabricate devices and structures to demonstrate novel device concepts and to characterize new materials. To carry out these functions this new facility consists of three instruments: a Tescan Electron-Beam Lithography Tool, an OAI high resolution Mask Aligner and Advanced Vacuum/Plasma Therm Reactive Ion Etcher.

Proper citation: UConn Nanofabrication Facility (RRID:SCR_012346) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/metabolite-profiling-facility-purdue

The Metabolite Profiling Facility (MPF) provides state-of-the-art technologies that enable both qualitative (defining all components of a metabolome) and quantitative (determining differential concentrations of metabolites) metabolomics in complex biological systems. This facility employs highly sensitive mass spectrometry coupled with liquid chromatography and multi-dimensional gas chromatography for precise sample analysis. Metabolite profiling is an integral component of systems biology, an exciting field that combines genomics, transcriptomics and proteomics to define cellular functionality. Our elite scientists will empower researchers with new technologies, methods development, expert training and consultation.

Proper citation: Bindley Bioscience Metabolite Profiling Facility (RRID:SCR_012352) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/eicosanoid-core-laboratory

Eicosanoid is an umbrella term used to describe any oxidized derivative of arachidonic acid, a ubiquitous polyunsaturated fatty acid (PUFA) in humans. Arachidonic acid can be oxidized in vivo via both enzymatic and non-enzymatic mechanisms to yield bioactive lipid mediators that are of central importance to human physiology and pathophysiology. The Eicosanoid Core Laboratory at Vanderbilt University was established in 1988 in order to provide investigators at the university with a central location for analysis of prostaglandins, leukotrienes, and isoprostanes. Today the Eicosanoid Core Laboratory serves investigators not only at Vanderbilt but indeed around the world.

Proper citation: VUSM Eicosanoid Core Laboratory (RRID:SCR_012357) Copy   

•   Source: SciCrunch Registry

https://www.urmc.rochester.edu/research/rochester-genomics-center.aspx

Provides core laboratory support, technical consultation, assistance with experimental design and data analysis for investigators using high throughput genomic sequencing, genotyping and gene expression in their research programs.Provides support for RNA-Seq, ATAC-seq, ChIP-Seq, Single Cell RNA-seq, Spatial Transcriptomics, Exome/Genome sequencing, Whole Genome and Reduced Representation Bisulfite Sequencing (WGBS, RRBS), 16S rRNA Sequencing, Small RNA-Seq, Metatranscriptomics, qRT-PCR, processing of RNA/DNA, as well as custom applications and approaches. Bioinformatic analysis support is also available.

Proper citation: University of Rochester Genomics Research Center Core Facility (RRID:SCR_012359) Copy   

•   Source: SciCrunch Registry

https://www.urmc.rochester.edu/research/flow-core.aspx

Provides investigators with instrumentation along with expertise. Core instrumentation includes traditional analytical cytometers, full spectrum cytometer, cell sorters, imaging cytometers, small(nano) particle detection system, metabolomics instrument, and mass cytometer.

Proper citation: University of Rochester Medical Center Flow Cytometry Core Facility (RRID:SCR_012360) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/multiphoton-microscopy-core-rochester

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 16,2024.The mission of the URSMD Multiphoton Core Facility is to provide state-of-the-art multiphoton imaging capabilities to further the biomedical and bio-optical research at the URSMD and the University of Rochester with emphasis on intravital imaging and systems physiology. The Multiphoton Core Facility provides access to an Olympus Fluoview 1000 AOM-MPM imaging system and a Spectra-Physics MaiTai HP DeepSee Ti:Sa laser system with dispersion compensation. Further capabilities include engineering applications for opto-electronics and spectroscopy. Initial meeting with the director regarding the design of the experiments begins the process. Imaging will be initially performed by highly skilled staff to make sure all features of software are added for the study, thereafter, the investigator is trained until they are able to operate the microscope independently. Also offered is a blood gas analysis machine and supporting equipment.

Proper citation: URMC Multiphoton Microscopy Core (RRID:SCR_012362) Copy   

•   Source: SciCrunch Registry

https://www.moffitt.org/research-science/shared-resources/tissue/

Biorepository resource with mission of proper collection, handling, processing and storage of irreplaceable biological specimens to support spectrum of related basic science, translational and clinical research. Provides expertise in nucleic acid extractions, quantification, aliquoting and quality assurance; liquid specimen centrifugation, processing and aliquoting; histological tissue processing, immunohistochemistry and tissue microarray microtomy; pathologist consultation services. Tissue Core operations are divided into four distinct pillars of service that work collaboratively to ensure specimen quality is maintained from procurement to preservation.

Proper citation: Moffitt Cancer Center Tissue Core Facility (RRID:SCR_012364) Copy   

•   Source: SciCrunch Registry

https://www.urmc.rochester.edu/research/electron-microscope.aspx

Electron Microscopy Resource supports ultra-structural interrogation of tissues, biologic solutions and nanomaterials for investigators utilizing transmission electron microscopy (TEM), scanning electron microscopy (SEM) and cryo-TEM.

Proper citation: University of Rochester Medical Center Electron Microscopy Core Facility (RRID:SCR_012366) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/macromolecular-x-ray-crystallography-core-facility--2

X-ray crystallography is the principal technique used to determine three-dimensional structures of biological macromolecules. The central goal of the UNC Crystallography Core Facility is to provide the support and infrastructure necessary to enable individual investigators of any experience level to initiate and successfully complete a structural biology project. The facility is state of the art, offering a variety of services in these three areas: crystallization, x-ray diffraction, structure determination. The primary mission of the MX Facility is to work with researchers here at UNC, however, we are also able to work with researchers at non-UNC academic institutions and commercial companies.

Proper citation: UNC School of Medicine Macromolecular X-Ray Crystallography Core Facility (RRID:SCR_012327) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/magnetic-resonance-laboratory-georgia-tech

The Nanomedicine Research Institute Magnetic Resonance Laboratory at Georgia Tech operates a Bruker Pharmascan 7T with a magnet bore of 160 mm. We have a large expertise in the use of MRI as a tool in Biomedical and Chemical Engineering. Previous research projects were concerned with: MRI of anatomical preparations; evaluation of tumor growth; bio-compatibility of implants; cardiac MRI; Diffusion Tensor Imaging; pharmacokinetics; fluid ingress and distribution in complex substrates; flow MRI; 1H, 19F and 13P in vivo spectroscopy and relaxometry; development of MRI contrast agents; solid-state MRI.

Proper citation: Georgia Tech Magnetic Resonance Laboratory (RRID:SCR_012326) Copy   

•   Source: SciCrunch Registry

https://www.med.unc.edu/csb/pep/

Core specializes in production of pure, functional proteins for structural, biophysical, and biochemical studies. Has ability to produce and purify milligram amount of protein.

Proper citation: University of North Carolina at Chapel Hill School of Medicine Protein Expression and Purification Core Facility (RRID:SCR_012328) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/east-quad-nmr-facility-hms-harvard

Formerly the NERCE NMR Resource. Nuclear magnetic resonance spectroscopy is a powerful tool for studying structural and conformational parameters of molecules. This tool is vital for the chemical analysis of both small molecules (like those discovered in small-molecule screens) and large molecules, such as carbohydrates and proteins found to have potential biologic importance. This is a user-based NMR facility; users run their own experiments on the NMR spectrometer.

Proper citation: HMS East Quad NMR Facility (RRID:SCR_012295) Copy   

•   Source: SciCrunch Registry

http://nextgen.mgh.harvard.edu

Core facility that provides the following services: NextGen sequencing, Data Analysis. The NextGen Core is a collaboration between the Department of Molecular Biology, the Center for Human Genetics Research, the Center for Computational Biology, and the Executive Committee on Research (ECOR). Currently, the Core operates using a single Ilumina HiSeq instrument, accompanied by Illumina''''s cBot for cluster generation. This upgrade from our Genome Analyzer II doubled our capacity and greatly increased the data amount, quality, and stability over extra-long reads. The Core is located in the state-of-the-art Richard Simches Research Center on Cambridge St. as part of the MGH main campus in Boston. The many multi-investigator groups in the building - including those that study human genetics, stem cells, genomics, and more - make it the perfect location for the Core to service the researchers in those groups. The majority of customers come from MGH, but they also service customers at other academic medical centers and industry.

Proper citation: MGH NextGen Sequencing Core (RRID:SCR_012294) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/antibody-core-facility

The primary objective of our facility is to produce monoclonal antibody-producing hybridoma cell lines for UNC investigators. The core develops monoclonal antibodies in mice, rats and hamsters. The core can assist in the screening of hybridomas of interest by ELISA or flow cytometry. The facility can also produce large amounts of crude antibody in vitro for investigators as well as purify both polyclonal and monoclonal antibodies from tissue culture media or ascites.

Proper citation: UNC School of Medicine Antibody Core Facility (RRID:SCR_012330) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/yale-pathology-tissue-services

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 15,2024. Mission- Developmental Histology The mission of the Developmental Histology unit is to provide 1. Timely high quality histology services to the Yale community 2. Access to tissue services from Yale Pathology archives 3. To maximize the value of the resources in the Yale Pathology Tissue Archive. 4. To provide Tissue Microarrays to assess multiple tissue samples Mission- Yale Pathology Tissue Services To provide the maximum amount and quality of human tissue for research at Yale University without impacting diagnostic quality, accuracy and safety in anatomic pathology.

Proper citation: Yale Pathology Tissue Services (RRID:SCR_012290) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/analytical-ultracentrifugation-facility

The Analytical Ultracentrifugation Facility located at the University of Connecticut engages in collaborative research as well as training scientists, technicians, and students. The Facility has three Beckman XL-I ultracentrifuges along with associated instruments, hardware and computers. In addition, University scientists are on hand to provide user support and advice.

Proper citation: UConn Analytical Ultracentrifugation Facility (RRID:SCR_012340) Copy   

•   Source: SciCrunch Registry