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http://jsu.eagle-i.net/i/0000012a-86f9-8ca4-8463-ad4580000000

The Visualization Core Laboratory / GIS Remote Core Laboratories were established to bond existing capabilities and talents in the areas of Geographic Information Systems (GIS), Remote Sensing (RS) and Scientific Visualization (Sci-Viz) and co-locate them in a centralized facility. This created an infrastructure of technology, data, people and institutional linkages that enables the discovery, evaluation and application of geospatial and visual data for adding value to research across various areas and disciplines. The GIS/RS laboratories support the development, enhancement and transfer of GIS/RS applications, make geospatial data available and accessible and promote research and development innovation among users. The Sci-Viz laboratory supports the need of scientists and researchers relative to modeling, program application development and production of high quality advanced visualizations for all fields or disciplines. The TLGVRC addresses human resource development to ensure a skilled workforce which is vital for sustenance of any high level technology activity.

Proper citation: JSU Remote Sensing Core Laboratory (RRID:SCR_009898) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/00000131-6bd2-db1d-75a1-b5a380000000

Core facility that provides the following services: Recombinant protein expression and purification in yeast Pichia pastoris, Large-scale production of immunotoxins for cell depletion studies, Large scale production of recombinant cytokines, Cost effective small-scale production using E.coli system.

The Recombinant Protein Expression and Purification (RPrEP) Core was established in 2009 to provide a cost-effective resource to the MGH and DF/ HCC community for expression and purification of recombinant proteins necessary for pre-clinical studies as well as for basic mechanistic studies by immunologists and cancer biologists. Recombinant Proteins can be manufactured by this Core for a variety of applications according to MGH-DF/ HCC investigator needs. In addition to large-scale production of recombinant proteins in yeast Pichia pastoris, a cost effective small-scale production service will be provided using E.coli or yeast Pichia pastoris expression system (e.g. for small animal studies, use as immunogens, ELISAs, or high throughput microarray platforms).

Proper citation: MGH Recombinant Protein Expression and Purification Core (RRID:SCR_009931) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-6de9-a291-55da-381e80000000

Core facility that provides the following services: Sperm Cryoperservation - Standard Mouse Backgrounds; including quality test (QC), 129 or Hybrid ES Cell transfection package for conventional or BAC vector (from DNA transfection to DNA preparation) ~200 colonies, C57BL/6 (JM8A) ES Cell transfection package for conventional or BAC vector (from DNA transfection to DNA preparation) ~200 colonies, Microinjection of one targeted 129, JM8A, or hybrid ES Cell clone, Microinjection of one targeted C57BL/6 (JM8 & others) ES Cell clone, Transgenic / DNA pronuclear Microinjection, Transgenic/ BAC DNA pronuclear Microinjection to hybrid mouse strain, Mice colony breeding, Mice ID tag & tail biopsy, Mice tail DNA preparation, Sperm Cryoperservation - Non-Standard Mouse Backgrounds; including quality test(QC), Recovery live born pups for testing following QC, IVF recovery of one mouse line from cryopreserved sperm for most strains (~10 pups provided), Recovery of cryopreserved mice embryos (up to 80 embryos), Special DNA Prep.

The MGH Transgenic and Gene Targeting Facility generates transgenic and knockout or knock-in mice to study gene function in embryonic stem cell and somatic cell systems. Services include: microinjection of DNA into fertilized embryos for the creation of transgenic mice, transfection of DNA into ES cells for the generation of recombinant ES cell clones, injection of gene-targeted ES cell clones into host blastocysts for the generation of gene knockout or knock-in mice, and other related ES cell based services. The facility is also equipped to perform in vitro fertilization projects, cryopreservation of mouse sperm and embryos, recovery of cryopreserved mouse sperm and embryos, and derivation of ES cell lines from a variety of genetic backgrounds. The facility provides consultation within reason on experimental design and vectors for gene targeting-related projects. The facility can also provide advice for the preparation of DNA, recombinant ES clones, mouse genotyping, handling and husbandry. The facility supports innovative and experimental approaches involving transgenic and knockout or knock-in mice to better help investigators study gene regulation and function, and develop appropriate animal models to study human genetic disorders.

Proper citation: MGH Transgenic and Gene Targeting Facility (RRID:SCR_009932) Copy   

•   Source: SciCrunch Registry

http://jsu.eagle-i.net/i/0000012a-c931-8969-0055-c4eb80000000

Core facility that provides the following services: Genomics service, Proteomics services, Functional assays service, Cell culture services, Stress enzyme analysis. The specific aims of the MCB Core Laboratory are: To provide a variety of services and technical support in molecular biology and DNA technology by offering equipment access, expert advice, demonstration of techniques, operation of equipment, participation in discussion and data interpretation, and hands-on-training in molecular biology and cell culture; to increase faculty training in recombinant DNA technology to strengthen faculty development and technology transfer; to provide a research environment and instrumentation for investigators to pursue biomedical research opportunities and enhance overall research productivity; to foster collaborative research relationships among RCMI investigators and other MCB core users at JSU and other research intensive institutions.

Proper citation: JSU Molecular and Cellular Biology Core Laboratory (RRID:SCR_009896) Copy   

•   Source: SciCrunch Registry

http://xula.eagle-i.net/i/00000135-81af-5452-a9f8-d64580000000

Core facility that provides the following services: Mass spectrometry services. The mission of Proteomics Core Facility is to help researchers advance their biomedical research programs. The Facility is equipped with gel electrophoresis units, image analyzers and digitizers, and robotics for mass spectrometry sample preparation. Currently, a Matrix-Assisted Laser Desorption/Ionization Mass Spectrometer instrument implements protein identification. The various applications include the studies of protein expression profile, posttranslational modifications, and partial sequencing of novel proteins. The staff also consult with researchers about their particular research interests and assist with the development of specific applications and solution to problems.

Proper citation: LCRC Proteomics Core Facility (RRID:SCR_009894) Copy   

•   Source: SciCrunch Registry

http://jsu.eagle-i.net/i/0000012b-00bb-9e00-3984-bcfb80000000

Core facility that provides the following services: Nanoindenter strain test service, UTM strain test service, Topography transmission electron microscopy service, Topography environmental scanning electron microscope service, Electron microscopy sample preparation service. The specific aims of the Electron Microscope Core Laboratory are: To provide investigators with access to microscopy instruments necessary for ultrastructural research in all the STEM areas; to train faculty, staff, and students on relevant methods in ultrastructural research; to help faculty, staff, and students on relevant approaches to address research questions involving morphological characterization; to improve JSU competitiveness in the innovative field of electron microscopy-based research.

Proper citation: JSU Electron Microscope Core Laboratory (RRID:SCR_009892) Copy   

•   Source: SciCrunch Registry

http://jsu.eagle-i.net/i/0000012a-c928-8ae0-0055-c4eb80000000

Core facility that provides the following services: Electron paramagnetic resonance (EPR) spectroscopy service. The specific aims of the MMR are to: 1. Provide high field FT-NMR spectrometers for all RCMI investigators and other researchers who need structural determination tools in their research. High field NMR spectrometers are key instruments in organic chemistry including biomedical and environmental research. Two high field FT-NMR spectrometers in the MMR Core Facility are made available for JSU researchers and off-campus users. 2. To offer technical support to users who need to apply NMR technology in their research but lack expertise. The sophisticated technology in NMR spectroscopy will be available for organic chemists as well as novice users and researchers from the biomedical and environmental areas. The MMR Core facility will host numerous workshops for new users including faculty and new graduate students.

Proper citation: JSU Molecular Magnetic Resonance Core Laboratory (RRID:SCR_009893) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-9c78-6bed-55da-381e80000000

Core facility that provides the following services: Synthesis of Radiopharmaceuticals for PET, PET scanning/imaging service.

The PET Core Laboratory provides a full range of technical and professional services for the design and execution of programs using Positron Emission Tomography (PET). The PET Core Facility provides the required facilities and personnel on a per study basis to allow investigators to use PET without requiring them to acquire the needed special expertise and equipment.

Proper citation: MGH PET Core (RRID:SCR_009927) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000013b-3d48-24a1-e81d-064c80000000

Core facility that provides the following services: 3D Imaging, Normative data comparison, Scan review. The High Resolution Peripheral Quantitative Computed Tomography (HR-pQCT) Core Facility offers measurements of the microscopic internal structure of cortical and trabecular bone in the distal radius and tibia. Additionally, the HR-pQCT Core Facility offers Finite Element Analysis to estimate key biomechanical properties of the bone including failure load and stiffness. By scanning the distal radius and tibia, the HR-pQCT Core can measure a variety of important parameters reflecting the integrity or cortical and trabecular bone. This information cannot be determined using standard clinical imaging techniques such as dual-energy x-ray absorptiometry (DXA). A scanning appointment is a 30 minute addition to a clinical research visit and involves less radiation exposure than traditional bone densitometry. With applications for both cross-sectional and longitudinal research, investigators have employed our facilities and expertise to study a variety of bone-related diseases with participants ranging in age from children to the elderly. The goal of the HR-pQCT Core is to provide facilities and personnel on a per study basis, allowing investigators access to important information about bone structure and function without requiring special expertise and equipment. Getting Started: To begin organizing a cohort for HR-pQCT studies or to inquire further, please contact the Core Director, Dr. Joel Finkelstein.

Proper citation: MGH High Resolution Peripheral Quantitative Computed Tomography Core Facility (RRID:SCR_009924) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-a1bd-151b-55da-381e80000000

Core facility that provides the following services: 4.7T/7T MRI, PET-CT, SPECT, FMT, BLI, Animal housing service, Multimodality imaging and image fusion, Quantitative image analysis and processing, Animal surgical services, Radiochemistry, Histopathology, Data Management, In vivo confocal microscopy.

The Mouse Imaging Program (MIP) at the Center for Systems Biology is a uniquely integrated imaging resource providing the larger Harvard/MIT research community with access to state-of-the-art in vivo imaging technologies. The program offers magnetic resonance imaging (MRI), positron emission tomography (PET-CT), single photon emission computed tomography (SPECT-CT), computed tomography (CT), bioluminescence (BLI), fluorescence mediated tomography (FMT), and various other fluorescence imaging technologies. The fully integrated program also provides mouse holding facilities for serial imaging, surgery, anesthesia and veterinary care. Image reconstruction, 3D display, fusion, quantitative image analysis and online data access are also available. The program performs its own research, aimed at continuously improving existing imaging technologies and has deep knowledge of cardiovascular, oncology and neurological mouse models of disease. A list of publications made possible by utilizing MIP resources is available on the Program web site. Imaging requests may be submitted through the MIP website.

Proper citation: MGH Mouse Imaging Program (RRID:SCR_009925) Copy   

•   Source: SciCrunch Registry

http://jsu.eagle-i.net/i/0000012a-2505-aadb-b307-36d480000000

Core facility that provides the following services: Flow cytometry and microarray training service. The Cellomics and Toxicogenomics Research Laboratory (CTRL) has been established to provide RCMI investigators and other JSU faculty and students with state-of-the art instrumentation that would allow them to perform laser-based flow cytometric analysis and cell sorting, as well as microarray analysis of gene expression in connection to human diseases. Hence, the application of flow cytometry and modern genomic DNA microarray-based technology is providing an excellent opportunity to CTRL users to examine alterations in gene expression patterns associated with environmental exposure, as well as to study the molecular mechanisms and biochemical effects associated with cellular responses to toxic exposures.(http://www.jsums.edu/cset/rcmi/ctrl.htm)

Proper citation: JSU Cellomics and Toxicogenomics Research Core Laboratory (RRID:SCR_009889) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-9143-a911-55da-381e80000000

Core facility that provides the following services: Offline assisted or self-performed analysis.

The HSCI-CRM Flow Cytometry Core Facility seeks to provide high quality, accessible cytometry sorting and analysis services to laboratories in the Center for Regenerative Medicine, Harvard Stem Cell Institute, and MGH research communities at an affordable rate. The Core''s equipment and highly trained operators provide an advanced level of sorting and analysis services to its investigators. Additionally, the Core is dedicated to training users on all aspects of flow cytometry, including practical issues, information about specific applications, and critical interpretation of sorting results. The Core''s three full-time staff members strive to ensure that each investigator''s visit benefits their individual experiments to the greatest extent possible. To ensure the best availability to all users, the Core offers an online scheduling system, and provides extended sorting hours until late evening. HSCI faculty have reduced pricing for use of the Core''s services.

Proper citation: MGH HSCI-CRM Flow Cytometry Core Facility (RRID:SCR_009923) Copy   

•   Source: SciCrunch Registry

http://jsu.eagle-i.net/i/0000012a-2505-e99e-b307-36d480000000

Core facility that provides the following services: Spectrofluorometry service, FTIR service, Atomic absorption spectrometry service, Raman spectrometry service, Gas chromatography service, GC/MS service, HPLC service, LC/MS/MS service, Capillary electrophoresis/mass spectrometry service, FPLC service. The Analytical Core Laboratory objectives are to: 1) provide spectroscopic and chromatographic equipment to investigators of pilot projects in the RCMI Program as well as investigators in other programs in the College of Science, Engineering and Technology for their research needs, 2) to acquire new analytical instruments as well as computers and printers to satisfy the needs of the user community, 3) to respond to the needs for obtaining analytical information in a timely manner, 4) To offer workshops for using major equipment including LC/MS/MS, CE/MS/MS, LC-ICP/MS, Raman microscope system, and FT-IR as well as other conventional instruments at least once each semester for each instrument.

Proper citation: JSU Analytical Core Laboratory (RRID:SCR_009885) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-6e37-beec-55da-381e80000000

Core facility that provides the following services: Hematology/immunology assay service. The major objective of the Specialized Assay Core is to create greater efficiency by providing radioimmunoassays (RIAs), enzyme-linked immnosorbent assays (ELISA), bead based multiplex assays, and other basic biochemical assays to support human and animal studies performed by individual investigators at the Joslin Diabetes Center and external users who do not have access to Core Facilities. The Core allows more economic use of expensive or limited materials, provides for training of junior investigators, fosters interactions among research fellows and provides a basis for generating productive collaborative studies between institutions.

Proper citation: JDC Specialized Assay Core (RRID:SCR_009884) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-c086-517c-cb22-be8c80000000

The main objective of the Joslin''s Media Core is to reduce the cost and labor of making tissue culture media and other reagents required by the Joslin investigators. By centralizing preparation of these reagents, the Core provides high quality reagents at a significantly reduced cost to the investigators. In addition, the Core provides services to overcome labor intensive reagent needs, like plate pouring services and preparation of specialized buffers and reagents for cell and molecular studies. The Media Core makes and provides over 10 different mammalian tissue culture media to the Joslin investigators for their studies. In addition, the Core prepares and provides several buffers and solutions to the Joslin investigators. The core also makes a variety of broths and agars for growing bacterial cultures, and provides agar plates and plate pouring service to the investigators. Over the past five years (2006-2010), by preparing and providing over 6250 liters of media and 2850 agar plates per year to the Joslin investigators the Media Core serves an important function in the efforts of these investigator to find cure for diabetes and its complications.

Proper citation: JDC Media Core (RRID:SCR_009882) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012d-c96b-3791-4882-b08d80000000

The Clinical Genetic Research Facility (CGRF) offers clinical investigators a convenient, modern research-dedicated facility for outpatient studies involving genetics. Our outpatient exam rooms and phlebotomy rooms are fully equipped and offer investigators an experienced medical assistant to facilitate the visit. Since the CGRF?s primary mission is to support and promote genetic clinical research, the facility?s investigators performing genetic studies supported by non-commercial sponsors are given priority. The CGRF also considers genetic studies sponsored by industry, as well as studies without a genetic component, on a space-available basis.

Proper citation: MGH CHGR Clinical Genetic Research Facility (RRID:SCR_009917) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-9766-17f0-55da-381e80000000

Core facility that provides the following services: DNA extraction from blood and cell lines.

This facility provides processing of cell lines, human blood and tissue samples for DNA, plasma and buffy coat storage and for initiation of lymphoblast and fibroblast cell lines in furtherance of the CHGR mission to promote the use of genetic strategies in basic and clinical research.

Proper citation: MGH CHGR DNA and Tissue Culture Resource (RRID:SCR_009918) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-97d7-0e06-55da-381e80000000

Core facility that provides the following services: Breeding pair service, Mouse Phenotyping Services.

This resource provides to MGH investigators a local source of breeding pairs of the 22 chromosome substitution strains (CSS)* of mice and access to basic phenotyping equipment for mapping of simple or complex traits, to promote the use of genetic mouse-based strategies in basic and clinical research. The CSS Resource comprises 22 mouse lines, each homozygous for a single A/J chromosome (Chr 1-19, X or Y and mitochondria) on a genetic background that is otherwise C57BL/J that were generated by Dr. Joseph Nadeau (Case Western Reserve University) and his colleagues. The CSS mice are available from The Jackson Laboratories. However, to save time and money, the MGH CSS Resource maintains CSS breeding colonies that are housed in the Simches-8 barrier facility, adjacent to a procedure room that will have equipment for basic standardized phenotyping, including behavioral and metabolic measurements.

Proper citation: MGH CHGR Chromosome Substitution Strain Resource (RRID:SCR_009916) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/00000135-342b-fcc8-0fb7-ab1580000000

Core facility that provides the following services: 9.4T Facility rodent, nonhuman primate, and small animal proton spectroscopy. The McLean Hospital Translational Imaging Laboratory aims to provide cutting edge magnetic resonance imaging, functional imaging, chemical imaging (spectroscopy), and multimodal imaging services to the Harvard Catalyst Community. We have 3 magnetic resonance (MR) scanners, an ultra high magnetic field (9.4 Tesla) dedicated animal scanner and 3.0 and 4.0 Tesla large bore human systems available for large animal scans. Our scanners are capable of conducting scans in animals ranging in size from mice to large dogs, and we have experience imaging mice, rats, rabbits, nonhuman primates, and several canine species. All 3 scanners have dedicated animal prep areas. We offer high level biophysics, engineering, and data analytic expertise, along with veterinary technologist anesthesia support.

Proper citation: McLean Translational Imaging Laboratory (RRID:SCR_009948) Copy   

•   Source: SciCrunch Registry

http://montana.eagle-i.net/i/0000012b-00be-f31e-df3b-3fdc80000000

Core facility that provides the following services: Training and access, Elemental spectroscopic imaging, Thin section imaging, Shadow casting, Negative staining, Electron diffraction, Brightfield imaging.

This facility is a resource center for transmission electron microscopy, providing investigators with consultation, training, access to equipment and other services.

Proper citation: MSU Transmission Electron Microscopy Core Laboratory (RRID:SCR_009946) Copy   

•   Source: SciCrunch Registry