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http://www.scienceexchange.com/facilities/center-for-macromolecular-interactions

The facility helps to produce highly purified recombinant proteins for functional and structural studies and to provide researchers with state-of-the art capabilities for the characterization of protein-protein, protein-lipid, protein-nucleic acid and protein-small ligand interactions.

Proper citation: UTHSCSA Center for Macromolecular Interactions (RRID:SCR_012234) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/flow-cytometry-core-facility--2

The UTHSCSA Flow Cytometry Core Facility operates at two locations; at the Long (main) campus and Greehey (north) campus in the newly-built South Texas Research Facility (STRF). The facility at the Long campus is located in room 5.044V and occupies 800 sq. ft. The STRF site is located in room 251 and occupies a total of 1306 sq. ft. The FCF is administered through the Office of the Vice President for Research in coordination with the Executive Director of the Cancer Center. Access to the flow labs is available to all UTHSCSA and external investigators with priority given to NIH-funded investigators. FCF services are based on the presence of a flow cytometry cell sorter and an analyzer at each of its two locations. The main campus site houses a Becton Dickinson Biosciences (BD) FACSAria and a BD SORP LSRII. The FACSAria cell sorter is equipped with 5-lasers enabling the analysis of up to 13 parameters and concurrent sorting of 4 different cell populations. The LSRII is equipped with 3 lasers and allows for detection of up to 8 colors at a time. The STRF site houses a MoFlow Astrios and a FACSCalibur. The MoFlow Astrios cell sorter is equipped with 4 lasers that enables analysis of up to 14 colors and concurrent sorting of 6 different cell populations. The FACSCalibur analyzer is equipped with 2-lasers and allows for the parallel detection of up to 4 colors.

Proper citation: UTHSCSA Flow Cytometry Core Facility (RRID:SCR_012238) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/mass-spectrometry-laboratory

The UTHSCSA Mass Spectrometry Laboratory provides state-of-the-art expertise and services in mass spectrometry and gel electrophoresis for identification, characterization and/or quantification of molecules of biomedical importance. The Mass Spectrometry Laboratory assists faculty members in their research endeavors and by promoting interdisciplinary and inter-institutional research. The activities of the Mass Spectrometry Laboratory continue to benefit the institution by enhancing ongoing research, by facilitating the acquisition of new research funding and by assisting with recruitment of new faculty members.

Proper citation: UTHSCSA Mass Spectrometry Laboratory (RRID:SCR_012240) Copy   

•   Source: SciCrunch Registry

https://www.uclahealth.org/departments/pathology/research-services/technology-center-genomics-bioinformatics-tcgb

Core is a fully automated, high-throughput genomic Center equipped with next generation sequencing and microarray platforms. TCGB provides genomics technologies, comprehensive services, specialized expertise and a wide range of trainings, enabling these services to serve basic science and translational/clinical research. In addition, TCGB provides pre-experiment consultation and post-experiment support, including preparation of grant applications, publications, and strategic planning for additional research steps. TCGB also provides educational training to faculty, staff, and students to raise awareness of new directions and major discoveries in the areas of genomics and bioinformatics.

Proper citation: University of California Los Angeles Technology Center for Genomics and Bioinformatics Core Facility (RRID:SCR_012204) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/keck-biophysics-facility-northwestern

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on January 31,2025. The award-wining Keck Biophysics Facility at Northwestern University has a comprehensive set of state of the art instruments for biophysical and biochemical characterization of macromolecules and their interactions. We provide staff-service, technical expertise and assistance to investigators and companies in the continental US and Canada. The Facility has 15 years of experience with a broad array of biophysical techniques and has generated over 500 publications in top-tier journals.

Proper citation: Northwestern University Keck Biophysics Facility (RRID:SCR_012203) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/ips-core

The new iPSC Core generates custom-designed iPSCs from mouse and human cells, including disease-specific human iPSCs. iPSCs from other species are currently under development. The Core is currently using both lentiviral- and sendai viral vector systems to deliver reprogramming factors to cells. Both systems are efficient, with the latter system having the advantage to generate iPSCs with a non-DNA-integrating vector system.

Proper citation: CU Denver iPSC Core (RRID:SCR_012176) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/university-of-colorado-denver

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on October 30,2023. Portal, Core facility

Proper citation: University of Colorado Denver Labs and Facilities (RRID:SCR_012175) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/transgenic-and-gene-targeting-core

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 22,2024. Transgenic and Gene Targeting Core is a full-service facility designed to assist you in generating genetically engineered mouse models for biomedical research. Our services include gene targeting in embryonic stem cells, the generation of ES cell-derived knockout and knockin mice, transgenic mice (conventional and BAC transgenic mice) and the cryo-preservation of mouse lines. The latter service is of particular importance for investigators that have long-term projects with non-commercial mouse lines. Changes in the genetic make-up of your mouse lines that occur spontaneously over time (gene drift) and disease outbreaks can significantly affect the outcome of your research. It is therefore advisable to preserve your mouse lines, providing you with a backup of your valuable research tools. We currently offer both embryo cryopreservation as well as sperm cryopreservation for this purpose.

Proper citation: CU Denver Transgenic and Gene Targeting Core (RRID:SCR_012177) Copy   

•   Source: SciCrunch Registry

http://www.mmc.edu/research/centers/research-centers/metrc/core-facilities.html

Core facility that aids investigators and trainees with high performance computation in proteomics, as well as other omics type applications needing efficient analysis of large-scale biological data sets. The ability to incorporate proteomics into translational and clinical biomedical research is critical for the discovery of therapeutic interventions and high fidelity biomarkers of disease and response to therapy. The Core provides state-of-the-art services, training, and bioinformatics-driven data analysis to the Meharry translational research community.

Proper citation: Meharry Proteomics Core (RRID:SCR_012179) Copy   

•   Source: SciCrunch Registry

https://www.monash.edu/researchinfrastructure/micromon

Provides complete sequencing and data analysis service based around second generation Illumina Genome Analyzer (GAIIx) and Illumina MiSeq sequencing platform. They also offer Agilent Bioanalyzer RNA and DNA analysis, Covaris focussed acoustic shearing of nucleic acids and tissues, qPCR assay design, execution and analysis, oligonucleotide synthesis and capillary electrophoresis (CE/Sanger) sequencing. Offers expertise in advanced DNA and RNA technologies.

Proper citation: Monash University Micromon Core Facility (RRID:SCR_012170) Copy   

•   Source: SciCrunch Registry

https://lsom.uthscsa.edu/dcsa/research/cores-facilities/optical-imaging/

Service resource which makes imaging technology available to investigators on UTHSCSA campus and neighboring scientific community. Core Optical Imaging Facility offers access to technology for imaging of living cells, tissues, and animals, consultation, education and assistance regarding theory and application of optical imaging techniques, technical advice on specimen preparation techniques and probe selection.

Proper citation: Texas University Health Science Center at San Antonio Long School of Medicine Department of Cell Systems and Anatomy Optical Imaging Core Facility (RRID:SCR_012171) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/cardiovascular-physiology-core-facility

The Cardiovascular Physiology Core Facility provides University of Wisconsin (UW) and non-UW researchers with a central resource for creating and studying animal models of disease on a fee-for-service basis. While the central focus of the facility is cardiovascular research, the techniques employed are often useful to investigators in other fields. Currently, the facility is conducting studies into diabetes, bone growth, drug toxicology, and gene therapy in liver and skeletal muscle, as well as cardiovascular disease. One of the most popular services provided by the facility is evaluation of the cardiovascular phenotype of transgenic mice.

Proper citation: UW-Madison Cardiovascular Physiology Core Facility (RRID:SCR_012214) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/afm-imaging-group-k-state

We specialize in atomic force microscopy (AFM). We offer: 1. Various AFM imaging assays in air, water, and biological buffers. 2. Single molecule force spectroscopy (FX-AFM and FC-AFM) on proteins and other biomolecules. 3. Hot-tip AFM surface modifications and imaging.

Proper citation: KSU AFM Imaging Group (RRID:SCR_012216) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/proteomics-shared-resource-facility-brown

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on April 25,2024. Proteomics Shared Resource Facility's mission is to provide well-maintained, state-of-the-art instrumentation and fundamental proteomics expertise to the Brown University and Rhode Island-EPSCoR scientific communities. It aims to be a focal point of intellectual activity in proteomics by enabling nationally recognized proteomics research within Rhode Island. As an NSF EPSCoR funded laboratory, the Proteomics Facility has a broadly-inclusive philosophy to ensure rapid and equal access to the facility's services for the entire Rhode Island research community. In addition to the acquisition of instrumentation, the Proteomics Core Facility will undertake the training of research in emerging proteomic techniques, a component that is essential to maintaining a productive and professional level of service. The Proteomics Facility has a strong commitment to be at the leading edge of current and developing technologies and provides consultation on their application.

Proper citation: Brown Proteomics Shared Resource Facility (RRID:SCR_012219) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/high-throughput-and-high-content-screening-core-facility

The High Throughput and High Content Screening (HTS/HCS) Core Facility specializes in chemical biology as it relates to drug discovery, biological probe discovery, and phenotypic characterization of small-molecule effects on cellular systems. In addition to housing the instrumentation and robotics required for traditional HTS, the Core houses a cutting-edge High Content image-based system for next-generation small-molecule discovery research and analysis in fixed or live cells and cellular systems.

Proper citation: CU Denver High Throughput and High Content Screening Core Facility (RRID:SCR_012218) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/dna-analysis-facility-yale

We are an academic Core Facility that supports the applications of DNA Sequencing and Fragment Analysis of Microsatellites and AFLP''''s. Our Facility was founded in 2003 and expanded in 2005 with funds from NSF Instrumentation Development Grant (#0500993). In 2008 a generous gift from the Yale Provost allowed us to upgrade our Applied Biosystems Genetic Analyzer from a 48 to a 96-capillary. In 2010, with funds from NIH Equipment Grant (1S10RR025478-01) we upgraded additional equipment to ensure that we are a an efficient throughput Core. We are housed in the Yale Institute for Biospheric Studies Molecular Systematics and Conservation Genetics Center both under the Direction of Dr. Adalgisa Caccone. The presence of our Core within this setting enhances training within the MSCG Center by allowing students to obtain genetic information from large data sets in a time frame that is appropriate to their academic schedules, and to do so within the budget available for training. Our services are utilized by over 600 users from Yale, other academic institutions and private companies from across the United States and around the world. By promoting access to our equipment we enhance cost effectiveness, reducing idle time and avoid wasting consumables. This in turn allows us to reduce rates and have our services available to users that could otherwise not afford it. While our user base continues to expand our focus remains the same: to offer high quality services at prices affordable to small and medium sized laboratories.

Proper citation: Yale DNA Analysis Facility (RRID:SCR_012187) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/electron-microscopy-and-histology-core-facility-cornell

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on August 8,2025. The EM & H Core Facility functions as a merger of the facility at WCMC and the Analytical Microscopy Facility at HSS. The microscopes are located at WCMC in the Department of Cell & Developmental Biology. The HSS facility staff performs the TEM specimen preparation for their clients and then comes to WCMC to use the TEM. SEM sample preps for both client groups may be performed in the facility at WCMC.

Proper citation: WCMC Electron Microscopy and Histology Core Facility (RRID:SCR_012222) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/drug-discovery-development-and-delivery-core

The Drug Discovery, Development and Delivery (D4) Core provides investigators with access to technological expertise enabling biochemical (100,000+ compounds) and siRNA library screening. We have expertise in development and screening, in both biochemical and cell-based assays. Our mission is to work with investigators to unlock the potential to discover chemical agents that affect cellular targets involved in human diseases.

Proper citation: Penn State Drug Discovery Development and Delivery Core (RRID:SCR_012221) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/center-for-protease-research-ndsu

We specialize in the synthesis of small molecules for biological applications and variety of analytical services. The facility works primarily with investigators from Center for Protease Research (CPR). However, we have always extended our services to neighboring institutions and other places all across US when possible. The facility enjoys a successful track record of achievements through service, collaborations, and interdisciplinary interactions.

Proper citation: NDSU Center for Protease Research (RRID:SCR_012223) Copy   

•   Source: SciCrunch Registry

http://www.scienceexchange.com/facilities/next-generation-sequencing-ngs-core

THIS RESOURCE IS NO LONGER IN SERVICE. Documented on May 15,2024. Laboratory: The Institute for Genomics and Systems Biology''''s Next Generation Sequencing Core (IGSB-NGS) is a state-of-the-art facility for ultra-high throughput sequencing. The core was established in 2007 at Argonne National Laboratory and is housed in Argonne''''s Computing, Environment and Life Sciences (CELS) directorate, providing world class computation power, software, and expertise critical to the acquisition, analysis, and interpretation of the unprecedented volume of genetic information being generated on next generation DNA sequencing platforms. The core provides resources and services to Argonne National Laboratory users, University of Chicago users, and to the broader scientific community. NGS is involved in a broad range of scientific research from the sequencing of metagenomic samples to both 16S and 18S rRNA amplicon sequencing for microbial community analysis using next generation sequencing. The NGS laboratory space at Argonne is approximately 1,200 square feet and is supplemented by 140 square feet of office space for the technical director, Ms. Sarah Owens, as well as two additional 140 square foot spaces for technicians. Equipment: The NGS maintains the following workflows: Illumina HiSeq2000 and MiSeq next generation DNA sequencing. The Illumina HiSeq2000 generates over 6 billion reads at 150 bp in length per read resulting in over 600 Gb worth of data across sixteen lanes available per run. The Illumina MiSeq generates over 24 million reads at 150 bp in length per read resulting in over 4.5 Gb worth of data available per run (over a single lane). Applications on both the Illumina HiSeq2000 and MiSeq include: shotgun metagenome sequencing; rRNA-based amplicon library sequencing; and genome sequencing and resequencing. All major equipment is housed within the main laboratory space including three 96-well PCR machines (Applied Biosystems), water baths, analytical balances, refrigerator/freezers (including a large-capacity -80 degree C freezer), incubators, and high and low speed centrifuges (table-top and floor models). Basic equipment and supplies for all advanced molecular techniques (deionized water (Millipore Milli-Q Advantage A10 system), multiple electrophoresis units and digital photographic documentation system) are housed here including equipment for high precision quantitation of nucleic acids (Agilent Bioanalyzer, NanoDrop, and Invitrogen Qubit). The facility also has a Covaris for sample shearing. Any additional equipment needed is located in or near by the NGS laboratory space including a real-time PCR machine (Roche LightCycler 480 with capabilities for both 96-well and 384-well plates) and a liquid handler, the Eppendorf epMotion 5075 robot. Some equipment (autoclaves, ice machine) is located in a common equipment room. Various instruments and methods have been implemented in the NGS''''s standard procedures to maximize quality. These include the use of the Roche Lightcycler 480 II, Agilent Bioanalyzer 2100, Invitrogen Qubit Fluorometer, and barcoding of libraries destined for sequencing. (The latter allows for a test sequencing run of each library to be performed to optimize sequencing lane loading density prior to each library''''s final sequencing run). Personnel overview. NGS operations are managed by Technical Director Sarah Owens. Ms. Owens has a Masters in Molecular Biology and Genetics, and 2 years experience working in high throughput facilities, with over 6 years of molecular biology experience. Ms. Owens was instrumental in trouble-shooting the application of rRNA-based amplicon sequencing for the Illumina HiSeq2000 and MiSeq, developing reproducible protocols in collaboration with Illumina. Under the guidance of the Technical Director, the NGS team helps users to determine the most efficient and cost effective approach to meet their research needs.

Proper citation: UChicago IGSB Next Generation Sequencing Core (RRID:SCR_011063) Copy   

•   Source: SciCrunch Registry