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http://montana.eagle-i.net/i/0000012b-00be-16ed-df3b-3fdc80000000

Core facility that provides the following services: Lab animal technician services, Animal husbandry service.

The Mission of the Animal Resources Center is to provide healthy animals for use in IACUC-approved research, educational and testing protocols at Montana State University,ensure that University research animals are cared for in a humane and appropriate manner by the provision of modern, well maintained facilities, trained personnel, technical support, veterinary care and monitoring of animal care and use, provide resources, technical assistance, and information for University researchers and educators in meeting the requirements of animal-related protocols, and ensure observance of ethical standards and federal regulations pertaining to the care and use of animals for research, education and testing at Montana State University.

Proper citation: MSU Animal Resource Center (RRID:SCR_009936) Copy   

•   Source: SciCrunch Registry

http://msm.eagle-i.net/i/0000012b-00c2-e053-353c-df7f80000000

The Analytical Chemistry and Protein Profiling Core is comprised of three primary labs: * Analytical Chemistry * Protein Profiling/2D Gel * 2D Gel Electrophoresis Lab

Proper citation: MSM Analytical Chemistry and Protein Profiling Core (RRID:SCR_009933) Copy   

•   Source: SciCrunch Registry

http://msm.eagle-i.net/i/0000012b-00c2-b0bd-353c-df7f80000000

THIS RESOURCE IS NO LONGER IN SERVCE, documented January 25, 2019. Core focuses on integration of MSM and affiliated health information systems into an interoperable repository. The long-term goal is to establish an integrated standards-based informatics platform to support MSM clinical and translational research investigators in their own work and in sharing research information with collaborators and other investigators in parallel fields.

Proper citation: Morehouse School of Medicine Biomedical Informatics Unit (RRID:SCR_009934) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/00000131-6bd2-db1d-75a1-b5a380000000

Core facility that provides the following services: Recombinant protein expression and purification in yeast Pichia pastoris, Large-scale production of immunotoxins for cell depletion studies, Large scale production of recombinant cytokines, Cost effective small-scale production using E.coli system.

The Recombinant Protein Expression and Purification (RPrEP) Core was established in 2009 to provide a cost-effective resource to the MGH and DF/ HCC community for expression and purification of recombinant proteins necessary for pre-clinical studies as well as for basic mechanistic studies by immunologists and cancer biologists. Recombinant Proteins can be manufactured by this Core for a variety of applications according to MGH-DF/ HCC investigator needs. In addition to large-scale production of recombinant proteins in yeast Pichia pastoris, a cost effective small-scale production service will be provided using E.coli or yeast Pichia pastoris expression system (e.g. for small animal studies, use as immunogens, ELISAs, or high throughput microarray platforms).

Proper citation: MGH Recombinant Protein Expression and Purification Core (RRID:SCR_009931) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-6de9-a291-55da-381e80000000

Core facility that provides the following services: Sperm Cryoperservation - Standard Mouse Backgrounds; including quality test (QC), 129 or Hybrid ES Cell transfection package for conventional or BAC vector (from DNA transfection to DNA preparation) ~200 colonies, C57BL/6 (JM8A) ES Cell transfection package for conventional or BAC vector (from DNA transfection to DNA preparation) ~200 colonies, Microinjection of one targeted 129, JM8A, or hybrid ES Cell clone, Microinjection of one targeted C57BL/6 (JM8 & others) ES Cell clone, Transgenic / DNA pronuclear Microinjection, Transgenic/ BAC DNA pronuclear Microinjection to hybrid mouse strain, Mice colony breeding, Mice ID tag & tail biopsy, Mice tail DNA preparation, Sperm Cryoperservation - Non-Standard Mouse Backgrounds; including quality test(QC), Recovery live born pups for testing following QC, IVF recovery of one mouse line from cryopreserved sperm for most strains (~10 pups provided), Recovery of cryopreserved mice embryos (up to 80 embryos), Special DNA Prep.

The MGH Transgenic and Gene Targeting Facility generates transgenic and knockout or knock-in mice to study gene function in embryonic stem cell and somatic cell systems. Services include: microinjection of DNA into fertilized embryos for the creation of transgenic mice, transfection of DNA into ES cells for the generation of recombinant ES cell clones, injection of gene-targeted ES cell clones into host blastocysts for the generation of gene knockout or knock-in mice, and other related ES cell based services. The facility is also equipped to perform in vitro fertilization projects, cryopreservation of mouse sperm and embryos, recovery of cryopreserved mouse sperm and embryos, and derivation of ES cell lines from a variety of genetic backgrounds. The facility provides consultation within reason on experimental design and vectors for gene targeting-related projects. The facility can also provide advice for the preparation of DNA, recombinant ES clones, mouse genotyping, handling and husbandry. The facility supports innovative and experimental approaches involving transgenic and knockout or knock-in mice to better help investigators study gene regulation and function, and develop appropriate animal models to study human genetic disorders.

Proper citation: MGH Transgenic and Gene Targeting Facility (RRID:SCR_009932) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/00000138-7c6f-afad-fbab-3b8480000000

The Cell Center Stockroom is a division of the Genetics Core Facilities (GCF). The GCF is a University service center, established in 1973 to provide consultation, training, and services in the areas of cell culture and hybridomas. Also, the GCF to provides a full range of cell culture media and molecular biology reagents needed by investigators to perform cell culture techniques in their own laboratories. The DNA Sequencing Facility, Genetic Diagnostic Laboratory and Transgenic/Chimeric Animal Facility are the remaining three divisions of the GCF. The Stockroom serves University of Pennsylvania investigators and affiliate institutions (Cancer Center, Chidren''s Hospital of Philadelphia, Hospital of the Unviersity of Pennsylvania, The Wistar Institute, Monell Chemical Senses Center, and Presbyterian Hospital) by coordinating relations with various suppliers of molecular biological research materials. This involves not only bulk purchasing of these products, but the negotiation of discounts and convenient delivery arrangements. There are over 1,400 products on-site for immediate delivery in the Stockroom. Special ordering of non-regularly stocked products is available from 24 bioreagent vendors with discounted pricing and overnight delivery. List of Stockroom Vendors: * Accutek Laboratories * Amaxa Biosystems * Ambion, Inc. * Applied Biosystems * Atlanta Biologicals * Bio-Rad Laboratories * Biowhittaker * Cell Center Services * Cell Signaling Technologies * Clontech Laboratories * Collaborative * Denville Scientific * Difco Laboratories * EMD Chemicals * Fermentas * Fisher (Thermo) Scientific * Fuji Film * GE/Amersham Bioscience * Gemini Bio-Products�� * Hyclone Laboratories * Integrated DNA Technologies * Invitrogen * ISC Bioexpress * Kodak * KPL, Inc. * Life Technologies * Lonz A* MediaTech * Millipore * New England Biolabs * Open Biosystems * Perkin Elmer Life Sciences * Promeg A* Qiagen * Rainin Instruments * Roche�� * Sigma-Aldrich * Stratagene/Agilent Technologies * TruMark Scientific * USB Corporation/Affymetrix * VWR International * Zen-Bio, Inc.

Proper citation: Penn Cell Center Stockroom (RRID:SCR_010003) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/00000138-ba8f-c231-9cd7-d7e280000000

Core facility that provides the following services: Cryopreservation, Clinical Cell and Vaccine Production Facility quality control and quality assurance services, Clinical Cell and Vaccine Production Facility quality control training, Conjugation of proteins or antibodies to magnetic beads and quality control, Clinical Cell and Vaccine Production Facility vaccine preparation service, Enrichment of lymphocytes or monocytes from apheresis collection, WBC, lymphocyte and monocyte count, Conversion of patient/donor plasma to serum, Depletion of cell subpopulation from apheresis or lymphocytes, Clinical Cell and Vaccine Production Facility quality control testing. The Clinical Cell and Vaccine Production Facility (CVPF) is a GMP facility accredited by the Foundation for the Accreditation of Cellular Therapy (FACT) and a Department of Pathology/Lab Medicine and NCI approved Abramson Cancer Center Shared Resource. The CVPF provides focused scientific, technical and regulatory support for investigator initiated investigational new drug applications (INDs) in cell and gene therapy. Under compliance of FDA 21 CFR Parts 210 and 211, the CVPF performs cell processing on a range of different cell types, to include bone marrow derived CD4+ and CD8+ T lymphocytes, dendritic cells, and marrow stromal cells (aka mesenchymal stem cells). In each of these cases, cells are expanded ex vivo with or without genetic modification to the cells before being reintroduced back into the patient, either alone or in combination with other therapies such as vaccines. The overall mission of the Clinical Cell and Vaccine Production Facility is to help translate insights into novel cellular therapies.

Proper citation: Penn Clinical Cell and Vaccine Production Facility (RRID:SCR_010007) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/00000141-5b51-0e1d-91c7-0c6080000000

Core facility that provides the following services: Community engagement and research consultation services. Mission: The purpose of the Community Engagement and Research Core in the Penn CTSA is to facilitate community-based research and community engagement, especially community-based participatory research, and enhance the translation of research and technological developments to key public health and community stakeholders. Goals: 1. Foster community-based participatory research projects through developing training programs and integrating lectures into existing academic programs 2. Determine community health needs and priorities 3. Promote community-based research within the area of health disparities through seminar series 4. Continue the involvement in community outreach and education events to engage the community 5. Fund the conduct of CEAR Core pilot studies 6. Facilitate the use of academic-community partnerships to aid in the recruitment of subjects

Proper citation: Penn Community Engagement and Research Core (RRID:SCR_010008) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/0000013f-631e-6095-a468-831a80000000

Core facility that provides the following services: Body composition measurements, Resting energy expenditure analysis. Nutrition plays a vital role in health at all ages. The Clinical and Translational Research Center offers a Bionutrition Research Unit (BRU) to facilitate and implement clinical and translational research services. Research dietitians assist investigators with research design, implementation, data collection and analysis in study protocols. The Dietary Assessment Unit of the Nutrition Core provides a broad range of nutrition-related research services to investigators at the Children''s Hospital of Philadelphia, the Hospital of the University of Pennsylvania (HUP) and Penn Presbyterian Medical Center (PMC).

Proper citation: Penn/CHOP CTRC Bionutrition Research Core Dietary Assessment (RRID:SCR_010009) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/00000138-9b9e-1bb6-9cd7-d7e280000000

Core facility that provides the following services: Biological specimen sample preparation for transmission electron microscopy, Phenotypic characterization and ultrastructural analysis of biological specimens, Consultation for transmission electron microscopy experiments, usage, and data presentation, Transmission electron microscopy image construction tomography service, Training in transmission electron microscope operation, Scanning electron microscopy service, Transmission electron microscope access. Structural organization is underlies nearly all cellular, molecular and biochemical processes in biological systems. The Electron Microscopy Resource Laboratory (EMRL) at Penn is dedicated to analysis of biological samples by electron microscopy (EM). The primary goal of the EMRL is to promote biomedical research by offering high quality EM imaging services at a low cost. With a team of experienced professional staff and state-of-the-art imaging equipment, the EMRL offers users a full spectrum of both transmission EM and scanning EM services. These services include: specimen preparation (including fixation, embedding, and sectioning of cells and tissues or preparation of non-cellular materials), operation of equipment, data acquisition, data interpretation, and free instruction on all aspects of EM analysis. We also offer free assistance on the preparation of manuscript and grant applications that incorporate various forms of EM analysis. For most users, the Core will perform a complete analysis from sample preparation through collection of data, most often with the user present during data collection. More experienced users can perform the work themselves, with the Core providing guidance and assistance as needed. The Core staff and affiliated Scientific Advisory Committee members are always available for consulting on the morphological aspects of a project, and the Core staff is willing to custom-design services to fit any investigator''s needs.

Proper citation: Penn Electron Microscopy Resource Laboratory (RRID:SCR_010010) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/0000013b-7127-463d-83a0-df0880000000

The Penn Gene Targeting Service (PGT) is run by the Penn Gene Targeting Core and Laboratory in collaboration with two other Penn Cores (DNA Sequencing Facility and the Transgenic and Chimeric Mouse Facility) and has the capability to generate from scratch almost any type of genetically modified mouse. This includes complete knockout of any gene, tissue-specific and/or drug-inducible knockout of any gene, targeted mutagenesis of any region of any gene (knockin), tissue-specific activation of an endogenous gene using loxP flanked stop cassettes, and tissue-specific and/or drug-inducible transgene expression from defined loci. For details regarding services and prices please consult the PGT home page of the Department of Genetics and/or directly contact Dr. Tobias Raabe. The Client lab does not need to be involved in any experimental step and only needs to breed the resulting mice. However, if desired, participation of the client lab in almost any experimental step is possible. PGT has an outstanding record of germ line transmission and so far over 32 targeted mice - more than 12 in the desirable C57BL6 background - have been made, starting either with molecular design and construction of the targeting vector or with electroporation of an existing targeting vector into ES cells.

Proper citation: Penn Gene Targeting Service (RRID:SCR_010013) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-9c78-6bed-55da-381e80000000

Core facility that provides the following services: Synthesis of Radiopharmaceuticals for PET, PET scanning/imaging service.

The PET Core Laboratory provides a full range of technical and professional services for the design and execution of programs using Positron Emission Tomography (PET). The PET Core Facility provides the required facilities and personnel on a per study basis to allow investigators to use PET without requiring them to acquire the needed special expertise and equipment.

Proper citation: MGH PET Core (RRID:SCR_009927) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000013b-3d48-24a1-e81d-064c80000000

Core facility that provides the following services: 3D Imaging, Normative data comparison, Scan review. The High Resolution Peripheral Quantitative Computed Tomography (HR-pQCT) Core Facility offers measurements of the microscopic internal structure of cortical and trabecular bone in the distal radius and tibia. Additionally, the HR-pQCT Core Facility offers Finite Element Analysis to estimate key biomechanical properties of the bone including failure load and stiffness. By scanning the distal radius and tibia, the HR-pQCT Core can measure a variety of important parameters reflecting the integrity or cortical and trabecular bone. This information cannot be determined using standard clinical imaging techniques such as dual-energy x-ray absorptiometry (DXA). A scanning appointment is a 30 minute addition to a clinical research visit and involves less radiation exposure than traditional bone densitometry. With applications for both cross-sectional and longitudinal research, investigators have employed our facilities and expertise to study a variety of bone-related diseases with participants ranging in age from children to the elderly. The goal of the HR-pQCT Core is to provide facilities and personnel on a per study basis, allowing investigators access to important information about bone structure and function without requiring special expertise and equipment. Getting Started: To begin organizing a cohort for HR-pQCT studies or to inquire further, please contact the Core Director, Dr. Joel Finkelstein.

Proper citation: MGH High Resolution Peripheral Quantitative Computed Tomography Core Facility (RRID:SCR_009924) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-a1bd-151b-55da-381e80000000

Core facility that provides the following services: 4.7T/7T MRI, PET-CT, SPECT, FMT, BLI, Animal housing service, Multimodality imaging and image fusion, Quantitative image analysis and processing, Animal surgical services, Radiochemistry, Histopathology, Data Management, In vivo confocal microscopy.

The Mouse Imaging Program (MIP) at the Center for Systems Biology is a uniquely integrated imaging resource providing the larger Harvard/MIT research community with access to state-of-the-art in vivo imaging technologies. The program offers magnetic resonance imaging (MRI), positron emission tomography (PET-CT), single photon emission computed tomography (SPECT-CT), computed tomography (CT), bioluminescence (BLI), fluorescence mediated tomography (FMT), and various other fluorescence imaging technologies. The fully integrated program also provides mouse holding facilities for serial imaging, surgery, anesthesia and veterinary care. Image reconstruction, 3D display, fusion, quantitative image analysis and online data access are also available. The program performs its own research, aimed at continuously improving existing imaging technologies and has deep knowledge of cardiovascular, oncology and neurological mouse models of disease. A list of publications made possible by utilizing MIP resources is available on the Program web site. Imaging requests may be submitted through the MIP website.

Proper citation: MGH Mouse Imaging Program (RRID:SCR_009925) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-9143-a911-55da-381e80000000

Core facility that provides the following services: Offline assisted or self-performed analysis.

The HSCI-CRM Flow Cytometry Core Facility seeks to provide high quality, accessible cytometry sorting and analysis services to laboratories in the Center for Regenerative Medicine, Harvard Stem Cell Institute, and MGH research communities at an affordable rate. The Core''s equipment and highly trained operators provide an advanced level of sorting and analysis services to its investigators. Additionally, the Core is dedicated to training users on all aspects of flow cytometry, including practical issues, information about specific applications, and critical interpretation of sorting results. The Core''s three full-time staff members strive to ensure that each investigator''s visit benefits their individual experiments to the greatest extent possible. To ensure the best availability to all users, the Core offers an online scheduling system, and provides extended sorting hours until late evening. HSCI faculty have reduced pricing for use of the Core''s services.

Proper citation: MGH HSCI-CRM Flow Cytometry Core Facility (RRID:SCR_009923) Copy   

•   Source: SciCrunch Registry

https://med-upenn.corefacilities.org/service_center/show_external/4515

Core provides full service whole genome and targeted molecular profiling of DNA and RNA on multiple platforms. The Facility offers a range of cost and performance options suitable for a variety of experimental projects. While the Facility staff performs most of the assays, investigator-performed studies are actively encouraged through the sharing of Facility procedures, individualized training of investigators or their technical staff, and use of core equipment.

Proper citation: University of Pennsylvania Molecular Profiling Facility (RRID:SCR_010014) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/00000138-b423-f2be-9cd7-d7e280000000

The High-Performance Computing (HPC) Facility provides the hardware and staff to support bioinformatics and biocomputational research. The central component of this facility is a large cluster of 64 high-speed compute nodes, along with approximately 900 terabyte of shared disk storage and nearly 1.8 petabytes of archival storage.

Proper citation: University of Pennsylvania High-performance Computing (RRID:SCR_010016) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/00000142-13cf-cf71-91c7-0c6080000000

In the Interventional Radiology Catheter Lab minimally invasive procedures are performed via fluoroscopy, ultrasound and endoscopy. Percutaneous vein and arterial access is performed via ultrasound-guided technique. Surgeons are then able to guide catheters, ballon dilation, and other small instrumentation through the blood vessels. Procedures that have been performed in the lab are: * Angiography * Aneurysm creation * Balloon angioplasty * Embolization (coil, glue, embospheres) * Inferior vena Cava (IVC) filter placement & retrieval * Selective arterial catheterization * Stent placement (renal, gastric, iliac) * Peroral gastroenteric anastomosis This lab has capabilities for full surgical and anesthesia protocols and full fluoroscopy imaging. Included in the lab are a small office space, an LCD monitor and computer for the fluoroscopy unit, eye wash station and a surgeon scrub sink.

Proper citation: Penn Interventional Radiology Animal Catheter Lab (RRID:SCR_010019) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012d-c96b-3791-4882-b08d80000000

The Clinical Genetic Research Facility (CGRF) offers clinical investigators a convenient, modern research-dedicated facility for outpatient studies involving genetics. Our outpatient exam rooms and phlebotomy rooms are fully equipped and offer investigators an experienced medical assistant to facilitate the visit. Since the CGRF?s primary mission is to support and promote genetic clinical research, the facility?s investigators performing genetic studies supported by non-commercial sponsors are given priority. The CGRF also considers genetic studies sponsored by industry, as well as studies without a genetic component, on a space-available basis.

Proper citation: MGH CHGR Clinical Genetic Research Facility (RRID:SCR_009917) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-9766-17f0-55da-381e80000000

Core facility that provides the following services: DNA extraction from blood and cell lines.

This facility provides processing of cell lines, human blood and tissue samples for DNA, plasma and buffy coat storage and for initiation of lymphoblast and fibroblast cell lines in furtherance of the CHGR mission to promote the use of genetic strategies in basic and clinical research.

Proper citation: MGH CHGR DNA and Tissue Culture Resource (RRID:SCR_009918) Copy   

•   Source: SciCrunch Registry