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http://harvard.eagle-i.net/i/00000139-4a28-1319-4d8e-943b80000000

The Partners Research Computing Core was created by Enterprise Research Infrastructure & Services (ERIS) to offer dedicated services, consultation, and support within the teaching hospitals. Please check the service catalog as new services are added, or contact us if you need a consultation. Initial discussion is at no charge.

Proper citation: Harvard Partners Research Computing Core (RRID:SCR_009861) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000013e-8557-6524-8a53-38db80000000

There is a growing need for animal models to carry out in vivo developmental and regenerative medicine studies of human cells, tissues and organs. The Humanized Neonatal Mouse Center (HNMC) was created to accelerate research in the stem cell field by providing humanized mouse models to study human stem cell engraftment and differentiation in regenerative medicine. We have over 4 years of experience in constructing different types of humanized mouse models, including neonatal heart, lung and kidney injury models. We have extensive experience in hematopoietic stem cell reconstruction. It is our goal at HNMC to facilitate collaborative research in human stem cell biology, where physiologically relevant microenvironments (niches) may be created in vivo to study human stem cell fate and function under experimental settings where disease, damage or degenerative conditions can be controlled. We can provide customized humanized mouse models to the HSCI research community, to collaborate on research studies of common interest, and to advance the general use of these models for a broad range of translational and preclinical studies.

Proper citation: HSCI Humanized Neonatal Mouse Center (RRID:SCR_009815) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/00000141-ec2a-514f-89f9-43eb80000000

Core facility that provides the following services: Project Consultation, CADD Design, and Fabrication. We have many years of experience designing and manufacturing custom tools for medical research. This has allowed us to compile a large collection of different solutions to a wide range of problems. We work on a daily basis with researchers working in these areas of medical science: * Cell Biology * Genetics * Anesthesiology Research * Surgical Research * Pathology Research * Respiratory Biology * Environmental Sciences

Proper citation: HMS Systems Biology Quad Machine Shop (RRID:SCR_009812) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012b-00c3-414f-db6e-7a3f80000000

Core facility that provides the following services: Protein identification from SDS-PAGE gel bands/spots (Coomassie stained level of protein), Protein phosphorylation service, TCA samples service. The Taplin Biological Mass Spectrometry Facility opened in February 2001 as a core facility for the analysis of proteins and peptides by mass spectrometry. The facility is focused on serving the needs of investigators at Harvard Medical School (HMS) and all the Harvard affiliated Institutions.

Proper citation: HMS Taplin Mass Spectrometry Core Facility (RRID:SCR_009813) Copy   

•   Source: SciCrunch Registry

https://nic.med.harvard.edu/

Core facility that provides the following services: User-based microscopy service, Live Specimen Imaging, Widefield Fluorescence, Spinning Disk Confocal Microscopy, Laser Scanning Confocal, Color Imaging, Image Analysis, Microinjection, Phase Contrast and Differential Interference Contrast (DIC), Photo-bleaching, Photo-activation, & Laser Ablation, Microfluidic Perfusion, Imaging and microscopy training. The mission of the NIC@HMS is to: enhance basic research by providing access to state-of-the-art microscopy and imaging equipment, provide training courses on basic and advanced light microscopy techniques for the benefit of HMS and the greater Boston research community, introduce the latest innovations in light microscopy and imaging to the HMS community, serve as a learning center for our corporate partners and contributions, and provide a dedicated NIC@HMS director for ongoing technical consultation and support.

Proper citation: HMS Nikon Imaging Center (RRID:SCR_009810) Copy   

•   Source: SciCrunch Registry

http://jsu.eagle-i.net/i/0000012a-86f9-8ca4-8463-ad4580000000

The Visualization Core Laboratory / GIS Remote Core Laboratories were established to bond existing capabilities and talents in the areas of Geographic Information Systems (GIS), Remote Sensing (RS) and Scientific Visualization (Sci-Viz) and co-locate them in a centralized facility. This created an infrastructure of technology, data, people and institutional linkages that enables the discovery, evaluation and application of geospatial and visual data for adding value to research across various areas and disciplines. The GIS/RS laboratories support the development, enhancement and transfer of GIS/RS applications, make geospatial data available and accessible and promote research and development innovation among users. The Sci-Viz laboratory supports the need of scientists and researchers relative to modeling, program application development and production of high quality advanced visualizations for all fields or disciplines. The TLGVRC addresses human resource development to ensure a skilled workforce which is vital for sustenance of any high level technology activity.

Proper citation: JSU Remote Sensing Core Laboratory (RRID:SCR_009898) Copy   

•   Source: SciCrunch Registry

http://jsu.eagle-i.net/i/0000012a-c931-8969-0055-c4eb80000000

Core facility that provides the following services: Genomics service, Proteomics services, Functional assays service, Cell culture services, Stress enzyme analysis. The specific aims of the MCB Core Laboratory are: To provide a variety of services and technical support in molecular biology and DNA technology by offering equipment access, expert advice, demonstration of techniques, operation of equipment, participation in discussion and data interpretation, and hands-on-training in molecular biology and cell culture; to increase faculty training in recombinant DNA technology to strengthen faculty development and technology transfer; to provide a research environment and instrumentation for investigators to pursue biomedical research opportunities and enhance overall research productivity; to foster collaborative research relationships among RCMI investigators and other MCB core users at JSU and other research intensive institutions.

Proper citation: JSU Molecular and Cellular Biology Core Laboratory (RRID:SCR_009896) Copy   

•   Source: SciCrunch Registry

http://xula.eagle-i.net/i/00000135-81af-5452-a9f8-d64580000000

Core facility that provides the following services: Mass spectrometry services. The mission of Proteomics Core Facility is to help researchers advance their biomedical research programs. The Facility is equipped with gel electrophoresis units, image analyzers and digitizers, and robotics for mass spectrometry sample preparation. Currently, a Matrix-Assisted Laser Desorption/Ionization Mass Spectrometer instrument implements protein identification. The various applications include the studies of protein expression profile, posttranslational modifications, and partial sequencing of novel proteins. The staff also consult with researchers about their particular research interests and assist with the development of specific applications and solution to problems.

Proper citation: LCRC Proteomics Core Facility (RRID:SCR_009894) Copy   

•   Source: SciCrunch Registry

http://jsu.eagle-i.net/i/0000012b-00bb-9e00-3984-bcfb80000000

Core facility that provides the following services: Nanoindenter strain test service, UTM strain test service, Topography transmission electron microscopy service, Topography environmental scanning electron microscope service, Electron microscopy sample preparation service. The specific aims of the Electron Microscope Core Laboratory are: To provide investigators with access to microscopy instruments necessary for ultrastructural research in all the STEM areas; to train faculty, staff, and students on relevant methods in ultrastructural research; to help faculty, staff, and students on relevant approaches to address research questions involving morphological characterization; to improve JSU competitiveness in the innovative field of electron microscopy-based research.

Proper citation: JSU Electron Microscope Core Laboratory (RRID:SCR_009892) Copy   

•   Source: SciCrunch Registry

http://jsu.eagle-i.net/i/0000012a-c928-8ae0-0055-c4eb80000000

Core facility that provides the following services: Electron paramagnetic resonance (EPR) spectroscopy service. The specific aims of the MMR are to: 1. Provide high field FT-NMR spectrometers for all RCMI investigators and other researchers who need structural determination tools in their research. High field NMR spectrometers are key instruments in organic chemistry including biomedical and environmental research. Two high field FT-NMR spectrometers in the MMR Core Facility are made available for JSU researchers and off-campus users. 2. To offer technical support to users who need to apply NMR technology in their research but lack expertise. The sophisticated technology in NMR spectroscopy will be available for organic chemists as well as novice users and researchers from the biomedical and environmental areas. The MMR Core facility will host numerous workshops for new users including faculty and new graduate students.

Proper citation: JSU Molecular Magnetic Resonance Core Laboratory (RRID:SCR_009893) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/00000130-08de-721d-de5a-673e80000000

Core facility that provides the following services: Confocal microscopy.

Confocal microscopy offers multiple benefits compared to conventional microscopy, particularly the ability to collect serial, high-resolution optical sections from thick specimens. Multicolor, three-dimensional images can be obtained, providing high-content information from single images. To assist NERCE investigators from throughout the region, NERCE has established a Confocal Microscope Facility at the University of Massachusetts Medical School. Funding through the NERCE has procured a state-of-the-art LEICA SP2 AOBS laser scanning confocal microscope, which combines spectrophotometric detection with confocal microscopy. The instrument is located at the BL2+ facility at the Lazare Research Building, at the University of Massachusetts Medical School, Worcester, MA. The use of live cell imaging combined with green fluorescent protein (GFP) technology is an exciting methodology with which to study the interactions between infectious agents and living cells. A variety of applications are amenable to confocal microscopy techniques and include: monitoring the localization of proteins in living or fixed cells, monitoring changes in the cellular distribution of proteins, and monitoring changes in the activation status and morphological changes in cells exposed to infectious agents.

Proper citation: HMS NERCE Confocal Microscope Resource (RRID:SCR_009805) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012c-c7b2-aa59-a061-4a6580000000

Core facility that provides the following services: Imaging system training, Live cell imaging.

Live-cell imaging is a powerful method that enables investigators to observe cellular trafficking events with a high degree of spatial and temporal resolution, including visualization of individual bacteria or viral particles engaged in the process of infecting eukaryotic cells. A quantitative description of bacterial and viral invasion mechanisms can be obtained through such approaches. NERCE has provided funding to support the use of live-cell imaging for any New England investigator studying NIAID priority pathogens and agents of emerging infectious disease. Investigators interested in working with the Live-Cell Imaging core laboratory should complete the Imaging Core Request Form and send it to Gerald Beltz. There are no fees for use of the live-cell imaging core for research related to NIAID priority pathogens and agents of emerging infectious disease. Please note that since the NERCE program will end in February 2014, our ability to support new requests for services is limited.

Proper citation: HMS NERCE Live-cell Imaging Core (RRID:SCR_009806) Copy   

•   Source: SciCrunch Registry

http://jsu.eagle-i.net/i/0000012a-2505-aadb-b307-36d480000000

Core facility that provides the following services: Flow cytometry and microarray training service. The Cellomics and Toxicogenomics Research Laboratory (CTRL) has been established to provide RCMI investigators and other JSU faculty and students with state-of-the art instrumentation that would allow them to perform laser-based flow cytometric analysis and cell sorting, as well as microarray analysis of gene expression in connection to human diseases. Hence, the application of flow cytometry and modern genomic DNA microarray-based technology is providing an excellent opportunity to CTRL users to examine alterations in gene expression patterns associated with environmental exposure, as well as to study the molecular mechanisms and biochemical effects associated with cellular responses to toxic exposures.(http://www.jsums.edu/cset/rcmi/ctrl.htm)

Proper citation: JSU Cellomics and Toxicogenomics Research Core Laboratory (RRID:SCR_009889) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-01e7-f2ed-b2b9-4d8780000000

The molecular electron microscopy facility at Harvard Medical School is predominantly used for our own research and can therefore not be considered a service facility. We are, however, committed to make our technology available to as many research groups in the community as possible. If you are interested to use molecular electron microscopy, please contact us by phone or email.

Proper citation: HMS Molecular Electron Microscopy Facility (RRID:SCR_009802) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/00000142-0084-cc9f-89f9-43eb80000000

Core facility that provides the following services: Instrument operation and data analysis.

Instrumentation for this facility includes an Agilent 6520 Accurate-Mass quadrupole time-of-flight (Q-TOF) LC/MS system with great mass accuracy, mass resolution, and sensitivity for small molecule mass identification/quantitation and metabolomics experiments. It is equipped with an Agilent 1200 series HPLC with DAD UV/V is detection for normal flow LC/MS and nitrogen CID for MS/MS. The Q-TOF LC/MS is located in laboratory of Dr. Suzanne Walker in the Department of Microbiology and Immunobiology.

Proper citation: HMS Microbiology and Immunobiology Biological Chemistry Mass Spec Facility (RRID:SCR_009800) Copy   

•   Source: SciCrunch Registry

http://jsu.eagle-i.net/i/0000012a-2505-e99e-b307-36d480000000

Core facility that provides the following services: Spectrofluorometry service, FTIR service, Atomic absorption spectrometry service, Raman spectrometry service, Gas chromatography service, GC/MS service, HPLC service, LC/MS/MS service, Capillary electrophoresis/mass spectrometry service, FPLC service. The Analytical Core Laboratory objectives are to: 1) provide spectroscopic and chromatographic equipment to investigators of pilot projects in the RCMI Program as well as investigators in other programs in the College of Science, Engineering and Technology for their research needs, 2) to acquire new analytical instruments as well as computers and printers to satisfy the needs of the user community, 3) to respond to the needs for obtaining analytical information in a timely manner, 4) To offer workshops for using major equipment including LC/MS/MS, CE/MS/MS, LC-ICP/MS, Raman microscope system, and FT-IR as well as other conventional instruments at least once each semester for each instrument.

Proper citation: JSU Analytical Core Laboratory (RRID:SCR_009885) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-6e37-beec-55da-381e80000000

Core facility that provides the following services: Hematology/immunology assay service. The major objective of the Specialized Assay Core is to create greater efficiency by providing radioimmunoassays (RIAs), enzyme-linked immnosorbent assays (ELISA), bead based multiplex assays, and other basic biochemical assays to support human and animal studies performed by individual investigators at the Joslin Diabetes Center and external users who do not have access to Core Facilities. The Core allows more economic use of expensive or limited materials, provides for training of junior investigators, fosters interactions among research fellows and provides a basis for generating productive collaborative studies between institutions.

Proper citation: JDC Specialized Assay Core (RRID:SCR_009884) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-c086-517c-cb22-be8c80000000

The main objective of the Joslin''s Media Core is to reduce the cost and labor of making tissue culture media and other reagents required by the Joslin investigators. By centralizing preparation of these reagents, the Core provides high quality reagents at a significantly reduced cost to the investigators. In addition, the Core provides services to overcome labor intensive reagent needs, like plate pouring services and preparation of specialized buffers and reagents for cell and molecular studies. The Media Core makes and provides over 10 different mammalian tissue culture media to the Joslin investigators for their studies. In addition, the Core prepares and provides several buffers and solutions to the Joslin investigators. The core also makes a variety of broths and agars for growing bacterial cultures, and provides agar plates and plate pouring service to the investigators. Over the past five years (2006-2010), by preparing and providing over 6250 liters of media and 2850 agar plates per year to the Joslin investigators the Media Core serves an important function in the efforts of these investigator to find cure for diabetes and its complications.

Proper citation: JDC Media Core (RRID:SCR_009882) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012b-00c0-1e2d-db6e-7a3f80000000

Core facility that provides the following services: Complex protein mixture analysis service, Project consultation service, Data analysis service, Protein identification service, Posttranslational modification site determination service, N-terminal Edman Sequence Analysis Service, C-terminal sequence analysis service, De novo sequence analysis service, Quantitative proteomics service, Labeled quantitative proteomics - SILAC, Labeled quantitative proteomics - ICAT service, Labeled quantitative proteomics - iTRAQ service, Labeled quantitative proteomics - AQUA service, Intact molecular weight determination service, Low resolution GC/MS service, Low resolution GC/MS/MS service, Exact mass MS & MS/MS electrospray for structural elucidation service. The FAS Center for Systems Biology Mass Spectrometry and Proteomics Resource Laboratory provides mass spectrometry and strategic consulting in Proteomics and Small Molecule analysis for Life Science and Chemistry researchers as well as others worldwide. This resource brings together the state-of-the-art expertise and instrumentation of the Microchemistry and Proteomics, CCB Mass Spectrometry, and Bauer Center Core laboratories, leveraging our breadth of experience to provide the best possible support for your research.

Proper citation: Harvard FAS Bauer Core: Mass Spectrometry and Proteomics Core Laboratory (RRID:SCR_009837) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/00000130-756e-db1e-1971-4f2080000000

Core facility that provides the following services: Nanofabrication cleanroom and instrumentation access, instrument training, staff assistance. The Center for Nanoscale Systems'' Nanofabrication Facility (CNS-NF), offers resource and staff support for fabricating and characterizing nanoscale devices and structures. The facility currently operates the 10,000 sq.ft. LISE Cleanroom with leading-edge equipment capable of electron-beam and optical lithography, physical and chemical vapor deposition, dry and wet processing, metrology, and device characterization.

Proper citation: Harvard CNS Nanofabrication Facility (RRID:SCR_009832) Copy   

•   Source: SciCrunch Registry