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http://harvard.eagle-i.net/i/0000012c-654b-2967-c437-ff0b80000000

Core facility that provides the following services: Fluorescence in situ hybridization.

The CytoGenomics Core provides an invaluable technical resource to the investigators of the BWH, MGH, and affiliated institutions. Services are also available to external academic and commercial laboratories; these should contact us via our website for sample submission and pricing. Cytogenetic studies can provide insight into regions of the genome that are pathogenetic in various neoplasms leading to an understanding of the molecular pathways participating in the biology of cancer. It is appropriate to consider cytogenetics as a fundamental adjunct to a variety of investigations underway, including basic and clinical research. For example, a rather simple cytogenetic analysis of mouse ES cells to determine ploidy prior to injections into blastulas leads to a greater success rate in establishing founders for knock-out and knock-in experiments. The primary chromosomal assignment of a gene by a FISH experiment may lead to correlation of a disease with that gene. Other cytogenetic studies may be important in establishing a diagnosis for correlation with clinical outcome. The advent of molecular probes for FISH analysis has facilitated cytogenetic studies in the mouse, and other model organisms and this Core aggressively implements such technologies. In addition to state-of-the-art analyses for human samples, the BWH CytoGenomics Core also performs routine mouse karyotyping and a variety of other molecular cytogenetic analyses, services not easily obtainable elsewhere.

Proper citation: BWH CytoGenomics (RRID:SCR_009681) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012c-64ed-0030-c437-ff0b80000000

Biostatistics support is available to investigators in the Brigham and Women''s and Harvard Medical research community for statistical consulting on issues such as study design and data analysis for manuscripts and grant applications. Resources are limited, so planning ahead is essential. The Biostatistics Consulting Service is part of the Biostatistics Core of the BWH Center for Clinical Investigation (CCI).

Proper citation: BWH Biostatistics Center (RRID:SCR_009680) Copy   

•   Source: SciCrunch Registry

http://www.med.upenn.edu/idom/drc/cores/cellbio.html

Core that gives support including experimental design, islet isolation, and performance of and training in an expansive range of assays for physiological and morphometric assessment of pancreatic islet function and growth. It contributes to the basic and translational research activities of the Institute of Diabetes, Obesity and Metabolism (IDOM) at the Perelman School of Medicine of the University of Pennsylvania. Its services include perform individual islet and single cell fluorescence imaging, respirometry with islet batches using a Seahorse Extracellular Flux Analyzer, perifusion coupled with respirometry, and closed respirometry experiments for our investigators.

Proper citation: University of Pennsylvania School of Medicine Penn Diabetes Research Center Pancreatic Islet Cell Biology Core Facility (RRID:SCR_008265) Copy   

•   Source: SciCrunch Registry

http://eagle-i.itmat.upenn.edu/i/00000139-4f55-f0f9-eb5b-b63c80000000

Core facility that provides the following services: Laser confocal microscope access. Penn Dental Medicine houses a Radiance 2100 laser confocal microscope available for use by researchers throughout the School as well as others inside and outside the University.

Proper citation: Penn Laser Confocal Microscope Core (RRID:SCR_009533) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-3502-595e-550e-f59280000000

An Core facility

Proper citation: HSPH Organic Chemistry Laboratory (RRID:SCR_008280) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/00000137-e1a0-4fec-d807-77a880000000

The Weld Hill Growth Facilities consist of 12 individually controlled greenhouses and several types of Conviron growth chambers for precise control of growing conditions.

Proper citation: Arnold Arboretum of Harvard University: Weld Hill Growth Facilities (RRID:SCR_009649) Copy   

•   Source: SciCrunch Registry

http://www.itmat.upenn.edu/ctsa/acard/

A core facility in the Center for Pharmacoepidemiology Research and Training created to foster epidemiologic research into therapeutics, using large population-based automated claims databases (Medicaid/Medicare) and medical records databases (GPRD and THIN), and the FDA''s adverse event reporting system (FAERS) database. Goals: * Encourage investigators with diverse training to conduct studies focused on translational therapeutics and drug safety * Provide access to large databases that allow for rapid and cost-effective research on therapeutics and drug safety * Foster collaboration with CTSA sites outside of Penn who wish to use these databases for clinical research

Proper citation: Penn Automated Claims and Medical Record Databases (RRID:SCR_009643) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-357f-dcfa-550e-f59280000000

Equipment access: All new users must be trained by the facility manager over two orientation sessions and be approved to use the equipment in the facility. All users must obtain the financial approval from their PI and financial manager. Please submit a PO number or the Harvard billing code prior to the first use of the facility.

Proper citation: HSPH Molecular Analysis Facility (RRID:SCR_008273) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012a-2517-1d49-5617-794280000000

Core facility that provides the following services: Data acquisition service, Data storage service.

The Research Electronic Data Collection Core can help you capture research data by supporting all aspects of data acquisition, storage and retrieval. The core is designed to significantly improve the efficiency, cost structure and overall quality of research data collection. The Data Collection Core will provide expert services including: study forms design and implementation; training in all aspects of using TELEform software; database construction and exporting / preparing data for statistical applications such as SAS and SPSS; and technical assistance with scanners and computers running electronic form capture process.

Proper citation: BIDMC eData Collection Core (RRID:SCR_009679) Copy   

•   Source: SciCrunch Registry

http://alaska.eagle-i.net/i/00000130-4c48-c245-67ac-ce7680000000

Core facility that provides the following services: Stable isotope analysis service. The Alaska Stable Isotope Facility is a state-of-the-art laboratory conducting stable isotope analyses of wide range of sample types for researchers from all over Alaska, the USA and the globe. Sample types include organic samples (C, N, O and H isotopes), inorganic samples (e.g. carbonate for C and O) and water (O and H).

Proper citation: UAF Alaska Stable Isotope Facility (RRID:SCR_009556) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012a-2519-e7a3-5617-794280000000

Core facility that provides the following services: Mouse breeding service, Mouse genotyping service, Tail vein injections service, Tissue service, Cancer mouse model service, Human tumor xenografts service.

Proper citation: BIDMC Preclinical Murine Pharmacogenetics Core (RRID:SCR_009675) Copy   

•   Source: SciCrunch Registry

http://bidmc.org/Research/CoreFacilities/MassSpectrometryCore.aspx

Core facility that provides the following services: Mapping of post-translational modifications by LC/MS/MS, Protein (complex) identification by LC/MS/MS, Relative quantification of peptides by LC/MS/MS, SILAC, iTRAQ, and Isotope-free ratio quantification service, Metabolomics profiling service.

The Mass Spectrometry Core Facility has been serving the BIDMC community since 2004. We specialize in a targeted mass spectrometry based proteomics approach for isolated proteins and protein complexes, especially phosphorylation and other post-translational modifications involved in cellular signaling using cutting edge instrumentation. Our trained staff offers the highest quality and reliable service with meticulous attention to detail for each sample. We routinely provide services including protein identification, post-translational modification mapping, and relative peptide/protein quantification by stable isotope labeling and label free methods using highly sensitive microcapillary LC/MS/MS techniques at nanoliter flow rates. Several different types of mass spectrometry are utilized depending upon the needs of the researcher including a fast scanning and highly sensitive 2D linear ion trap and a high resolution/high mass accuracy LTQ-Oribitrap mass spectrometer acquired in 2007. In 2005, in agreement with Harvard Medical School''s Pathology Dept., the BIDMC Mass Spectrometry Core became part of the NRB Mass Spectrometry and Proteomics Core, expanding its services and became part of the Cancer Proteomics Core for the Dana Farber Harvard Cancer Center. We serve all institutions regardless of affiliation and have an interest in samples related to many diseases such as cancer and diabetes.

Proper citation: BIDMC Mass Spectrometry Core (RRID:SCR_009672) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/00000131-09f6-d7d6-6a45-990480000000

Core facility that provides the following services: Multi-Gene transcriptional profiling (MGTP) service.

Multi-Gene Transcriptional Profiling (MGTP) is a real-time PCR based technique, developed in our lab, for quantifying mRNA copy numbers per cell with high reproducibility and accuracy. Primary Goals of the MGTP Core: * To make MGTP services available to investigators, and assist them in advancing their research and obtaining grants; * To assist studies of molecular signaling mechanisms and pathways, discovery of biomarkers, and development of clinical assays; and * To share the resources of our primer library, which currently includes about 2400 pre-validated human, and mouse genes. The MGTP Core makes these unique and powerful capabilities available to biomedical researchers. Thousands of pre-validated primers are available for use, and others can be designed on demand.

Proper citation: BIDMC Multi-Gene Transcriptional Profiling Core (RRID:SCR_009673) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012a-2513-1465-5617-794280000000

Core facility that provides the following services: User-based microscopy service, Microscopy training service. The Imaging Core provides access to standard digital and laser scanning confocal microscopy, multiphoton microscopy, unbiased stereology, and automated confocal microscopy for large scale genome-wide screens. In addition, the Core has substantial capabilities in quantitative and three-dimensional volumetric image reconstruction.

Proper citation: CHB Cellular Imaging Core (RRID:SCR_009671) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012a-2519-627b-5617-794280000000

Core facility that provides the following services: DNA sequencing service.

The BIDMC DNA Sequencing Facility is equipped with an ABI 3130xl Automated DNA Sequencer. Turn around time is 24 hours: drop off samples by 10am (at CLS-426E or SL-232) and obtain results by 11am of the following day. Some results can be posted the same day of sample submission. Sample pick up is available in Longwood Medical Area - please send requests by email. Also available through the BIDMC DNA sequencing core to the Harvard Research community is the newest model of the Arcturus Laser Capture Microdissection System!

Proper citation: BIDMC DNA Sequencing Core (RRID:SCR_009664) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012a-2519-7352-5617-794280000000

Core facility that provides the following services: Adult cardiac myocyte isolation service, Adult rat cardiac myocyte cultures service, Animal maintenance service, Aortic banding surgery service, Echocardiography service, Hind limb ischemia surgery service, I/R surgery service, Invasive cardiac output measurement service, Laser Doppler service, MI surgery service, Special animal care maintenance service, Tail vein blood collection service, Telemetric BP monitoring service.

The goal of Cardiac Physiology Core is to provide expertise in evaluation of cardiac pathology for non-cardiovascular and cardiovascular researchers who are not equipped for such analysis. The core provides non-invasive and invasive evaluation of cardiac physiology that may be difficult or time-consuming for those investigators without proper expertise, experience and equipments.

Proper citation: BIDMC Cardiac Physiology Core Laboratory (RRID:SCR_009662) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-5977-000a-55da-381e80000000

The Community Practice Research Core (CPRC) provides DF/HCC investigators access to a racially diverse population of over 11,000,000 patients within the community-based clinical practices of Harvard Vanguard Medical Associates (HVMA)/ Atrius Health, a Boston-based medical specialty group comprised of over 20 office locations across eastern Massachusetts providing care to more than 510,000 adult and pediatric patients; Harvard Pilgrim Health Care (HPHC), one of the largest health maintenance organizations in New England with close to 1,000,000 members and an extensive provider network that includes physicians who practice in a variety of settings; the Cancer Research Network is comprised of 9 health care systems and 6 affiliate sites across the nation with a total membership of 11,000,000 patients. The populations of HVMA/Atrius, HPHC, and the CRN are particularly ideal for studies: (1) involving basic, clinical, and population sciences; (2) addressing diverse communities; (3) investigating dissemination of proven technologies and interventions; (4) requiring large samples of patients and/or providers; (5) involving rare cancers; and (6) of cancer prevention.

Proper citation: DF/HCC Community Practice Research Core (RRID:SCR_009735) Copy   

•   Source: SciCrunch Registry

http://harvard.eagle-i.net/i/0000012e-5d8c-a118-55da-381e80000000

Core provides all of the tools of modern functional proteomics. Equipped with technologies for proteomics; protein profiling, protein identification, protein and peptide fractionation, and quantization. Personalized experimental design consultation, comprehensive individualized bioinformatics support. The mission of the DF/HCC Cancer Proteomics Core is to develop a comprehensive and interdisciplinary proteomics core for High Sensitivity, High Resolution and High Throughput Proteomics with particular emphasis on in depth proteomic consultation, referral to the optimal proteomics facility and a strong focus on clinical sample analysis. The core combines consultation, service and education into a comprehensive, translationally and clinically oriented proteomics core.

Proper citation: Dana Farber and Harvard Cancer Center Cancer Proteomics Center (RRID:SCR_009733) Copy   

•   Source: SciCrunch Registry

http://ccny-cuny.eagle-i.net/i/00000137-4cd7-8ff5-bb24-040880000000

Basic research equipment for RCMI Faculty

Proper citation: CCNY RCMI Core Facility (RRID:SCR_009698) Copy   

•   Source: SciCrunch Registry

http://ccny-cuny.eagle-i.net/i/00000137-4cd8-9a02-bb24-040880000000

The microscopy center is a shared central facility whose primary goal is to promote scientific research by providing training in basic operation of the scanning electron microscope (SEM), the transmission electron microscope (TEM) and the Confocal.RRRRR RRRRR New users of the facility are asked to submit an application then schedule an appointment with the manager to discuss the project or to begin training.

Proper citation: CCNY Microscopy Facility (RRID:SCR_009697) Copy   

•   Source: SciCrunch Registry