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Non profit bioscience research organization in Seattle, Washington dedicated to accelerating research globally and sharing that data within the science community. Allen Institute for Brain Science, Allen Institute for Cell Science, Allen Institute for Immunology, and The Paul G. Allen Frontiers Group are four divisions of this Institute with commitment to open science model within its research institutes.
Proper citation: Allen Institute (RRID:SCR_005435) Copy
http://www.massgeneral.org/children/services/treatmentprograms.aspx?id=1614
The Lurie Center for Autism is a highly successful program designed to evaluate and treat children and adults with a wide variety of developmental and handicapping conditions. Our mission is to provide the highest quality clinical, social and support services to those diagnosed with autism, pervasive developmental disorders and other developmental disabilities. The Lurie Center for Autism is unique because of the population it serves and because it uses a multidisciplinary approach that begins with comprehensive medical evaluations and extends to supporting the well-being of patients and families. Nurses, social workers, speech pathologists, occupational therapists, physical therapists, neuro-psychologists, special education professionals and family members are involved in the treatment processes in addition to physicians. Each has a depth of expertise in his/her respective field. The team, as a unit, plays an integral role in the continuum of care for individuals diagnosed with developmental disabilities. Our services and therapies include: * Extensive diagnostic evaluations * Medical, cognitive and behavioral interventions including speech and language * Speech therapy, occupational therapy, occupational with sensory integration therapy and physical therapy; psychological evaluation and counseling; * Parent skills training and family empowerment * Referral support for additional medical and educational resources at locations near each patient''s home and throughout the New England region The Lurie Center for Autism is committed to improving the medical, social and psychological well-being of children, adolescents, adults and families. To this end, our goals and objectives are to: * Provide a stable, consistent and structured environment within a medical context * Provide opportunities for each individual to achieve * Develop self control, social skills and self esteem in each individual * Support and educate families in order to transfer the learned skills to home, school, work and community environments * Provide teaching to physicians and professionals in training and to pursue research related to the treatment and causes of autism, pervasive developmental disorders and other devlopmental disorders of the central nervous system
Proper citation: Lurie Center for Autism (RRID:SCR_005456) Copy
The primary mission of the Nancy Lurie Marks (NLM) Family Foundation is to help people with autism lead fulfilling and rewarding lives. The Foundation is committed to understanding autism from a scientific perspective, increasing opportunities and services available to the autism community and educating the public about autism. In pursuit of its mission, the Foundation develops and provides grants to programs in research, clinical care, policy, advocacy and education. Founded by Nancy Lurie Marks over 25 years ago, the NLM Family Foundation is one of the largest supporters of initiatives in these areas. The principal goal of the scientific program is to achieve a deeper understanding of the biological basis of autism, focusing on genetics, synaptic chemistry, the neurobiology of communication, systems biology and the physiology of movement. The Foundation funds peer-reviewed research, the development of collaborative investigator projects, and research fellowship programs. Through sponsorship of scientific conferences, symposia and workshops, the Foundation seeks to encourage innovation and provide a springboard to generate new avenues of shared inquiry. The NLM Family Foundation supports programs which focus on novel ways to improve the communication and social abilities of those with autism. Other programs are designed to increase advocacy for legal rights and access to support services for persons with autism, and to increase community understanding and openness to inclusion through education and documentary films.
Proper citation: Nancy Lurie Marks Family Foundation (RRID:SCR_005455) Copy
http://www.musicianbrain.com/#index
The human brain has the remarkable ability to adapt in response to changes in the environment over the course of a lifetime. This is the mechanism for learning, growth, and normal development. Similar changes or adaptations can also occur in response to focal brain injuries, e.g., partially-adapted neighboring brain regions or functionally-related brain systems can either substitute for some of the lost function or develop alternative strategies to overcome a disability. Through ongoing research, the Music and Neuroimaging Laboratory''s mission is to: * Reveal the perceptual and cognitive aspects of music processing including the perception and memory for pitch, rhythmic, harmonic, and melodic stimuli. * Investigate the use of music and musical stimuli as an interventional tool for educational and therapeutic purposes. * Reveal the behavioral and neural correlates of learning, skill acquisition, and brain adaptation in response to changes in the environment or brain injury in the developing and adult brain. * Reveal the determinants and facilitators for recovery from brain injury. Project topics include: Aphasia Therapy, Singing and Speaking, Tone Deafness / Congenital Amusia, Motor Recovery Studies, Music and Emotions, Music and Autism, Children and Music Making, Brain Stimulation, Adult Musician Studies, Absolute Pitch Studies, Acute Stroke Studies
Proper citation: Music and Neuroimaging Laboratory (RRID:SCR_005447) Copy
The Beautiful Brain explores the latest findings from the ever-growing field of neuroscience through monthly long-form essays, reviews, galleries, short-form blog posts and more, with particular attention to the dialogue between the arts and sciences. The site illuminates important new questions about creativity, the mind of the artist, and the mind of the observer that modern neuroscience is helping us to answer, or at least to provide part of an answer. Instances where art seeks to answer questions of a traditionally scientific nature are also of great interest, and for that reason you will hear from artists as well as scientists on The Beautiful Brain. The Beautiful Brain Podcast also explores the latest findings from the ever-growing field of neuroscience, with particular attention to the dialogue between the arts and sciences. In this monthly program, host Noah Hutton reports on news from the world of brain science, interviews important thinkers about their work, and reviews new literature in the field. The show illuminates important new questions about creativity, the mind of the artist, and the mind of the observer that modern neuroscience is helping us to answer, or at least to provide part of an answer. Instances where art seeks to answer questions of a traditionally scientific nature are also of great interest, and for that reason you will hear from artists as well as scientists on The Beautiful Brain. Subscribe today to receive a brand new episode each month.
Proper citation: Beautiful Brain (RRID:SCR_005472) Copy
The GNIF is a non-profit charity organization for the advancement of neurological and mental health patient welfare, education, and research. We aim to further brain related studies, end mental health stigmatization and discrimination, improve the well-being of afflicted individuals, promote the free and open-access distribution of brain related information, and institute universal and multidisciplinary distance educational programs. The paramount GNIF mission is the betterment of neurological and mental health patient welfare, education, and research. With the development of novel free and open-access Therapeutic Recreational Centers, health promotion campaigns, and other charitable activities throughout the world, this organization can aid diagnosed individuals and their advocates. By presenting free and open-access information and educational courses via a distance, the GNIF aims to educate clinicians, teachers, scientists, patients, and the general public on neuroscience, medicine, psychology, biotechnology, and computer science. Moreover, the GNIF supports a variety of sound research programs ranging from biomedical to spiritual studies on the nature of the mind-body connection, biopsychosocial model of health and disease, and health psychology/behavioral medicine practices. The Global Neuroscience Initiative Foundation (GNIF) offers several projects and partnerships adherent to its missions. The following is an alphabetical listing of the GNIF Project Directory: * Brain Blogger * Brain Sciences & Neuropsychiatry * Distance Education Division * Ethics in Mental Health * Knowledge Center * Living with a Brain Disorder * Neuropsychiatry for Kids * Surgical Webcasts * Therapeutic Recreational Centers * Visual Brain Application
Proper citation: Global Neuroscience Initiative Foundation (RRID:SCR_005468) Copy
Neuromorphometrics provides brain labeling and measurement services. Given raw MRI brain scans, we make precise quantitative measurements of the volume, shape, and location of specific neuroanatomical structures. Web tool for brain measurement services. Used for modeling living human brain and make quantitative measurements of volume, shape, and location of specific neuroanatomical structures using given MRI brain scans. Automated analyses are manually guided, inspected and certified by a neuroanatomical expert. Resource of neuroanatomically labeled MRI brain scans database. Resource for neuroanatomical localization and identification: NeuAtlas.
Proper citation: Neuromorphometrics (RRID:SCR_005656) Copy
http://archive.cnbc.cmu.edu/Resources/disordermodels/index.html
THIS RESOURCE IS NO LONGER IN SERVICE, documented August 23, 2016. This site aims to provide a discussion and source list for connectionist and neural network models of disorders associated with mental or brain conditions. Recent connectionist and neural network models of behavior, information processing patterns, and brain activity present in people with cognitive, affective, brain, and behavioral disorders are reviewed on this web site. Ways that assumptions regarding normal and disordered behavior may be represented in connectionist models are discussed for features of various disorders. Similarities and differences between the models and criteria for their evaluation are presented, and suggestions for inclusion of information which may help to make these models more directly comparable in the future are considered. References to Connectionist Models of Cognitive, Affective, Brain, and Behavioral Disorders include: General Neural Network Information Reviews, General Introductions, and Calls for More Connectionist Models of Mental Disorders Models of Psychopathologies and Psychiatric Disorders Models of Cognitive, Affective, Brain, and Behavioral Disorders Not Associated with Psychopathology Additionally, Web Sites for Neural Network Modelers of Disorder are provided.
Proper citation: Connectionist Models of Cognitive, Affective, Brain, and Behavioral Disorders (RRID:SCR_008088) Copy
THIS RESOURCE IS NO LONGER IN SERVICE, documented on February 07, 2013. A framework for understanding human cognition, grounded in principles specifying the character of human cognitive processes, and constrained by properties, of the underlying neural mechanisms. The Center will exploit this framework to guide formulation of explicit, testable models of normal and disordered cognition, including models of the development of cognitive functions and of their disintegration as a result of brain damage or disease. This site is intended as a public service and as a focal point for exchange of ideas among the participants in the Interdisciplinary Behavioral Science Center (IBSC). Public areas of the site provide information about the Center as a whole and about the various projects in the Center, as well as web-accessible documents and tools that we are making available as a public service. A fundamental tenet is that cognition is an emergent phenomenon, arising from the interactions of cooperating processing elements organized into specialized populations. One aim of the center will be to investigate the utility of explicit models that are formulated in terms of this approach, addressing many aspects of cognition including semantic knowledge, language processing, cognitive control, perception, learning and memory. A second aim will also investigate the principles that are embodied in the models, including principles of learning, processing and representation. Learning will be a central focus, since it plays a crucial role in cognitive development, acquisition of skills, formation of memories, and remediation of cognitive functions. A third aim of the Center will be to incorporate constraints from neuroscience. Findings from neuroscience will guide the specification of the principles and the formulation of domain-specific details of particular models, and will provide target experimental observations against which to assess the adequacy of the models. In addition, the Center will make use of neurophysiological methods in animals and functional brain imaging in humans to test predictions and generate additional data needed to constrain and inform model development. The Center will provide training funds for interdisciplinary research fellowships, to train junior scientists in the convergent use of behavioral, computational, and neuroscience methodologies. The outcome of the Centers efforts will be a fuller characterization of the nature of human cognitive processes, a clearer formulation of the underlying principles, and a more complete understanding of normal and disordered functions across many domains of cognition. This Center includes eight projects dedicated to various aspects of cognition and various general issues that arise in the effort to build explicit models that capture different aspects of cognition, and also includes an administrative core to help foster integration and provide computing resources. * Project 1: Functional and Neural Organization of Semantic Memory * Project 2: Interactive Processes in Language: Lexical Processing * Project 3: Interactive Processes in Language: Sentence Processing * Project 4: Mechanisms of Cognitive Control * Project 5: Interactive Processes in Perception: Neurophysiology of Figure-Ground Organization * Project 6: Basic Mechanisms and Cooperating Systems in Learning Memory * Project 7: Age and Experience Dependent Processes in Learning * Project 8: Theoretical Foundations * Core: Integration, Computational Resources, and Administration
Proper citation: NIMH Interdisciplinary Behavioral Science Center (RRID:SCR_008085) Copy
A research center associated with the University of Pittsburgh that specializes in the diagnosis of Alzheimer's disease and related disorders. The overall objective of the ADRC is to study the pathophysiology of Alzheimer's disease, with the aim of improving the reliability of diagnosis of Alzheimer's and developing effective treatment strategies. Current research foci emphasize neuropsychiatry and neuropsychology, molecular genetics and epidemiology, basic neuroscience, and structural and functional imaging that aid in the diagnosis and treatment of Alzheimer's disease. Specific services at the ADRC include: comprehensive diagnostic evaluation of patients with suspected Alzheimer's disease and other forms of dementia; evaluation of memory, language, judgment, and other cognitive abilities; and education and counseling for patients and families.
Proper citation: University of Pittsburgh Alzheimer Disease Research Center (RRID:SCR_008084) Copy
Atlas of developing human brain for studying transcriptional mechanisms involved in human brain development. Consists of RNA sequencing and exon microarray data profiling up to sixteen cortical and subcortical structures across full course of human brain development, high resolution neuroanatomical transcriptional profiles of about 300 distinct structures spanning entire brain for four midgestional prenatal specimens, in situ hybridization image data covering selected genes and brain regions in developing and adult human brain, reference atlas in full color with high resolution anatomic reference atlases of prenatal (two stages) and adult human brain along with supporting histology, magnetic resonance imaging (MRI) and diffusion weighted imaging (DWI) data.
Proper citation: Allen Human Brain Atlas: BrainSpan (Atlas of the Developing Brain) (RRID:SCR_008083) Copy
Campaign to help educate the public about the symptoms of stroke and the importance of getting to the hospital quickly, with a wide range of materials about stroke prevention, treatment, and rehabilitation available through the site. The campaign includes outreach to consumers and health care professionals using mass media, grassroots outreach, partnerships, and community education.
Proper citation: Know Stroke Campaign (RRID:SCR_008073) Copy
The Centre d''Etude du Polymorphisme Humain (CEPH) is a research laboratory, the main activities of which are the setting up, storage, processing and distribution of DNA collections for the identification of genetic factors conferring susceptibility to complex disorders. These collections are established in partnership and full collaboration with external French or international research groups. The Foundation currently hosts the CEPH reference panel, the HGDP panel (Human genome Diversity Cell Line Panel) and several collections amounting mid-2008 to more than 250 000 samples. The goal of CEPH is to understand complex multifactorial disorders necessitates the establishment of structures facilitating access to large and integrated collection of individuals, characterized by a large number of variables emanating from different technologies and platforms. To achieve this goal, CEPH facilitates the setting up of integrated analyses combining clinical, genetic and environmental data, for the identification of susceptibility factors to complex multifactorial disorders Additionally, CEHP allows the reception, storage, processing and distribution of biological sample collections. At the same time, it promotes and participates in the design and setting up of genetic studies: - in partnership and full collaboration with external research groups - giving access to a large number of variables - in a sufficient number of subjects - allowing large scale integrated analyses
Proper citation: Centre dEtude du Polymorphisme Humain (RRID:SCR_008026) Copy
An animated primer on the basics of DNA, genes, and heredity organized around three key concepts: Classical Genetics, Molecules of Genetics, and Genetic Organization and Control. The science behind each concept is explained by: animation, image gallery, video interviews, problem, biographies, and links.
Proper citation: DNA From The Beginning: AN Animated Primer on the Basics of DNA, Genes, and Heredity (RRID:SCR_008028) Copy
The E. coli Genome Project has the goal of completely sequencing the E. coli and human genomes. They began isolation of an overlapping lambda clonebank of E. coli K-12 strain MG1655. Those clones served as the starting material in our initial efforts to sequence the whole genome. Improvements in sequencing technology have since reached the point where whole-genome sequencing of microbial genomes is routine, and the human genome has in fact been completed. They initiated additional sequencing efforts, concentrating on pathogenic members of the family Enterobacteriaceae -- to which E. coli belongs. They also began a systematic functional characterization of E. coli K-12 genes and their regulation, using the whole genome sequence to address how the over 4000 genes of this organism act together to enable its survival in a wide range of environments.
Proper citation: E. coli Genome project (RRID:SCR_008139) Copy
http://neuroinformatics.usc.edu/
The USC Brain Project is engaged in the effort to develop new tools and methodologies for neuroinformatics in modeling neural mechanisms of visuomotor coordination and exploring the evolution of the human language-ready brain, as well as conducting work in both neural modeling and database construction in relation to rehabilitation after stroke. Sponsors: USCBP is funded by the University of Southern California.
Proper citation: University of Southern California Brain Project (RRID:SCR_008044) Copy
http://www.scripps.edu/np/inia/index.html
Consortium set out to identify the molecular, cellular, and behavioral neuroadaptations that occur in the brain reward circuits associated with the extended amygdala and its connections. It is hypothesized that genetic differences and/or neuroadaptations in this circuitry are responsible for the individual differences in vulnerability to the excessive consumption of alcohol. Chronic exposure to alcohol results in neuroadaptive phenomena, including tolerance, sensitization, dependence, withdrawal, loss of control of drinking, and relapse that contribute to the development of excessive alcohol consumption. The INIA has the following goals: 1) To establish animal models to study specific neurobiological targets for vulnerability that lead to excessive consumption of alcohol at the molecular, cellular and neural circuit level of analysis, 2) To identify specific clusters of genes whose expression is regulated by alcohol and which are responsible for any given model of excessive alcohol consumption using gene expression arrays, differential display, mutagenesis directed at specific brain areas, and the development of new informatics tools to analyze and interpret gene expression, cellular circuitry and brain circuitry data with the use of transgenic and knockout approaches, and 3) To attract new and innovative investigators to the field of alcohol research by recruiting individuals for development of U01 grants and pilot projects and by developing online interactive capacity among INIA scientists and others, and by making the neuroinformatics integrated data sets accessible, searchable and interactive with other databases for all scientists interested in alcoholism research. The structure of INIA is envisioned as two domains, Dependence-induced drinking and Binge drinking, comprised of multiple U01 research grants. The flow of information within each domain moves from molecular, to cellular, to neurocircuitry levels of analysis. These U01s share information with the core facilities, which act as data depositories. The Administrative Core coordinates the flow of information among the Domains and Cores and disseminates the information back to the U01s. A Pilot Project program will identify exciting new areas for research and the continual recruitment of new investigators to the alcohol field. The INIA program is directed by an Administrative Core in close cooperation with the Animal Models, Gene Array and Neurocircuitry Cores via a Steering Committee and with the continual advice of the Scientific Advisory Committee.
Proper citation: Integrative Neuroscience Initiative on Alcoholism (RRID:SCR_008042) Copy
http://www.nia.nih.gov/research/scientific-resources
A resource that provides information on the vast number of resources available from the National Institute of Aging. NIA maintains approximately 150 primates (Macaca mulatta) at four regional primate centers where aging-related research is conducted. NIA also maintains colonies of aged rats and mice that are used for age-related disease research. This resource supports a multi-institutional study, the Interventions Testing Program (ITP), that investigates diets and dietary supplements that extend lifespan, delay disease and avoid dysfunction. NIA is also in charge of a microarray facility which provides filter arrays of 17,000 mouse cDNA clone sets that were developed at the NIA Intramural Research Program Laboratory of Genetics. NIA supports studies that provide biospecimens that can be shared for later research. This resource also helps the C. elegans Genetic Center at the University of Minnesota, which contains 1,000 strains of C. elegans that can be used for aging studies. This resource also provides a searchable database for epidemiological research on aging. There is access to social and behavioral research materials, including books on aging and health, from the research was conducted and supported by NIA. There are links to federal web sites that are further resources for aging research that were supported by NIA.
Proper citation: NIA Scientific Resources (RRID:SCR_008269) Copy
http://www.vet.ohio-state.edu/211.htm
Laboratory animals are used in nearly half of all research projects supported by the National Institutes of Health. Significant needs exist at the national level for skilled scientists trained to work with and interpret the data generated from the use of rodent animal models. In response to this national need a research training program has been established through funding by the National Centers for Research Resources to provide an environment for veterinarians (D.V.M. or V.M.D.) and D.V.M./Ph.D.''s to effectively utilize mouse models of human disease. Specifically, veterinarian scientists are trained in state of-the-art molecular and cellular techniques to systematically evaluate the mechanistic pathobiology and phenotype of experimental mouse models of human disease. The training program is coordinated through an established graduate program in the College of Veterinary Medicine, Department of VeterinaryBiosciences and supported by a unified group of basic and clinical scientists with ongoing collaborative programs at The Ohio State University and Children''s Hospital. The scientists have expertise in endocrinology, infectious disease, genetics, oncology, molecular biology, immunology, physiology, biochemistry, and pathology. Trainees gain knowledge and skills to fully understand and evaluate pathophysiologic alterations of murine models of human disease through both didactic coursework and applied training in pathology and molecular biology. In addition, trainees interact with our multidisciplinary faculty to identify the range of research problems that use murine models. They acquaint themselves with the ongoing basic and clinical research studies in the laboratories and clinical sites of the participating faculty, and select a research problem that utilizes a murine model for endpoint evaluation. Following the selection of a preceptor and research problem, the trainee participates in the design and performance of experiments, as well as analysis and presentation of data regarding a murine model. Trainees develop skills in clinical, gross, and histologic pathology, molecular and immunologic techniques, and use transgenic and immunodeficient mouse models to identify and characterize alterations in embryonic and postnatal development. Therefore, trainees acquire a broad background in molecular biology, genetics, pathology, laboratory animal medicine, as well as research design methodology to fulfill national needs in the development of skilled scientists in mouse pathobiology. :Sponsors: Mouse Pathology Training Grant is funded by the National Centers for Research Resources.
Proper citation: Mouse Pathology Training Grant (RRID:SCR_008300) Copy
A portal to educate, engage and create an online community. The Fisher Center for Alzheimer''s Research Foundation, founded in 1995, was created in answer to the recommendations of three U.S. Senate commissioned symposia held in the 1990s by the National Institutes of Health (NIH) to gather information on the cause, care and cure of Alzheimer''s disease. The Fisher Center was created following this design. The funding initiatives of the Foundation are appropriated accordingly to the three areas cited by the NIH task force cause, care and cure. The primary resources of the Foundation are directed toward scientific research into the cause and hopefully the cure of Alzheimer''s disease. To this end, the Foundation under the direction of its founder, Zachary Fisher, and in collaboration with David Rockefeller, constructed the Fisher Center for Alzheimer''s Disease Research at The Rockefeller University, headed by 2000 Nobel Prize winner, Paul Greengard, Ph.D. The 10,000 square foot laboratory is the most advanced facility of its kind in the country equipped with the latest in equipment necessary to undertake an interdisciplinary assault on this disease. The Fisher Center also has collaborative programs at the University of Genoa and supports the work of well over 60 scientists and researchers across the United States and in 17 foreign countries. The Foundation also funds projects for the care of people with Alzheimer''s disease and their caregivers. The Fisher Alzheimer''s Disease Education and Resources Program at the New York University School of Medicine was established under the direction of Barry Reisberg, M.D., internationally known expert in the care of Alzheimer''s patients. The Foundations Alzheimer''s Information Program was created in 2001 to answer the primary need of caregivers for comprehensive, easily accessible information. Our goals are to: Understand the Cause of Alzheimer''s To find a Cure for this devastating disease Improve the Care of people living with the disease to enhance their quality of life and that of their caregivers and families About Our Research Beating Back Beta Amyloid Improving the Quality of Life for Alzheimers Patients Reversing Nerve Cell Damage Using Hormones to Slow the Progress of Disease Curing Early-Onset Alzheimers The Science of Caregiving Scientific Studies
Proper citation: Fisher Center For Alzheimers Research Foundation: ALZinfo.org (RRID:SCR_008255) Copy
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Welcome to the Neuroscience Information Framework Project, designed to serve the biomedical research community. NIF maintains the largest searchable collection of neuroscience data, the largest catalog of biomedical resources, and the largest ontology for neuroscience on the web. We welcome all feedback and suggestions and are actively looking for resource providers to make their resources accessible through NIF. Learn about the tools available to help you share your data and discover a dynamic inventory of Web-based neuroscience resources.
