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| Resource Name | Proper Citation | Abbreviations | Resource Type |
Description |
Keywords | Resource Relationships | |||||||||||||
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New York Obesity Nutrition Research Center Animal Phenotyping Core Resource Report Resource Website |
New York Obesity Nutrition Research Center Animal Phenotyping Core (RRID:SCR_015414) | core facility, access service resource, service resource, resource | Core that allows investigators to efficiently and cost effectively define the phenotypes of small rodents in ways that are relevant to the study of obesity, nutrition, and metabolism. Its services range from whole animal measurements of body composition and energy utilization, to ex vivo measurements of substrate fluxes, to histological analyses of adipose tissue. | animal phenotyping, adipose tissue, body composition analysis |
is listed by: NIDDK Information Network (dkNET) has parent organization: Columbia University; New York; USA has parent organization: New York Obesity Nutrition Research Center is organization facet of: New York Obesity Nutrition Research Center |
Obesity | NIDDK P30DK026687 | Available to the research community, Acknowledgement requested | SCR_015414 | 2026-02-14 02:07:58 | 0 | ||||||||
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MMPC Vanderbilt University School of Medicine Body Weight Regulation Core Resource Report Resource Website |
MMPC Vanderbilt University School of Medicine Body Weight Regulation Core (RRID:SCR_015905) | core facility, access service resource, service resource | Core facility for MMPC Vanderbilt University School of Medicine for studying impact of genetic, surgical, dietary and pharmacologic manipulations on body weight regulation. Core provides measurement of food intake, energy expenditure, and behavioral factors. Energy balance studies are performed in mouse home cage to minimize stress. Mitochondrial function is assessed on permeabilized tissues, isolated cells, or isolated mitochondria. Mouse models of bariatric surgery have been developed and studied extensively. | mouse, body, weight, regulation, nutrition, medicine | is organization facet of: MMPC-Vanderbilt University School of Medicine | NIDDK DK135073; NIDDK DK020593 |
SCR_015923 | https://labnodes.vanderbilt.edu/resource/view/id/14699/community_id/1418 | SCR_015905 | Body Weight Regulation Core | 2026-02-14 02:08:30 | 0 | |||||||
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Penn machine learning benchmark repository Resource Report Resource Website |
Penn machine learning benchmark repository (RRID:SCR_017138) | PMLB | data or information resource, data set | Python wrapper for Penn Machine Learning Benchmark data repository. Large, curated repository of benchmark datasets for evaluating supervised machine learning algorithms. Part of PyPI https://pypi.org/ | benchmark, suite, machine, learning, evaluation, comparison, repository, curated, dataset | NIAID AI116794; NIDDK DK112217; NIEHS ES013508; NEI EY022300; NHLBI HL134015; NLM LM009012; NLM LM010098; NLM LM011360; NCATS TR001263; Warren Center for Network and Data Science |
PMID:29238404 | Free, Restricted | https://github.com/EpistasisLab/penn-ml-benchmarks | SCR_017138 | Penn Machine Learning Benchmark | 2026-02-14 02:08:01 | 0 | ||||||
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Stanford Diabetes Research Center Diabetes Clinical and Translational Core Resource Report Resource Website 1+ mentions |
Stanford Diabetes Research Center Diabetes Clinical and Translational Core (RRID:SCR_016212) | DCTC, SDRC-DCTC | core facility, access service resource, service resource | With the following services from the Diabetes Clinical and Translational Core (DCTC), members will receive training in biospecimen preservation, study design, data analysis, data management, use of statistical software and clinical trial conduct. | diabetes, clinical, translation, specimen, study, design, data, statistic |
is related to: Stanford Diabetes Research Center Diabetes Genomics Analysis Core is organization facet of: Stanford Diabetes Research Center |
NIDDK P30 DK116074 | SCR_016212 | Diabetes Clinical and Translational Core, Clinical and Translational Core, SDRC Diabetes Clinical and Translational Core | 2026-02-14 02:08:39 | 1 | ||||||||
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Stanford Diabetes Research Center Diabetes Immune Monitoring Core Resource Report Resource Website |
Stanford Diabetes Research Center Diabetes Immune Monitoring Core (RRID:SCR_016210) | DIMC, SDRC-DIMC | core facility, access service resource, service resource | Core facility that provides immune monitoring assays at the RNA, protein, and cellular level, as well as archiving, reporting, and data mining support for clinical and translational studies related to Diabetes. The DIMC is a specialized subcore of the Human Immune Monitoring Center (HIMC) at Stanford. | diabetes, assay, immune, system, clinical, translational, human, data |
is related to: Stanford Diabetes Research Center Diabetes Genomics Analysis Core is organization facet of: Stanford Diabetes Research Center |
NIDDK P30 DK116074 | SCR_016210 | Diabetes Immune Monitoring Core, SDRC Diabetes Immune Monitoring Core | 2026-02-14 02:08:30 | 0 | ||||||||
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Stanford Diabetes Research Center Stanford Islet Research Core Resource Report Resource Website |
Stanford Diabetes Research Center Stanford Islet Research Core (RRID:SCR_016211) | SIRC, SDRC-SIRC | core facility, access service resource, service resource | Core facility whose services include: Islet Isolation, Islet transplantation, Islet Culture, Islet Perifusion & Islet Hormone Assays. The SIRC is supported by the Stanford Diabetes Research Center (SDRC). | islet, isolation, transplant, culture, perifusion, assay, hormone |
is related to: Stanford Diabetes Research Center Diabetes Genomics Analysis Core is organization facet of: Stanford Diabetes Research Center |
NIDDK P30 DK116074 | SCR_016211 | SDRC Stanford Islet Research Core, Stanford Islet Research Core | 2026-02-14 02:08:08 | 0 | ||||||||
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University of Colorado Diabetes Research Center Resource Report Resource Website |
University of Colorado Diabetes Research Center (RRID:SCR_022897) | nonprofit organization | Center to facilitate diabetes research at University of Colorado by integrating interdisciplinary basic, translational, and clinical diabetes research base; providing infrastructure and resources that are indispensable for continued discovery and progress towards diabetes research and developing improved prediction and disease prevention;providing P&F and enrichment programs to support DRC investigators and their trainees, and recruit new and young investigators into diabetes research. | diabetes, clinical diabetes research, infrastructure and resources |
is related to: University of Colorado Denver; Colorado; USA is related to: University of Colorado Anschutz Medical Campus Diabetes Research Center Disease Modeling Core Facility is related to: University of Colorado Anschutz Medical Campus Diabetes Research Center Clinical Resource Core Facility is related to: University of Colorado Anschutz Medical Campus Diabetes Research Center Tissue Procurement and Processing Core Facility is related to: University of Colorado Anschutz Medical Campus Diabetes Research Center Cell and Tissue Analysis Core Facility has parent organization: University of Colorado; Colorado; USA |
NIDDK P30DK116073 | SCR_022897 | 2026-02-14 02:04:59 | 0 | ||||||||||
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North Carolina Diabetes Research Center Resource Report Resource Website |
North Carolina Diabetes Research Center (RRID:SCR_022896) | NCDRC | nonprofit organization | Interactive regional diabetes research community across four premiere research institutions in North Carolina, who currently garner over $70 million annually for support of their diabetes research: Duke University (Duke), The University of North Carolina at Chapel Hill (UNC), Wake Forest School of Medicine (WF), and North Carolina A&T State University (NC A&T State). NCDRC supports Research Cores that represent unique strengths at each institution. | Interactive regional diabetes research community |
is parent organization of: North Carolina Diabetes Research Center Metabolomics Core Facility is parent organization of: North Carolina Diabetes Research Center Advanced Clinical Study Methods Core Facility is parent organization of: North Carolina Diabetes Research Center Genomics and Proteomics Core Facility |
NIDDK P30DK124723 | SCR_022896 | 2026-02-14 02:04:42 | 0 | |||||||||
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University of Chicago Digestive Diseases Research Core Center Resource Report Resource Website 1+ mentions |
University of Chicago Digestive Diseases Research Core Center (RRID:SCR_015601) | DDRCC | data or information resource, organization portal, portal, training resource | Center whose goals include fostering collaboration among basic and clinical investigators, facilitating the use of new technologies in the study of treatment of digestive diseases, and providing education and training for improved treatment and diagnosis. | DDRCC, digestive disease, uchicago |
is listed by: NIDDK Information Network (dkNET) is parent organization of: University of Chicago Digestive Diseases Research Core Center Integrated Translational Research Core is parent organization of: University of Chicago Digestive Diseases Research Core Center Administrative Core is parent organization of: University of Chicago Digestive Diseases Research Core Center Host-Microbe Core is parent organization of: University of Chicago Digestive Diseases Research Core Center Tissue and Cell Imaging Core is parent organization of: University of Chicago Digestive Diseases Research Core Center Tissue Engineering and Cell Models Core has organization facet: University of Chicago Digestive Diseases Research Core Center Administrative Core has organization facet: University of Chicago Digestive Diseases Research Core Center Integrated Translational Research Core has organization facet: University of Chicago Digestive Diseases Research Core Center Tissue Engineering and Cell Models Core has organization facet: University of Chicago Digestive Diseases Research Core Center Host-Microbe Core has organization facet: University of Chicago Digestive Diseases Research Core Center Tissue and Cell Imaging Core is organization facet of: Digestive Disease Centers |
digestive disease | NIDDK P30 DK042086 | Available to the research community | SCR_015601 | 2026-02-14 02:05:08 | 1 | |||||||
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Diabetes Prevention Program Resource Report Resource Website |
Diabetes Prevention Program (RRID:SCR_001501) | DPP | bibliography, clinical trial, resource, data or information resource, database | Multicenter clinical research study aimed at discovering whether modest weight loss through dietary changes and increased physical activity or treatment with the oral diabetes drug metformin (Glucophage) could prevent or delay the onset of type 2 diabetes in study participants. At the beginning of the DPP, all 3,234 study participants were overweight and had blood glucose levels higher than normal but not high enough for a diagnosis of diabetesa condition called prediabetes. In addition, 45 percent of the participants were from minority groups-African American, Alaska Native, American Indian, Asian American, Hispanic/Latino, or Pacific Islander-at increased risk of developing diabetes. The DPP found that participants who lost a modest amount of weight through dietary changes and increased physical activity sharply reduced their chances of developing diabetes. Taking metformin also reduced risk, although less dramatically. In the DPP, participants from 27 clinical centers around the United States were randomly divided into different treatment groups. The first group, called the lifestyle intervention group, received intensive training in diet, physical activity, and behavior modification. By eating less fat and fewer calories and exercising for a total of 150 minutes a week, they aimed to lose 7 percent of their body weight and maintain that loss. The second group took 850 mg of metformin twice a day. The third group received placebo pills instead of metformin. The metformin and placebo groups also received information about diet and exercise but no intensive motivational counseling. A fourth group was treated with the drug troglitazone (Rezulin), but this part of the study was discontinued after researchers discovered that troglitazone can cause serious liver damage. The participants in this group were followed but not included as one of the intervention groups. In the years since the DPP was completed, further analyses of DPP data continue to yield important insights into the value of lifestyle changes in helping people prevent type 2 diabetes and associated conditions. For example, one analysis confirmed that DPP participants carrying two copies of a gene variant, or mutation, that significantly increased their risk of developing diabetes benefited from lifestyle changes as much as or more than those without the gene variant. Another analysis found that weight loss was the main predictor of reduced risk for developing diabetes in DPP lifestyle intervention group participants. The authors concluded that diabetes risk reduction efforts should focus on weight loss, which is helped by increased exercise. | prevention, lifestyle, metformin, intervention, dietary change, physical activity, minority, african-american, alaska native, american indian, asian american, hispanic, latino, pacific islander, male, female, slide, adult human, late adult human, dna |
is listed by: ClinicalTrials.gov is listed by: NIDDK Information Network (dkNET) is listed by: NIDDK Central Repository has parent organization: George Washington University; Washington D.C.; USA |
Type 2 diabetes, Prediabetes, Overweight, Non-insulin-dependent diabetes mellitus | NIDDK 1ZIADK075078-04 | Free, Freely available | nlx_152799 | SCR_001501 | 2026-02-14 02:05:03 | 0 | ||||||
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TIGER Data Portal Resource Report Resource Website 10+ mentions |
TIGER Data Portal (RRID:SCR_023626) | disease-related portal, data or information resource, portal, topical portal | Resource enables integrative exploration of genetic and epigenetic basis of development of Type 2 Diabetes, together with other associated functional, molecular and clinical data, centered in biology and role of pancreatic beta cells.The gene expression regulatory variation landscape of human pancreatic islets. | Type 2 Diabetes, genetic and epigenetic, functional data, molecular data, clinical data, pancreatic beta cells. | is related to: T2DSystems | Type 2 Diabetes | European Union Horizon 2020 ; Spanish government ; Swiss State Secretariat for Education‚ Research and Innovation ; American Diabetes Association Innovative and Clinical Translational Award ; Research England ; Wellcome Trust ; NIDDK U01 DK105535; NIDDK U01 DK085545 |
PMID:34644572 | SCR_023626 | Translational Human Pancreatic Islet Genotype Tissue-Expression Resource | 2026-02-14 02:05:12 | 18 | |||||||
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nPOD TCR/BCR Search Resource Report Resource Website 1+ mentions |
nPOD TCR/BCR Search (RRID:SCR_015851) | data or information resource, database | Database of sequence data generated from high-throughput immunosequencing of the TCR beta chain (TRB) and B cell receptor (BCR) immunoglobulin heavy chain (IGH). This data comes from cells from NPOD donors. | tcr, bcr, beta chain, tcr beta chain, b cell receptor, immunosequencing, immunoglobulin heavy chain, igh | Adaptive Biotechnologies ; NIAID P01 AI42288; NIDDK R01 DK096492; NIDDK R01 DK106191; NIDDK U01 DK104147; NIDDK UC4 DK104194; NIDDK U01 DK104162; NIDDK R01 DK099317; Juvenile Diabetes Research Foundation 1-2008-994; Juvenile Diabetes Research Foundation 27-2012-450; Juvenile Diabetes Research Foundation 2-2012-280; Juvenile Diabetes Research Foundation 25-2013-268; Helmsley Charitable Trust |
PMID:27942583 | Freely available, Acknowledgement requested | SCR_015851 | TCRBCR Search, TCR/BCR Search, nPOD TCRBCR Search | 2026-02-14 02:06:23 | 3 | ||||||||
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Pancreatlas Resource Report Resource Website 10+ mentions |
Pancreatlas (RRID:SCR_018567) | data or information resource, atlas | Collection of human pancreas data and images. Platform to share data from human pancreas samples. Houses reference datasets from human pancreas samples, achieved through generosity of organ donors and their families. | Human pancreas data, pancreas image, reference dataset, human pancreas sample, organ donor pancreas data |
lists: Exeter Archival Diabetes Biobank (EADB) is related to: Vanderbilt University; Tennessee; USA is related to: Human Islet Research Network (HIRN) works with: Exeter Archival Diabetes Biobank (EADB) |
Type 1 diabetes, Diabetes, Type 2 diabetes, Cystic Fibrosis-Related Diabetes | Leona M. and Harry B. Helmsley Charitable Trust ; NIDDK DK104211; NIDDK DK108120; NIDDK DK112232; NIDDK DK106755; NIDDK DK20593; NCI CA68485; NIDDK DK58404; NIDDK DK59637; NEI EY08126 |
Free, Freely available | SCR_018567 | 2026-02-14 02:06:25 | 10 | ||||||||
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Chronic Renal Insufficiency Cohort Study Resource Report Resource Website 1+ mentions |
Chronic Renal Insufficiency Cohort Study (RRID:SCR_009016) | CRIC Study, CRIC | biomaterial supply resource, material resource | A prospective observational national cohort study poised to make fundamental insights into the epidemiology, management, and outcomes of chronic kidney disease (CKD) in adults with intended long-term follow up. The major goals of the CRIC Study are to answer two important questions: * Why does kidney disease get worse in some people, but not in others? * Why do persons with kidney disease commonly experience heart disease and stroke? The CRIC Scientific and Data Coordinating Center at Penn receives data and provides ongoing support for a number of Ancillary Studies approved by the CRIC Cohort utilizing both data collected about CRIC study participants as well as their biological samples. The CRIC Study has enrolled over 3900 men and women with CKD from 13 recruitment sites throughout the country. Following this group of individuals over the past 10 years has contributed to the knowledge of kidney disease, its treatment, and preventing its complications. The NIDDKwill be extending the study for an additional 5 years, through 2018. An extensive set of study data is collected from CRIC Study participants. With varying frequency, data are collected in the domains of medical history, physical measures, psychometrics and behaviors, biomarkers, genomics/metabolomics, as well as renal, cardiovascular and other outcomes. Measurements include creatinine clearance and iothalamate measured glomerular filtration rate. Cardiovascular measures include blood pressure, ECG, ABI, ECHO, and EBCT. Clinical CV outcomes include MI, ischemic heart disease-related death, acute coronary syndromes, congestive heart failure, cerebrovascular disease, peripheral vascular disease, and composite outcomes. The CRIC Study has delivered in excess of 150,000 bio-samples and a dataset characterizing all 3939 CRIC participants at the time of study entry to the NIDDKnational repository. The CRIC Study will also be delivering a dataset to NCBI''''s Database for Genotypes and Phenotypes. | clinical, epidemiology, management, outcome, adult human, medical history, physical measure, psychometrics, behavior, renal, biomarker, genomics, gwas, kidney, data sharing, bibliography, observational cohort study, male, female, cardiovascular, heart, kidney, risk factor, metabolomics |
is listed by: One Mind Biospecimen Bank Listing is listed by: NIDDK Information Network (dkNET) is listed by: NIDDK Research Resources is listed by: Diabetes Research Centers is related to: NCBI database of Genotypes and Phenotypes (dbGap) is related to: NIDDK Central Repository is related to: AASK Clinical Trial and Cohort Study has parent organization: University of Pennsylvania Perelman School of Medicine; Pennsylvania; USA |
Chronic kidney disease, Cardiovascular disease | NIDDK | Proposals to carry out ancillary studies are welcome | nlx_152758 | SCR_009016 | Chronic Renal Insufficiency Cohort (CRIC) Study | 2026-02-14 02:07:06 | 2 | |||||
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Irritable Bowel Syndrome Outcome Study Resource Report Resource Website |
Irritable Bowel Syndrome Outcome Study (RRID:SCR_001504) | IBSOS | clinical trial, resource | Multi-center placebo-controlled randomized clinical trial to assess the short-term and long-term efficacy of cognitive behavior therapy (CBT) for irritable bowel syndrome (IBS) using two treatment delivery systems: self administered CBT and therapist administered CBT. Long term project goals are to develop an effective self-administered behavioral treatment program that can enhance the quality of patient care, improve clinical outcomes, and decrease the economic and personal costs of one of the most prevalent and intractable gastrointestinal disorders. | gastrointestinal disorder, cognitive behavior therapy, self-management, self-administered |
is listed by: NIDDK Information Network (dkNET) has parent organization: University at Buffalo; New York; USA |
Irritable bowel syndrome | NIDDK 5U01DK077738-07 | PMID:22846389 | Free | nlx_152839 | SCR_001504 | 2026-02-14 02:07:49 | 0 | |||||
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Folic Acid for Vascular Outcome Reduction in Transplantation Resource Report Resource Website 1+ mentions |
Folic Acid for Vascular Outcome Reduction in Transplantation (RRID:SCR_001505) | FAVORIT | clinical trial, resource | Multi-center, randomized, double blind controlled clinical trial to determine whether treatment with a standard multivitamin augmented with high doses of folic acid, vitamin B6 and vitamin B12 reduces the rate of cardiovascular disease outcomes in renal transplant recipients relative to participants receiving a similar multivitamin that contains no folic acid. This study hopes to show that by reducing the level of homocysteine in the body, the risk of heart disease is also reduced among kidney transplant patients. | multivitamin, folic acid, vitamin b6, vitamin b12, outcome, homocysteine, adult human, middle adult human, late adult human, vitamin, bibliography |
is listed by: ClinicalTrials.gov is listed by: NIDDK Information Network (dkNET) has parent organization: University of North Carolina at Chapel Hill; North Carolina; USA |
Cardiovascular disease, Kidney transplant recipient | NIDDK U01DK061700 | PMID:16923411 | Free, Freely available | nlx_152827 | http://www.cscc.unc.edu/favorit/ | http://www.cscc.unc.edu/favorit/favdescrip.htm | SCR_001505 | Folic Acid for Vascular Outcome Reduction in Transplantation (FAVORIT) | 2026-02-14 02:07:18 | 1 | ||
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Family Investigation of Nephropathy of Diabetes Resource Report Resource Website |
Family Investigation of Nephropathy of Diabetes (RRID:SCR_001525) | FIND, F.I.N.D. | clinical trial, resource | Multicenter observational study designed to identify genetic determinants of diabetic nephropathy. It is conducted in eleven U.S. clinical centers and a coordinating center, and with four ethnic groups (European Americans, African Americans, Mexican Americans, and American Indians). Two strategies are used to localize susceptibility genes: a family-based linkage study and a case-control study using mapping by admixture linkage disequilibrium (MALD). In the family-based study, probands with diabetic nephropathy are recruited with their parents and selected siblings. Linkage analyses will be conducted to identify chromosomal regions containing genes that influence the development of diabetic nephropathy or related quantitative traits such as serum creatinine concentration, urinary albumin excretion, and plasma glucose concentrations. Regions showing evidence of linkage will be examined further with both genetic linkage and association studies to identify genes that influence diabetic nephropathy or related traits. Two types of MALD studies are being done. One is a case-control study of unrelated individuals of Mexican American heritage in which both cases and controls have diabetes, but only the case has nephropathy. The other is a case-control study of African American patients with nephropathy (cases) and their spouses (controls) unaffected by diabetes and nephropathy; offspring are genotyped when available to provide haplotype data. The specific goals of this program: * Delineate genomic regions associated with the development and progression of renal disease(s) * Evaluate whether there is a genetic link between diabetic nephropathy and diabetic retinopathy * Improve outcomes * Provide protection for people at risk and slow the progression of renal disease * Help establish a resource for genetic studies of kidney disease and diabetic complications by creating a repository of genetic samples and a database * Encourage studies of the genetics of progressive renal disease | genetic susceptibility, genetic pathway, renal, kidney, outcome, gene, genetics, european-american, african-american, mexican-american, american-indian, linkage association study, admixture linkage disequilibrium, mapping by admixture linkage disequilibrium, serum creatinine, urinary protein excretion, plasma glucose level, blood pressure, blood lipid level, trait, linkage, adult human, male, female, clinical |
is listed by: ClinicalTrials.gov is listed by: NIDDK Information Network (dkNET) has parent organization: NIDDK - National Institute of Diabetes and Digestive and Kidney Diseases |
NIDDK 5R01DK053591 | PMID:15642484 | Free, Freely available | nlx_152825 | https://www.niddkrepository.org/studies/find/ | SCR_001525 | Family Investigation of Nephropathy and Diabetes (F.I.N.D.), Family Investigation of Nephropathy & Diabetes | 2026-02-14 02:07:49 | 0 | ||||
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HALT PKD Resource Report Resource Website 1+ mentions |
HALT PKD (RRID:SCR_001529) | HALT PKD, HALT-PKD | clinical trial, resource | Consortium established to design and implement clinical trials of treatments that might slow the progressive loss of renal function in Polycystic Kidney Disease (PKD). Two multicenter randomized, double-blind, placebo controlled clinical trials are running concurrently to study the efficacy of renin-angiotensin-aldosterone system blockade on the progression of cystic disease (kidney volume) and on the decline in renal function in autosomal dominant polycystic kidney disease (ADPKD). Study A is to study whether intensive ACE-I/ARB blockade decrease the progression of cystic disease compared to ACE-I monotherapy patients with early disease, relatively preserved renal function, and high-normal BP or hypertension. Study B is to study whether intensive ACE-I/ARB blockade as compared to ACE-I monotherapy slow the decline in kidney function, end-stage of renal disease, or death in the setting of standard blood pressure control in hypertensive patients with moderately advanced disease. | treatment, renal function, lisinopril, placebo, telmisartan, male, female, adolescent, adult human |
is listed by: ClinicalTrials.gov is listed by: NIDDK Information Network (dkNET) is listed by: NIDDK Research Resources has parent organization: Washington University School of Medicine in St. Louis; Missouri; USA |
Polycystic kidney disease, Autosomal dominant polycystic kidney disease | NIDDK 5U01DK062408 | Free, Freely available | nlx_152832 | https://www.niddkrepository.org/studies/halt-pkd/ | http://www.pkd.wustl.edu/pkdtn/ | SCR_001529 | Polycystic Kidney Disease-Treatment Network | 2026-02-14 02:07:45 | 1 | |||
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Clinical Islet Transplantation Study Resource Report Resource Website 1+ mentions |
Clinical Islet Transplantation Study (RRID:SCR_001515) | CIT Study | clinical trial, resource | Network of centers to conduct studies of islet transplantation in patients with type 1 diabetes to improve the safety and long-term success of methods for transplanting islets. It is the aim of this trial to improve methods of isolating islets, to improve techniques for the administering those transplanted islets; and to develop approaches to minimize the toxic effects of immunosuppressive drugs required for transplantation. | islet transplantation, islet, insulin, beta cell, pancreas, autoimmune, clinical | is listed by: NIDDK Information Network (dkNET) | Type 1 diabetes, Diabetes | NIDDK U01DK070431 | Free, Freely available | nlx_152840 | SCR_001515 | Clinical Islet Transplantation Trial, Islet Transplantation Trials for Type 1 Diabetes | 2026-02-14 02:07:27 | 4 | |||||
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RiVuR Resource Report Resource Website 1+ mentions |
RiVuR (RRID:SCR_001539) | RIVUR | clinical trial, resource | Multicenter, randomized, double-blind, placebo-controlled trial is designed to determine whether daily antimicrobial prophylaxis is superior to placebo in preventing recurrence of urinary tract infection (UTI) in children with vesicoureteral reflux (VUR). The basic eligibility criteria are: (1) age at randomization of at least 2 months, but less than 6 years, (2) a diagnosed first febrile or symptomatic UTI within 42 days prior to randomization that was appropriately treated, and (3) presence of Grade I-IV VUR based on voiding cystourethrogram (VCUG). Patients will be randomly assigned to treatment for 2 years with daily antimicrobial prophylaxis (trimethoprim-sulfamethoxazole) or placebo. The study is designed to recruit 600 children (approximately 300 in each treatment group) over an 18-24 month period. The primary endpoint is recurrence of UTI. In addition, patients will be evaluated for secondary endpoints related to renal scarring and antimicrobial resistance. Scarring will be determined based on renal scintigraphy by 99mTc dimercaptosuccinic (DMSA) scan. Quality of life, compliance, safety parameters, utilization of health resources, and change in VUR will be assessed periodically throughout the study. | child, antimicrobial prophylaxis, placebo, antibiotic, renal scarring, pediatric, trimethoprim-sulfamethoxazole, intervention, kidney, antibiotic resistance, young human, infant, bibliography, clinical, trimethoprim, sulfamethoxazole |
is listed by: ClinicalTrials.gov is listed by: NIDDK Information Network (dkNET) is listed by: NIDDK Research Resources has parent organization: University of North Carolina at Chapel Hill; North Carolina; USA |
Vesico-ureteral reflux, Urinary tract infection | NIDDK | PMID:19570724 PMID:19018048 PMID:18076937 PMID:19018047 PMID:19086141 |
Free, Freely available | nlx_152848 | http://www.cscc.unc.edu/rivur/ | SCR_001539 | Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR), Randomized Intervention for Children with Vesicoureteral Reflux, Randomized Intervention for Vesicoureteral Reflux | 2026-02-14 02:07:49 | 1 |
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