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https://www.uab.edu/medicine/obriencenter/cores/biostatistics-core

Core provides statistical expertise in the conceptualization and design of projects, expertise in data management for the resulting clinical and bioinformatics data, and assistance with the preparation of project reports, presentations and manuscripts.

Proper citation: University of Alabama at Birmingham-University of California San Diego O'Brien Center for Acute Kidney Injury Research Biostatistical Core (RRID:SCR_015283) Copy   

•   Source: SciCrunch Registry

http://sharedresources.fredhutch.org/core-facilities/genomics

THIS RESOURCE IS NO LONGER IN SERVICE.Documented on July 27,2022. Core facility that provides expertise and support for generating genomics-based data. Services for DNA arrays, genetic analysis, and high-throughput screening are provided through three specialized laboratories.

Proper citation: Fred Hutchinson Cancer Research Center Co-operative Center for Excellence in Hematology Genomics Shared Resource (RRID:SCR_015327) Copy   

•   Source: SciCrunch Registry

http://obriencenter.yale.edu/mousecelllines.aspx

Core provides services to generate unique in vivo mouse models and kidney specific cell lines.

Proper citation: George M. O'Brien Kidney Center at Yale Mouse Genetics and Cell Line Core (RRID:SCR_015299) Copy   

•   Source: SciCrunch Registry

http://obriencenter.yale.edu/humangenetics.aspx

Core that provides infrastructure support for several key steps in translational research, including development of HIC protocols, patient recruitment, patient DNA extraction and archiving, tools for high throughput SNP genotyping and DNA sequencing, and analysis of genetic linkage and linkage disequilibrium.

Proper citation: George M. O'Brien Kidney Center at Yale Human Genetics and Clinical Research Core (RRID:SCR_015298) Copy   

•   Source: SciCrunch Registry

http://cihd.cores.utah.edu/ironheme/

Core facility that provides analysis of metals, precursor porphyrins and heme for cell pellets, tissue, whole blood, urine, feces and other complex biological materials. It also provides measurements of activity of the enzymes responsible for heme biosynthesis for cell pellets, tissue and blood.

Proper citation: Center for Iron and Heme Disorders at the University of Utah Iron and Heme Core (RRID:SCR_015336) Copy   

•   Source: SciCrunch Registry

http://www.utsouthwestern.edu/research/core-facilities/obrien-kidney/core-services/clinical-translational-core.html

Core whose aim is to translate basic science research into effective diagnostic and therapeutic strategies that will improve the lives of patients by interrupting the pathogenesis of chronic kidney disease and its attendant high risk of cardiovascular disability and death. It combines comprehensive human genetics with phenotyping of subjects.

Proper citation: George M. O'Brien Kidney Research Core Center - UT Southwestern Medical Center Clinical and Translational Core (RRID:SCR_015295) Copy   

•   Source: SciCrunch Registry

http://obriencenter.yale.edu/renalphyscore.aspx

Core provides specialized services and training for assessing renal function in small animals at the level of single tubules in vitro and in vivo (e.g. micropuncture, microperfusion, and tubule-specific microdissection), the whole kidney (e.g. clearance studies in anesthetized animals, perfusion fixation for histology studies), and the intact organism (e.g. balance studies in metabolic cages, acute and chronic BP measurements).

Proper citation: George M. O'Brien Kidney Center at Yale Renal Physiology Core (RRID:SCR_015296) Copy   

•   Source: SciCrunch Registry

https://www.cincinnatichildrens.org/research/divisions/n/nephrology/biomarker-lab

Core whose goals are to provide high throughput Clinical Biofluid Profiling Services (including initial web-based and in-person consultation, study design, sample preparation and processing, data acquisition, data analysis, protein purification, target identification, and specific assay development and validation) and services pertaining to Biomarker measurement and validation (including design of ELISA and Western Blots, measurement of known and emerging markers of acute and chronic kidney diseases, as well as consultation for biomarker statistics and clinical trials design).

Proper citation: Pediatric Centers of Excellence in Nephrology at Cincinnati Children's Hospital Medical Center Biomarker Core (RRID:SCR_015300) Copy   

•   Source: SciCrunch Registry

https://www.med.unc.edu/marsicolunginstitute/core-facilities/histology-core

Core that provides light microscopy services like prosection, tissue fixation, processing, embedding, sectioning, staining and cover slipping of paraffin, frozen and soft plastic tissue sections, as well as specialized and routine fixation, tissues processing, ultramicrotomy, staining, photomicrograph production, and analysis.

Proper citation: Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center Histology Core (RRID:SCR_015385) Copy   

•   Source: SciCrunch Registry

http://www.mayo.edu/research/centers-programs/human-imaging-core/overview

Core provides semiautomated MRI and computed tomography (CT) image and volumetric analyses of polycystic kidneys and liver as well as functional assessment of the kidney and heart, including measurements of renal blood flow. It also facilitates the transmission, collection and storage of anonymized imaging data used in translational PKD research and provides a system that enables PKD researchers to exchange images.

Proper citation: Translational Polycystic Kidney Disease (PKD) Center at Mayo Clinic Rochester Human Imaging Core (RRID:SCR_015304) Copy   

•   Source: SciCrunch Registry

https://www.med.unc.edu/marsicolunginstitute/core-facilities/mousemodelscore

Core that provides support and expertise for mouse colony maintenance, breeding strategies, mouse lung phenotyping protocols, and submission of live-animal applications to maintain compliance with IACUC guidelines.

Proper citation: Cystic Fibrosis and Pulmonary Diseases Research and Treatment Center Mouse Models Core (RRID:SCR_015389) Copy   

•   Source: SciCrunch Registry

https://labnodes.vanderbilt.edu/resource/view/id/10822/community_id/1418

Core that ensures the health and welfare of mouse models by assuring that mice admitted to the MMPC meet defined health criteria and that post-quarantine protocol assignment. It diagnoses disease and identifies unique metabolic or cardiovascular phenotypes of mice through interaction with the Comparative Pathology Subcore.

Proper citation: MMPC-Vanderbilt University School of Medicine Animal Health and Welfare Core (RRID:SCR_015380) Copy   

•   Source: SciCrunch Registry

http://www.uab.edu/medicine/hrfdcc/cores

Core whose goals are to establish a national resource for clinical data, DNA, and tissue biopsies from human patients with HRFDs, develop algorithms to identify causative genetic mutations in HRFD patients and utilize a suite of new tools to assess the pathogenicity of sequence variants, and expand the portfolio of educational information and tools to encompass the HRFD spectrum of disorders.

Proper citation: UAB Hepatorenal Fibrocystic Diseases Core Center Hepato-Renal Fibrocystic Diseases Translational Resource (RRID:SCR_015309) Copy   

•   Source: SciCrunch Registry

https://www.uab.edu/medicine/cysticfibrosis/about/translational-core

Core that provides human primary nasal airway epithelial cells and bronchial airway epithelial cells, expertise in the nasal potential difference measurement, and a means to understand pathogenesis of cystic fibrosis and other metabolic diseases.

Proper citation: Gregory Fleming James Cystic Fibrosis Research Center Cystic Fibrosis Clinical and Translational Core (RRID:SCR_015399) Copy   

•   Source: SciCrunch Registry

https://www.uab.edu/medicine/cysticfibrosis/about/animal-core

Core that assists in mouse line generation by both oocyte micro-injection and by embryonic stem cell gene targeting technologies. It also establishes breeding colonies of cystic fibrosis mice, and genotypes and provides these to UAB investigators and furnishes electrophysiology tests of CFTR activation, including murine nasal potential difference assays and intestinal short circuit current measurements.

Proper citation: Gregory Fleming James Cystic Fibrosis Research Center Cystic Fibrosis Animal Models Core (RRID:SCR_015396) Copy   

•   Source: SciCrunch Registry

http://medicine.iupui.edu/neph/obrien/digital

Core facility which develops and implements software and methods of image segmentation for fluorescence microscopy data.

Proper citation: Indiana O'Brien Center for Advanced Microscopic Analysis Digital Image Analysis Core (RRID:SCR_015276) Copy   

•   Source: SciCrunch Registry

https://www.uab.edu/medicine/cysticfibrosis/about/cftr-expression-core

Core that maintains a repository of reagents for studying CFTR and assists with expression technologies using vaccinia, adenovirus and other methodologies and antibody based detection of cystic fibrosis related gene products.

Proper citation: Gregory Fleming James Cystic Fibrosis Research Center Cystic Fibrosis Transmembrane Conductance Regulator Expression Core (RRID:SCR_015397) Copy   

•   Source: SciCrunch Registry

http://www.uab.edu/medicine/hrfdcc/cores/d

Core goals include to develop in vitro predictive assays to identify and characterize HRFD lead compounds, develop in vivo predictive translational HRFD models to enhance efficacy assessment in preclinical testing, and develop advanced HRFD-specific toxicology and safety screens.

Proper citation: UAB Hepatorenal Fibrocystic Diseases Core Center Therapeutic Screening and Drug Development Resource (RRID:SCR_015314) Copy   

•   Source: SciCrunch Registry

http://medicine.iupui.edu/neph/obrien/probe

Core facility which develops and characterizes methods for expressing fluorescent biosensors in the rodent kidney to be paried with intravital microscopy.

Proper citation: Indiana O'Brien Center for Advanced Microscopic Analysis Probe Delivery Core (RRID:SCR_015274) Copy   

•   Source: SciCrunch Registry

http://www.mmpc.org/shared/showCenterCore.aspx?id=30

Core that provides investigators with services to accurately measure the major components of energy balance in their mouse models and tests that allow investigators to examine physiological factors that may influence food intake or energy expenditure.

Proper citation: MMPC-University of California Davis Energy Balance Exercise and Behavior Core (RRID:SCR_015364) Copy   

•   Source: SciCrunch Registry