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SciCrunch Registry is a curated repository of scientific resources, with a focus on biomedical resources, including tools, databases, and core facilities - visit SciCrunch to register your resource.

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Resource Name Proper Citation Abbreviations Resource Type Description Keywords Resource Relationships Related Condition Funding Defining Citation Availability Website Status Alternate IDs Alternate URLs Old URLs Parent Organization Resource ID Synonyms Record Last Update Mentions Count
ShoRAH
 
Resource Report
Resource Website
10+ mentions
ShoRAH (RRID:SCR_005211) ShoRAH software resource A software package that allows for inference about the structure of a population from a set of short sequence reads as obtained from ultra-deep sequencing of a mixed sample. The package contains programs that support mapping of reads to a reference genome, correcting sequencing errors by locally clustering reads in small windows of the alignment, reconstructing a minimal set of global haplotypes that explain the reads, and estimating the frequencies of the inferred haplotypes. linux, mac os x, windows, next-generation sequencing, c++, python, perl, structure, population, short sequence read, haplotype, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: ETH Zurich; Zurich; Switzerland
PMID:21521499 GNU General Public License, v3 biotools:shorah, OMICS_00231 https://bio.tools/shorah SCR_005211 Short Reads Assembly into Haplotypes, ShoRAH - Short Reads Assembly into Haplotypes 2026-02-07 02:06:37 34
V-Phaser 2
 
Resource Report
Resource Website
1+ mentions
V-Phaser 2 (RRID:SCR_005212) V-Phaser 2 software resource A software tool to call variants in genetically heterogeneous populations from ultra-deep sequence data. It combines information regarding the covariation (i.e. phasing) between observed variants to increase sensitivity and an expectation maximization algorithm that iteratively recalibrates base quality scores to increase specificity. V-Phaser can reliably detect rare variants in diverse populations that occur at frequencies of <1%. V-Phaser 2 is a complete rewrite of the original V-Phaser. It contains a new model for length polymorphisms (indels) and incorporates paired end read information in its phasing model. The data access and probability computation sections of the code have also been highly optimized, resulting in substantial improvements in running time and memory usage. variant, polymorphism, indel, virus, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: Broad Institute
NIAID PMID:24088188 Free for academic use, Non-commercial, Http://www.broadinstitute.org/scientific-community/science/projects/viral-genomics/viral-genomics-software-license-v-phaser-2 biotools:v-phaser, OMICS_00232 https://bio.tools/v-phaser SCR_005212 2026-02-07 02:07:07 2
RNA-eXpress
 
Resource Report
Resource Website
1+ mentions
RNA-eXpress (RRID:SCR_005167) RNA-eXpress software resource Software designed as a user friendly solution to extract and annotate biologically important transcripts from next generation RNA sequencing data. bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: Monash University; Melbourne; Australia
PMID:23396121 Acknowledgement requested, Non-Profit biotools:rna-express, OMICS_01285 https://bio.tools/rna-express SCR_005167 2026-02-07 02:07:05 5
SAMtools/BCFtools
 
Resource Report
Resource Website
500+ mentions
SAMtools/BCFtools (RRID:SCR_005227) BCFtools software resource Provide various utilities for manipulating alignments in the SAM format, including sorting, merging, indexing and generating alignments in a per-position format. snp, indel, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: SAMTOOLS
DOI:10.1101/090811 biotools:bcftools, OMICS_13458 https://bio.tools/bcftools
https://sources.debian.org/src/bcftools/
SCR_005227 2026-02-07 02:06:37 829
ORMAN
 
Resource Report
Resource Website
1+ mentions
ORMAN (RRID:SCR_005188) ORMAN software resource A software tool for resolving multi-mappings within an RNA-Seq SAM file. bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: SourceForge
PMID:24130305 OMICS_01284, biotools:orman https://bio.tools/orman SCR_005188 ORMAN : Optimal Resolution of Ambiguous RNA-Seq Multi-mappings in the Presence of Novel Isoforms 2026-02-07 02:06:41 4
Knime4Bio
 
Resource Report
Resource Website
1+ mentions
Knime4Bio (RRID:SCR_005376) Knime4Bio software resource A set of custom nodes for the KNIME (The Konstanz Information Miner) graphical workbench, for analysing next-generation sequencing (NGS) data without the requirement of programming skills. node, next-generation sequencing, knime, bioinformatics, workflow, sequencing, flow, data, bam, wig, bed, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: Google Code
PMID:21984761 GNU General Public License, v3 biotools:knime4bio, OMICS_01143 https://bio.tools/knime4bio SCR_005376 Knime4Bio: custom nodes for the interpretation of Next Generation Sequencing data with KNIME 2026-02-07 02:06:46 2
PhenoMan
 
Resource Report
Resource Website
1+ mentions
PhenoMan (RRID:SCR_005249) PhenoMan software resource An interactive software program that integrates phenotypic data exploration, selection, management and quality control using a unified platform for association studies of rare and common variants. phenotype, quality control, statistical genetics, association study, python, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: Google Code
has parent organization: Baylor University; Texas; USA
GNU General Public License, v3 biotools:phenoman, OMICS_00301 https://bio.tools/phenoman SCR_005249 phenoman - Phenotypic data exploration selection management and quality control for association studies of rare and common variants 2026-02-07 02:07:08 1
KGGSeq
 
Resource Report
Resource Website
50+ mentions
KGGSeq (RRID:SCR_005311) KGGSeq software resource A biological Knowledge-based mining platform for Genomic and Genetic studies using Sequence data. The software platform, constituted of bioinformatics and statistical genetics functions, makes use of valuable biologic resources and knowledge for sequencing-based genetic mapping of variants / genes responsible for human diseases / traits. It facilitates geneticists to fish for the genetic determinants of human diseases / traits in the big sea of DNA sequences. KGGSeq has paid attention to downstream analysis of genetic mapping. The framework was implemented to filter and prioritize genetic variants from whole exome sequencing data. genomic, genetic, sequence, mutation, exome sequencing, disease, gene, variant, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
Monogenic disorder, Cancer PMID:22241780 biotools:kggseq, OMICS_02260 https://bio.tools/kggseq SCR_005311 KGGSeq: A biological Knowledge-based mining platform for Genomic and Genetic studies using Sequence data 2026-02-07 02:07:10 53
Scripture
 
Resource Report
Resource Website
10+ mentions
Scripture (RRID:SCR_005269) Scripture software resource Software for transcriptome reconstruction that relies solely on RNA-Seq reads and an assembled genome to build a transcriptome ab initio. The statistical methods to estimate read coverage significance are also applicable to other sequencing data. Scripture also has modules for ChIP-Seq peak calling. transcriptome, rna-seq read, genome sequence, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
is related to: Alt Event Finder
has parent organization: Broad Institute
PMID:20436462 biotools:scripture, OMICS_01265 https://bio.tools/scripture SCR_005269 2026-02-07 02:07:09 11
PeakSeq
 
Resource Report
Resource Website
10+ mentions
PeakSeq (RRID:SCR_005349) PeakSeq software resource A software program for identifying and ranking peak regions in ChIP-Seq experiments. It takes as input, mapped reads from a ChIP-Seq experiment, mapped reads from a control experiment and outputs a file with peak regions ranked with increasing Q-values. bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: Yale University; Connecticut; USA
PMID:19122651 biotools:peakseq, OMICS_00453 https://bio.tools/peakseq SCR_005349 2026-02-07 02:06:45 38
Segemehl
 
Resource Report
Resource Website
10+ mentions
Segemehl (RRID:SCR_005494) Segemehl software resource A software to map short sequencer reads to reference genomes. It is able to detect not only mismatches but also insertions and deletions. Furthermore, it is not limited to a specific read length and is able to mapprimer- or polyadenylation contaminated reads correctly. segemehl implements a matching strategy based on enhanced suffix arrays (ESA). Segemehl now supports the SAM format, reads gziped queries to save both disk and memory space and allows bisulfite sequencing mapping and split read mapping. bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
is related to: ANNOgesic
has parent organization: University of Leipzig; Saxony; Germany
PMID:24512684
PMID:22581174
PMID:19750212
DOI:10.1371/journal.pcbi.1000502
Acknowledgement requested, Free, Public biotools:segemehl, OMICS_00683 https://bio.tools/segemehl
https://sources.debian.org/src/segemehl/
SCR_005494 segemehl - short read mapping with gaps 2026-02-07 02:07:16 45
PASS
 
Resource Report
Resource Website
1000+ mentions
PASS (RRID:SCR_005490) PASS software resource THIS RESOURCE IS NO LONGER IN SERVICE. Documented on October 19, 2020.A program to align short sequences that has been developed with an innovative strategy to perform fast gapped and ungapped alignment onto a reference sequence. It supports several data formats and allows the user to modulate very finely the sensitivity of the alignments. The program is designed to handle huge amounts of short reads generated by ILLUMINA, SOLiD and Roche-454 technology. The optimization of the internal data structure and a filter based on precomputed short-word alignments allow the program to skip false positives in the extension phase, thus reducing the execution time without loss of sensitivity. The final alignment is performed by dynamic programming., THIS RESOURCE IS NO LONGER IN SERVICE. Documented on September 16,2025. bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
is listed by: SoftCite
is related to: PASS-bis
has parent organization: University of Padua; Padua; Italy
PMID:19218350 THIS RESOURCE IS NO LONGER IN SERVICE biotools:pass, OMICS_00673 https://bio.tools/pass SCR_005490 PASS: a program to align short sequences 2026-02-07 02:07:16 2085
Maq
 
Resource Report
Resource Website
50+ mentions
Maq (RRID:SCR_005485) Maq software resource A set of programs that map and assemble fixed-length Solexa/SOLiD reads in a fast and accurate way. command-line, curses/ncurses, opengl, c, c++, perl, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
is listed by: SoftCite
has parent organization: SourceForge
DOI:10.1101/gr.078212.108 GNU General Public License, v2 biotools:maq, OMICS_00668 https://bio.tools/maq
https://sources.debian.org/src/maq/
SCR_005485 mapass2, Mapping and Assembly with Quality, Mapping and Assembly with Qualities, Maq: Mapping and Assembly with Qualities 2026-02-07 02:06:49 68
MOSAIK
 
Resource Report
Resource Website
50+ mentions
MOSAIK (RRID:SCR_005486) MOSAIK software resource A reference-guided assembler comprising of two main modular programs: MosaikBuild and MosaikAligner. MosaikBuild converts various sequence formats into Mosaik?s native read format. MosaikAligner pairwise aligns each read to a specified series of reference sequences and produces BAMs as outputs. At this time, the workflow consists of supplying sequences in FASTA, FASTQ, Illumina Bustard & Gerald, or SRF file formats and producing results in the BAM format. Unlike many current read aligners, MOSAIK produces gapped alignments using the Smith-Waterman algorithm. MOSAIK is written in highly portable C++ and currently targetted for the following platforms: Microsoft Windows, Apple Mac OS X, FreeBSD, and Linux operating systems. Other platforms can easily be supported upon request. MOSAIK is multithreaded. If you have a machine with 8 processors, you can use all 8 processors to align reads faster while using the same memory footprint as when using one processor. MOSAIK supports multiple sequencing technologies. In addition to legacy technologies such as Sanger capillary sequencing, our program supports next generation technologies such as Roche 454, Illumina, AB SOLiD, and experimental support for the Helicos Heliscope. next-generation sequencing, alignment, smith-waterman algorithm, c++, computational biology, reference guided aligner is listed by: OMICtools
is listed by: Debian
is related to: 1000 Genomes: A Deep Catalog of Human Genetic Variation
has parent organization: Google Code
Free, Freely available OMICS_00669 https://sources.debian.org/src/mosaik-aligner/ SCR_005486 mosaik-aligner 2026-02-07 02:06:44 86
ea-utils
 
Resource Report
Resource Website
100+ mentions
ea-utils (RRID:SCR_005553) ea-utils software resource Command-line software tools for processing biological sequencing data. Barcode demultiplexing, adapter trimming, etc. Primarily written to support an Illumina based pipeline - but should work with any FASTQs. bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
DOI:10.2174/1875036201307010001 MIT License OMICS_01041, biotools:ea-utils https://bio.tools/ea-utils
https://sources.debian.org/src/ea-utils/
SCR_005553 ea-utils: FASTQ processing utilities 2026-02-07 02:06:51 280
MethylExtract
 
Resource Report
Resource Website
10+ mentions
MethylExtract (RRID:SCR_005446) MethylExtract software resource A user friendly software tool to generate i) high quality, whole genome methylation maps and ii) to detect sequence variation within the same sample preparation. bisulfite sequencing, methylation map, methylation, sequence variation, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
has parent organization: University of Granada; Granada; Spain
Acknowledgement requested biotools:methylextract, OMICS_00605 https://bio.tools/methylextract SCR_005446 High-Quality methylation maps and SNV calling from BS-Seq experiments 2026-02-07 02:06:43 14
GobyWeb
 
Resource Report
Resource Website
1+ mentions
GobyWeb (RRID:SCR_005443) GobyWeb software resource Web application that facilitates the management and analysis of high-throughput sequencing (HTS) data. In the back-end, it uses the Goby framework, BWA, STAR, Last, GSNAP, Samtools, VCF-tools, along with a cluster of servers to provide rapid alignment and efficient analyses. GobyWeb makes it possible to analyze hundreds of samples in consistent ways without having to use command line tools. GobyWeb provides tools that streamline frequent data analyses for RNA-Seq, Methyl-Seq, RRBS, or DNA-Seq datasets and to enable teams of investigators to share reads and results of analyses. GobyWeb can be extended for new analyses by developing plugins. high-throughput sequencing, gene expression, dna methylation, sequencing, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: Weill Cornell Medical College; New York; USA
PMID:23936070 Acknowledgement requested, GNU Lesser General Public License, v3 OMICS_00601, biotools:gobyweb https://bio.tools/gobyweb SCR_005443 2026-02-07 02:06:47 3
TreQ
 
Resource Report
Resource Website
TreQ (RRID:SCR_005505) TreQ software resource A software read mapper for high-throughput DNA sequencing reads, in particular one to several hundred nucleotides in length, and for large edit distance between sequencing read and match in the reference genome. It can cope particularly well with indels for single-best hit recall of 200nt reads simulated from the human reference genome. TreQ performs best at a running time comparable to BWA at large edit distance settings. bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: SourceForge
has parent organization: Rutgers University; New Jersey; USA
PMID:22962448 GNU General Public License OMICS_00695, biotools:treq https://bio.tools/treq SCR_005505 TreQ: Indel-tolerant Read Mapper 2026-02-07 02:06:44 0
DiProGB
 
Resource Report
Resource Website
1+ mentions
DiProGB (RRID:SCR_005651) DiProGB software resource Genome browser that encodes the genome sequence by physico-chemical dinucleotide properties such as stacking energy, melting temperature or twist angle. Analyses can be performed for the + and ?, as well as for the double strand. genome, browser, bio.tools is listed by: OMICtools
is listed by: bio.tools
is listed by: Debian
is related to: Dinucleotide Property Database
PMID:19605418 Free, Freely available biotools:diprogb, OMICS_00880 https://bio.tools/diprogb SCR_005651 DiProGB - The Dinucleotide Properties Genome Browser, Dinucleotide Properties Genome Browser 2026-02-07 02:07:21 4
DMRforPairs
 
Resource Report
Resource Website
1+ mentions
DMRforPairs (RRID:SCR_005702) software resource Software for identifying differentially methylated regions between unique samples using array based methylation profiles. It allows researchers to compare n greater than or equal to 2 unique samples with regard to their methylation profile. The (pairwise) comparison of n unique single samples distinguishesit from other existing pipelines as these often compare groups of samples in either single CpG locus or region based analysis. DMRforPairs defines regions of interest as genomic ranges with sufficient probes located in close proximity to each other. Probes in one region are optionally annotated to the same functional class(es). Differential methylation is evaluated by comparing the methylation values within each region between individual samples and (if the difference is sufficiently large), testing this difference formally for statistical significance. standalone software, mac os x, unix/linux, windows, r, annotation, dna methylation, differential methylation, microarray, report writing, visualization, bio.tools is listed by: OMICtools
is listed by: Debian
is listed by: bio.tools
has parent organization: Bioconductor
PMID:24884391 GNU General Public License, v2 or greater biotools:dmrforpairs, OMICS_04059 https://bio.tools/dmrforpairs SCR_005702 DMR2+, DMRforPairs: identifying Differentially Methylated Regions between unique samples using array based methylation profiles 2026-02-07 02:06:55 4

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