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https://www.forsyth.org/research/services/

Core offers micro 3D X-ray imaging of small samples in high resolution and provides images and quantitative analyses of internal structures of ex vivo samples without any destructive procedures.Scanco CT40 system allows for visualization, measurement, and quantification of the structure of mineralized specimens. Contrast reagents permit visualization of soft tissue structures such as blood vessels.System creates 3D model from stack of 2D X-ray images taken around single axis of rotation. High-resolution scanner can capture detail at resolution of 6 to 32 microns. Non- destructive nature of this technology allows investigators to carry out complementary analyses of the same sample. There are two dedicated workstations for analyzing microCT data, the SCANCO analysis software or the Amira software package with XImagePAQ extension.

Proper citation: Forsyth Institute Micro Computed Tomography Core Facility (RRID:SCR_021180) Copy   

•   Source: SciCrunch Registry

https://www.colorado.edu/lab/cufemm/

Facility features electron microscopes housed in vibration, static-free, and temperature-controlled environment.

Proper citation: Colorado University at Boulder Facility for Electron Microscopy of Materials Core Facility (RRID:SCR_019306) Copy   

•   Source: SciCrunch Registry

https://www.colorado.edu/facility/mimic/

Facility provides specialized services for assessment of material properties, chemistry and structure across multiple length scales with emphasis on assessment of biological tissues, biomaterials, and biologically inspired systems.

Proper citation: Colorado University at Boulder Materials Instrumentation and Multimodal Imaging Core Facility (RRID:SCR_019307) Copy   

•   Source: SciCrunch Registry

https://www.colorado.edu/sharedinstrumentation/core-facilities/biofrontiers-sequencing-core

Core instruments include Agilent Bioanalyzer 2100 system provides sizing, quantitation and quality control of DNA, RNA and proteins, Illumina MiSeq sequencer, able to sequence prepared Illumina DNA or RNA libraries at low- to mid- output (0.75 to 13 Gbp per run), Illumina NextSeq sequencer capable of sequencing Illumina DNA or RNA libraries, QuantStudio 6 Real-Time PCR uses fluorescence detection method for quantitative and qualitative analysis of nucleic acid sequences including gene expression, regulation and variation, Qubit Fluorimeter 3.0 capable of measuring DNA or RNA concentrations with high accuracy.

Proper citation: Colorado University at Boulder BioFrontiers Next-Gen Sequencing Facility Core Facility (RRID:SCR_019308) Copy   

•   Source: SciCrunch Registry

http://smrc.colorado.edu/facilities/xrd_saxs.html

Provides cutting edge capabilities for probing large lengthscale structures such as polymers, biological macromolecules, meso- and nano-porous materials, and molecular self-assemblies.Techniques that can be applied to study materials include SAXS, GISAXS, WAXS, and GIWAXS. The 30W Xenocs Genix 3D x-ray source and state-of-the-art Dectris Eiger R 1M detector provide an excellent way to probe almost any material of interest. In-situ x-ray studies may be carried out using temperature controlled sample holders in both SAXS and GISAXS modes..

Proper citation: Colorado University at Boulder Soft Materials Research Center X-Ray Diffraction Facility Core Facility (RRID:SCR_019304) Copy   

•   Source: SciCrunch Registry

https://biotech.wisc.edu/age/

Provides services and expertise to unlock genome editing tools to advance your research. Routinely generates new genome edited models, particularly mouse, rats, swine, and cell lines, as well as supports in vivo editing, novel preclinical therapeutic strategies, pooled lentiCRISPR screening, and other applications.

Proper citation: University of Wisconsin-Madison Advanced Genome Editing Laboratory (RRID:SCR_021070) Copy   

•   Source: SciCrunch Registry

https://www.colorado.edu/sharedinstrumentation/core-facilities/flow-cytometry-shared-core

Provides instruments including BD Accuri C6 Cytometer with Automated, multisampler/Flow Cytometer,BDFACSCelesta Flow Cytometer Analyzer,BD FACSAria Fusion Cell Sorter.

Proper citation: Colorado University at Boulder Flow Cytometry Shared Core Facility (RRID:SCR_019309) Copy   

•   Source: SciCrunch Registry

https://web.sas.upenn.edu/electronicshop/

Provides electronic design services and medical device development including Embedded systems (Firmware, Hardware, and Software solutions), Electronic prototype design services,PLM (Product Life-cycle Management) for electronic design. Supports Product Management from concept to final customer deployment. Expertise to make electronic device complete consumer product that can be deployed for mass production,Sustaining and maintenance engineering for electronic products,Consulting services in the areas of CE/FCC compliance, EMI, and ESD for lab products and certain consumer electronics,Troubleshooting and repair of released electronic systems.

Proper citation: University of Pennsylvania Penn Electronic Design Shop Core Facility (RRID:SCR_021107) Copy   

•   Source: SciCrunch Registry

https://fccf.mskcc.org/

Provides advanced instrumentation as well as high level technical and scientific expertise in multi dimensional Flow Cytometry and Cell Sorting, to facilitate science, improve the quality, and advance the scope of MSK research.

Proper citation: Memorial Sloan Kettering Cancer Center Flow Cytometry Core Facility (RRID:SCR_021105) Copy   

•   Source: SciCrunch Registry

https://www.colorado.edu/facility/biomolecular-x-ray-crystallography/

Provides resources for crystallization and structure determination of biological macromolecules and complexes. Supports research in the Department of Biochemistry. We are happy to extend our help to researchers from the broader CU community and to researchers outside the university, if time and availability allow us too.

Proper citation: Colorado University at Boulder Macromolecular X-ray Crystallography Core Facility (RRID:SCR_019310) Copy   

•   Source: SciCrunch Registry

https://medicine.uky.edu/centers/cobre/genetic-technologies-core

Core provides services related to manipulation and delivery of nucleic acids to biological systems. Services include Production and titering of recombinant viral vectors,including Lentiviruses, Adenoviruses, and Adeno associated viruses;Subcloning;Tagging of open reading frames;Development of plasmids and/or RNAs for CRISPR/Cas manipulation;piggyBac transposon delivery systems;Real-time PCR analysis;Recombineering;In vitro transcription; Core maintains stock of plasmids that provide components for building constructs envisioned by investigator and provides consultative services.Provides training opportunities in the technologies described above, either as a for-credit, one semester class or on a project-related, fee-based basis.

Proper citation: University of Kentucky College of Medicine Genetic Technologies Core Facility (RRID:SCR_021285) Copy   

•   Source: SciCrunch Registry

https://cancer.dartmouth.edu/scientists-researchers/mouse-modeling

Supports generation and utilization of genetically modified mice, design and production of genetic constructs with methods including yeast and E.coli recombineering, ES cell targeting (transfection, drug selection, and expansion). Produces transgenic mice: DNA injections into oocytes, ES cell injections into blastocysts.Provides humanized immune system mouse models.Offers start to finish experiment services to assist your many needs, please ask for more info.Other services include animal husbandry, IP and IV injections, blood drawing, necropsy and surgeries- embryo transfers, ovariectomy, vasectomy, tumor removal.

Proper citation: Dartmouth Geisel School of Medicine Mouse Modeling Core Facility (RRID:SCR_021284) Copy   

•   Source: SciCrunch Registry

https://sites.manchester.ac.uk/bioms/

Core offers mass spectrometry services and associated technologies to the University of Manchester and beyond with focus on biological molecules such as proteins and metabolites in proteomics and metabolomics areas.Provides support from experimental design to advanced sample preparation and data processing and interpretation.

Proper citation: University of Manchester BioMS Core Facility (RRID:SCR_020987) Copy   

•   Source: SciCrunch Registry

http://www.rockefeller.edu/ddrc/

Core guides researchers in drug discovery by improving efficiency of their bioassays, identifying compounds and targets of function, and in utilizing technologies for measurement of drug/receptor interactions.Center also has spectroscopic and calorimetric equipment for use in studies of interactions of drugs with their targets.

Proper citation: Rockefeller University Fisher Drug Discovery Core Facility (RRID:SCR_020985) Copy   

•   Source: SciCrunch Registry

http://www.rockefeller.edu/genomics/

Core offers services and instruments to support genomics research. Houses Illumina NovaSeq, NextSeq, MiSeq sequencers, 10X Genomics Chromium Single Cell System, and Life Technologies QuantStudio 12K flex realtime PCR system. Provides several accessory instruments for sample quantity and quality validation: Agilent Bioanalyzer, Agilent TapeStation, NanoDrop spectrophotometer, and Qubit spectrophotometer.Offers full services for genomic DNA-Seq and RNA-Seq, specializing in preparation of libraries from very small amount of starting total RNA. Users can also prepare their own libraries and use the center�s sequencing-only services. Offers free consultations on experimental designs, library preparation options, sequencer choice, sequencing depth and coverage, and biological replicates.Performs initial sequencing data analysis for all users, and can assist with downstream analysis.

Proper citation: Rockefeller University Genomics Resource Center Core Facility (RRID:SCR_020986) Copy   

•   Source: SciCrunch Registry

https://bsp.web.unc.edu/

Centralized, quality controlled facility and biorepository for processing, storage and disbursement of human specimens.Offers high throughput processing of human biospecimens, with specific emphasis on DNA and RNA isolation and purification.Provides laboratory support for investigator initiated large scale clinical, epidemiologic, and other studies.Functions as human specimen biorepository resource for clinicians who wish to store and study samples from unusual or potentially important patients.Biorepository is managed by custom LIMS, with sample accessioning, tracking and audits at each step.Provides scientific resource for investigators seeking advice or consultation on study design including specimen collection and storage methods, and human subject issues. Core staff act as liaison to other UNC core facilities and outside collaborators.

Proper citation: University of North Carolina at Chapel Hill Biospecimen Processing Core Facility (RRID:SCR_021290) Copy   

•   Source: SciCrunch Registry

https://pennstatehealthnews.org/topics/cryo-em/

Cryo-electron microscopy (cryo-EM) facility providesTitan Krios cryo-transmission electron microscope that is fully equipped for high-throughput data collection of the utmost quality possible. It has the ability to determine the atomic structure of a single protein or view molecules interacting in their cellular context. Provides guidance, training or data collection for researchers at the College of Medicine.Equipment includes Zeiss LSM 980 Cryo-Confocal Microscope,300 kV Krios Cryo-TEM for SPA and tomography, Equipped with Volta phase plates, bioquantum energy filter and K3 direct electron detector,200 kV thermionic JEOL 2100 for cryo-imaging, cryo-tomography, and standard imaging of stained grids.

Proper citation: Penn State Hershey College of Medicine cryo-EM Core Facility (RRID:SCR_021178) Copy   

•   Source: SciCrunch Registry

http://dnaseq.med.harvard.edu

Core offers high throughput Sanger sequencing for any number of samples with 24 hour turn around time,PCR cleanups and mini-preps as well as sample prep from colonies or pellets.Provides large plasmid repository with over 300,000 constructs.Provides ORFs from MGC, Yeast, Xenopus, Drosophila, mouse, as well as several many other organisms including bacterial species. Accept deposits.

Proper citation: Harvard Medical School DNA Resource Core Facility (RRID:SCR_021292) Copy   

•   Source: SciCrunch Registry

https://cancer.dartmouth.edu/scientists-researchers/molecular-biology-resource

Genomics Section provides services and instrumentation that enable DNA/RNA extraction and quality control, next-generation Illumina and Nanopore sequencing, epigenetic profiling, and microarray analysis on a whole-genome scale, from the level organisms to single cells. Molecular Biology Section provides DNA fragment analysis qPCR, Sanger sequencing and NanoString Technology.

Proper citation: Dartmouth Genomics and Molecular Biology Shared Resource (GMBSR) (RRID:SCR_021293) Copy   

•   Source: SciCrunch Registry

https://www.unmc.edu/vcr/cores/vcr-cores/compchem/index.html

Core offers wide variety of services, including access to the Schrodinger platform and high-throughput computing. Services include examining molecular structures and mechanisms in atomic detail and provide graphically rich analysis suitable for inclusion in publications and grants.

Proper citation: University of Nebraska Medical Center Computational Chemistry Core Facility (RRID:SCR_021023) Copy   

•   Source: SciCrunch Registry