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URL: http://rgd.mcw.edu/tools/strains/strains_view.cgi?id=14695063
Proper Citation: RRID:RRRC_00752
Description: Rattus norvegicus with name BN.LEW-(D10Rat258 and D10Rat51)/Ssn from RGD.
Species: Rattus norvegicus
Notes: Severe osteopetrosis with numerous non-functioning osteoclasts. Locus on chromosome 10. Homozygotes not fertile, need to test breed to ID heterozygotes. Homozygotes have no teeth, require ground food. One of only 4 osteopetrotic mutations in rat. Genetic lesion is not yet known but mutation is inherited in an autosomal recessive manner. The candidate gene region has been localized to Chr 10 between D10Rat258 and D10Rat51. original background strain is LEW/Ssn. Deposited at Rat Resource and Research Center
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Source: Integrated Animals
Source Database: Rat Resource and Research Center (RRRC)
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