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Proper Citation: RRID:MGI:3768518
Description: Allele Detail: Transgenic This is a legacy resource.
Species: Mus musculus
Notes: Allele Detail: Transgenic This is a legacy resource.
Phenotype: limb grasping, abnormal spatial learning, weight loss, hunched posture, neurofibrillary tangles, paralysis, paresis, premature death, dilated brain ventricles, brain atrophy, abnormal CNS synaptic transmission, tau protein deposits, neurodegeneration, neurofibrillary tangles, paralysis, tau protein deposits, premature death, progressive muscle weakness, hippocampal neuron degeneration, reduced long term potentiation, tau protein deposits, weakness, abnormal spinal cord white matter morphology, abnormal hippocampal mossy fiber morphology, abnormal amygdala morphology, hunched posture, decreased paired-pulse facilitation, loss of hippocampal neurons, hippocampus atrophy, abnormal entorhinal cortex morphology, abnormal excitatory postsynaptic potential, abnormal dentate gyrus morphology, abnormal cerebral cortex morphology, dystrophic muscle, abnormal hippocampus pyramidal cell morphology, decreased hippocampus volume, astrocytosis
Affected Gene: Tg(Prnp-MAPT*P301S)PS19Vle
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Source: Integrated Animals
Source Database: MGI, Mouse Genome Informatics MGI
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