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Proper Citation: Integrated Risk Information System (RRID:SCR_013005)
Description: IRIS is a toxicology data file on the National Library of Medicine''s (NLM) Toxicology Data Network. It contains data in support of human health risk assessment. It is compiled by the U.S. Environmental Protection Agency (EPA) and contains over 500 chemical records. It is a compilation of electronic reports on specific substances found in the environment and their potential to cause human health effects. IRIS was initially developed for EPA staff in response to a growing demand for consistent information on substances for use in risk assessments, decision-making and regulatory activities. The information in IRIS is intended for those without extensive training in toxicology, but with some knowledge of health sciences. The Integrated Risk Information System (IRIS) is an electronic database containing information on human health effects that may result from exposure to various substances in the environment. IRIS is prepared and maintained by the EPAs National Center for Environmental Assessment (NCEA) within the Office of Research and Development (ORD). The heart of the IRIS system is its collection of searchable documents that describe the health effects of individual substances and that contain descriptive and quantitative information in the following categories: -Noncancer effects: Oral reference doses and inhalation reference concentrations (RfDs and RfCs, respectively) for effects known or assumed to be produced through a nonlinear (possibly threshold) mode of action. In most instances, RfDs and RfCs are developed for the noncarcinogenic effects of substances. -Cancer effects: Descriptors that characterize the weight of evidence for human carcinogenicity, oral slope factors, and oral and inhalation unit risks for carcinogenic effects. Where a nonlinear mode of action is established, RfD and RfC values may be used.
Synonyms: IRIS
Resource Type: data or information resource, database
Keywords: effect, environmental, cancer, carcinogenicity, chemical, health, human, inhalation, medicine, noncancer, noncarcinogenic, oral, rfc, rfd, risk, science, substance, toxicology, toxicology databases, FASEB list
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